Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.

abstract：:This laboratory recently reported the development of a biotin-cellulose/streptavidin affinity chromatography method based on the DNase I sensitivity of active chromatin to isolate a DNA fraction from murine erythroleukemia (MEL) cells that is more than 15-fold enriched in active genes (Dawson et al.: Journal of Biolog...

journal_title：Journal of cellular biochemistry

authors： Dawson BA,Herman T,Haas AL,Lough J

更新日期：1991-06-01 00:00:00

abstract：:Suppressor of cytokine signaling-3 (SOCS3) has multiple functions including inhibition of Janus kinase (Jak) activity, regulation of protein degradation, and suppression of cytokine signaling. SOCS3 modulates macrophage response to cytokines such as IL-6 and leptin that are systemically induced in obesity. Obesity is ...

journal_title：Journal of cellular biochemistry

authors： Scheller EL,Hankenson KD,Reuben JS,Krebsbach PH

更新日期：2011-11-01 00:00:00

abstract：:The effects of serum on inositol 1,4,5-trisphosphate (IP3) formation and Ca2+ mobilization in the human submandibular cell line A253 were studied. Exposure of A253 cells to fetal bovine serum (FBS) elicited a 3.3-fold increase in IP3 formation and a concentration-dependent transient increase in cytosolic free Ca2+ con...

journal_title：Journal of cellular biochemistry

authors： Sun X,Mörk AC,Helmke RJ,Martinez JR,Zhang GH

更新日期：1999-06-15 00:00:00

abstract：:Sertoli cells provide the nutritional and metabolic support for germ cells. Wnt/β-catenin signaling is important for the development of the seminiferous epithelium during embryonic age, although after birth this pathway is downregulated. Cx43 gene codes for a protein that is critical during testicular development. The...

journal_title：Journal of cellular biochemistry

authors： López C,Aguilar R,Nardocci G,Cereceda K,Vander Stelt K,Slebe JC,Montecino M,Concha II

更新日期：2019-04-01 00:00:00

abstract：:The Skp1-Cul1-F-box protein (SCF) E3 ligase complex is one of the largest ubiquitin E3 ligase families. FBXL19, a F-box protein in SCFFBXL19 E3 ligase complex, regulates a variety of cellular responses including cell migration. We have shown that FBXL19 is not stable and its degradation is mediated by the ubiquitin-pr...

journal_title：Journal of cellular biochemistry

authors： Dong S,Wei J,Bowser RK,Chen BB,Mallampalli RK,Miao J,Ye Q,Tran KC,Zhao Y,Zhao J

更新日期：2020-10-14 00:00:00

abstract：:Vascular pathologies induced by ischemia/reperfusion involve the production of reactive oxygen species (ROS) that in part cause tissue injury. The production of ROS that occurs upon reperfusion activates specific second messenger pathways. In diabetic retinopathy there is a characteristic loss of the microvascular per...

journal_title：Journal of cellular biochemistry

authors： Shojaee N,Patton WF,Hechtman HB,Shepro D

更新日期：1999-10-01 00:00:00

abstract：:Epidemiological studies and animal models suggest a link between high levels of dietary fat intake and an increased risk of developing breast cancer. Hyperinsulinemia is a feature of obesity, diabetes, and metabolic syndrome that is associated with an increased breast cancer risk. Insulin is a hormone involved in meta...

journal_title：Journal of cellular biochemistry

authors： Rodriguez-Monterrosas C,Diaz-Aragon R,Cortes-Reynosa P,Salazar EP

更新日期：2018-07-01 00:00:00

abstract：:The T-box family of transcription factors has been shown to have major impact on human development and disease. In animal studies Tbx20 is essential for the development of the atrioventricular channel, the outflow tract and valves, suggesting its potential causative role for the development of Tetralogy of Fallot (TOF...

journal_title：Journal of cellular biochemistry

authors： Hammer S,Toenjes M,Lange M,Fischer JJ,Dunkel I,Mebus S,Grimm CH,Hetzer R,Berger F,Sperling S

更新日期：2008-06-01 00:00:00

abstract：:Due to the increasing incidence and mortality, the early diagnosis, specific targeted therapies, and prognosis for colorectal cancer (CRC) attract more and more attention. Wild-type p53-induced phosphatase 1 (Wip1) and karyopherin α2 (KPNA2) have been regarded as oncogenes in many cancers, including CRC. Wip1 dephosph...

