Functional analysis of DNA sequences located within a cluster of DNase I hypersensitive sites colocalizing with a MAR element at the upstream border of the chicken alpha-globin gene domain.

abstract：:Plasminogen activator inhibitor type-1 (PAI-1), a major regulator of the plasmin-dependent pericellular proteolytic cascade, is prominently expressed during the tissue response to injury although the factors that impact PAI-1 induction and their role in the repair process are unclear. Kinetic modeling using establishe...

journal_title：Journal of cellular biochemistry

authors： Qi L,Higgins CE,Higgins SP,Law BK,Simone TM,Higgins PJ

更新日期：2014-10-01 00:00:00

abstract：:Poor clinical outcomes of tendon repair, together with limited regenerative capacity of the tissue, have triggered the search for alternative regenerative medicine strategies. Human adipose-derived stem cells (hASCs) are being investigated as a promising cell source in contributing for tendon repopulation and reconstr...

journal_title：Journal of cellular biochemistry

authors： Costa-Almeida R,Berdecka D,Rodrigues MT,Reis RL,Gomes ME

更新日期：2018-04-01 00:00:00

abstract：:The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important role in the antioxidant defenses of the spermatogenic epithelium. Autophagy can act as a pro-survival response during oxidative stress or nutrient deficiency. In this work...

journal_title：Journal of cellular biochemistry

authors： Mancilla H,Maldonado R,Cereceda K,Villarroel-Espíndola F,Montes de Oca M,Angulo C,Castro MA,Slebe JC,Vera JC,Lavandero S,Concha II

更新日期：2015-10-01 00:00:00

abstract：:In our previous study, we screened and isolated genes that were up-regulated after partial pancreatectomy using transcriptomic analysis and glutamate-ammonia ligase (GLUL) was selected for further study based on its effect on differentiation and proliferation. In the immunohistochemical analysis, GLUL was highly up-re...

journal_title：Journal of cellular biochemistry

authors： Choi JH,Lim KH,Park E,Kim JY,Choi YK,Baek KH

更新日期：2013-02-01 00:00:00

abstract：:The core binding factor (CBF) acute myeloid leukemias (AMLs) are a prognostically distinct subgroup that includes patients with the inv(16) and t(8:21) chromosomal rearrangements. Both of these rearrangements result in the formation of fusion proteins, CBFB-MYH11 and AML1-ETO, respectively, that involve members of the...

journal_title：Journal of cellular biochemistry

authors： Hyde RK,Liu PP

更新日期：2010-08-01 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial-mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in an inflammatory microenvironment. B...

journal_title：Journal of cellular biochemistry

authors： Ye K,Chen QW,Sun YF,Lin JA,Xu JH

更新日期：2018-02-01 00:00:00

abstract：:We have previously demonstrated that hydrogen peroxide (H(2)O(2)) treatment of murine 70Z/3 pre-B lymphocytes inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase (JNK) activation. In the present study, we further examined the signaling intermediates responsible f...

journal_title：Journal of cellular biochemistry

authors： Lee M,Koh WS

更新日期：2003-02-15 00:00:00

abstract：:Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postnatal growth plate (G...

journal_title：Journal of cellular biochemistry

authors： Wu LN,Lu M,Genge BR,Guo GY,Nie D,Wuthier RE

更新日期：2002-01-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is devastating for its delayed presence, difficulty in diagnosis, and high mortality. Other studies have supported the important role of microRNAs (miRNAs) in the pathogenesis of CCA, and the role of miR-194 was investigated in several human cancers, though, the molecular mechanism of miR-194 ...

journal_title：Journal of cellular biochemistry

authors： Gao J,Dai C,Yu X,Yin XB,Zhou F

更新日期：2020-10-01 00:00:00

abstract：:It has been reported that the antitumor drug doxorubicin (Dox) exerts its toxic effects via GATA-4 depletion and that over-expression of GATA-4 reverses Dox-induced toxicity and apoptosis; however, the precise mechanisms remain unclear. In this study, we observed, for the first time, that EGF protects cells against Do...

