Abstract:
:Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role of FOXO6 in colorectal cancer (CRC) is still unclear. The study aimed to investigate the potential roles of FOXO6 in the development of CRC. Our results showed that FOXO6 was overexpressed in CRC tissues and cell lines. FOXO6 knockdown inhibited cell proliferation, as well as repressed the migration and invasion of CRC cells. Additionally, we found that FOXO6 knockdown altered cellular metabolism by inhibiting glycolysis and promoting mitochondrial respiration. Furthermore, FOXO6 knockdown inhibited the activation of PI3K/Akt/mTOR pathway in CRC cells. The results herein indicated that FOXO6 knockdown inhibited cell proliferation, migration, invasion, and glycolysis in CRC cells. PI3K/Akt/mTOR pathway was involved in the effects of FOXO6 on CRC cells. These findings suggested that FOXO6 might be a potential target for the CRC therapy.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Li Q,Tang H,Hu F,Qin Cdoi
10.1002/jcb.27667subject
Has Abstractpub_date
2019-03-01 00:00:00pages
3853-3860issue
3eissn
0730-2312issn
1097-4644journal_volume
120pub_type
杂志文章abstract::We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we hav...
journal_title:Journal of cellular biochemistry
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4644(19960601)61:3%3C459::AID-J
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abstract::The initiation of DNA replication in T lymphocytes appears to be regulated by two distinct activities: one associated with proliferation which mediates initiation, and another associated with quiescence which blocks initiation. Activated lymphocytes and proliferating lymphoid cell lines produce an activity, termed ADR...
journal_title:Journal of cellular biochemistry
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journal_title:Journal of cellular biochemistry
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更新日期:2014-06-01 00:00:00
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journal_title:Journal of cellular biochemistry
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更新日期:2014-09-01 00:00:00
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更新日期:2003-02-15 00:00:00
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journal_title:Journal of cellular biochemistry
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更新日期:1995-06-01 00:00:00
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journal_title:Journal of cellular biochemistry
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doi:10.1002/jcb.20625
更新日期:2005-12-15 00:00:00
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journal_title:Journal of cellular biochemistry
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