The exosomes released from different cell types and their effects in wound healing.

Abstract:

:Despite important advances in regenerative medicine and tissue engineering, still, wound healing remains a challenging clinical problem. Cell therapy has opened a new viewpoint in medicine as well as wound management, although it has some limitations. On the other hand, there are some hopes for the eliminated of cellular therapies limitations by "exosomes." The term "exosome" has been frequently used to describe all vesicles released by different cells into the extracellular environment and can influence tissue responses to injury, infection, immune system, and healing. Exosomes contain cytokines and growth factors, signaling lipids, mRNAs, and regulatory miRNAs that have been found in some body fluids and can be transferred between cells to mediating cell-to-cell communication and interactions. Recently, several studies have demonstrated that exosomes are one of the key secretory products of various cell type especially mesenchymal stem cells (MSCs) to regulate many biological processes such wound healing. Hence, understanding these exosomes effects may help to improve wound management and highlight a new therapeutic model for cell-free therapies with decreased side effects for the wound repair.

journal_name

J Cell Biochem

authors

Golchin A,Hosseinzadeh S,Ardeshirylajimi A

doi

10.1002/jcb.26706

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

5043-5052

issue

7

eissn

0730-2312

issn

1097-4644

journal_volume

119

pub_type

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