CD133(+) CD44(+) Cells Mediate in the Lung Metastasis of Osteosarcoma.

abstract：:Osteosarcoma (OS) is the most malignant primary bone tumor in children and adolescents with limited treatment options and poor prognosis. Recently, aberrant expression of Runx2 has been found in OS, thereby contributing to the development, and progression of OS. However, the upstream signaling molecules that regulate ...

journal_title：Journal of cellular biochemistry

authors： Liang GH,Liu N,He MT,Yang J,Liang ZJ,Gao XJ,Rahhal AH,He QY,Zhang HT,Zha ZG

更新日期：2018-01-01 00:00:00

abstract：:The PML protein and PML nuclear bodies (PML-NB) are implicated in multiple cellular functions relevant to tumor suppression, including DNA damage response. In most cases of acute promyelocytic leukemia, the PML and retinoic acid receptor alpha (RARA) genes are translocated, resulting in expression of oncogenic PML-RAR...

journal_title：Journal of cellular biochemistry

authors： Yeung PL,Denissova NG,Nasello C,Hakhverdyan Z,Chen JD,Brenneman MA

更新日期：2012-05-01 00:00:00

abstract：:Prostate cancer (PCa) cells frequently invade the surrounding stroma, leading to heterogeneous formation of structural atypia. The surrounding stroma contains multiple functionally diverse populations of fibroblasts that trigger numerous changes in PCa cells including motility. Thus, we hypothesized that direct or ind...

journal_title：Journal of cellular biochemistry

authors： Ishii K,Nakagawa Y,Matsuda C,Katoh D,Ichishi M,Shirai T,Hirokawa Y,Fujiwara M,Sugimura Y,Watanabe M

更新日期：2021-01-22 00:00:00

abstract：:The sequences from several independent cDNA clones encoding the chicken vitamin D receptor as well as primer extension assay have clearly delineated the 5' terminus and the transcriptional start site. Screening a chicken genomic library produced genomic clones containing vitamin D receptor (VDR) gene fragments. Restri...

journal_title：Journal of cellular biochemistry

authors： Lu Z,Jehan F,Zierold C,DeLuca HF

更新日期：2000-02-01 00:00:00

abstract：:The signal transduction system that mediates bacterial chemotaxis allows cells to modulate their swimming behavior in response to fluctuations in chemical stimuli. Receptors at the cell surface receive information from the surroundings. Signals are then passed from the receptors to cytoplasmic chemotaxis components: C...

journal_title：Journal of cellular biochemistry

authors： Lukat GS,Stock JB

更新日期：1993-01-01 00:00:00

abstract：:Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role of FOXO6 in colorectal cancer (CRC) is still unclear. The study aimed to investigate the potential roles of FOXO6 in the development of CRC. Our results showed that ...

journal_title：Journal of cellular biochemistry

authors： Li Q,Tang H,Hu F,Qin C

更新日期：2019-03-01 00:00:00

abstract：:Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β-cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross-talk between these cells. To elucidate the influence of PSCs on β-cell function, mouse PSCs wer...

journal_title：Journal of cellular biochemistry

authors： Bynigeri RR,Mitnala S,Talukdar R,Singh SS,Duvvuru NR

更新日期：2020-01-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases have been implicated as important mediators of the inflammatory response. Here we report that c-Jun NH(2)-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 MAP kinase activities are reprogrammed during the IL-6 induced macrophage-like differentiation of...

journal_title：Journal of cellular biochemistry

authors： Hall JP,Davis RJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:It has been reported that the fastigial nucleus (FSN) plays an important role in the development of vascular dementia (VD). Both autophagy and inflammation are functionally involved in the pathogenesis of VD. In this study, we aimed to evaluate the therapeutic effect of electrical cerebellar fastigial nucleu...

journal_title：Journal of cellular biochemistry

authors： Xia D,Sui R,Min L,Zhang L,Zhang Z

更新日期：2019-04-01 00:00:00

abstract：:The p27(Kip1) (p27) cyclin-dependent kinase inhibitor and c-Myc oncoprotein play essential roles in control of cell cycle progression and apoptosis. Induction of p27 (CDKN1B) gene transcription by Forkhead box O proteins such as FOXO3a leads to growth arrest and apoptosis. Previously, we observed that B cell receptor ...

