Network analysis of icb-1 gene function in human breast cancer cells.

abstract：:Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer molecules. N-end rule pathway has been shown to be involved...

journal_title：Journal of cellular biochemistry

authors： Pore SK,Ganguly A,Sau S,Godeshala S,Kanugula AK,Ummanni R,Kotamraju S,Banerjee R

更新日期：2020-01-01 00:00:00

abstract：:Magnolol, a substance purified from the bark of Magnolia officialis, inhibits cell proliferation and induces apoptosis in a variety of cancer cells. The aim of this study was to study the effects of magnolol on CGTH W-2 thyroid carcinoma cells. After 24 h treatment with 80 microM magnolol in serum-containing medium, a...

journal_title：Journal of cellular biochemistry

authors： Huang SH,Chen Y,Tung PY,Wu JC,Chen KH,Wu JM,Wang SM

更新日期：2007-07-01 00:00:00

abstract：:The influence of concentration of simvastatin (SIM) on free radicals in A-2058 human melanoma malignum cells was studied. The proliferation assay for melanoma A-2058 cells with SIM in concentration range from 0.1 to 20 µM was performed. SIM in the concentrations of 0.1, 0.3, and 1 μM only slightly changed the growth o...

journal_title：Journal of cellular biochemistry

authors： Zdybel M,Chodurek E,Pilawa B

更新日期：2018-09-11 00:00:00

abstract：:Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

journal_title：Journal of cellular biochemistry

authors： Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

更新日期：1982-01-01 00:00:00

abstract：:The study aims to investigate the analgesic effects of microRNA-129-5p (miR-129-5p) on bone cancer pain (BCP) by targeting Eph receptor B1 (EphB1) through the EphB1/EphrinB2 signaling pathway. BCP mice models were established, and C3H/HeJ female mice were classified into the normal, blank, negative control (NC), miR-1...

journal_title：Journal of cellular biochemistry

authors： Yu SN,Liu GF,Li LY,Zhao GQ,Liu L,Li XF

更新日期：2019-03-01 00:00:00

abstract：:Protein synthesis inhibitors paradoxically increase the expression of early-gene products, including various cytokines, through a process known as superinduction. Superinduction is cell-specific and the mechanisms involved are not fully understood but are usually attributed to decreased mRNA degradation. There is, how...

journal_title：Journal of cellular biochemistry

authors： Hershko DD,Robb BW,Wray CJ,Luo GJ,Hasselgren PO

更新日期：2004-04-01 00:00:00

abstract：:Pancreatic AR42J cells have the feature of pluripotency of the precursor cells of the gut endoderm. Betacellulin (BTC) and activin A (Act) convert them into insulin-secreting cells. Using mRNA differential display techniques, we have identified a novel mitochondrial transporter, which is highly expressed during the co...

journal_title：Journal of cellular biochemistry

authors： Yoshikumi Y,Mashima H,Ueda N,Ohno H,Suzuki J,Tanaka S,Hayashi M,Sekine N,Ohnishi H,Yasuda H,Iiri T,Omata M,Fujita T,Kojima I

更新日期：2005-08-15 00:00:00

abstract：:Rad51-mediated homologous recombination (HR) is essential for maintenance of genome integrity. The Xrcc3 protein functions in HR DNA repair, and studies suggest it has multiple roles at different stages in this pathway. Defects in vertebrate XRCC3 result in elevated levels of spontaneous and DNA damage-induced chromos...

journal_title：Journal of cellular biochemistry

authors： Forget AL,Bennett BT,Knight KL

更新日期：2004-10-15 00:00:00

abstract：:Scribble (Scrib) is a large multi-domain cytoplasmic protein that was first identified through its requirement for the establishment of epithelial polarity. We tested the hypotheses that Scrib asssociates with the basolateral membrane via multiple domains, binds specific protein partners, and is part of a multimeric c...

journal_title：Journal of cellular biochemistry

authors： Kallay LM,McNickle A,Brennwald PJ,Hubbard AL,Braiterman LT

更新日期：2006-10-01 00:00:00

abstract：:Hypoxia inducible factor 1α (HIF-1α), an essential transcriptional factor, is negatively regulated by two different types of oxygen and Fe(2+) -dependent HIF hydroxylases, proline hydroxylase (PHD) and factor inhibiting HIF (FIH), under normoxia. Iron chelators have therefore been used for inducing HIF-1α expression b...

journal_title：Journal of cellular biochemistry

authors： Cho EA,Song HK,Lee SH,Chung BH,Lim HM,Lee MK

更新日期：2013-04-01 00:00:00

abstract：:The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on met...

