Vaccines for colorectal cancer: an update.


:Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have introduced for detecting CRC in different stages particularly in early stages. The standard treatments for CRC are surgery, chemotherapy and radiotherapy, in alone or combination. Immunotherapy is a set of novel approaches with the aim of remodeling the immune system battle with metastatic cancer cells, such as immunomodulatory monoclonal antibodies (immune checkpoint inhibitors), adoptive cell transfer (ACT) and cancer vaccine. Cancer vaccines are designed to trigger the intense response of immune system to tumor-specific antigens. In two last decades, introduction of new cancer vaccines and designing several clinical trials with vaccine therapy, have been taken into consideration in colon cancer patients. This review will describe the treatment approaches with the special attention to vaccines applied to treat colorectal cancer.


J Cell Biochem


Sarvizadeh M,Ghasemi F,Tavakoli F,Sadat Khatami S,Razi E,Sharifi H,Biouki NM,Taghizadeh M




Has Abstract


2019-06-01 00:00:00












  • Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II.

    abstract::Focal adhesion kinase (FAK) is a structurally unique nonreceptor protein-tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G-protein coupled receptors for mitoge...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Polte TR,Naftilan AJ,Hanks SK

    更新日期:1994-05-01 00:00:00

  • Neonatal treatment with fluoxetine improves mitochondrial respiration and reduces oxidative stress in liver of adult rats.

    abstract::Recent studies have shown that exposure to fluoxetine treatment induces excessive production of ROS, and alters the antioxidant defense system in various tissues and cell types, mainly the liver. When fluoxetine is administered intraperitoneally, the drug rapidly reaches high concentrations in the liver, has potential...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Simões-Alves AC,Silva-Filho RC,Braz GRF,Silva SCA,da Silva AI,Lagranha CJ,Fernandes MP

    更新日期:2018-08-01 00:00:00

  • Differential expression profile analysis of PSTK-regulated mRNAs in podocytes.

    abstract::This study aimed to elucidate the precise mechanisms underlying the protective effects of phosphoseryl-tRNA kinase (PSTK) against cisplatin-induced podocyte injury. PSTK overexpression and knockdown vectors were generated and transfected into murine podocyte cells-5. PSTK levels were measured, and transcriptome sequen...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zheng D,Zhao Y,Liu L,Sun X,Xia Y,Sun L,Xie K

    更新日期:2019-06-01 00:00:00

  • The detergent solubility properties of a malarial (Plasmodium knowlesi) variant antigen expressed on the surface of infected erythrocytes.

    abstract::Four detergents have been compared for identification of the Plasmodium knowlesi variant antigen on infected erythrocytes by immunoprecipitation analysis. Erythrocytes infected with late trophozoite and schizont forms of cloned asexual parasites were labeled by lactoperoxidase-catalyzed radioiodination and extracted e...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Howard RJ,Barnwell JW

    更新日期:1984-01-01 00:00:00

  • Non-apoptogenic killing of hela cervical carcinoma cells after short exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

    abstract::We examined the action of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on HeLa cells and compared it with that of cisplatin (CP). MNNG directly killed a substantial number of cells within 1 hour and resulted in strong DNA-damage as evidenced by Comet measurements. Despite appearance of DNA lesions, p53 protein was not ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wesierska-Gadek J,Gueorguieva M,Schloffer D,Uhl M,Wojciechowski J

    更新日期:2003-08-15 00:00:00

  • Insulin-regulated protein kinases during postnatal development of rat heart.

    abstract::The control of glucose uptake and glycogen metabolism by insulin in target organs is in part mediated through the regulation of protein-serine/threonine kinases. In this study, the expression and phosphotransferase activity levels of some of these kinases in rat heart ventricle were measured to investigate whether the...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kim SO,Hasham MI,Katz S,Pelech SL

    更新日期:1998-12-01 00:00:00

  • Transcriptional regulation of basic fibroblast growth factor gene expression in capillary endothelial cells.

    abstract::The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Weich HA,Iberg N,Klagsbrun M,Folkman J

    更新日期:1991-10-01 00:00:00

  • PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis.

    abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non-toxic to most normal cells, therefore, it is a promising agent for cancer therapy. However, some cancer cell lines were resistant to TRAIL cytoxicity, including...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang J,Liu N,Zhang J,Liu S,Liu Y,Zheng D

    更新日期:2005-10-15 00:00:00

  • Effect of LPS on basal and induced apo E secretion by 25-OH chol and 9cRA in differentiated CaCo-2.

