Abstract:
:Inverted repeats occur nonrandomly in the DNA of most organisms. Stem-loops and cruciforms can form from inverted repeats. Such structures have been detected in pro- and eukaryotes. They may affect the supercoiling degree of the DNA, the positioning of nucleosomes, the formation of other secondary structures of DNA, or directly interact with proteins. Inverted repeats, stem-loops, and cruciforms are present at the replication origins of phage, plasmids, mitochondria, eukaryotic viruses, and mammalian cells. Experiments with anti-cruciform antibodies suggest that formation and stabilization of cruciforms at particular mammalian origins may be associated with initiation of DNA replication. Many proteins have been shown to interact with cruciforms, recognizing features like DNA crossovers, four-way junctions, and curved/bent DNA of specific angles. A human cruciform binding protein (CBP) displays a novel type of interaction with cruciforms and may be linked to initiation of DNA replication.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Pearson CE,Zorbas H,Price GB,Zannis-Hadjopoulos Mdoi
10.1002/(SICI)1097-4644(199610)63:1%3C1::AID-JCB1%subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1-22issue
1eissn
0730-2312issn
1097-4644pii
10.1002/(SICI)1097-4644(199610)63:1<1::AID-JCB1>3.journal_volume
63pub_type
杂志文章,评审abstract::Breast cancer is a highly aggressive disease contributing to high mortality rate among females across the globe owing to wide geographical variations, change in lifestyle along with rapid tumor growth, drug resistance, and high metastasis rate. To understand the molecular and genetic basis of breast cancer progression...
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pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of cellular biochemistry
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更新日期:2014-11-01 00:00:00
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更新日期:2012-08-01 00:00:00
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