journal_title：Journal of cellular biochemistry

authors： Wang P,Zhao Y,Liu K,Liu X,Liang J,Zhou H,Wang Z,Zhou Z,Xu N

更新日期：2019-09-01 00:00:00

abstract：:During neonatal development, cardiac myocytes undergo a transition from hyperplastic to hypertrophic growth. Whether these cells are terminally differentiated and permanently withdrawn from the cell cycle shortly after birth is controversial. Nevertheless, the clinical observation that functionally significant myocard...

journal_title：Journal of cellular biochemistry

authors： Chim SS,Fung K,Waye MM,Lee C,Tsui SK

更新日期：2000-06-12 00:00:00

abstract：:The 17,180 base-pair Eco-RI-C fragment of Epstein-Barr virus has been sequenced in its entirety. This same fragment has also been analyzed for RNA polymerase II promoters, which are active in a soluble in vitro assay. These data are compared to the availability of predicted open reading frames and potential nucleotide...

journal_title：Journal of cellular biochemistry

authors： Deininger PL,Bankier A,Farrell P,Baer R,Barrell B

更新日期：1982-01-01 00:00:00

abstract：:The activity of α-type cytosolic phospholipase A2 (cPLA2 α, group IVA PLA2 ), which releases arachidonic acid (AA), is mainly regulated by the Ca2+ -induced intracellular translocation/attachment of the enzyme to substrate membranes and its phosphorylation. We previously reported that tumor necrosis factor-α (TNFα) st...

journal_title：Journal of cellular biochemistry

authors： Nakamura H,Moriyama Y,Watanabe K,Tomizawa S,Yamazaki R,Takahashi H,Murayama T

更新日期：2017-12-01 00:00:00

abstract：:Interleukin-1 beta-converting enzyme (ICE) is a cysteine protease responsible for proteolytic activation of the biologically inactive interleukin-1 beta precursor to the proinflammatory cytokine. ICE and homologous proteases also appear to mediate intracellular protein degradation during programmed cell death. Inhibit...

journal_title：Journal of cellular biochemistry

authors： Livingston DJ

更新日期：1997-01-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have shown that the cdk5/p35 complex associates with and phosphorylates the neuronal delta-catenin. I...

journal_title：Journal of cellular biochemistry

authors： Muñoz JP,Huichalaf CH,Orellana D,Maccioni RB

更新日期：2007-02-15 00:00:00

abstract：:Reveromycin A (RM-A), a small natural product isolated from Streptomyces bacteria, is a potential osteoporosis therapeutic in that it specifically induces apoptosis in osteoclasts but not osteoblasts. The purpose of the study presented here was to further elucidate the intracellular mechanisms of RM-A death effects in...

journal_title：Journal of cellular biochemistry

authors： Mead B,Morgan H,Mann-Knowlton A,Tedeschi L,Sloan C,Lang S,Hines C,Gragg M,Stofer J,Riemann K,Derr T,Heller E,Collins D,Landis P,Linna N,Jones D

更新日期：2015-08-01 00:00:00

abstract：:Cytology and cell biology are two separate fields that share a focus on cancer. Cancer is still diagnosed based on morphology, and surprisingly little is known about the molecular basis of the defining structural features. Cytology uses the smallest possible biopsy for diagnosis by reducing morphologic "criteria of ma...

journal_title：Journal of cellular biochemistry

authors： Fischer AH,Zhao C,Li QK,Gustafson KS,Eltoum IE,Tambouret R,Benstein B,Savaloja LC,Kulesza P

更新日期：2010-07-01 00:00:00

abstract：:The mass and function of bones depend on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. An inhibitor of osteoclast differentiation and/or function is expected to be useful for treatment of bone lytic diseases such as osteoporosis, rheumatoid...

journal_title：Journal of cellular biochemistry

authors： Yonezawa T,Mase N,Sasaki H,Teruya T,Hasegawa S,Cha BY,Yagasaki K,Suenaga K,Nagai K,Woo JT

更新日期：2012-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is the most prevalent viral pathogen that infects more than 185 million people worldwide. HCV infection leads to chronic liver diseases such as liver cirrhosis and hepatocellular carcinoma. Direct-acting antivirals (DAAs) are the recent combination therapy for HCV infection with reduced side ef...

