Genome-wide screening and cohorts validation identifying novel lncRNAs as prognostic biomarkers for clear cell renal cell carcinoma.

abstract：:A new method of protein nucleation and crystallization based on Langmuir-Blodgett technology is here utilized for the template stimulation of crystal growth of so far non-crystallized proteins. Microcrystals (60-120 microm) of bovine cytochrome P450scc and human protein kinase CKII alpha subunit were obtained with use...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Nicolini C

更新日期：2002-01-01 00:00:00

abstract：:Genomic imprinting is an epigenetic mechanism that restricts gene expression to one inherited allele. Improper maintenance of imprinting has been implicated in a number of human diseases and developmental syndromes. Assays are needed that can quantify the contribution of each paternal allele to a gene expression profi...

journal_title：Journal of cellular biochemistry

authors： Yang B,Damaschke N,Yao T,McCormick J,Wagner J,Jarrard D

更新日期：2015-07-01 00:00:00

abstract：:Pulmonary fibrosis (PF) is a fibroproliferative disease that can eventually lead to fatal lung failure. It is characterized by abnormal proliferation of fibroblasts, dysregulated fibroblast differentiation to myofibroblast, and disorganized collagen and extracellular matrix production, deposition and degradation. Ther...

journal_title：Journal of cellular biochemistry

authors： Li J,Kong X,Jiang S,Liao W,Zhang Z,Song J,Liang Y,Zhang W

更新日期：2019-03-01 00:00:00

abstract：:Endogenous peptides play crucial roles in various biological processes. Their effects on the pathogenesis of human infantile hemangioma remains poorly understood. In this study, we construct a comparative peptidomic profiling between human infantile hemangioma tissue and matched normal skin using liquid chromatography...

journal_title：Journal of cellular biochemistry

authors： Li Q,Li J,Chen L,Gao Y,Li J

更新日期：2018-06-01 00:00:00

abstract：:The recently identified 53-kDa substrate of the insulin receptor family was further characterized in several retroviral-generated stable cell lines overexpressing the wild type and various mutant forms of the protein. To facilitate the study of its subcellular localization in NIH3T3 cells overexpressing insulin recept...

journal_title：Journal of cellular biochemistry

authors： Yeh TC,Li W,Keller GA,Roth RA

更新日期：1998-02-01 00:00:00

abstract：:Skin is a representative self-renewing tissue containing stem cells. Although many attempts have been made to define and isolate skin-derived stem cells, establishment of a simple and reliable isolation procedure remains a goal to be achieved. Here, we report the isolation of cells having stem cell properties from mou...

journal_title：Journal of cellular biochemistry

authors： Medina RJ,Kataoka K,Takaishi M,Miyazaki M,Huh NH

更新日期：2006-05-01 00:00:00

abstract：:TNF is a key inflammatory cytokine with antiviral properties. Human adenoviruses encode several intracellular proteins that mediate the effects of TNF. Expression of the adenovirus immediate early E1A proteins induces viral genes and a host of cellular genes, drives G0 cells into S-phase, and induces apoptosis and sus...

journal_title：Journal of cellular biochemistry

authors： Wold WS

更新日期：1993-12-01 00:00:00

abstract：:Obesity and aging lead to abnormal transforming growth factor-β1 (TGF-β1) signaling in the hypothalamus, triggering the imbalance on glucose metabolism and energy homeostasis. Here, we determine the effect of acute exercise on TGF-β1 expression in the hypothalamus of two models of obesity in mice. The bioinformatics a...

journal_title：Journal of cellular biochemistry

authors： Silva VRR,Lenhare L,Katashima CK,Morari J,M-Assis A,Gaspar RS,da Silva ASR,Moura LP,Pauli JR,Cintra DE,Velloso LA,Ropelle ER

更新日期：2019-10-01 00:00:00

abstract：:The SON protein is a ubiquitously expressed DNA- and RNA-binding protein primarily localized to nuclear speckles. Although several early studies implicated SON in DNA-binding, tumorigenesis and apoptosis, functional significance of this protein had not been recognized until recent studies discovered SON as a novel RNA...