journal_title：Journal of cellular biochemistry

authors： Yao CX,Shi JC,Ma CX,Xiong CJ,Song YL,Zhang SF,Zhang SF,Zang MX,Xue LX

更新日期：2015-08-01 00:00:00

abstract：:Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic humans and animals. We recently reported that, targeted deletion of insulin receptor (IR) from proximal tubules (PT) resulted in hyperglycemia in non-obese mice. To elucidate the mechanism, we examined human proximal tubule c...

journal_title：Journal of cellular biochemistry

authors： Pandey G,Shankar K,Makhija E,Gaikwad A,Ecelbarger C,Mandhani A,Srivastava A,Tiwari S

更新日期：2017-02-01 00:00:00

abstract：:Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

journal_title：Journal of cellular biochemistry

authors： Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

更新日期：2019-02-19 00:00:00

abstract：:We investigated the association of DNA polymerase and DNA primase activity with the nuclear matrix in HeLa S3 cells diluted with fresh medium after having been cultured without any medium change for 7 days. Flow cytometric analysis demonstrated that just before dilution about 85% of the cells were in the G1 phase of t...

journal_title：Journal of cellular biochemistry

authors： Martelli AM,Capitani S,Neri LM

更新日期：1998-10-01 00:00:00

abstract：:Thymoquinone (TQ) is the major active compound derived from the medicinal Nigella sativa. A few studies have shown that TQ exhibits anti-inflammatory activities in experimental models of rheumatoid arthritis (RA) through mechanisms that are not fully understood. The aim of this work was to evaluate the in vitro and in...

journal_title：Journal of cellular biochemistry

authors： Vaillancourt F,Silva P,Shi Q,Fahmi H,Fernandes JC,Benderdour M

更新日期：2011-01-01 00:00:00

abstract：:The adaptor protein-2 (AP-2) complex refers to a class of proteins that play an important role in cargo recognition and are involved in clathrin-mediated endocytosis of cargo proteins from the plasma membrane in animal cells. However, there have been few studies of AP-2 in insects. Here, we isolated an AP-2 gene from ...

journal_title：Journal of cellular biochemistry

authors： Wang X,Chao Y,Wang Y,Xu B,Wang C,Li H

更新日期：2019-10-01 00:00:00

abstract：:The BRCA1 tumor suppressor involved in breast and ovarian cancer is linked to several fundamental cell regulatory processes. Recently, it was reported that BRCA1 supports localization of XIST RNA to the inactive X chromosome (Xi) in women. The apparent cytological overlap between BRCA1 and XIST RNA across the Xi raise...

journal_title：Journal of cellular biochemistry

authors： Pageau GJ,Hall LL,Lawrence JB

更新日期：2007-03-01 00:00:00

abstract：:Extracts of thymic lymphoma that are obtained from AKR mice and are kept in the cold for at least several days can induce lipolytic activity in rat adipocyte suspensions. Freshly prepared extracts have low activity but contain a low molecular weight material of less than 10,000 daltons that aggregates on standing in t...

journal_title：Journal of cellular biochemistry

authors： Kitada S,Hays EF,Mead JF,Zabin I

更新日期：1982-01-01 00:00:00

abstract：:Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

journal_title：Journal of cellular biochemistry

authors： Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

更新日期：1982-01-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is known to have a number of biological properties including promoting tumor progression of human carcinomas. Metastasis involves a number of events that are attributed to induction by paracrine factors such as HGF. Identification of natural inhibitors of these events would allow better ...

journal_title：Journal of cellular biochemistry

authors： Uchiyama A,Essner R,Doi F,Nguyen T,Ramming KP,Nakamura T,Morton DL,Hoon DS

更新日期：1996-09-15 00:00:00

abstract：:The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-alpha (ER-alpha) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-alpha protein concentration by 3 h, and the amount of ER-al...

