LPS promotes the expression of PD-L1 in gastric cancer cells through NF-κB activation.

abstract：:Epidemiological studies and animal models suggest a link between high levels of dietary fat intake and an increased risk of developing breast cancer. Hyperinsulinemia is a feature of obesity, diabetes, and metabolic syndrome that is associated with an increased breast cancer risk. Insulin is a hormone involved in meta...

journal_title：Journal of cellular biochemistry

authors： Rodriguez-Monterrosas C,Diaz-Aragon R,Cortes-Reynosa P,Salazar EP

更新日期：2018-07-01 00:00:00

abstract：:Hyperglycemia and elevation of methylglyoxal (MG) are symptoms of diabetes mellitus (DM). We previously showed that high glucose (HG; 30 mM) or MG (50-400 microM) could induce apoptosis in mammalian cells, but these doses are higher than the physiological concentrations of glucose and MG in the plasma of DM patients. ...

journal_title：Journal of cellular biochemistry

authors： Chan WH,Wu HJ

更新日期：2008-03-01 00:00:00

abstract：:Recently increasing emphasis is placed on preventive health and management of chronic comorbidities avoiding long-term toxicities of antiretroviral therapy (ART). Drawing from this background we decided to use the Saos-2, osteosarcoma cell line, as a cellular model, to evaluate the effects of some antiretroviral drugs...

journal_title：Journal of cellular biochemistry

authors： Esposito V,Perna A,Lucariello A,Carleo MA,Viglietti R,Sangiovanni V,Coppola N,Guerra G,De Luca A,Chirianni A

更新日期：2015-10-01 00:00:00

abstract：:The perinucleolar compartment (PNC) is a distinct nuclear body that localizes to the nucleolar periphery. The PNC is predominantly found in cancer cells, and recent evidence suggests that PNC prevalence can be a pan-cancer marker for tumors of solid tissue origin. The PNC is a heritable structure enriched with newly t...

journal_title：Journal of cellular biochemistry

authors： Pollock C,Huang S

更新日期：2009-05-15 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial-mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in an inflammatory microenvironment. B...

journal_title：Journal of cellular biochemistry

authors： Ye K,Chen QW,Sun YF,Lin JA,Xu JH

更新日期：2018-02-01 00:00:00

abstract：:Electrical activity in embryonic brain tissue has typically been studied using Micro Electrode Array (MEA) technology to make dozens of simultaneous recordings from dissociated neuronal cultures, brain stem cell progenitors, or brain slices from fetal rodents. Although these rodent neuronal primary culture electrical ...

journal_title：Journal of cellular biochemistry

authors： Napoli A,Obeid I

更新日期：2016-03-01 00:00:00

abstract：:We investigated the effects of vitamin D3 on the signaling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), an active form of vitamin D3, significantly inhibited cAMP accumulation induced by 10 microM PGE2 in a dose-dependent manner i...

journal_title：Journal of cellular biochemistry

authors： Tokuda H,Kotoyori J,Suzuki A,Oiso Y,Kozawa O

更新日期：1993-06-01 00:00:00

abstract：:We investigated the association of DNA polymerase and DNA primase activity with the nuclear matrix in HeLa S3 cells diluted with fresh medium after having been cultured without any medium change for 7 days. Flow cytometric analysis demonstrated that just before dilution about 85% of the cells were in the G1 phase of t...

journal_title：Journal of cellular biochemistry

authors： Martelli AM,Capitani S,Neri LM

更新日期：1998-10-01 00:00:00

abstract：:Fourteen stable subclones derived from the murine chondrogenic cell line MC615 were established and characterised regarding their differentiation stages and responsivity to BMP2. Based on their gene expression profiles which revealed remarkable variances in Col2a1 and Col10a1 expression, subclones could be grouped int...

journal_title：Journal of cellular biochemistry

authors： Surmann-Schmitt C,Widmann N,Mallein-Gerin F,von der Mark K,Stock M

更新日期：2009-10-15 00:00:00

abstract：:Phosphoinositides (PIs) and proteins involved in the PI signaling pathway are distributed in the nucleus as well as at the plasma membrane and in the cytoplasm, although their nuclear localization mechanisms have not been clarified in detail. Generally, proteins that shuttle between the cytoplasm and nucleus contain n...

