miR-152/LIN28B axis modulates high-glucose-induced angiogenesis in human retinal endothelial cells via VEGF signaling.

abstract：:Platelets, which play a central role in thrombosis and hemostasis, develop from megakaryocytes. Signal transduction originated from the megakaryocyte growth and development factor, the Mpl ligand, which leads to megakaryocyte differentiation, polyploidization, and maturation, has been gradually characterized. In this ...

journal_title：Journal of cellular biochemistry

authors： Sun S,Ravid K

更新日期：1999-11-01 00:00:00

abstract：:Occupational exposure to nickel has been epidemiologically linked to increased cancer risk in the respiratory tract. Nickel-induced cell transformation is associated with both genotoxic and epigenetic mechanisms that are poorly understood. Prolidase [E.C.3.4.13.9] is a cytosolic Mn(II)-activated metalloproteinase that...

journal_title：Journal of cellular biochemistry

authors： Miltyk W,Surazynski A,Kasprzak KS,Fivash MJ Jr,Buzard GS,Phang JM

更新日期：2005-04-15 00:00:00

abstract：:Bone formation is under the control of a set of transcription factors. Ids are inhibitory helix-loop-helix (HLH) transcription factors and expression of Id genes in osteoblasts is under the control of calciotropic agents such as BMP and vitamin D. However, the function of Ids during bone formation in vivo has not yet ...

journal_title：Journal of cellular biochemistry

authors： Maeda Y,Tsuji K,Nifuji A,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α-modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expre...

journal_title：Journal of cellular biochemistry

authors： Liang Y,Zhang T,Shi M,Zhang S,Guo Y,Gao J,Yang X

更新日期：2019-04-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postnatal growth plate (G...

journal_title：Journal of cellular biochemistry

authors： Wu LN,Lu M,Genge BR,Guo GY,Nie D,Wuthier RE

更新日期：2002-01-01 00:00:00

abstract：:Chemotherapy drug resistance frequently happens in more than 50% of bladder cancer patients and is the major obstacle for the bladder cancer therapy. Recent studies have shown that long noncoding RNA (lncRNA) is involved in the development of chemoresistance. In this study, we reported hypoxia inducible factor 1α-anti...

journal_title：Journal of cellular biochemistry

authors： Chen X,Liu M,Meng F,Sun B,Jin X,Jia C

更新日期：2019-01-01 00:00:00

abstract：:Large osteoclasts (>or=10 nuclei) predominate at sites of pathological bone resorption. We hypothesized this was related to increased resorptive activity of large osteoclasts and have demonstrated previously that larger osteoclasts are 8-fold more likely to be resorbing than small osteoclasts (2-5 nuclei). Here we ask...

journal_title：Journal of cellular biochemistry

authors： Trebec DP,Chandra D,Gramoun A,Li K,Heersche JN,Manolson MF

更新日期：2007-05-01 00:00:00

abstract：:Osteosarcoma (OS) is the most malignant primary bone tumor in children and adolescents with limited treatment options and poor prognosis. Recently, aberrant expression of Runx2 has been found in OS, thereby contributing to the development, and progression of OS. However, the upstream signaling molecules that regulate ...

journal_title：Journal of cellular biochemistry

authors： Liang GH,Liu N,He MT,Yang J,Liang ZJ,Gao XJ,Rahhal AH,He QY,Zhang HT,Zha ZG

更新日期：2018-01-01 00:00:00

abstract：:We examined the mRNA expression of scleraxis, a non-myogenic helix-loop-helix type transcription factor in C2C12 myogenic cells. Scleraxis mRNA has been shown to be expressed in sclerotome and perichondrium of the embryos. We found that C2C12 cells express 1.2 kb scleraxis mRNA constitutively. Since BMP was reported t...

journal_title：Journal of cellular biochemistry

authors： Liu Y,Nifuji A,Tamura M,Wozney JM,Olson EN,Noda M

更新日期：1997-10-01 00:00:00

abstract：:Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting. Androgen independent prostate cancer cell lines DU145 and PC3 have constitutive expression of CYP1A and CYP1A1 and CYP1A2, respectively. Four microm...

journal_title：Journal of cellular biochemistry

authors： Sterling KM Jr,Cutroneo KR

更新日期：2004-02-01 00:00:00

abstract：:Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expre...

