Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells.

Abstract:

:Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role of FOXO6 in colorectal cancer (CRC) is still unclear. The study aimed to investigate the potential roles of FOXO6 in the development of CRC. Our results showed that FOXO6 was overexpressed in CRC tissues and cell lines. FOXO6 knockdown inhibited cell proliferation, as well as repressed the migration and invasion of CRC cells. Additionally, we found that FOXO6 knockdown altered cellular metabolism by inhibiting glycolysis and promoting mitochondrial respiration. Furthermore, FOXO6 knockdown inhibited the activation of PI3K/Akt/mTOR pathway in CRC cells. The results herein indicated that FOXO6 knockdown inhibited cell proliferation, migration, invasion, and glycolysis in CRC cells. PI3K/Akt/mTOR pathway was involved in the effects of FOXO6 on CRC cells. These findings suggested that FOXO6 might be a potential target for the CRC therapy.

journal_name

J Cell Biochem

authors

Li Q,Tang H,Hu F,Qin C

doi

10.1002/jcb.27667

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

3853-3860

issue

3

eissn

0730-2312

issn

1097-4644

journal_volume

120

pub_type

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