journal_title：Journal of cellular biochemistry

authors： Satué M,Ramis JM,del Mar Arriero M,Monjo M

更新日期：2015-04-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains a huge challenge due to its high mortality and morbidity; gene therapy might be a promising treatment for PDAC. The critical role of Wnt-signaling pathway in cancer pathogenesis has been widely recognized; cyclin-dependent kinase 14 (CDK14, PFTK1)-induced low-density lip...

journal_title：Journal of cellular biochemistry

authors： Sun Y,Zhu Q,Yang W,Shan Y,Yu Z,Zhang Q,Wu H

更新日期：2019-03-01 00:00:00

abstract：:In order to better understand the mechanism by which changes in the fatty acid composition of cellular lipids occur in leukemia cell lines induced to differentiate, the activity of the first enzyme of fatty acid biosynthesis, acetyl-CoA carboxylase (EC 6.4.1.2) was measured in HL-60 promyelocytic leukemia cells before...

journal_title：Journal of cellular biochemistry

authors： Fischkoff SA,Papuchis GC,Nickols WA

更新日期：1984-01-01 00:00:00

abstract：:The recently identified 53-kDa substrate of the insulin receptor family was further characterized in several retroviral-generated stable cell lines overexpressing the wild type and various mutant forms of the protein. To facilitate the study of its subcellular localization in NIH3T3 cells overexpressing insulin recept...

journal_title：Journal of cellular biochemistry

authors： Yeh TC,Li W,Keller GA,Roth RA

更新日期：1998-02-01 00:00:00

abstract：:Acute kidney injury (AKI) is a common kidney disorder that affects public health and the incidence of AKI. Sepsis, acute ischemia or hypoxia is the main reason for the occurrence of AKI. Recently, noncoding RNA that include microRNA and long noncoding RNA (lncRNAs) were reported to play important roles in AKI as well ...

journal_title：Journal of cellular biochemistry

authors： Jiang X,Li D,Shen W,Shen X,Liu Y

更新日期：2019-09-01 00:00:00

abstract：:Roscovitine (ROSC), a selective cyclin-dependent kinase (CDK) inhibitor, arrests human estrogen receptor-α (ER-α) positive MCF-7 breast cancer cells in the G(2) phase of the cell cycle and concomitantly induces apoptosis via a p53-dependent pathway. The effect of ROSC is markedly diminished in MCF-7 cells maintained i...

journal_title：Journal of cellular biochemistry

authors： Węsierska-Gądek J,Gritsch D,Zulehner N,Komina O,Maurer M

更新日期：2011-03-01 00:00:00

abstract：:D-Glucose serves many roles in cellular functions, but its role in human periodontal ligament-derived mesenchymal stem cells (hPSLSCs) is yet unknown. Here, the roles of high glucose concentration on neurogenic differentiation by hPDLSCs were investigated. Two-stage neurogenic induction protocol was employed. Cells we...

journal_title：Journal of cellular biochemistry

authors： Sawangmake C,Pavasant P,Chansiripornchai P,Osathanon T

更新日期：2014-05-01 00:00:00

abstract：:We have previously demonstrated that the antagonists of calmodulin (CaM) induce apoptosis of cholangiocarcinoma cells partially through Fas-mediated apoptosis pathways. Recently, CaM has been shown to bind to Fas, which is regulated during Fas or CaM antagonist-mediated apoptosis in Jurkat cells and osteoclasts. Accor...

journal_title：Journal of cellular biochemistry

authors： Chen Y,Pawar P,Pan G,Ma L,Liu H,McDonald JM

更新日期：2008-02-15 00:00:00

abstract：:Currently, traditional predictors of prognosis (tumor size, nodal status, progesterone receptor [PR], estrogen receptor [ER], or human epidermal growth factor receptor-2 [HER2]) are insufficient for precise survival prediction for triple-negative breast cancer (TNBC). Long noncoding RNAs (lncRNAs) have been observed t...

journal_title：Journal of cellular biochemistry

authors： Fan CN,Ma L,Liu N

更新日期：2019-03-01 00:00:00

abstract：:Annexin II is a multifunctional calcium-dependent phospholipid binding protein whose presence in epidermis has previously been reported. However, like other members of annexin family, annexin II has been regarded as either an intracellular protein or associated with the cellular membrane. Here, we report the presence ...

journal_title：Journal of cellular biochemistry

authors： Karimi-Busheri F,Marcoux Y,Tredget EE,Li L,Zheng J,Ghoreishi M,Weinfeld M,Ghahary A