journal_title：Journal of cellular biochemistry

authors： Zhuang B,Hu Y,Fan X,Li M,Zhu J,Liu H,Cao L,Liang D,Zhang J,Yu Z,Han S

更新日期：2018-01-01 00:00:00

abstract：:MUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression. In this study, qRT-PCR screening of mouse tissues determined that Muc4 mRNA also was robustly expressed in mouse ...

journal_title：Journal of cellular biochemistry

authors： Chapela PJ,Broaddus RR,Hawkins SM,Lessey BA,Carson DD

更新日期：2015-11-01 00:00:00

abstract：:The effect of regucalcin, which is a regulatory protein of Ca(2+) signaling, on Ca(2+)-ATPase activity in isolated rat renal cortex mitochondria was investigated. The presence of regucalcin (50, 100, and 250 nM) in the enzyme reaction mixture led to a significant increase in Ca(2+)-ATPase activity. Regucalcin signific...

journal_title：Journal of cellular biochemistry

authors： Xue JH,Takahashi H,Yamaguchi M

更新日期：2000-10-20 00:00:00

abstract：:Cholangiocarcinoma (CCA) is devastating for its delayed presence, difficulty in diagnosis, and high mortality. Other studies have supported the important role of microRNAs (miRNAs) in the pathogenesis of CCA, and the role of miR-194 was investigated in several human cancers, though, the molecular mechanism of miR-194 ...

journal_title：Journal of cellular biochemistry

authors： Gao J,Dai C,Yu X,Yin XB,Zhou F

更新日期：2020-10-01 00:00:00

abstract：:Previously, we reported that anti-apoptotic Bfl-1 is converted to a pro-apoptotic protein following fusion at its N-terminus with green fluorescent protein (GFP) (GFP-Bfl-1). In this study, we performed a Bfl-1 deletion study in order to elucidate the underlying mechanism of GFP-Bfl-1-induced cell death. We found that...

journal_title：Journal of cellular biochemistry

authors： Yang WS,Ko JK,Park SO,Choi HY,Kim YN,Kim CW

更新日期：2005-04-15 00:00:00

abstract：:Inflammation in vascular (mostly arterial) walls and heart valves triggered by the trans-endothelial influx of LDL particles and the action of subsequently modified (e.g., by oxidation) LDL particles can trigger true bone formation by valvar fibroblasts, by a subpopulation of re-differentiation-competent VSMCs (vascul...

journal_title：Journal of cellular biochemistry

authors： Whitfield JF

更新日期：2005-06-01 00:00:00

abstract：:Individual protein kinase C (PKC) isoforms fulfill distinct roles in the regulation of the commitment to differentiation, cell cycle arrest, and apoptosis in both monocytes and T-cells. The human monocyte like cell line U937 and T-cells were exposed to microgravity, during spaceflight and the translocation (a critical...

journal_title：Journal of cellular biochemistry

authors： Hatton JP,Gaubert F,Cazenave JP,Schmitt D

更新日期：2002-01-01 00:00:00

abstract：:Sexual differences on thyroxin 5'-deiodinase (5'-D) in the Harderian gland of Syrian hamsters were investigated. We compared the 24-h profile of 5'-D activity in male and female hamsters, observing a clear rhythm in males but not in females. Female values were always significantly higher than male ones. After pinealec...

journal_title：Journal of cellular biochemistry

authors： Rubio A,Menendez-Pelaez A,Buzzell GR,Vaughan MK,Vaughan GM,Reiter RJ

更新日期：1996-09-01 00:00:00

abstract：:The bone marrow provides a protective environment for acute myeloid leukemia (AML) cells that often allows leukemic stem cells to survive standard chemotherapeutic regimens. Targeting these leukemic stem cells within the bone marrow is critical for preventing relapse. We recently demonstrated that SDF-1, a chemokine a...

journal_title：Journal of cellular biochemistry

authors： Kremer KN,Dudakovic A,McGee-Lawrence ME,Philips RL,Hess AD,Smith BD,van Wijnen AJ,Karp JE,Kaufmann SH,Westendorf JJ,Hedin KE