journal_title：Journal of cellular biochemistry

authors： Venkatesan A,Prabhu Dass J F

更新日期：2019-08-01 00:00:00

abstract：:Skin is a representative self-renewing tissue containing stem cells. Although many attempts have been made to define and isolate skin-derived stem cells, establishment of a simple and reliable isolation procedure remains a goal to be achieved. Here, we report the isolation of cells having stem cell properties from mou...

journal_title：Journal of cellular biochemistry

authors： Medina RJ,Kataoka K,Takaishi M,Miyazaki M,Huh NH

更新日期：2006-05-01 00:00:00

abstract：:Endochondral bone formation is one of the most extensively examined developmental sequences within vertebrates. This process involves the coordinated temporal/spatial differentiation of three separate tissues (cartilage, bone, and the vasculature) into a variety of complex structures. The differentiation of chondrocyt...

journal_title：Journal of cellular biochemistry

authors： Gerstenfeld LC,Shapiro FD

更新日期：1996-07-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is still an unresolved source of tumor-related death internationally. Current studies have discovered that microRNAs (miRNAs) are associated with diverse cancers development, including NSCLC. Our paper focused on the functional character of miR-4286 in NSCLC. miR-4286 level in 68 cas...

journal_title：Journal of cellular biochemistry

authors： An X,Ge J,Guo H,Mi H,Zhou J,Liu Y,Weiyue,Wu Z

更新日期：2019-10-01 00:00:00

abstract：:The pathways of transduction of oxidative stress signals have been studied using the Jurkat T cell model. The oxidative stress was induced by exposure of the cells to 100 microM H(2)O(2). DNA damage was detected within 15 min after commencement of treatment. DNA damage repair occurred within about 1 h in cells exposed...

journal_title：Journal of cellular biochemistry

authors： Chiaramonte R,Bartolini E,Riso P,Calzavara E,Erba D,Testolin G,Comi P,Sherbet GV

更新日期：2001-01-01 00:00:00

abstract：:Transplantation of functional insulin-producing cells (IPCs) provides a novel mode for insulin replacement, but is often accompanied by many undesirable side effects. Our previous studies suggested that IPCs could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells. To obtain...

journal_title：Journal of cellular biochemistry

authors： Shi Q,Luo S,Jia H,Feng L,Lu X,Zhou L,Cai J

更新日期：2013-10-01 00:00:00

abstract：:High concentrations of nonesterified fatty acids (NEFAs) and β-hydroxybutyric acid (BHBA) induce lipid peroxidation, resulting in liver damage. Choline and methionine (Met) can promote energy balance and benefit liver health in transition dairy cows; however, the regulating mechanism remains unclear. In the present st...

journal_title：Journal of cellular biochemistry

authors： Shen J,Sun B,Yu C,Cao Y,Cai C,Yao J

更新日期：2019-11-03 00:00:00

abstract：OBJECTIVE:This study aimed to investigate the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population. METHODS:In this study, 232 patients were divided into the SCA group and the coronary disease group with c...

journal_title：Journal of cellular biochemistry

authors： Liu A,Wang S,Zhang C,Sun D,Song X

更新日期：2019-03-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) exhibits an inverse correlation with estrogen receptor (ER) expression in the majority of breast cancers, predicting a poor response to endocrine therapy and poor survival rate. Inappropriate overexpression of EGFR in breast cancer is associated with a more aggressive phenot...

journal_title：Journal of cellular biochemistry

authors： Wilson MA,Chrysogelos SA

更新日期：2002-01-01 00:00:00

abstract：:Sarcopenia and osteoporosis have recently been noted for their relationship with locomotive syndrome and increased number of older people. Sarcopenia is defined by decreased muscle mass and impaired muscle function, which may be associated with frailty. Several clinical data have indicated that increased muscle mass i...

journal_title：Journal of cellular biochemistry

authors： Kawao N,Kaji H

更新日期：2015-05-01 00:00:00

abstract：:Stimulation of transient receptor potential M3 (TRPM3) cation channels with pregnenolone sulfate induces an influx of Ca2+ ions into the cells and a rise in the intracellular Ca2+ concentration, leading to the activation of the activator protein-1 (AP-1) transcription factor. Here, we show that expression of a constit...

journal_title：Journal of cellular biochemistry

authors： Lesch A,Rössler OG,Thiel G

更新日期：2017-08-01 00:00:00

abstract：:The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances pe...

journal_title：Journal of cellular biochemistry

authors： Reddi AH

更新日期：1994-10-01 00:00:00