Identification of NPAC as a novel biomarker and regulator for hepatocellular carcinoma.

abstract：:Cigarette smoking has been suggested as a risk factor for several periodontal diseases. It has also been found that smokers respond less favorably than non-smokers to periodontal therapy. Previous work in our lab has shown that nicotine inhibits human gingival cell migration. Since myofibroblasts play an important rol...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Svoboda KK

更新日期：2005-08-15 00:00:00

abstract：:Evidence indicates that agonists of neuronal nicotinic receptors (nAChRs), including nicotine, can induce neuroprotective and anti-apoptotic effects in the CNS. To study these mechanisms, the present study focused on nicotine-mediated modulation of the extracellular regulated kinase 1 and 2 (ERK1/2) pathway in culture...

journal_title：Journal of cellular biochemistry

authors： Toborek M,Son KW,Pudelko A,King-Pospisil K,Wylegala E,Malecki A

更新日期：2007-02-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) can participate in the pathological process of multiple myeloma (MM) via regulation of specific gene expression and function. This research aimed to study the role of MALAT-1 and the underlying mechanism in MM. In this study, the expression of MALAT-1 and HMGB1 protein in the bone marrow...

journal_title：Journal of cellular biochemistry

authors： Gao D,Lv AE,Li HP,Han DH,Zhang YP

更新日期：2017-10-01 00:00:00

abstract：:Esophageal carcinoma is aggressive in nature and its prognosis is largely dependent on the degree of invasion. Histone deacetylase 6 (HDAC6), as the most unique member of HDACs family, has the positive activity to promote initiation and progression of various cancers via targeting multiple non-histone proteins in cyto...

journal_title：Journal of cellular biochemistry

authors： Tao H,Chen YY,Sun ZW,Chen HL,Chen M

更新日期：2018-08-01 00:00:00

abstract：:Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that help...

journal_title：Journal of cellular biochemistry

authors： Upadhyay S,Sharma N,Gupta KB,Dhiman M

更新日期：2018-07-01 00:00:00

abstract：:Bladder cancer is the most common malignancy with high recurrence. Currently, the long noncoding RNAs (lncRNAs) have been suggested to play vital roles in the pathogenesis of bladder cancer. The present study investigated the role of lncRNA MIR503 host gene (MIR503HG) in the pathogenesis of bladder cancer by using bot...

journal_title：Journal of cellular biochemistry

authors： Qiu F,Zhang MR,Zhou Z,Pu JX,Zhao XJ

更新日期：2019-06-01 00:00:00

abstract：:The 25-hydroxyvitamin D(3)-24-hydroxylase mRNA is tightly and reciprocally regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and parathyroid hormone (PTH). The upregulation of the 24-hydroxylase by 1,25(OH)(2)D(3) is well established and occurs at the transcriptional level through two vitamin D response elemen...

journal_title：Journal of cellular biochemistry

authors： Zierold C,Mings JA,DeLuca HF

更新日期：2003-02-01 00:00:00

abstract：:Micromolar concentrations (0.5 approximately 5 microM) of all-trans geranylgeranoic acid (GGA) induced cell death in a guinea pig cell line, 104C1, whereas under the same conditions GGA was unable to kill 104C1/O4C, a clone established from 104C1 cells by transfection of them with the human phospholipid hydroperoxide ...

journal_title：Journal of cellular biochemistry

authors： Shidoji Y,Okamoto K,Muto Y,Komura S,Ohishi N,Yagi K

更新日期：2006-01-01 00:00:00

abstract：:All-trans retinoic acid and 9-cis-retinoic acid stimulate the activity of steroid sulfatase in HL60 acute myeloid leukemia cells in a concentration- and time-dependent manner. Neither of these 'natural retinoids' augmented steroid sulfatase activity in a HL60 sub-line that expresses a dominant-negative retinoic acid r...

journal_title：Journal of cellular biochemistry

authors： Hughes PJ,Zhao Y,Chandraratna RA,Brown G

更新日期：2006-02-01 00:00:00

abstract：:Inverted repeats occur nonrandomly in the DNA of most organisms. Stem-loops and cruciforms can form from inverted repeats. Such structures have been detected in pro- and eukaryotes. They may affect the supercoiling degree of the DNA, the positioning of nucleosomes, the formation of other secondary structures of DNA, o...

