Alternative splicing during chondrogenesis: cis and trans factors involved in splicing of fibronectin exon EIIIA.

abstract：:We examined the action of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on HeLa cells and compared it with that of cisplatin (CP). MNNG directly killed a substantial number of cells within 1 hour and resulted in strong DNA-damage as evidenced by Comet measurements. Despite appearance of DNA lesions, p53 protein was not ...

journal_title：Journal of cellular biochemistry

authors： Wesierska-Gadek J,Gueorguieva M,Schloffer D,Uhl M,Wojciechowski J

更新日期：2003-08-15 00:00:00

abstract：:Countercurrent centrifugal elutriation was used to separate growth plate chondrocytes from porcine basing on their differences in sizes and densities. Eighteen fractions of cells with different sizes and densities were obtained. The mean cellular volumes increased progressively in each of successive fractions, and tha...

journal_title：Journal of cellular biochemistry

authors： Lee KM,Fung KP,Leung PC,Leung KS

更新日期：1996-03-15 00:00:00

abstract：:Exposure of cells to ionizing radiation (IR) determines cellular lesions, such as DNA and membrane damage, which involve a coordinate network of signal transduction pathways responsible for resistance to or delay of apoptosis, depending on cell type and administered dose. Since, after IR exposure, the apoptotic profil...

journal_title：Journal of cellular biochemistry

authors： Cataldi A,Rapino M,Centurione L,Sabatini N,Grifone G,Garaci F,Rana R

更新日期：2003-08-01 00:00:00

abstract：:Hypoxia promotes angiogenesis by modulating the transcriptional regulator hypoxia-inducible factor 1alpha (HIF-1alpha). HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF). The remodeling of ...

journal_title：Journal of cellular biochemistry

authors： Corley KM,Taylor CJ,Lilly B

更新日期：2005-12-01 00:00:00

abstract：:Pyrimidine-specific ribonucleases are a superfamily of structurally related enzymes with distinct catalytic and biological properties. We used a combination of enzymatic and non-enzymatic assays to investigate the release of such enzymes by isolated cells in serum-free and serum-containing media. We found that human e...

journal_title：Journal of cellular biochemistry

authors： Landré JB,Hewett PW,Olivot JM,Friedl P,Ko Y,Sachinidis A,Moenner M

更新日期：2002-01-01 00:00:00

abstract：:Epidermal Differentiation Complex (EDC) is a gene cluster on human chromosome 1 q21, which comprises genes encoding four protein families: S100, S100 fused (SFTP), small proline-rich region (SPRR) and late cornified envelope (LCE) proteins. Contrary to the latter three families, which group proteins important for skin...

journal_title：Journal of cellular biochemistry

authors： Sobiak B,Graczyk-Jarzynka A,Leśniak W

更新日期：2016-05-01 00:00:00

abstract：:Fluorescent proteins have enabled the color-coding of cells growing in vivo. Noninvasive imaging of cells expressing fluorescent proteins has allowed the real-time determination of the behavior of cancer cells, the progression of infection, the differentiation of stem cells, and interaction of stromal and cancer cells...

journal_title：Journal of cellular biochemistry

authors： Hoffman RM

更新日期：2017-09-01 00:00:00

abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

journal_title：Journal of cellular biochemistry

authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

更新日期：1989-02-01 00:00:00

abstract：:The study was conducted for comparing the effects of 12 DNA damage response gene mutations (CHEK1, CHEK2, RAD51, BRCA1, BRCA2, MLH1, MSH2, ATM, ATR, MDC1, PARP1, and FANCF) on the overall survival (OS) of breast cancer (BC) patients. We searched the Cancer Genome Atlas (TCGA) database from inception to September 2016....

journal_title：Journal of cellular biochemistry

authors： Liu C,Chang H,Li XH,Qi YF,Wang JO,Zhang Y,Yang XH

更新日期：2017-12-01 00:00:00

abstract：:The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bones, and it's crucial to understand the mechanism of tumor progression to metastasis in order to develop therapies that may reduce the morbidity and mortality of PCa patients. Although we had identified that microRNA(miR)-14...

journal_title：Journal of cellular biochemistry

authors： Guo W,Ren D,Chen X,Tu X,Huang S,Wang M,Song L,Zou X,Peng X

更新日期：2013-07-01 00:00:00

abstract：:Papillary renal cell carcinoma (pRCC) is a heterogeneous disease containing multifocal or solitary tumors with an aggressive phenotype. Increasing evidence has indicated the involvement of aberrant splicing variants in renal cell cancer, while systematic profiling of aberrant alternative splicing (AS) in pRCC was lack...

