The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells.

abstract：:Vascular pathologies induced by ischemia/reperfusion involve the production of reactive oxygen species (ROS) that in part cause tissue injury. The production of ROS that occurs upon reperfusion activates specific second messenger pathways. In diabetic retinopathy there is a characteristic loss of the microvascular per...

journal_title：Journal of cellular biochemistry

authors： Shojaee N,Patton WF,Hechtman HB,Shepro D

更新日期：1999-10-01 00:00:00

abstract：:Bovine calf articular chondrocytes, either primary or expanded in monolayers (2D) with or without 5 ng/ml fibroblast growth factor-2 (FGF-2), were cultured on three-dimensional (3D) biodegradable polyglycolic acid (PGA) scaffolds with or without 10 ng/ml bone morphogenetic protein-2 (BMP-2). Chondrocytes expanded with...

journal_title：Journal of cellular biochemistry

authors： Martin I,Suetterlin R,Baschong W,Heberer M,Vunjak-Novakovic G,Freed LE

更新日期：2001-06-26 00:00:00

abstract：:Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α-modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expre...

journal_title：Journal of cellular biochemistry

authors： Liang Y,Zhang T,Shi M,Zhang S,Guo Y,Gao J,Yang X

更新日期：2019-04-01 00:00:00

abstract：:TNF-a is an important cytokine mediator of inflammation which suggests that inhibition of TNF activity may provide potential for clinical application. Recent data indicated that treatment of both human and mouse cells with Kavain significantly modulates P. gingivalis- and LPS-induced TNF-α expression. In order to obta...

journal_title：Journal of cellular biochemistry

authors： Tang X,Alasiri M,Bamashmous A,Aljahdali B,Cao F,Dibart S,Salih E

更新日期：2018-07-01 00:00:00

abstract：:Pancreatic beta-cells metabolise both lipid and glucose nutrients but chronic exposure (>24 h) to elevated fatty acid (FA) concentrations results in deleterious metabolic and morphological changes. The aims of this study were to assess the adaptive morphological, metabolic and secretory responses of islet beta-cells t...

journal_title：Journal of cellular biochemistry

authors： Pinnick K,Neville M,Clark A,Fielding B

更新日期：2010-03-01 00:00:00

abstract：:Glioblastoma is one of the most malignant cancers, with a distinguishing dismal prognosis: surgery followed by chemo- and radiotherapy represents the current standard of care, and chemo- and radioresistance underlie disease recurrence and short overall survival of patients suffering from this malignancy. ATM is a kina...

journal_title：Journal of cellular biochemistry

authors： Romano FJ,Guadagno E,Solari D,Borrelli G,Pignatiello S,Cappabianca P,Del Basso De Caro M

更新日期：2018-06-01 00:00:00

abstract：:Icb-1 is a human gene previously described by our group to exert important functions in cancer cells of different origin. We now performed microarray-based gene expression profiling with subsequent network modeling to further elucidate the role of icb-1 in breast cancer cells. Analyzing the effect of icb-1 knockdown o...

journal_title：Journal of cellular biochemistry

authors： Treeck O,Belgutay D,Häring J,Schüler S,Lattrich C,Ortmann O

更新日期：2012-09-01 00:00:00

abstract：:Myopia has become a major public health issue worldwide. Identification of genetic loci related to myopia in young children may advance our knowledge of the pathogenesis of myopia. Fibroblast growth factor 10 (FGF10) plays essential roles for the development of myopia through modulating extracellular matrix-associated...

journal_title：Journal of cellular biochemistry

authors： Sun W,Li Y,Li J,Zhang X,Feng Q,Zhang Z,Kang J,Huang X

更新日期：2019-09-01 00:00:00

abstract：:The role of circular RNAs (circRNAs) in regulating cartilage homeostasis in osteoarthritis (OA) has been reported. However, the regulatory mechanisms of circRNAs in OA synovium remains basically unidentified. The current study intended to divulge the expression profile of circRNAs in OA synovium and investigate the po...

journal_title：Journal of cellular biochemistry

authors： Xiang S,Li Z,Bian Y,Weng X

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) has a high morbidity and mortality around the world, yet the effective therapeutic option for HCC is still limited. NPAC, also known as glyoxylate reductase 1 homolog, is a new nuclear protein recently implicated in tumor biology. However, the role of NPAC in HCC remains unclear...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Sun N,Guo W,Wu X,Yang X,Jin H,Zhang Y,Wu X,Zhang F,Hu L,Hu H,Gao Y