journal_title：Journal of cellular biochemistry

authors： Pearson CE,Zorbas H,Price GB,Zannis-Hadjopoulos M

更新日期：1996-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) were once viewed only as mediators of toxicity, but it is now recognized that they also contribute to redox signaling through oxidation of specific cysteine thiols on regulatory proteins. Cells in sparse cultures have increased ROS relative to confluent cultures, but it is not known wheth...

journal_title：Journal of cellular biochemistry

authors： Spielberger JC,Moody AD,Watson WH

更新日期：2008-08-01 00:00:00

abstract：:We have investigated the actions of transforming growth factor (TGF) type alpha on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGF alpha results in elevated levels of EGF receptor mRNA. This increase in ...

journal_title：Journal of cellular biochemistry

authors： Fernandez-Pol JA,Klos DJ,Hamilton PD

更新日期：1989-11-01 00:00:00

abstract：:It has been proposed that buckling of actin stress fibers (SFs) may be associated with their disassembly. However, much of the detail remains unknown partly because the use of an elastic membrane sheet, conventionally necessary for inducing SF buckling with a mechanical compression to adherent cells, may limit high qu...

journal_title：Journal of cellular biochemistry

authors： Deguchi S,Matsui TS,Sato M

更新日期：2012-03-01 00:00:00

abstract：:Occupational exposure to nickel has been epidemiologically linked to increased cancer risk in the respiratory tract. Nickel-induced cell transformation is associated with both genotoxic and epigenetic mechanisms that are poorly understood. Prolidase [E.C.3.4.13.9] is a cytosolic Mn(II)-activated metalloproteinase that...

journal_title：Journal of cellular biochemistry

authors： Miltyk W,Surazynski A,Kasprzak KS,Fivash MJ Jr,Buzard GS,Phang JM

更新日期：2005-04-15 00:00:00

abstract：:The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration an...

journal_title：Journal of cellular biochemistry

authors： Li S,Huang NF,Hsu S

更新日期：2005-12-15 00:00:00

abstract：:The nucleolus is a multifunctional nuclear compartment widely known to be involved in several cellular processes, including mRNA maturation and shuttling to cytoplasmic sites, control of the cell cycle, cell proliferation, and apoptosis; thus, it is logical that many viruses, including herpesvirus, target the nucleolu...

journal_title：Journal of cellular biochemistry

authors： Arcangeletti MC,Rodighiero I,Mirandola P,De Conto F,Covan S,Germini D,Razin S,Dettori G,Chezzi C

更新日期：2011-01-01 00:00:00

abstract：:Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatmen...

journal_title：Journal of cellular biochemistry

authors： Zhu D,Wu L,Li CR,Wang XW,Ma YJ,Zhong ZY,Zhao HB,Cui J,Xun SF,Huang XL,Zhou Z,Wang SQ

更新日期：2009-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly disabling demyelinating disease, which mainly affects young adults and is difficult to cure. Activated microglia may be involved in the process of neuronal cell damage and release inflammatory cytokines to injure neurons. Rapamycin (RAPA), an immunosuppressant, can induce autophagy ...

journal_title：Journal of cellular biochemistry

authors： Xu L,Zhang C,Jiang N,He D,Bai Y,Xin Y

更新日期：2019-04-01 00:00:00

abstract：:Elucidation of the mechanisms by which environmental pH affects or regulates the functions of polymorphonuclear leukocytes (PMNs) is important because severe acidification of the microenvironment often prevails at sites of inflammation where they act in host defense. In the present study, we investigated the effect of...

journal_title：Journal of cellular biochemistry

authors： Suzuki K,Namiki H

更新日期：2012-03-01 00:00:00

abstract：:A23187 stimulates the metabolism of endogenous as well as exogenous arachidonic acid (AA) and eicosapentaenolc acid (EPA) to their corresponding leukotrienes in human neutrophils. In contrast, conflicting results have been obtained concerning the effect of FMLP on the metabolism of these fatty acids. In the present st...

journal_title：Journal of cellular biochemistry

authors： Mahadevappa VG,Powell WS

更新日期：1989-07-01 00:00:00

abstract：:Tumor cells display different bioenergetic profiles when compared to normal cells. In the present work we showed metabolic reprogramming by means of inhibitors of histone deacetylase (HDACis), sodium butyrate and trichostatin A in breast cancer cells representing different stages of aggressiveness and metabolic profil...