journal_title：Journal of cellular biochemistry

authors： Duan Y,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:AKT and its substrate BAD have been shown to promote prostate cancer cell survival. Agonists, such as carbachol, and hormones that increase intracellular calcium concentration can activate AKT leading to cancer cell survival. The LNCaP prostate cancer cells express the carbachol-sensitive M(3) -subtype of G protein-co...

journal_title：Journal of cellular biochemistry

authors： Schmitt JM,Smith S,Hart B,Fletcher L

更新日期：2012-05-01 00:00:00

abstract：:Curcumin, the active component of the spice turmeric, induce global DNA hypomethylation as it has been shown to inhibit DNA methyltransferases. It promotes cell death in cancer cells by arresting in the G1 phase. It was explained to cause increased expression of cell cycle regulator, p21 (WAF1/Cip1); however, the mech...

journal_title：Journal of cellular biochemistry

authors： Chatterjee B,Ghosh K,Kanade SR

更新日期：2019-01-01 00:00:00

abstract：:Lysozyme (LYZ) c-like proteins are primarily present in the testis and epididymis of male reproductive tissues. Here, we report a novel member of the c-type LYZ family, the seminal vesicle-secreted LYZ c-like protein (SVLLP). Three forms of SVLLP were purified from mouse seminal vesicle secretions and characterized as...

journal_title：Journal of cellular biochemistry

authors： Ou CM,Lee RK,Lin MH,Lu CH,Yang TH,Yeh LY,Tsai PJ,Li SH

更新日期：2021-01-19 00:00:00

abstract：:Matrine, a natural product extracted from the root of Sophora flavescens Ait, was the main chemical ingredient of compounds of Kushen injection, which has been widely used for its remarkable anticancer effects for years. The underlying mechanisms for Matrine regulations of human breast cancer stem cells (BrCSCs) are b...

journal_title：Journal of cellular biochemistry

authors： Li X,Liang T,Chen SS,Wang M,Wang R,Li K,Wang JC,Xu CW,Du N,Qin S,Ren H

更新日期：2020-03-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined the estrogenicity of the fully ortho-substituted PCB, 2,2',6,6'-tetrachlorobiphenyl (2,2',6,6'-TeCB). ...

journal_title：Journal of cellular biochemistry

authors： Arcaro KF,Yi L,Seegal RF,Vakharia DD,Yang Y,Spink DC,Brosch K,Gierthy JF

更新日期：1999-01-01 00:00:00

abstract：:The deficiency of the enzyme glutaryl-CoA dehydrogenase, known as glutaric acidemia type I (GA-I), leads to the accumulation of glutaric acid (GA) and glutarilcarnitine (C5DC) in the tissues and body fluids, unleashing important neurotoxic effects. l-carnitine (l-car) is recommended for the treatment of GA-I, aiming t...

journal_title：Journal of cellular biochemistry

authors： Guerreiro G,Faverzani J,Jacques CED,Marchetti DP,Sitta A,de Moura Coelho D,Kayser A,Kok F,Athayde L,Manfredini V,Wajner M,Vargas CR

更新日期：2018-12-01 00:00:00

abstract：:Because irradiation may cause osteoradionecrosis, antioxidant supplementation is often used to suppress irradiation-mediated injury. This study examined whether a synthetic phenethyl urea compound, (E)-1-(3,4-dihydroxyphenethyl)-3-(3,4-dihydroxystyryl)urea (DPDS-U), prevents irradiation-mediated cellular damage in MC3...

journal_title：Journal of cellular biochemistry

authors： Kim KA,Kook SH,Song JH,Lee JC

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The impact of aberrant expression of miRNAs, small noncoding RNAs of 19 to 23 nucleotide, has been reported in different types of cancer, such as breast cancer. Authors aim to investigate the role of circulating miRNA-335 as a diagnostic and prognostic marker for breast cancer. MATERIALS AND METHODS:miRNA-3...

journal_title：Journal of cellular biochemistry

authors： Swellam M,Mahmoud MS,Hashim M,Hassan NM,Sobeih ME,Nageeb AM

更新日期：2019-06-01 00:00:00

abstract：:To determine the role of thrombin high-affinity receptor occupancy and enzymic activity in thrombin initiation of cell proliferation, we have utilized thrombin derivatives which separate these functions. We previously showed that enzymically active gamma-thrombin stimulates ion fluxes without binding to high-affinity ...