journal_title：Journal of cellular biochemistry

authors： Stoica A,Saceda M,Fakhro A,Joyner M,Martin MB

更新日期：2000-01-01 00:00:00

abstract：:Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote cell proliferation, migration, and invasion, while its molecular mechanisms were still largely unclear. In this study, we investigated the expression and functi...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Yang N,Du G,Li C,Liu G,Liu S,Xu Y,Di Y,Pan W,Li X

更新日期：2018-11-14 00:00:00

abstract：:The pro-oxidant effect of L-ascorbic acid (LAA) is toxic to leukemia cells. LAA induces the oxidation of glutathione to its oxidized form (GSSG) and this is followed by a concentration-dependent H(2)O(2) accumulation, which occurs in parallel to the induction of apoptosis. To identify early protein targets of LAA in l...

journal_title：Journal of cellular biochemistry

authors： Park S,Lee J,Yeom CH

更新日期：2006-12-15 00:00:00

abstract：:Endothelins (ETs) are vasoconstrictive peptides produced mainly by endothelial cells. The ET receptors are expressed in many types of cells including osteoblast-like cells. The purpose of this study was to examine the effects of endothelin on the expression of osteoblastic phenotype-related genes. We found that endoth...

journal_title：Journal of cellular biochemistry

authors： Shioide M,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Resident T lymphocytes have been found to exert helper and suppressor regulatory influences with regard to polyclonal activation of murine splenic B lymphocytes elicited by lipopolysaccharide. In the normal adult spleen, only T cell helper influences are exercised over polyclonal B cell activation. This activity is a ...

journal_title：Journal of cellular biochemistry

authors： Goodman MG,Weigle WO

更新日期：1982-01-01 00:00:00

abstract：:Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated...

journal_title：Journal of cellular biochemistry

authors： Yang F,Li T,Dong Z,Mi R

更新日期：2018-02-01 00:00:00

abstract：:Fibroblasts play a major role in processes such as wound repair, scarring, and fibrosis. Differentiation into myofibroblasts, characterized by upregulation of smooth muscle alpha-actin (smalpha) in response to profibrotic agents such as TGFbeta is believed to be an important step in fibrosis. Therefore, elucidating me...

journal_title：Journal of cellular biochemistry

authors： Sousa AM,Liu T,Guevara O,Stevens J,Fanburg BL,Gaestel M,Toksoz D,Kayyali US

更新日期：2007-04-15 00:00:00

abstract：:Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to fin...

journal_title：Journal of cellular biochemistry

authors： Zhang C,Jiang F,Su C,Xie P,Xu L

更新日期：2019-02-14 00:00:00

abstract：:Because irradiation may cause osteoradionecrosis, antioxidant supplementation is often used to suppress irradiation-mediated injury. This study examined whether a synthetic phenethyl urea compound, (E)-1-(3,4-dihydroxyphenethyl)-3-(3,4-dihydroxystyryl)urea (DPDS-U), prevents irradiation-mediated cellular damage in MC3...

journal_title：Journal of cellular biochemistry

authors： Kim KA,Kook SH,Song JH,Lee JC

更新日期：2014-11-01 00:00:00

abstract：:Despite important advances in regenerative medicine and tissue engineering, still, wound healing remains a challenging clinical problem. Cell therapy has opened a new viewpoint in medicine as well as wound management, although it has some limitations. On the other hand, there are some hopes for the eliminated of cellu...

journal_title：Journal of cellular biochemistry

authors： Golchin A,Hosseinzadeh S,Ardeshirylajimi A

更新日期：2018-07-01 00:00:00

abstract：:Human bone marrow stromal cells (hBMSC) are pluripotent cells that have the ability to differentiate into bone, cartilage, hematopoietic-supportive stroma, and adipocytes in a process modulated by dexamethasone (DEX). To characterize changes in hBMSC in response to DEX, we carried out differential display experiments ...

journal_title：Journal of cellular biochemistry

authors： Dieudonné SC,Kerr JM,Xu T,Sommer B,DeRubeis AR,Kuznetsov SA,Kim IS,Gehron Robey P,Young MF

更新日期：1999-12-01 00:00:00