Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia: a possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation.

abstract：:Nucleic acids and regulatory proteins are architecturally organized in nuclear microenvironments. The compartmentalization of regulatory machinery for gene expression, replication and repair, is obligatory for fidelity of biological control. Perturbations in the organization, assembly and integration of regulatory mac...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Davie JR,Knowlton JR,Zaidi SK

更新日期：2008-08-15 00:00:00

abstract：:The P-glycoprotein (p170, P-gp) encoded by human MDR1 gene functions as a pump to extrude anticancer drugs from cancer cells. Over-expression of p170 is closely related to primary and induced drug resistance phenotype of tumor cells. Recent studies have demonstrated that expression of cyclooxygenase-2 (COX-2) is posit...

journal_title：Journal of cellular biochemistry

authors： Xia W,Zhao T,Lv J,Xu S,Shi J,Wang S,Han X,Sun Y

更新日期：2009-09-01 00:00:00

abstract：:Wnt/β-catenin signaling regulates various cellular events involved in the proliferation and differentiation and these events are affected sensitively by applying to mechanical stimuli. However, the mechanisms by which mechanical force stimulates cardiomyogenesis are not extensively explored. In this study we investiga...

journal_title：Journal of cellular biochemistry

authors： Heo JS,Lee JC

更新日期：2011-07-01 00:00:00

abstract：:Antibodies against pure discoidin I have been used as a tool to ascertain the role of this lectin in aggregation of Dictyostelium discoideum. Discoidin I is widely expressed over the cell surface of aggregation-competent AX-2 cells, as ascertained by indirect immunofluorescence with specific (antidiscoidin I) antibodi...

journal_title：Journal of cellular biochemistry

authors： Cano A,Pestaña A

更新日期：1984-01-01 00:00:00

abstract：:The vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors that controls mineral ion homeostatis and has potential tumor-suppressive functions for various cancer types, specifically prostate cancer. A VDR ablated transgenic animal model (VDDRII, vitamin D-dependent ricke...

journal_title：Journal of cellular biochemistry

authors： Guzey M,Jukic D,Arlotti J,Acquafondata M,Dhir R,Getzenberg RH

更新日期：2004-09-01 00:00:00

abstract：:The smallest rotary motor of living cells, F0F1-ATP synthase, couples proton flow-generated by the OXPHOS system-from the intermembrane space back to the matrix with the conversion of ADP to ATP. While all mutations affecting the multisubunit complexes of the OXPHOS system probably impact on the cell's output of ATP, ...

journal_title：Journal of cellular biochemistry

authors： Vazquez-Memije ME,Rizza T,Meschini MC,Nesti C,Santorelli FM,Carrozzo R

更新日期：2009-04-01 00:00:00

abstract：:In the heart, Ca2+/calmodulin-dependent protein kinase II is critically involved in the regulation of Ca2+ homeostasis. Previously the predominant expression of a subclass of Ca2+/calmodulin-dependent protein kinase II delta-subunit, containing a second variable domain, was demonstrated in cardiac tissue. Here we repo...

journal_title：Journal of cellular biochemistry

authors： Hagemann D,Hoch B,Krause EG,Karczewski P

更新日期：1999-08-01 00:00:00

abstract：:In this study, we purpose to investigate a novel five-gene signature for predicting the prognosis of patients with laryngeal cancer. The laryngeal cancer datasets were obtained from The Cancer Genome Atlas (TCGA). Both univariate and multivariate Cox regression analysis was applied to screening for prognostic differen...

journal_title：Journal of cellular biochemistry

authors： Zhang G,Fan E,Yue G,Zhong Q,Shuai Y,Wu M,Feng G,Chen Q,Gou X

更新日期：2019-10-31 00:00:00

abstract：:Rat liver regeneration after partial hepatectomy (PH) is a good model to study the regulation of cell proliferation. We isolated hepatocytes from regenerating liver at different time points after PH and used microarray Rat Genome 230 2.0 chip to analyze the functional profiles of all up- or down-regulated genes manual...

journal_title：Journal of cellular biochemistry

authors： Jiang Y,Zhang LX,Chang CF,Wang GP,Shi RJ,Yang YJ,Xu CS

更新日期：2011-11-01 00:00:00

abstract：:We have a long-standing interest in a nuclear protease which appears to be involved in carcinogenesis. We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases. HtrA1 has been classified as a secret...