journal_title：Journal of cellular biochemistry

authors： Hickey CJ,Kim JH,Ahn EY

更新日期：2014-02-01 00:00:00

abstract：:Cytology and cell biology are two separate fields that share a focus on cancer. Cancer is still diagnosed based on morphology, and surprisingly little is known about the molecular basis of the defining structural features. Cytology uses the smallest possible biopsy for diagnosis by reducing morphologic "criteria of ma...

journal_title：Journal of cellular biochemistry

authors： Fischer AH,Zhao C,Li QK,Gustafson KS,Eltoum IE,Tambouret R,Benstein B,Savaloja LC,Kulesza P

更新日期：2010-07-01 00:00:00

abstract：:The following thiol-containing peptide analogues of the carboxyl side of the collagenase-sensitive bond of collagen were synthesized and tested as inhibitors of collagenases partially purified from homogenates of rabbit V-2 tumor and culture medium of pig synovium: HSCH2CH(CH3)CO-Ala-OEt (I), HSCH2CH(CH2Ph)CO-Ala-OEt ...

journal_title：Journal of cellular biochemistry

authors： Gray RD,Miller RB,Spatola AF

更新日期：1986-01-01 00:00:00

abstract：:Pyrimidine-specific ribonucleases are a superfamily of structurally related enzymes with distinct catalytic and biological properties. We used a combination of enzymatic and non-enzymatic assays to investigate the release of such enzymes by isolated cells in serum-free and serum-containing media. We found that human e...

journal_title：Journal of cellular biochemistry

authors： Landré JB,Hewett PW,Olivot JM,Friedl P,Ko Y,Sachinidis A,Moenner M

更新日期：2002-01-01 00:00:00

abstract：:Countercurrent centrifugal elutriation was used to separate growth plate chondrocytes from porcine basing on their differences in sizes and densities. Eighteen fractions of cells with different sizes and densities were obtained. The mean cellular volumes increased progressively in each of successive fractions, and tha...

journal_title：Journal of cellular biochemistry

authors： Lee KM,Fung KP,Leung PC,Leung KS

更新日期：1996-03-15 00:00:00

abstract：:Betulinic acid (BA), a pentacyclic triterpene derived from the bark of the white birch tree, has been reported to have a variety of pharmacological effects, including antioxidant, anti-inflammatory, antitumor, immunomodulatory, and antiarthritis properties. However, the role of BA in rheumatoid arthritis (RA) remains ...

journal_title：Journal of cellular biochemistry

authors： Wang J,Zhao Q

更新日期：2018-10-26 00:00:00

abstract：:Several molecules extracted from natural products exhibit different biological activities, such as ion channel modulation, activation of signaling pathways, and anti-inflammatory or antitumor activity. In this study, we tested the antitumor ability of natural compounds extracted from the Raputia praetermissa plant. Am...

journal_title：Journal of cellular biochemistry

authors： Vital WD,Torquato HFV,Jesus LOP,Judice WAS,Silva MFDGFD,Rodrigues T,Justo GZ,Veiga TAM,Paredes-Gamero EJ

更新日期：2019-06-01 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) increases steady-state mRNA levels of several extracellular matrix proteins in mineralized connective tissues. Bone sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate and regulate the formation of mineral crystals. To determine the molecular pat...

journal_title：Journal of cellular biochemistry

authors： Ogata Y,Niisato N,Furuyama S,Cheifetz S,Kim RH,Sugiya H,Sodek J

更新日期：1997-06-15 00:00:00

abstract：:Active nucleo-cytoplasmic transport is mediated by dynamic signal-mediated pathways. We investigated the effects of transcription inhibitors or fluorescent lectins on nuclear import mediated by nuclear localization signals (NLSs). Therefore, a novel experimental approach that allows the controlled sequential introduct...

journal_title：Journal of cellular biochemistry

authors： Stauber RH,Krätzer F,Schneider G,Hirschmann N,Hauber J,Rosorius O

更新日期：2001-01-01 00:00:00

abstract：:Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis. Hyperphosphorylation of p70(s6k) and 4E-BP1 in response to insulin or amino acids is mediated through the mammalian target ...

journal_title：Journal of cellular biochemistry

authors： Pham PT,Heydrick SJ,Fox HL,Kimball SR,Jefferson LS Jr,Lynch CJ

更新日期：2000-09-07 00:00:00

abstract：:Lysozyme is expressed in serous, but not mucous, cells of the tracheobronchial glands and thereby constitutes a marker of the serous cell lineage in these glands. To identify DNA regulatory elements and transcription factors mediating the commitment of progenitor cells to the serous cell lineage, we have characterized...