    abstract::The infection and inflammation process is associated with disturbances in lipid and lipoprotein metabolism. The apolipoprotein E (apo E) plays an important role in the lipoprotein metabolism and has been linked to inflammatory disease such as atherosclerosis and Alzheimer disease. An anti-inflammatory effect has also ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ripollés Piquer B,Nazih H,Neunlist M,Huvelin JM,Bard JM

    更新日期:2004-03-01 00:00:00

  • Profiling and characterization of microRNAs responding to sodium butyrate treatment in A549 cells.

    abstract::Butyrate inhibits growth of lung cancer. However, the molecular mechanism is still unclear. Here we profiled miRNAs that responded to sodium butyrate(NaB) stimulation in A549 cells, a non-small cell lung cancer cell line, using microarray. We found 33 up-regulated microRNAs and 22 down-regulated microRNAs (log2 ≥1.5 f...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Xiao X,Cao Y,Chen H

    更新日期:2018-04-01 00:00:00

  • Down regulation of miR200c promotes radiation-induced thymic lymphoma by targeting BMI1.

    abstract::The miR-200c has recently been implicated in the epithelial to mesenchymal transition (EMT) process by directly target the EMT related transcriptional factors ZEB1 and ZEB2. The expression of this miRNA is inversely correlated with tumorgenecity and invasiveness in several human cancers. However, little is known about...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Cui J,Cheng Y,Zhang P,Sun M,Gao F,Liu C,Cai J

    更新日期:2014-06-01 00:00:00

  • MicroRNA-330 inhibits growth and migration of melanoma A375 cells: In vitro study.

    abstract::Melanoma skin cancer is one of the main causes of male cancer-related deaths worldwide. It has been suggested that miR-330-5p can act as a tumor suppressor in various types of cancers. So, in this study, we replaced miR-330 in melanoma cancer cells by vector-based miR-330 to evaluate the effects of this microRNA on th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sehati N,Sadeghie N,Mansoori B,Mohammadi A,Shanehbandi D,Baradaran B

    更新日期:2020-01-01 00:00:00

  • Protein kinase Cε targets respiratory chain and mitochondrial membrane potential but not F0 F1 -ATPase in renal cells injured by oxidant.

    abstract::We have previously shown that protein kinase Cε (PKCε) is involved in mitochondrial dysfunction in renal proximal tubular cells (RPTC). This study examined mitochondrial targets of active PKCε in RPTC injured by the model oxidant tert-butyl hydroperoxide (TBHP). TBHP exposure augmented the levels of phosphorylated (ac...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Nowak G,Bakajsova-Takacsova D

    更新日期:2018-11-01 00:00:00

  • Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest.

    abstract::Melphalan (MEL) is a chemotherapeutic agent used in breast cancer therapy; however, MEL's side effects limit its clinical applications. In the last 20 years, resveratrol (RSV), a polyphenol found in grape skins, has been proposed to reduce the risk of cancer development. The aim of this study was to investigate whethe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Casanova F,Quarti J,da Costa DC,Ramos CA,da Silva JL,Fialho E

    更新日期:2012-08-01 00:00:00

  • HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145.

    abstract::The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bones, and it's crucial to understand the mechanism of tumor progression to metastasis in order to develop therapies that may reduce the morbidity and mortality of PCa patients. Although we had identified that microRNA(miR)-14...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Guo W,Ren D,Chen X,Tu X,Huang S,Wang M,Song L,Zou X,Peng X

    更新日期:2013-07-01 00:00:00

  • Effects of phenytoin and Echinacea purpurea extract on proliferation and apoptosis of mouse embryonic palatal mesenchymal cells.

    abstract::Cleft palate is one of the most common birth defects. Several environment factors are involved in the disorder, such as smoking, vitamin deficiency and teratogens. We investigated the teratogenic agent phenytoin and extract of the immunostimulant Echinacea purpurea in the etiology of cleft palate associated with the p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hu X,Chen Z,Mao X,Tang S

    更新日期:2011-05-01 00:00:00

  • Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.

    abstract::Heparan sulfate proteoglycans (HSPGs), via their interactions with numerous effector molecules such as FGF-2, IL-8, and VEGF, regulate the biological activity of cells by acting as co-receptors that promote signaling. The extent and nature of their role as co-receptors is often misregulated in cancer as manifested by ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Sanderson RD,Yang Y,Kelly T,MacLeod V,Dai Y,Theus A

    更新日期:2005-12-01 00:00:00

  • Lipophilic statins antagonistically alter the major epithelial-to-mesenchymal transition signaling pathways in breast cancer stem-like cells via inhibition of the mevalonate pathway.