journal_title：Journal of cellular biochemistry

authors： Yagisawa H

更新日期：2006-02-01 00:00:00

abstract：:The role of excision repair cross-complimentary group 1 (ERCC1) gene polymorphisms in breast and ovarian cancer development has long been controversial and existing data were inconsistent. Here, we conducted a comprehensive meta-analysis to better clarify the association. Case-control studies published from December 2...

journal_title：Journal of cellular biochemistry

authors： Yang F,Mu X,Bian C,Zhang H,Yi T,Zhao X,Lin X

更新日期：2019-09-01 00:00:00

abstract：:We studied how deficiency in lamins A/C and lamina-associated polypeptide 2α (Lap2α) affects DNA repair after irradiation. A-type lamins and Lap2α were not recruited to local DNA lesions and did not accumulate to γ-irradiation-induced foci (IRIF), as it is generally observed for well-known marker of DNA lesions, 53BP1...

journal_title：Journal of cellular biochemistry

authors： Bártová E,Legartová S,Krejčí J,Řezníčková P,Kovaříková AS,Suchánková J,Fedr R,Smirnov E,Hornáček M,Raška I

更新日期：2018-11-01 00:00:00

abstract：:The c-myc oncoprotein plays a critical role in the regulation of cellular proliferation and apoptosis. To mediate these biological functions, a variety of target genes are activated or repressed by c-myc, but few genes have yet been identified that directly mediate c-myc's role in proliferation or apoptosis. During a ...

journal_title：Journal of cellular biochemistry

authors： Vaknin UA,Hann SR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Exposure to pesticides is associated with an increase in the incidence of cancer. We aimed to investigate the association of serum organochlorine pesticides (OCPs) and organophosphorus pesticides (OPs) levels and GSTM1/GSTT1 gene polymorphism with bladder cancer (BC). METHODS:This study was performed on 57 ...

journal_title：Journal of cellular biochemistry

authors： Mortazavi N,Asadikaram G,Ebadzadeh MR,Kamalati A,Pakmanesh H,Dadgar R,Moazed V,Paydar P,Fallah H,Abolhassani M

更新日期：2019-09-01 00:00:00

abstract：:The role of regucalcin in the regulation of osteoblastic cell function was investigated. Osteoblastic MC3T3-E1 cells with subconfluent monolayers were cultured in a medium containing regucalcin (10(-10)-10(-8) M) without fetal bovine serum (FBS). The proliferation of osteoblastic cells was not significantly altered in...

journal_title：Journal of cellular biochemistry

authors： Yamaguchi M,Kobayashi M,Uchiyama S

更新日期：2005-10-15 00:00:00

abstract：:The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl-inositol-3 (PI-3) kinases such as DNA-dependent protein kina...

journal_title：Journal of cellular biochemistry

authors： Solhaug A,Refsnes M,Holme JA

更新日期：2004-12-15 00:00:00

abstract：:Cyclosporin A (CsA) induces osteoporosis but not through direct activation of osteoclasts. CsA also inhibits cell-mediated mineralization in marrow stromal cell culture, whereas the tyrphostin AG-1478 increases mineralization. These antagonistic effects on mineralization were used to discern molecules that underwent p...

journal_title：Journal of cellular biochemistry

authors： Stekelenburg J,Klein BY,Ben-Bassat H,Rojansky N

更新日期：1998-10-01 00:00:00

abstract：:The aim of this study was to determine: (1) whether the Short Chain Fatty Acids (SCFA) Acetate, Propionate, and Butyrate enhance the synthesis and secretion of intestinal apolipoprotein A-IV-containing lipoproteins and (2) if so, whether these particles are able to promote cholesterol efflux in vitro. For this purpose...

journal_title：Journal of cellular biochemistry

authors： Nazih H,Nazih-Sanderson F,Krempf M,Michel Huvelin J,Mercier S,Marie Bard J

更新日期：2001-08-01 00:00:00

abstract：:Epidermal Differentiation Complex (EDC) is a gene cluster on human chromosome 1 q21, which comprises genes encoding four protein families: S100, S100 fused (SFTP), small proline-rich region (SPRR) and late cornified envelope (LCE) proteins. Contrary to the latter three families, which group proteins important for skin...

