Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappaB.

abstract：:Cyclin-dependent kinases (cdks) are the catalytic subunits of a large family of serine/threonine protein kinases whose best-characterized members are key regulators of eukaryotic cell cycle progression. They are activated by binding to regulatory subunits generally termed as cyclins. Cdk10 is a cdc2-related kinase tha...

journal_title：Journal of cellular biochemistry

authors： Bagella L,Giacinti C,Simone C,Giordano A

更新日期：2006-10-15 00:00:00

abstract：:Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types, androgen-deprivation insensitive cells exist prior to hormonal manipulation. We established several LNCaP subclones with distinct insensitivities to androgen deprivation from a p...

journal_title：Journal of cellular biochemistry

authors： Terada N,Shiraishi T,Zeng Y,Aw-Yong KM,Mooney SM,Liu Z,Takahashi S,Luo J,Lupold SE,Kulkarni P,Getzenberg RH

更新日期：2014-09-01 00:00:00

abstract：:Fibroblast growth factor-1 (FGF1), a prototypic member of the FGF family, is a potent angiogenic factor. Although FGF-stimulated angiogenesis has been extensively studied, the molecular mechanisms regulating FGF1-induced angiogenesis are poorly understood in vivo. Fumagillin, an antiangiogenic fungal metabolite, has t...

journal_title：Journal of cellular biochemistry

authors： Chen GJ,Weylie B,Hu C,Zhu J,Forough R

更新日期：2007-08-15 00:00:00

abstract：:Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that help...

journal_title：Journal of cellular biochemistry

authors： Upadhyay S,Sharma N,Gupta KB,Dhiman M

更新日期：2018-07-01 00:00:00

abstract：:Primary cultures fill a unique niche among the repertoire of in vitro model systems available to investigate the biology of the normal and malignant human prostate. This review summarizes some of the properties of primary cultures, with special emphasis on two questions: are primary cultures from adenocarcinomas reall...

journal_title：Journal of cellular biochemistry

authors： Peehl DM

更新日期：2004-01-01 00:00:00

abstract：:Cysteine-rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression of Cyr61 is found to be associated with human cancers. Here we show that Cyr61 was up-regulated in prostate c...

journal_title：Journal of cellular biochemistry

authors： Lv H,Fan E,Sun S,Ma X,Zhang X,Han DM,Cong YS

更新日期：2009-03-01 00:00:00

abstract：:Embryonic data and ultrastructural analyses suggest that the primitive endothelium signals undifferentiated mesenchymal cells to migrate to the forming blood vessel and subsequently regulates mural cell growth and behavior. Upon maturation of the blood vessel, chemotactic and mitogenic signals are apparently diminishe...

journal_title：Journal of cellular biochemistry

authors： Dodge AB,Lu X,D'Amore PA

更新日期：1993-09-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) can modulate the signalling capacity of tyrosine kinase receptors; in particular, TNF-alpha has been shown to mediate the insulin resistance associated with animal models of obesity and noninsulin-dependent diabetes mellitus. In order to determine whether the effects of TNF-alph...

journal_title：Journal of cellular biochemistry

authors： Ahmad F,Goldstein BJ

更新日期：1997-01-01 00:00:00

abstract：:Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer molecules. N-end rule pathway has been shown to be involved...

journal_title：Journal of cellular biochemistry

authors： Pore SK,Ganguly A,Sau S,Godeshala S,Kanugula AK,Ummanni R,Kotamraju S,Banerjee R

更新日期：2020-01-01 00:00:00

abstract：:Herbal plants are enriched with compounds with a wide range of biological activities. Furanodiene is a sesquiterpene isolated from Rhizoma Curcumae. Growing evidence shows furanodiene exhibits diversified activities of hepatoprotection, anti-inflammation, anti-angiogenesis, and anti-tumor. However, its biological acti...

journal_title：Journal of cellular biochemistry

authors： Zhong ZF,Li YB,Wang SP,Tan W,Chen XP,Chen MW,Wang YT

更新日期：2012-08-01 00:00:00

abstract：:Stimulation of osteoblast survival signals may be an important mechanism of regulating bone anabolism. Protein kinase B (PKB/Akt), a serine-threonine protein kinase, is a critical regulator of normal cell growth, cell cycle progression, and cell survival. In this study we have investigated the signaling pathways activ...