journal_title：Journal of cellular biochemistry

authors： Clawson GA,Bui V,Xin P,Wang N,Pan W

更新日期：2008-09-01 00:00:00

abstract：:The influence of concentration of simvastatin (SIM) on free radicals in A-2058 human melanoma malignum cells was studied. The proliferation assay for melanoma A-2058 cells with SIM in concentration range from 0.1 to 20 µM was performed. SIM in the concentrations of 0.1, 0.3, and 1 μM only slightly changed the growth o...

journal_title：Journal of cellular biochemistry

authors： Zdybel M,Chodurek E,Pilawa B

更新日期：2018-09-11 00:00:00

abstract：:The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the c...

journal_title：Journal of cellular biochemistry

authors： Fofie CK,Katekhaye S,Borse S,Sharma V,Nivsarkar M,Nguelefack-Mbuyo EP,Kamanyi A,Singh V,Nguelefack TB

更新日期：2019-02-14 00:00:00

abstract：:All-trans-retinoic acid (ATRA) has been shown to inhibit the growth of a number of ovarian tumor cell lines while others have been found to be resistant to retinoid suppression of growth. Interestingly, two synthetic retinoids, CD437 and 4-HPR, inhibit the growth of both ATRA-sensitive (CA-OV-3) and ATRA-resistant (SK...

journal_title：Journal of cellular biochemistry

authors： Holmes WF,Soprano DR,Soprano KJ

更新日期：2003-05-15 00:00:00

abstract：:Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induct...

journal_title：Journal of cellular biochemistry

authors： Al-Rasheed NM,Al-Rasheed NM,Al-Rabeeah DA,Al-Barrak HS,Al-Salman SA,Ibrahim SA,Al-Hassab SA,Al-Amin MA,Hasan IH,Al-Ajmi HN,Al-Shammari TK

更新日期：2018-05-01 00:00:00

abstract：:Extracellular nucleotides and nucleosides have emerged as important elements regulating tissue homeostasis. Acting through specific receptors, have the ability to control gene expression patterns to direct cellular fate. We observed that SKOV-3 cells express the ectonucleotidases: ectonucleotide pyrophosphatase 1 (ENP...

journal_title：Journal of cellular biochemistry

authors： Martínez-Ramírez AS,Díaz-Muñoz M,Battastini AM,Campos-Contreras A,Olvera A,Bergamin L,Glaser T,Jacintho Moritz CE,Ulrich H,Vázquez-Cuevas FG

更新日期：2017-12-01 00:00:00

abstract：:Choline-deficiency causes liver cells to die by apoptosis, and it has not been clear whether the effects of choline-deficiency are mediated by methyl-deficiency or by lack of choline moieties. SV40 immortalized CWSV-1 hepatocytes were cultivated in media that were choline-sufficient, choline-deficient, choline-deficie...

journal_title：Journal of cellular biochemistry

authors： Shin OH,Mar MH,Albright CD,Citarella MT,da Costa KA,Zeisel SH

更新日期：1997-02-01 00:00:00

abstract：:The cellular basis of metastasis is poorly understood. An important step to understanding this process is to be able to visualize the routes by which cancer cells migrate from the primary tumor to various distant sites to eventually form metastasis. Our laboratory previously developed single-cell in vivo imaging using...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Wang X,Hoffman RM,Seki N

更新日期：2016-04-01 00:00:00

abstract：:During inflammation, overproduction of nitric oxide (NO) can damage chondrocytes. In this study, we separately evaluated the toxic effects of exogenous and endogenous NO on human chondrocytes and their possible mechanisms. Human chondrocytes were exposed to sodium nitroprusside (SNP), an NO donor, or a combination of ...

journal_title：Journal of cellular biochemistry

authors： Wu GJ,Chen TG,Chang HC,Chiu WT,Chang CC,Chen RM

更新日期：2007-08-15 00:00:00

abstract：:Ligamentum flavum (LF)-derived mesenchymal stem cells (MSCs) have been implicated in the pathogenesis of calcification of the ligamentum flavum (CLF) leading to the increased presence of chondrocyte-like cells and calcium deposition in CLF; however, the mechanisms of LF-MSCs in differentiation are not defined. In this...

journal_title：Journal of cellular biochemistry

authors： Zhang Q,Wang S,Sheng Y,Zhao S,Jiang Y,Zhou D,Yang H

更新日期：2019-03-01 00:00:00

abstract：:Our previous studies have shown that vanadium, a dietary micronutrient, has an inhibitory effect against experimentally induced rat hepatocarcinogenesis. In this study, we evaluated the role of vanadium on some potential protein expression markers of carcinogenesis, such as metallothionein (MT), an intracellular metal...