journal_title：Journal of cellular biochemistry

authors： Rodrigues MF,Carvalho É,Pezzuto P,Rumjanek FD,Amoêdo ND

更新日期：2015-05-01 00:00:00

abstract：:Adamts17 is a member of a family of secreted metalloproteinases. In this report, we show that knockdown of Adamts17 expression induces apoptosis and inhibits breast cancer cell growth. Adamts17 expression can rapidly be induced by estrogens. siRNA knockdown of Sp1 or Myc demonstrated that Sp1 is required to induce Ada...

journal_title：Journal of cellular biochemistry

authors： Jia Z,Gao S,M'Rabet N,De Geyter C,Zhang H

更新日期：2014-10-01 00:00:00

abstract：:In a human lymphoblastoid cell line (Z83) in which rDNA genes on chromosome 22 are amplified but transcribed at a low level, immunocytological studies with antibodies to 5 methylcytidine provided evidence for hypermethylation of the rDNA. The extent of methylation of the 5' flanking sequences of the ribosomal DNA was ...

journal_title：Journal of cellular biochemistry

authors： Dante R,Percy ME,Baldini A,Markovic VD,Miller DA,Rocchi M,Niveleau A,Miller OJ

更新日期：1992-12-01 00:00:00

abstract：:A variant human H2B histone gene (GL105), previously shown to encode a 2300 nt replication independent mRNA, has been cloned. We demonstrate this gene expresses alternative mRNAs regulated differentially during the HeLa S3 cell cycle. The H2B-Gl105 gene encodes both a 500 nt cell cycle dependent mRNA and a 2300 nt con...

journal_title：Journal of cellular biochemistry

authors： Collart D,Romain PL,Huebner K,Pockwinse S,Pilapil S,Cannizzaro LA,Lian JB,Croce CM,Stein JL,Stein GS

更新日期：1992-12-01 00:00:00

abstract：:Molecular mechanisms responsible for tumor resistance to apoptosis often involve the Fas/FasL pathway. While squamous cell carcinomas of the head and neck (SCCHN) express both Fas and FasL, their resistance to self-induced apoptosis or apoptosis mediated by Fas agonistic antibody (CH-11Ab) was independent of the level...

journal_title：Journal of cellular biochemistry

authors： Wieckowski E,Atarashi Y,Stanson J,Sato TA,Whiteside TL

更新日期：2007-01-01 00:00:00

abstract：:This study aims to explore the effect of miR-330 targeting VAV1 on amyloid β-protein (Aβ) production, oxidative stress (OS), and mitochondrial dysfunction in Alzheimer's disease (AD) mice through the MAPK signaling pathway. Putative targeted gene of miR-330 was performed by a miRNA target prediction website and dual-l...

journal_title：Journal of cellular biochemistry

authors： Zhou Y,Wang ZF,Li W,Hong H,Chen J,Tian Y,Liu ZY

更新日期：2018-07-01 00:00:00

abstract：:Cultured human melanoma cells were found to secrete TGF-beta mostly in latent biologically inactive form but in addition five of six melanoma cell lines studied produced in conditioned culture medium active TGF-beta in the range from 370 to 610 pg per 10(6) cells per 24 h. A distinct characteristic of these melanoma c...

journal_title：Journal of cellular biochemistry

authors： Bizik J,Felnerova D,Grofova M,Vaheri A

更新日期：1996-07-01 00:00:00

abstract：:Phospholipids, sphingolipids, and cholesterol are integral components of eukaryotic cell organelles, including the nucleus. Recent evidence shows characteristic features of nuclear lipid composition and signaling, which are distinct from that of the cytoplasm and plasma membrane. While the nuclear phosphoinositol lipi...

journal_title：Journal of cellular biochemistry

authors： Fu P,Ebenezer DL,Ha AW,Suryadevara V,Harijith A,Natarajan V

更新日期：2018-08-01 00:00:00

abstract：:Transcription of the heat shock genes is regulated by the activation of the heat shock transcription factor (HSF-1). After heat shock, HSF-1 forms oligomers and binds to the heat shock element (HSE), which consists of several repeats of NGAAN located in the promoter region of the heat shock genes. HSF-1 is then phosph...

journal_title：Journal of cellular biochemistry

authors： Mivechi NF,Shi XY,Hahn GM

更新日期：1995-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF), characterized by irreversible scarring and progressive destruction of the lung tissue, is one of the most common types of idiopathic interstitial pneumonia worldwide. However, there are no reliable candidates for curative therapies. Hence, elucidation of the mechanisms of IPF genes...

journal_title：Journal of cellular biochemistry

authors： Wang H,Xie Q,Ou-Yang W,Zhang M

更新日期：2018-12-02 00:00:00