journal_title：Journal of cellular biochemistry

authors： Chaudhary LR,Hruska KA

更新日期：2001-03-26 00:00:00

abstract：:Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Defects in this mechanism correlate with severe obstetric complications as implantation failure and preeclampsia. Lysophosphatidic acid (LPA) participates in embr...

journal_title：Journal of cellular biochemistry

authors： Beltrame JS,Sordelli MS,Cañumil VA,Franchi AM,Ribeiro ML

更新日期：2018-01-01 00:00:00

abstract：:Circular RNA (circRNA) is a new noncoding RNAs and plays an important role in many pathological processes. Recently, studies have shown that circular RNA_PRKCI (circ-PRKCI) regulates cell proliferation and cell migration of tumor cells. Esophageal carcinoma is a highly malignant digestive tract tumor, which is divided...

journal_title：Journal of cellular biochemistry

authors： Shi N,Shan B,Gu B,Song Y,Chu H,Qian L

更新日期：2019-06-01 00:00:00

abstract：:To evaluate the diagnosis and prognosis of the tumor microenvironment (immunization and stromal cells) in kidney renal clear cell carcinoma (KIRC), KIRC cases selected from The Cancer Genome Atlas database were divided into two groups according to the ESTIMATE algorithm-derived immune scores. Our data suggested that t...

journal_title：Journal of cellular biochemistry

authors： Li S,Xu W

更新日期：2019-11-07 00:00:00

abstract：:Lung cancer (LC) is the second common cancer for both women and men all over the world. Unfortunately, the number of LC deaths is increasing rapidly each year so early diagnosis of LC can be lifesaving. MicroRNAs are involved in multiple processes, such as cell differentiation, transcription, inflammation, proliferati...

journal_title：Journal of cellular biochemistry

authors： Asghariazar V,Sakhinia E,Mansoori B,Mohammadi A,Baradaran B

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation between serum protein level of insulin growth factor 1 (IGF-1) and the degree of liver fibrosis in patients with chronic hepatitis C (CHC) combined with type 2 diabetes mellitus (T2DM). METHODS:The cases are divided into four groups. Then serum levels of IFG-1, alanine aminotra...

journal_title：Journal of cellular biochemistry

authors： Cao LH,Lu FM,Lu XJ,Zhu LY

更新日期：2018-11-01 00:00:00

abstract：:In response to tissue injury connective tissue synthesis occurs either normally or abnormally, which is mediated by transforming growth factor-beta (TGF-beta) and other growth factors. This article will be primarily concerned with the response of injured tissues at the gene level of Type I procollagen synthesis in res...

journal_title：Journal of cellular biochemistry

authors： Cutroneo KR

更新日期：2003-09-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a serious complication of diabetes contributing to blindness in patients. Inhibiting retinal neovascularization is a potent strategy for diabetic retinopathy treatment. Reportedly, the stable expression of lin-28 homolog B (LIN28B), a member of the highly conserved RNA-binding protein LIN2...

journal_title：Journal of cellular biochemistry

authors： Fu X,Ou B

更新日期：2020-02-01 00:00:00

abstract：:3,6-Anhydro-l-galactose (l-AHG) is a bioactive sugar that is a major component of agarose. Recently, l-AHG was reported to have anti-melanogenic potential in human epidermal melanocytes (HEMs) and B16F10 melanoma cells; however, its underlying molecular mechanisms remain unknown. At noncytotoxic concentrations, l-AHG ...

journal_title：Journal of cellular biochemistry

authors： Kim JH,Kim DH,Cho KM,Kim KH,Kang NJ

更新日期：2018-09-01 00:00:00

abstract：:lncRNAs are responsible for a variety of diseases, including gastric cancer (GC). Many recent studies have reported that lncRNAs can serve as crucial regulators of various genes. Nevertheless, the biological function of lncRNA damage induced noncoding (DINO) remained poorly investigated in GC. Therefore, in our presen...