journal_title：Journal of cellular biochemistry

authors： Chandramohan V,Mineva ND,Burke B,Jeay S,Wu M,Shen J,Yang W,Hann SR,Sonenshein GE

更新日期：2008-08-15 00:00:00

abstract：:This study aims to investigate how microRNA-375 (miR-375) improves immune function by regulating liver macrophages (Kupffer cells) in mice with liver failure. Forty mice were divided into ConA-1h, ConA-3h, ConA-6h, and control groups, with 10 mice in each group. Mice models of liver failure were established by injecti...

journal_title：Journal of cellular biochemistry

authors： Ke QH,Chen HY,He ZL,Lv Z,Xu XF,Qian YG,Zheng SS

更新日期：2019-01-01 00:00:00

abstract：:Fracture repair is a complex process involving timed cellular recruitment, gene expression, and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, and thus function of injured bone. While the majority of fractures heal without complication, this takes time and a subset of patient...

journal_title：Journal of cellular biochemistry

authors： Komatsu DE,Warden SJ

更新日期：2010-02-01 00:00:00

abstract：:Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead to better treatment strategies. The chemokine stromal-derived factor-1 (SDF-1 or CXCL12) and its...

journal_title：Journal of cellular biochemistry

authors： Sun YX,Wang J,Shelburne CE,Lopatin DE,Chinnaiyan AM,Rubin MA,Pienta KJ,Taichman RS

更新日期：2003-06-01 00:00:00

abstract：UNLABELLED:Chemotherapy treatment is the standard in triple negative breast cancers, a cancer subgroup which lacks a specific target. The mechanisms leading to the response, as well as any markers that allow the differentiation between responder and non-responder groups prior to treatment are unknown. In parallel, miRN...

journal_title：Journal of cellular biochemistry

authors： Tormo E,Pineda B,Serna E,Guijarro A,Ribas G,Fores J,Chirivella E,Climent J,Lluch A,Eroles P

更新日期：2015-09-01 00:00:00

abstract：:The complex nuclear structure of somatic cells is important to epigenomic regulation, yet little is known about nuclear organization of human embryonic stem cells (hESC). Here we surveyed several nuclear structures in pluripotent and transitioning hESC. Observations of centromeres, telomeres, SC35 speckles, Cajal Bodi...

journal_title：Journal of cellular biochemistry

authors： Butler JT,Hall LL,Smith KP,Lawrence JB

更新日期：2009-07-01 00:00:00

abstract：:Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to induce the inhibitory effect. In this study, we constructed HepG2 cell c...

journal_title：Journal of cellular biochemistry

authors： Shirako E,Hirayama N,Tsukada Y,Tanaka T,Kitamura N

更新日期：2008-05-01 00:00:00

abstract：:The comet assay is one of the most widely used approaches for detecting DNA damage; generally, it provides information on the cell population-averaged level of DNA damage. Here, we present an automatic technique for easy measurement of standard comet characteristics and an annotation of the cell cycle phase of each co...

journal_title：Journal of cellular biochemistry

authors： Luzhin AV,Velichko AK,Razin SV,Kantidze OL

更新日期：2016-10-01 00:00:00

abstract：:The retinoblastoma protein (RB) recruits histone deacetylase (HDAC) to repress E2F-mediated transactivation that plays a critical role in cell cycle regulation. RB is also involved in activation of expression of a number of tissue specific- and differentiation-related genes. In this study, we examined the mechanism by...

journal_title：Journal of cellular biochemistry

authors： Charles A,Tang X,Crouch E,Brody JS,Xiao ZX

更新日期：2001-08-21 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. The pathogenesis of H. pylori is believed to be associated with infection-initiated chronic gastritis, which is characterized by enhanced expression of many i...

journal_title：Journal of cellular biochemistry

authors： Lamb A,Chen LF

更新日期：2013-03-01 00:00:00

abstract：:The core binding factor (CBF) acute myeloid leukemias (AMLs) are a prognostically distinct subgroup that includes patients with the inv(16) and t(8:21) chromosomal rearrangements. Both of these rearrangements result in the formation of fusion proteins, CBFB-MYH11 and AML1-ETO, respectively, that involve members of the...