journal_title：Journal of cellular biochemistry

authors： Kai H,Takeuchi K,Ohmori H,Li JD,Gallup M,Basbaum C

更新日期：1996-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short non-coding single-stranded RNAs, which play significant roles in the regulation of a myriad of biological processes. Overwhelmingly increasing high-impact research has also deepened our understanding about the central role of miRNAs in cancer development, metastatic spread, and development...

journal_title：Journal of cellular biochemistry

authors： Wen R,Umeano AC,Essegian DJ,Sabitaliyevich UY,Wang K,Farooqi AA

更新日期：2018-11-01 00:00:00

abstract：:In the last 20 years, more than 1,500 gene therapy clinical trials have been approved worldwide targeting a variety of indications, from inherited monogenic diseases to acquired conditions such as cancer, cardiovascular and infectious diseases. However, concerns about the safety and efficacy of gene therapy pharmaceut...

journal_title：Journal of cellular biochemistry

authors： Coutu DL,Yousefi AM,Galipeau J

更新日期：2009-10-15 00:00:00

abstract：:Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induct...

journal_title：Journal of cellular biochemistry

authors： Al-Rasheed NM,Al-Rasheed NM,Al-Rabeeah DA,Al-Barrak HS,Al-Salman SA,Ibrahim SA,Al-Hassab SA,Al-Amin MA,Hasan IH,Al-Ajmi HN,Al-Shammari TK

更新日期：2018-05-01 00:00:00

abstract：:Thymoquinone (TQ) is the major active compound derived from the medicinal Nigella sativa. A few studies have shown that TQ exhibits anti-inflammatory activities in experimental models of rheumatoid arthritis (RA) through mechanisms that are not fully understood. The aim of this work was to evaluate the in vitro and in...

journal_title：Journal of cellular biochemistry

authors： Vaillancourt F,Silva P,Shi Q,Fahmi H,Fernandes JC,Benderdour M

更新日期：2011-01-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP) is an ATP-binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemotherapy. For stable reversal of BCRP-...

journal_title：Journal of cellular biochemistry

authors： Lv H,He Z,Liu X,Yuan J,Yu Y,Chen Z

更新日期：2007-09-01 00:00:00

abstract：:The infection and inflammation process is associated with disturbances in lipid and lipoprotein metabolism. The apolipoprotein E (apo E) plays an important role in the lipoprotein metabolism and has been linked to inflammatory disease such as atherosclerosis and Alzheimer disease. An anti-inflammatory effect has also ...

journal_title：Journal of cellular biochemistry

authors： Ripollés Piquer B,Nazih H,Neunlist M,Huvelin JM,Bard JM

更新日期：2004-03-01 00:00:00

abstract：:The objective of this study was to evaluate the genotoxic and mutagenic effects of the toxins present in Lachesis muta muta's venom on human peripheral blood leukocytes and the protective potential of ascorbic acid on DNA fragmentation. The venom of L. muta muta was incubated in different concentrations (1, 2.5, 5, 7....

journal_title：Journal of cellular biochemistry

authors： Cardoso Trento MV,de Faria Eleutério MW,Silva Abreu T,Andrade Machado GH,Cesar PHS,Assaid Simão A,Marcussi S

更新日期：2019-03-01 00:00:00

abstract：:Stimulation of gonadotropin-releasing hormone (GnRH) receptors with the GnRH analogue buserelin enhances expression of the zinc finger transcription factor Egr-1 in a pituitary gonadotroph cell line. The signaling cascade is blocked by overexpression of MAP kinase phosphatase-1 that dephosphorylates extracellular sign...

journal_title：Journal of cellular biochemistry

authors： Mayer SI,Willars GB,Nishida E,Thiel G

更新日期：2008-12-01 00:00:00

abstract：:Vitamin D is one of the oldest hormones that have been made in the earliest life forms for over 750 million years. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D. Vitamin D is critically important for the development, growth, and maintenance of ...

journal_title：Journal of cellular biochemistry

authors： Holick MF

更新日期：2003-02-01 00:00:00

abstract：:Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

journal_title：Journal of cellular biochemistry

authors： Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

更新日期：2018-12-01 00:00:00