更新日期：2002-01-01 00:00:00

abstract：:In 1981, Chugai Pharmaceutical succeeded in marketing alfacalcidol, a prodrug of calcitriol, as a therapeutic agent for renal osteodystrophy. In 1983, Chugai succeeded in extending the application of alfacalcidol to the treatment of osteoporosis as well. Clinicians in Japan have accepted alfacalcidol as a remedy for o...

journal_title：Journal of cellular biochemistry

authors： Nishii Y

更新日期：2003-02-01 00:00:00

abstract：:It is known that the MyoD family members (MyoD, Myf5, myogenin, and MRF4) play a pivotal role in the complex mechanism of skeletal muscle cell differentiation. However, fragmentary information on transcription factor-specific regulation is available and data on their post-transcriptional and post-translational behavio...

journal_title：Journal of cellular biochemistry

authors： Ferri P,Barbieri E,Burattini S,Guescini M,D'Emilio A,Biagiotti L,Del Grande P,De Luca A,Stocchi V,Falcieri E

更新日期：2009-12-15 00:00:00

abstract：:AIMP1 was first found as a factor associated with the aminoacyl-tRNA synthetase (ARS) complex. However, it is also secreted and acts on different target cells such as endothelial cells, macrophages, and fibroblasts as an extracellular regulator, respectively, of angiogenesis, inflammatory responses and dermal regenera...

journal_title：Journal of cellular biochemistry

authors： Jackson VC,Dewilde S,Albo AG,Lis K,Corpillo D,Canepa B

更新日期：2011-07-01 00:00:00

abstract：:Oxidized low-density lipoprotein (ox-LDL)-induced endothelial injury plays crucial roles in the development of arteriosclerosis (AS). Golgi apparatus (GA) fragmentation is involved in various pathological processes, including endothelial injury. However, the role of GA fragmentation in ox-LDL-induced endothelial injur...

journal_title：Journal of cellular biochemistry

authors： Ji G,Song X,Wang L,Li Z,Wu H,Dong H

更新日期：2019-11-01 00:00:00

abstract：:Cell proliferation requires the coordinate synthesis and degradation of many proteins. In addition to the well-characterized involvement of the proteasome in the degradation of several cell cycle-regulated proteins, it has been established that cysteine proteinases are also involved in the control of cell proliferatio...

journal_title：Journal of cellular biochemistry

authors： Torres C,Li M,Walter R,Sierra F

更新日期：2000-09-18 00:00:00

abstract：:The effect of regucalcin, which is a regulatory protein of Ca(2+) signaling, on Ca(2+)-ATPase activity in isolated rat renal cortex mitochondria was investigated. The presence of regucalcin (50, 100, and 250 nM) in the enzyme reaction mixture led to a significant increase in Ca(2+)-ATPase activity. Regucalcin signific...

journal_title：Journal of cellular biochemistry

authors： Xue JH,Takahashi H,Yamaguchi M

更新日期：2000-10-20 00:00:00

abstract：:Procyanidins have been associated with a reduced risk of cardiovascular diseases such as atherosclerosis. However, the molecular mechanisms underlying this benefit are not fully understood. Increased reactive oxygen species (ROS) production generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a ...

journal_title：Journal of cellular biochemistry

authors： Álvarez E,Rodiño-Janeiro BK,Jerez M,Ucieda-Somoza R,Núñez MJ,González-Juanatey JR

更新日期：2012-04-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses, and is often significantly overexpressed in solid tumors, but little is known of its role in human lung cancer. In this study, we demonstrated the aberrant expression of HDAC2 in lung cancer ti...

journal_title：Journal of cellular biochemistry

authors： Jung KH,Noh JH,Kim JK,Eun JW,Bae HJ,Xie HJ,Chang YG,Kim MG,Park H,Lee JY,Nam SW

更新日期：2012-06-01 00:00:00

abstract：:We have shown previously that the promotion of myofiber survival by the basement membrane component merosin (laminin-2 [alpha2beta1gamma1]/laminin-4 [alpha2beta2gamma1]) is dependent on the activity of the tyrosine kinase Fyn, whereas myofiber anoikis induced by merosin deficiency is dependent on the stress-activated ...

journal_title：Journal of cellular biochemistry

authors： Laprise P,Vallée K,Demers MJ,Bouchard V,Poirier EM,Vézina A,Reed JC,Rivard N,Vachon PH

更新日期：2003-08-15 00:00:00

abstract：:Cocultures of rabbit fibroblasts and mouse B-16 melanoma cells produce increased levels of collagenase against type I collagen. This stimulatory effect was also found when fibroblasts were cultured in conditioned media from tumor cells. However, the level of the stimulatory factor in conditioned media was influenced b...

journal_title：Journal of cellular biochemistry

authors： Biswas C

更新日期：1985-01-01 00:00:00