Abstract:
:Despite important advances in regenerative medicine and tissue engineering, still, wound healing remains a challenging clinical problem. Cell therapy has opened a new viewpoint in medicine as well as wound management, although it has some limitations. On the other hand, there are some hopes for the eliminated of cellular therapies limitations by "exosomes." The term "exosome" has been frequently used to describe all vesicles released by different cells into the extracellular environment and can influence tissue responses to injury, infection, immune system, and healing. Exosomes contain cytokines and growth factors, signaling lipids, mRNAs, and regulatory miRNAs that have been found in some body fluids and can be transferred between cells to mediating cell-to-cell communication and interactions. Recently, several studies have demonstrated that exosomes are one of the key secretory products of various cell type especially mesenchymal stem cells (MSCs) to regulate many biological processes such wound healing. Hence, understanding these exosomes effects may help to improve wound management and highlight a new therapeutic model for cell-free therapies with decreased side effects for the wound repair.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Golchin A,Hosseinzadeh S,Ardeshirylajimi Adoi
10.1002/jcb.26706subject
Has Abstractpub_date
2018-07-01 00:00:00pages
5043-5052issue
7eissn
0730-2312issn
1097-4644journal_volume
119pub_type
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