journal_title：Journal of cellular biochemistry

authors： Chakraborty T,Samanta S,Ghosh B,Thirumoorthy N,Chatterjee M

更新日期：2005-03-01 00:00:00

abstract：:Glioblastoma (GB) has a poor prognosis, despite current multimodality treatment. Beside surgical resection, adjuvant ionizing radiation (IR) combined with Temozolomide (TMZ) drug administration is the standard therapy for GB. This currently combined radio-chemotherapy treatment resulted in glial tumor cell death induc...

journal_title：Journal of cellular biochemistry

authors： Palumbo S,Pirtoli L,Tini P,Cevenini G,Calderaro F,Toscano M,Miracco C,Comincini S

更新日期：2012-07-01 00:00:00

abstract：:In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited...

journal_title：Journal of cellular biochemistry

authors： Butera ST,Perez VL,Besansky NJ,Chan WC,Wu BY,Nabel GJ,Folks TM

更新日期：1991-04-01 00:00:00

abstract：:Membrane receptors for steroid hormones affect signaling pathways that modulate nuclear function, influence neuronal activity, ion flow, and the circulatory system. Indeed, 'new' steroid hormones have been identified by their interaction with membrane-initiated signaling systems. A brief summary of the FASEB Summer Re...

journal_title：Journal of cellular biochemistry

authors： Nemere I,Pietras RJ,Blackmore PF

更新日期：2003-02-15 00:00:00

abstract：:PKCalpha was found to be expressed (mRNA and protein) throughout the in vitro maturation of primary human erythroblasts but its activity (phosphorylation levels and nuclear localization) was consistently higher in cells derived from human neonatal rather than adult blood. Since the gamma/gamma + beta globin expression...

journal_title：Journal of cellular biochemistry

authors： Di Baldassarre A,Di Rico M,Di Noia A,Bonfini T,Iacone A,Marchisio M,Miscia S,Alfani E,Migliaccio AR,Stamatoyannopoulos G,Migliaccio G

更新日期：2007-05-15 00:00:00

abstract：:The ATP-dependent transformation of crenated white human erythrocyte ghosts into smoothed disc and cup forms is inhibited by the soluble 40-45-kilodalton (kDa) cytoplasmic portion of the major transmembrane protein, band 3. The band 3 fragment was prepared by chymotryptic treatment of inverted vesicles stripped of per...

journal_title：Journal of cellular biochemistry

authors： Carter DP,Fairbanks G

更新日期：1984-01-01 00:00:00

abstract：:Transplantation of functional insulin-producing cells (IPCs) provides a novel mode for insulin replacement, but is often accompanied by many undesirable side effects. Our previous studies suggested that IPCs could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells. To obtain...

journal_title：Journal of cellular biochemistry

authors： Shi Q,Luo S,Jia H,Feng L,Lu X,Zhou L,Cai J

更新日期：2013-10-01 00:00:00

abstract：:Cocultures of rabbit fibroblasts and mouse B-16 melanoma cells produce increased levels of collagenase against type I collagen. This stimulatory effect was also found when fibroblasts were cultured in conditioned media from tumor cells. However, the level of the stimulatory factor in conditioned media was influenced b...

journal_title：Journal of cellular biochemistry

authors： Biswas C

更新日期：1985-01-01 00:00:00

abstract：:Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

journal_title：Journal of cellular biochemistry

authors： Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

更新日期：2018-09-06 00:00:00

abstract：:Multiple sclerosis (MS) is a highly disabling demyelinating disease, which mainly affects young adults and is difficult to cure. Activated microglia may be involved in the process of neuronal cell damage and release inflammatory cytokines to injure neurons. Rapamycin (RAPA), an immunosuppressant, can induce autophagy ...

journal_title：Journal of cellular biochemistry

authors： Xu L,Zhang C,Jiang N,He D,Bai Y,Xin Y

更新日期：2019-04-01 00:00:00

abstract：:Metastatic variant cell lines of the murine RAW117 large cell lymphoma were used to study the cell surface components involved in syngeneic tumor cell/microvessel endothelial cell interactions. Poorly liver-metastatic parental RAW117-P cell line adhered to murine hepatic sinusoidal endothelial cell monolayers at signi...

journal_title：Journal of cellular biochemistry

authors： Tressler RJ,Nicolson GL

更新日期：1992-02-01 00:00:00