journal_title：Journal of cellular biochemistry

authors： Sobiak B,Graczyk-Jarzynka A,Leśniak W

更新日期：2016-05-01 00:00:00

abstract：:Deregulation of microRNAs contributes to the abnormal cell growth which is frequently observed in cancer. In the current study, we detected the expression and regulatory relationship between miR-10a and Lysine-specific demethylase 4A (KDM4A) to reveal their function in prostate cancer (PCa) progression. We found that ...

journal_title：Journal of cellular biochemistry

authors： Mu H,Xiang L,Li S,Rao D,Wang S,Yu K

更新日期：2019-04-01 00:00:00

abstract：:Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when one of their ADMIDAS (adjacent to ...

journal_title：Journal of cellular biochemistry

authors： Raborn J,Luo BH

更新日期：2012-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that participate in the regulation of gene expression. Although many studies have demonstrated the involvement of miR-17-5p in different cancers, little is known to its function in ovarian cancer. In this study, we demonstrated that overexpression of miR-17-5p was able to ...

journal_title：Journal of cellular biochemistry

authors： Li L,He L,Zhao JL,Xiao J,Liu M,Li X,Tang H

更新日期：2015-06-01 00:00:00

abstract：:Receptor activator of NF-kappaB ligand (RANKL) is crucial in osteoclastogenesis but signaling events involved in osteoclast differentiation are far from complete and other signals may play a role in osteoclastogenesis. A more direct pathway for cellular crosstalk is provided by gap junction intercellular channel, whic...

journal_title：Journal of cellular biochemistry

authors： Matemba SF,Lie A,Ransjö M

更新日期：2006-10-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor has recently been identified in bone, but the molecular composition of this receptor expressed by bone cells is unknown. NMDA receptor (NMDAR) is a hetero-oligomeric protein composed of two classes of subunits, the essential subunit NR1 and NR2A to D su...

journal_title：Journal of cellular biochemistry

authors： Itzstein C,Cheynel H,Burt-Pichat B,Merle B,Espinosa L,Delmas PD,Chenu C

更新日期：2001-04-02 00:00:00

abstract：:Pyrazinamide is an essential first-line antitubercular drug which plays pivotal role in tuberculosis treatment. It is a prodrug that requires amide hydrolysis by mycobacterial pyrazinamidase enzyme for conversion into pyrazinoic acid (POA). POA is known to target ribosomal protein S1 (RpsA), aspartate decarboxylase (P...

journal_title：Journal of cellular biochemistry

authors： Singh A,Somvanshi P,Grover A

更新日期：2018-11-02 00:00:00

abstract：:Inverted repeats occur nonrandomly in the DNA of most organisms. Stem-loops and cruciforms can form from inverted repeats. Such structures have been detected in pro- and eukaryotes. They may affect the supercoiling degree of the DNA, the positioning of nucleosomes, the formation of other secondary structures of DNA, o...

journal_title：Journal of cellular biochemistry

authors： Pearson CE,Zorbas H,Price GB,Zannis-Hadjopoulos M

更新日期：1996-10-01 00:00:00

abstract：:Cancer prevalence is critically increasing worldwide; accordingly, improved prediction and therapeutic tools are necessary. Interleukin (IL)-21 is a potent antitumor cytokine, and the relationship between its gene variations and cancer risk is well established. Nevertheless, so far no study has investigated its role i...

journal_title：Journal of cellular biochemistry

authors： Bakr NM,Awad A,Moustafa EA,El-Gebaly AM

更新日期：2019-10-01 00:00:00

abstract：:Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (M...

journal_title：Journal of cellular biochemistry

authors： Xiang Z,Zhou Q,Hu M,Sanders YY

更新日期：2020-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. We analyzed 11 data sets from Gene Expression Omnibus Database and found that MMP7 and MMP15 were highly expressed in multiple carcinomas. GSE13204 showed that MMP7 and MM...

journal_title：Journal of cellular biochemistry

authors： Wu Y,Pan S,Leng J,Xie T,Jamal M,Yin Q,Li J,He C,Dong X,Shao L,Zhang Q

更新日期：2019-06-01 00:00:00