Abstract:
:Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatment with ginsenoside Rg1 (60-120 microM) reduced lactate dehydrogenase release and increased cell viability in a dose-dependent manner. Fluorescence analysis demonstrated ginsenoside Rg1 reduced intracellular ROS and suppressed the intracellular [Ca(2+)] level. Cell lysate detected an increase of T-SOD, CAT, and GSH levels. The myocardial protection of ginsenoside Rg1 during H/R is partially due to its antioxidative effect and intracellular calcium homeostasis.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Zhu D,Wu L,Li CR,Wang XW,Ma YJ,Zhong ZY,Zhao HB,Cui J,Xun SF,Huang XL,Zhou Z,Wang SQdoi
10.1002/jcb.22233subject
Has Abstractpub_date
2009-09-01 00:00:00pages
117-24issue
1eissn
0730-2312issn
1097-4644journal_volume
108pub_type
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