    abstract::Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

    更新日期:2018-09-06 00:00:00

  • MicroRNA-410 is involved in mitophagy after cardiac ischemia/reperfusion injury by targeting high-mobility group box 1 protein.

    abstract::Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yang F,Li T,Dong Z,Mi R

    更新日期:2018-02-01 00:00:00

  • Retraction: "Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells" by Bao et al.

    abstract::The above article, published online on April 18, 2011 in Wiley Online Library (, has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the sec...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,撤回出版物



    更新日期:2016-08-01 00:00:00

  • Identification and characterization of various differentiative growth plate chondrocytes from porcine by countercurrent centrifugal elutriation.

    abstract::Countercurrent centrifugal elutriation was used to separate growth plate chondrocytes from porcine basing on their differences in sizes and densities. Eighteen fractions of cells with different sizes and densities were obtained. The mean cellular volumes increased progressively in each of successive fractions, and tha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lee KM,Fung KP,Leung PC,Leung KS

    更新日期:1996-03-15 00:00:00

  • Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro.

    abstract::Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Defects in this mechanism correlate with severe obstetric complications as implantation failure and preeclampsia. Lysophosphatidic acid (LPA) participates in embr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Beltrame JS,Sordelli MS,Cañumil VA,Franchi AM,Ribeiro ML

    更新日期:2018-01-01 00:00:00

  • Medulloblastoma cell invasion is inhibited by green tea (-)epigallocatechin-3-gallate.

    abstract::Epigallocatechin-3-gallate (EGCG), the major green tea polyphenol, can reach the brain following oral intake and could thus act as an anti-tumoral agent targeting several key steps of brain cancer cells invasive activity. Because integrin-mediated extracellular matrix recognition is crucial during the cell adhesion pr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Pilorget A,Berthet V,Luis J,Moghrabi A,Annabi B,Béliveau R

    更新日期:2003-11-01 00:00:00

  • Potential roles of microRNAs in redox state: An update.

    abstract::Oxidative stress is an important underlying cause of many disease processes and may arise due to either increasing free radical generation or decreasing antioxidant defense systems. MicroRNAs (miRs) are 22-nucleotide non-coding RNAs that may regulate many intracellular processes; and, more recently, they have been imp...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yaribeygi H,Atkin SL,Sahebkar A

    更新日期:2018-08-30 00:00:00

  • Isolation and characterization of the chicken vitamin D receptor gene and its promoter.

    abstract::The sequences from several independent cDNA clones encoding the chicken vitamin D receptor as well as primer extension assay have clearly delineated the 5' terminus and the transcriptional start site. Screening a chicken genomic library produced genomic clones containing vitamin D receptor (VDR) gene fragments. Restri...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lu Z,Jehan F,Zierold C,DeLuca HF

    更新日期:2000-02-01 00:00:00

  • The stem cell hypothesis in head and neck cancer.

    abstract::Cancer stem cells (CSCs) are tumoral cells which have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. In the last 10 years the pathological meaning and the existence of CSCs have been matter of discussion and a large number of articles have been published abo...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Graziano A,d'Aquino R,Tirino V,Desiderio V,Rossi A,Pirozzi G

    更新日期:2008-02-01 00:00:00

  • Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells.

    abstract::We recently demonstrated the activation of extracellular signal- regulated protein kinase 1 and 2 (ERK1 and ERK2) by IGF-1, FGF-2, and PDGF-BB in normal human osteoblastic (HOB) cells as well as in rat and mouse osteoblastic cells. In this report, we have examined whether c-Jun NH2-Terminal Kinase (JNK) pathway is act...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Chaudhary LR,Avioli LV

    更新日期:1998-04-01 00:00:00

  • Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.

    abstract::p150(glued) is the largest subunit of dynactin protein complex, through which cargo vesicles link to the microtubule minus-end directed motor protein dynein. In addition, p150(glued) also locates in the mother centriole where it organizes the subdistal appendage. The components of appendage are dynamically regulated t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

    更新日期:2015-09-01 00:00:00

  • A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims.

    abstract::Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apop...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Panahi Y,Abdolghaffari AH,Sahebkar A

    更新日期:2018-01-01 00:00:00

  • Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial.

    abstract::Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,随机对照试验


    authors: Gharipour M,Ouguerram K,Nazih EH,Salehi M,Behmanesh M,Roohafza H,Hosseini SM,Nezafati P,Dianatkhah M,Gharipour A,Haghjoo S,Sarrafzadegan N,Sadeghi M

    更新日期:2018-11-01 00:00:00