journal_title：Journal of cellular biochemistry

authors： Liu Q,Xiao Y,Cai P,Li J,Li D

更新日期：2019-02-18 00:00:00

abstract：:The vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors that controls mineral ion homeostatis and has potential tumor-suppressive functions for various cancer types, specifically prostate cancer. A VDR ablated transgenic animal model (VDDRII, vitamin D-dependent ricke...

journal_title：Journal of cellular biochemistry

authors： Guzey M,Jukic D,Arlotti J,Acquafondata M,Dhir R,Getzenberg RH

更新日期：2004-09-01 00:00:00

abstract：:The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the c...

journal_title：Journal of cellular biochemistry

authors： Fofie CK,Katekhaye S,Borse S,Sharma V,Nivsarkar M,Nguelefack-Mbuyo EP,Kamanyi A,Singh V,Nguelefack TB

更新日期：2019-02-14 00:00:00

abstract：:Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. I...

journal_title：Journal of cellular biochemistry

authors： Nie YQ,Cao J,Zhou YJ,Liang X,Du YL,Wan YJ,Li YY

更新日期：2014-05-01 00:00:00

abstract：:Connexin43 (Cx43) forms gap junctions that mediate intercellular communication between osteoblasts. We have examined the effects of prostaglandin E2 (PGE2) and parathyroid hormone (PTH) on gap junctional communication in the rat osteogenic sarcoma cells UMR 106-01. Incubation with either PGE2 or PTH rapidly (within 30...

journal_title：Journal of cellular biochemistry

authors： Civitelli R,Ziambaras K,Warlow PM,Lecanda F,Nelson T,Harley J,Atal N,Beyer EC,Steinberg TH

更新日期：1998-01-01 00:00:00

abstract：:Relatively little is known about the spatial organization of RNA synthesis, processing, and transport in (mammalian) cell nuclei. This review summarizes results of electron microscopic mapping of RNA synthetic sites and macromolecules involved directly, or indirectly, in the metabolism of RNAs in somatic cell mammalia...

journal_title：Journal of cellular biochemistry

authors： Raska I

更新日期：1995-09-01 00:00:00

abstract：:Mouse strains which develop tumors at a high incidence with characteristics very similar to human cancers have been derived over the last 8 years. The tumors are caused by defined genetic alterations in the mouse genome. Three areas of research have contributed to the derivation of these mouse strains: (1) Molecular a...

journal_title：Journal of cellular biochemistry

authors： Groner B

更新日期：1992-06-01 00:00:00

abstract：:The PML protein and PML nuclear bodies (PML-NB) are implicated in multiple cellular functions relevant to tumor suppression, including DNA damage response. In most cases of acute promyelocytic leukemia, the PML and retinoic acid receptor alpha (RARA) genes are translocated, resulting in expression of oncogenic PML-RAR...

journal_title：Journal of cellular biochemistry

authors： Yeung PL,Denissova NG,Nasello C,Hakhverdyan Z,Chen JD,Brenneman MA

更新日期：2012-05-01 00:00:00

abstract：:Regulation of cytoplasmic free calcium concentration [Ca(2+)]i is a key factor for the maintenance of cellular homeostasis in different cell types, including lymphocytes. During T lymphocyte activation as well as production of cytokines, sustained Ca(2+) influx is essential, however, it remains unclear how this influx...

journal_title：Journal of cellular biochemistry

authors： Tomilin VN,Cherezova AL,Negulyaev YA,Semenova SB

更新日期：2016-01-01 00:00:00

abstract：:Recombinant human apolipoprotein E3 (apoE), purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor cells in a dose- and time-dependent manner. ApoE inhibited both de novo DNA synthesis and proliferation as assessed by an increase in cell number. Maximal inhibiti...

journal_title：Journal of cellular biochemistry

authors： Vogel T,Guo NH,Guy R,Drezlich N,Krutzsch HC,Blake DA,Panet A,Roberts DD

更新日期：1994-03-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by bone and exerts its function in the target organs by binding the FGF receptor (FGFR) and Klotho. Since recent studies suggested that extracellular inorganic phosphate (Pi) itself triggers signal transduction and regulates gene expression in some...

journal_title：Journal of cellular biochemistry

authors： Yamazaki M,Ozono K,Okada T,Tachikawa K,Kondou H,Ohata Y,Michigami T

更新日期：2010-12-01 00:00:00