journal_title：Journal of cellular biochemistry

authors： Hyde RK,Liu PP

更新日期：2010-08-01 00:00:00

abstract：:Icb-1 is a human gene previously described by our group to exert important functions in cancer cells of different origin. We now performed microarray-based gene expression profiling with subsequent network modeling to further elucidate the role of icb-1 in breast cancer cells. Analyzing the effect of icb-1 knockdown o...

journal_title：Journal of cellular biochemistry

authors： Treeck O,Belgutay D,Häring J,Schüler S,Lattrich C,Ortmann O

更新日期：2012-09-01 00:00:00

abstract：:The examination of scaffold attachment factor B1 (SAFB1) and its multiple functions and tasks in cellular processes provides insight into its role in diseases, such as cancer. SAFB1 is a large multi-domain protein with well-described functions in transcriptional repression, and RNA splicing. It is ubiquitously express...

journal_title：Journal of cellular biochemistry

authors： Garee JP,Oesterreich S

更新日期：2010-02-01 00:00:00

abstract：:Tributyltin oxide (TBTO) has been widely used as marine antifouling composition, preservative, biocide, and a stabilizer in plastic industry. Previous studies have indicated that TBTO can cause immunotoxicity as an environmental pollutant. However, little is known about its reproductive toxicity, especially on female ...

journal_title：Journal of cellular biochemistry

authors： Yang LL,Cui YX,Ma JY,Ge ZJ,Shen W,Yin S

更新日期：2019-01-01 00:00:00

abstract：:Chronic renal failure is often associated with a resistance to the biologically active form of vitamin D(3), the nuclear hormone 1alpha, 25-dihydroxyvitamin D(3) (VD). The actions of VD are mediated by the vitamin D receptor (VDR), a ligand-dependent transcription factor that binds as a dimeric complex with the retino...

journal_title：Journal of cellular biochemistry

authors： Toell A,Degenhardt S,Grabensee B,Carlberg C

更新日期：1999-09-01 00:00:00

abstract：:Arsenic is a well-known environmental toxicant but the mechanism by which it causes cytotoxicity is poorly understood. Arsenite induces apoptosis in glutathione (GSH)-deficient GCS-2 cells by causing cell cycle dysfunction and down-regulating critical signaling pathways. This study was designed to examine the effect o...

journal_title：Journal of cellular biochemistry

authors： Habib GM

更新日期：2010-05-15 00:00:00

abstract：:C. difficile toxin B is a potent cytotoxin known to disrupt the microfilaments of cultured cells. We have recently shown also increased phospholipase A2 activity in cells treated with toxin B. The activity was detected as a toxin-induced, dose-dependent release of 14C-arachidonic acid from prelabeled fibroblasts. Here...

journal_title：Journal of cellular biochemistry

authors： Shoshan MC,Florin I,Thelestam M

更新日期：1993-05-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) exhibits an inverse correlation with estrogen receptor (ER) expression in the majority of breast cancers, predicting a poor response to endocrine therapy and poor survival rate. Inappropriate overexpression of EGFR in breast cancer is associated with a more aggressive phenot...

journal_title：Journal of cellular biochemistry

authors： Wilson MA,Chrysogelos SA

更新日期：2002-01-01 00:00:00

abstract：:In a human lymphoblastoid cell line (Z83) in which rDNA genes on chromosome 22 are amplified but transcribed at a low level, immunocytological studies with antibodies to 5 methylcytidine provided evidence for hypermethylation of the rDNA. The extent of methylation of the 5' flanking sequences of the ribosomal DNA was ...

journal_title：Journal of cellular biochemistry

authors： Dante R,Percy ME,Baldini A,Markovic VD,Miller DA,Rocchi M,Niveleau A,Miller OJ

更新日期：1992-12-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) has been implicated in smooth muscle cell (SMC) proliferation, a key event in the development of myointimal hyperplasia in vascular grafts. Recent evidence suggests that the PDGF receptor (PDGFR) tyrosine kinase inhibitor, imatinib, can prevent arterial proliferative diseases. Bec...

journal_title：Journal of cellular biochemistry

authors： Li L,Blumenthal DK,Masaki T,Terry CM,Cheung AK

更新日期：2006-12-15 00:00:00

abstract：:In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited...

journal_title：Journal of cellular biochemistry

authors： Butera ST,Perez VL,Besansky NJ,Chan WC,Wu BY,Nabel GJ,Folks TM

更新日期：1991-04-01 00:00:00