Abstract:
:Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on other sirtuins (SIRT2-7) are unknown. The present study shows that exposure of H9c2 cells to 50 microM H(2)O(2) for 6 h caused a significant increase in apoptosis, as evaluated by TUNEL and flow cytometry (FCM), but pretreatment of resveratrol (20 microM) eliminated H(2)O(2)-induced apoptosis. Resveratrol also prevented H(2)O(2)-induced caspase-3 activation. Exposure of cells to resveratrol caused rapid activation of SIRT1,3,4,7. Sirtuin inhibitor, nicotinamide (20 mM) attenuated resveratrol's inhibitory effect on cell apoptosis and caspase-3 activity. These results suggest that resveratrol protects cardiomyocytes from H(2)O(2)-induced apoptosis by activating SIRT1,3,4,7.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Yu W,Fu YC,Zhou XH,Chen CJ,Wang X,Lin RB,Wang Wdoi
10.1002/jcb.22169subject
Has Abstractpub_date
2009-07-01 00:00:00pages
741-7issue
4eissn
0730-2312issn
1097-4644journal_volume
107pub_type
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