更新日期：2014-06-01 00:00:00

abstract：:Breast cancer cells preferentially metastasize to bone, leading to the formation of primarily osteolytic lesions. Osteoprotegerin (OPG) plays multifactorial roles in the development of osteolytic bone metastases. An increase in the ratio of receptor activator of nuclear factor kappaB ligand (RANKL) to OPG increases os...

journal_title：Journal of cellular biochemistry

authors： Kapoor P,Suva LJ,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:Previously, we have reported that inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels by glibenclamide induced intracellular Ca2+ release from IP(3)-sensitive stores and apoptosis in HepG2 human hepatoblastoma cells (Kim JA, Kang YS, Lee SH, Lee EH, Yoo BH, Lee YS. 1999. Biochem Bioph...

journal_title：Journal of cellular biochemistry

authors： Kim JA,Kang YS,Lee SH,Lee EH,Lee YS

更新日期：2001-01-01 00:00:00

abstract：:Phosphoinositides (PIs) and proteins involved in the PI signaling pathway are distributed in the nucleus as well as at the plasma membrane and in the cytoplasm, although their nuclear localization mechanisms have not been clarified in detail. Generally, proteins that shuttle between the cytoplasm and nucleus contain n...

journal_title：Journal of cellular biochemistry

authors： Yagisawa H

更新日期：2006-02-01 00:00:00

abstract：:Fracture repair is a complex process involving timed cellular recruitment, gene expression, and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, and thus function of injured bone. While the majority of fractures heal without complication, this takes time and a subset of patient...

journal_title：Journal of cellular biochemistry

authors： Komatsu DE,Warden SJ

更新日期：2010-02-01 00:00:00

abstract：:Undecylenic acid (UDA), a naturally occurring 11-carbon unsaturated fatty acid, has been used for several years as an economical antifungal agent and a nutritional supplement. Recently, the potential usefulness of UDA as a neuroprotective drug has been suggested based on the ability of this agent to inhibit μ-calpain ...

journal_title：Journal of cellular biochemistry

authors： Jantas D,Piotrowski M,Lason W

更新日期：2015-12-01 00:00:00

abstract：:Glomerular podocytes are the major components of the renal filtration barrier, and altered podocyte permselectivity is a key event in the pathogenesis of proteinuric conditions. Clinical conditions such as ischemia and sleep apnea and extreme physiological conditions such as high-altitude sickness are presented with r...

journal_title：Journal of cellular biochemistry

authors： Nakuluri K,Mukhi D,Mungamuri SK,Pasupulati AK

更新日期：2018-11-01 00:00:00

abstract：:Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic humans and animals. We recently reported that, targeted deletion of insulin receptor (IR) from proximal tubules (PT) resulted in hyperglycemia in non-obese mice. To elucidate the mechanism, we examined human proximal tubule c...

journal_title：Journal of cellular biochemistry

authors： Pandey G,Shankar K,Makhija E,Gaikwad A,Ecelbarger C,Mandhani A,Srivastava A,Tiwari S

更新日期：2017-02-01 00:00:00

abstract：:Astrocytes, the major glial population in the central nervous system (CNS), can secrete thrombospondin (TSP)-1 that plays the role in synaptogenesis and axonal sprouting during CNS development and tissue repair. However, little is known about the regulation of TSP-1 expression in astrocytes under oxidative stress cond...

journal_title：Journal of cellular biochemistry

authors： Chen JK,Zhan YJ,Yang CS,Tzeng SF

更新日期：2011-01-01 00:00:00

abstract：:X-ray atomic structure of recombinant Hell's gate globin I (HGbI) from Methylacidophilum infernorum was calculated from the X-ray diffraction data of two different types of crystals: obtained by classical hanging drop and by LB nanotemplate method under the same crystallization conditions. After the accurate compariso...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Scudieri D,Belmonte L,Nicolini C

更新日期：2012-07-01 00:00:00

abstract：:The role of regucalcin in the regulation of osteoblastic cell function was investigated. Osteoblastic MC3T3-E1 cells with subconfluent monolayers were cultured in a medium containing regucalcin (10(-10)-10(-8) M) without fetal bovine serum (FBS). The proliferation of osteoblastic cells was not significantly altered in...

journal_title：Journal of cellular biochemistry

authors： Yamaguchi M,Kobayashi M,Uchiyama S

更新日期：2005-10-15 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00