更新日期：2018-11-26 00:00:00

abstract：:Curcumin, the active component of the spice turmeric, induce global DNA hypomethylation as it has been shown to inhibit DNA methyltransferases. It promotes cell death in cancer cells by arresting in the G1 phase. It was explained to cause increased expression of cell cycle regulator, p21 (WAF1/Cip1); however, the mech...

journal_title：Journal of cellular biochemistry

authors： Chatterjee B,Ghosh K,Kanade SR

更新日期：2019-01-01 00:00:00

abstract：:CD19+ CD24hi CD38hi cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19+ CD24hi CD38hi cells. Changes in B-cell subpopulations and CD19+ CD24hi CD38hi cells have been observed in systemic lupus erythematosus (SLE) patients. Whether...

journal_title：Journal of cellular biochemistry

authors： Wang H,Liu C,Chen W,Ding G

更新日期：2019-02-16 00:00:00

abstract：:Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largel...

journal_title：Journal of cellular biochemistry

authors： Sui J,Liu Q,Zhang H,Kong Y

更新日期：2019-06-01 00:00:00

abstract：:Primary cultures fill a unique niche among the repertoire of in vitro model systems available to investigate the biology of the normal and malignant human prostate. This review summarizes some of the properties of primary cultures, with special emphasis on two questions: are primary cultures from adenocarcinomas reall...

journal_title：Journal of cellular biochemistry

authors： Peehl DM

更新日期：2004-01-01 00:00:00

abstract：:Diclofenac is the most commonly used phenylacetic acid derivative non-steroidal anti-inflammatory drug (NSAID) that demonstrates significant analgesic, antipyretic, and anti-inflammatory effects. Several epidemiological studies have demonstrated anti-proliferative activity of NSAIDs and examined their apoptotic induct...

journal_title：Journal of cellular biochemistry

authors： Amanullah A,Upadhyay A,Chhangani D,Joshi V,Mishra R,Yamanaka K,Mishra A

更新日期：2017-05-01 00:00:00

abstract：:Exposure of cells to ionizing radiation (IR) determines cellular lesions, such as DNA and membrane damage, which involve a coordinate network of signal transduction pathways responsible for resistance to or delay of apoptosis, depending on cell type and administered dose. Since, after IR exposure, the apoptotic profil...

journal_title：Journal of cellular biochemistry

authors： Cataldi A,Rapino M,Centurione L,Sabatini N,Grifone G,Garaci F,Rana R

更新日期：2003-08-01 00:00:00

abstract：:Many cases of acute myelogenous leukemia (AML) are characterized by non-random chromosomal translocations that fuse a DNA-binding protein with a transcriptional regulator, which in turn may aberrantly recruit a co-repressor complex. The similarities in this pattern between different AML chimeric fusions have led to a ...

journal_title：Journal of cellular biochemistry

authors： Redner RL,Liu JM

更新日期：2005-04-01 00:00:00

abstract：:The retinal pigmented epithelium (RPE) is a monolayer of polarized cells located between retinal photoreceptors and blood vessels of the choroid. The basal surface of RPE cells rests on Bruch's membrane, a complex extracellular matrix structure which becomes abnormal in several disease processes, including age-related...

journal_title：Journal of cellular biochemistry

authors： Mousa SA,Lorelli W,Campochiaro PA

更新日期：1999-07-01 00:00:00

abstract：:ZC3H12D belongs to a recently discovered family of proteins containing four members of which the most studied and best described is the RNase ZC3H12A (MCPIP1/Regnase-1). ZC3H12A is a crucial negative regulator of inflammation. It accelerates the turnover of transcripts of a spectrum of proinflammatory cytokines, as we...

journal_title：Journal of cellular biochemistry

authors： Wawro M,Kochan J,Krzanik S,Jura J,Kasza A

更新日期：2017-03-01 00:00:00

abstract：:Skeletal muscle atrophy is a well-known adverse effect of chronic treatment with glucocorticoids and it also occurs when stress conditions such as sepsis and cachexia increase the release of endogenous glucocorticoids. Although the mechanisms of action of these hormones have been elucidated, the possible molecular mec...

