Abstract:
:Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have introduced for detecting CRC in different stages particularly in early stages. The standard treatments for CRC are surgery, chemotherapy and radiotherapy, in alone or combination. Immunotherapy is a set of novel approaches with the aim of remodeling the immune system battle with metastatic cancer cells, such as immunomodulatory monoclonal antibodies (immune checkpoint inhibitors), adoptive cell transfer (ACT) and cancer vaccine. Cancer vaccines are designed to trigger the intense response of immune system to tumor-specific antigens. In two last decades, introduction of new cancer vaccines and designing several clinical trials with vaccine therapy, have been taken into consideration in colon cancer patients. This review will describe the treatment approaches with the special attention to vaccines applied to treat colorectal cancer.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Sarvizadeh M,Ghasemi F,Tavakoli F,Sadat Khatami S,Razi E,Sharifi H,Biouki NM,Taghizadeh Mdoi
10.1002/jcb.28179subject
Has Abstractpub_date
2019-06-01 00:00:00pages
8815-8828issue
6eissn
0730-2312issn
1097-4644journal_volume
120pub_type
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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更新日期:2020-06-01 00:00:00
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doi:10.1002/jcb.20506
更新日期:2005-08-15 00:00:00
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