journal_title：Journal of cellular biochemistry

authors： Carney DH,Stiernberg J,Fenton JW 2nd

更新日期：1984-01-01 00:00:00

abstract：:The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. A novel transcript of the MDMX gene has been previously identified that has a short internal deletion of 68 base pairs, producing a shift in the reading frame after codon 114, resulting in the inclusion of 1...

journal_title：Journal of cellular biochemistry

authors： Rallapalli R,Strachan G,Tuan RS,Hall DJ

更新日期：2003-06-01 00:00:00

abstract：:Large doses of bone morphogenetic protein 2 (BMP2) are used clinically to induce bone formation in challenging bone defects. However, complications after treatment include swelling, ectopic bone formation, and adjacent bone resorption. While BMP2 can be effective, it is important to characterize the mechanism of the d...

journal_title：Journal of cellular biochemistry

authors： Hyzy SL,Olivares-Navarrete R,Schwartz Z,Boyan BD

更新日期：2012-10-01 00:00:00

abstract：:ERK1 and ERK2 share a great deal of homology and have been presumed to have similar functions. Available antibodies recognize both isoforms making the elucidation of functional differences challenging. Mitogen-activated protein (MAP) kinase networks are commonly depicted in the literature as linear and sequential phos...

journal_title：Journal of cellular biochemistry

authors： Kang BS,Hwang YJ,Dong Z

更新日期：2017-08-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) stimulates the expression of a number of genes associated with entry of quiescent Balb/c-3T3 fibroblasts into the cell cycle. We determined that two of these genes, c-myc and c-fos, are induced equivalently in medium supplemented with platelet-poor plasma (PPP) and either PDGF-BB ...

journal_title：Journal of cellular biochemistry

authors： Coats SR,Olson JE,Pledger WJ

更新日期：1992-03-01 00:00:00

abstract：:We investigated the role of tetracycline in the transcriptional regulation of matrix metalloproteinases. Using interleukin-1beta (IL-1) induced stromelysin as a model system, we describe the repression of the endogenous stromelysin RNA accumulation, as well as the transcriptional inhibition of various stromelysin prom...

journal_title：Journal of cellular biochemistry

authors： Jonat C,Chung FZ,Baragi VM

更新日期：1996-03-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common cancers worldwide and has especially high morbidity and mortality in China. LEM domain containing 1 (LEMD1), an important cancer-testis antigen, has been reported to be overexpressed in various cancers and promotes the progression of cancers. However, the biological charac...

journal_title：Journal of cellular biochemistry

authors： Li Q,Ge Y,Chen X,Wang L,Xia Y,Xu Z,Li Z,Wang W,Yang L,Zhang D,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:The conditions favoring expression of a reporter gene microinjected into a male pronucleus of naturally ovulated and fertilized rabbit eggs have been studied. Injection of the reporter gene during S phase of the cell-cycle allows the highest level of expression of the gene. Incorporation of DNA loop anchorage regions ...

journal_title：Journal of cellular biochemistry

authors： Goldman IL,Razin SV,Kadulin SG,Vassetzky YS

更新日期：2004-08-15 00:00:00

abstract：:To obtain sufficient numbers of cells for tissue engineering applications, human bone marrow-derived mesenchymal stem cells (hBM-MSC) are commonly cultured as monolayers in incubators containing room air. In this study, we investigated whether three-dimensional (3D) culture conditions and incubator gas concentrations ...

journal_title：Journal of cellular biochemistry

authors： Karlsen TA,Mirtaheri P,Shahdadfar A,Fløisand Y,Brinchmann JE

更新日期：2011-02-01 00:00:00

abstract：:Lack of guidelines for personalized chemotherapy treatment after surgery has caused gastric cancer (GC) patients' unnecessary exposure to toxicity and the financial burden of chemotherapy treatments. In our study, we aimed to identify potential biomarkers to predict GC patients' susceptibility to platinum-based on Gen...

journal_title：Journal of cellular biochemistry

authors： Pan J,Xiang Z,Dai Q,Wang Z,Liu B,Li C

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study is to observe the changes in osteoprotegerin (OPG) and receptor activator for the nuclear factor-κB ligand (RANKL) in a rabbit model, and to explore the therapeutic effect of tissue engineering bone on femoral head necrosis. A total of 60 rabbits were randomly divided into 5 groups. The necrosis ...

journal_title：Journal of cellular biochemistry

authors： Peng W,Zhang J,Zhang F,Zhao Y,Dong W

更新日期：2018-10-18 00:00:00