journal_title：Journal of cellular biochemistry

authors： Massaccesi L,Goi G,Tringali C,Barassi A,Venerando B,Papini N

更新日期：2016-08-01 00:00:00

abstract：:Although effective for the treatment of hematological malignancies, the FDA approved proteasome inhibitors bortezomib and carfilzomib have limited efficacy in solid tumors including triple negative breast cancer (TNBC). Chemotherapy is the only option for treating TNBC due to the absence of specific therapeutic target...

journal_title：Journal of cellular biochemistry

authors： Deshmukh RR,Kim S,Elghoul Y,Dou QP

更新日期：2017-05-01 00:00:00

abstract：:Cumulating evidence has led to the idea that nuclear functions such as DNA replication, RNA transcription, RNA splicing and nucleocytoplasmic transport are facilitated by a proteinaceous architectural framework within the nuclear compartment and at the nuclear envelope. In the present study, we have used immunofluores...

journal_title：Journal of cellular biochemistry

authors： Haddad N,Paulin-Levasseur M

更新日期：2008-12-15 00:00:00

abstract：:To determine the role of thrombin high-affinity receptor occupancy and enzymic activity in thrombin initiation of cell proliferation, we have utilized thrombin derivatives which separate these functions. We previously showed that enzymically active gamma-thrombin stimulates ion fluxes without binding to high-affinity ...

journal_title：Journal of cellular biochemistry

authors： Carney DH,Stiernberg J,Fenton JW 2nd

更新日期：1984-01-01 00:00:00

abstract：:The activity of membrane-bound alkaline phosphatase (ALP) expressed on the external surface of cultured murine P19 teratocarcinoma and human HL-60 myeloblastic leukemia cells was studied at physiological pH using p-nitrophenylphosphate (pNPP) as substrate. The rate of substrate hydrolysis catalyzed by intact viable ce...

journal_title：Journal of cellular biochemistry

authors： Scheibe RJ,Kuehl H,Krautwald S,Meissner JD,Mueller WH

更新日期：2000-01-01 00:00:00

abstract：:The basement membrane (BM) protein laminin-332 (Lm332) (laminin-5) has unique activity and structure as compared with other laminins: it strongly promotes cellular adhesion and migration, and its alpha3, beta3, and gamma2 chains are all truncated in their N-terminal regions (short arms). In the present study, we inves...

journal_title：Journal of cellular biochemistry

authors： Nakashima Y,Kariya Y,Miyazaki K

更新日期：2007-02-15 00:00:00

abstract：:As an aggressive breast cancer (BCa) subtype, triple-negative breast cancer (TNBC) responses poorly to chemotherapy and endocrine therapy, and usually has a worse prognosis. This is largely due to the lack of specific therapeutic targets, laying claim to an imperious demand to clarify the key signaling pathways potent...

journal_title：Journal of cellular biochemistry

authors： Tang X,Zhou Y,Liu Y,Zhang W,Liu C,Yan C

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population. METHODS:In this study, 232 patients were divided into the SCA group and the coronary disease group with c...

journal_title：Journal of cellular biochemistry

authors： Liu A,Wang S,Zhang C,Sun D,Song X

更新日期：2019-03-01 00:00:00

abstract：:Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β-cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross-talk between these cells. To elucidate the influence of PSCs on β-cell function, mouse PSCs wer...

journal_title：Journal of cellular biochemistry

authors： Bynigeri RR,Mitnala S,Talukdar R,Singh SS,Duvvuru NR

更新日期：2020-01-01 00:00:00

abstract：:The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental role during proliferation and adipogenic induction of preadipocytes. Using 3T3-L1 cells as model, we de...

journal_title：Journal of cellular biochemistry

authors： Pagano E,Coso O,Calvo JC

更新日期：2008-05-01 00:00:00

abstract：:Osteoclasts are macrophage-derived polykaryons that degrade bone in an acidic extracellular space. This differentiation includes expression of proteinases and acid transport proteins, cell fusion, and bone attachment, but the sequence of events is unclear. We studied two proteins expressed at high levels only in the o...

journal_title：Journal of cellular biochemistry

authors： Blair HC,Sidonio RF,Friedberg RC,Khan NN,Dong SS

更新日期：2000-06-12 00:00:00