当前位置： SCI文献检索 > JOURNAL OF CELLULAR BIOCHEMISTRY期刊下所有文献 > Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database.

Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database.

Abstract：

:The study was conducted for comparing the effects of 12 DNA damage response gene mutations (CHEK1, CHEK2, RAD51, BRCA1, BRCA2, MLH1, MSH2, ATM, ATR, MDC1, PARP1, and FANCF) on the overall survival (OS) of breast cancer (BC) patients. We searched the Cancer Genome Atlas (TCGA) database from inception to September 2016. Studies that investigated the association between 12 DNA damage responses related genes and BC consolidated into this Network meta-analysis, by comparing directly or indirectly to evaluate the hazard rate (HR) value and the surface under the cumulative sequence ranking curves (SUCRA). In total four articles were involved. Our results demonstrated 12 DNA damage response gene mutations were associated to the poor prognosis of BC patients (CHEK1: HR = 9.9, 95%CI = 3.6-26.0; CHEK2: HR = 6.9, 95%CI = 3.1-15.0; RAD51: HR = 5.8, 95%CI = 2.2-15.0; BRCA1: HR = 2.8, 95%CI = 1.3-6.1; BRCA2: HR = 3.9, 95%CI = 2.0-7.7; MLH1: HR = 11.0, 95%CI = 3.4-33.0; MSH2: HR = 6.5, 95%CI = 2.1-20.0; ATM: HR = 5.6, 95%CI = 2.6-12.0; ATR: HR = 2.9, 95%CI = 1.3-6.9; MDC1: HR = 15.0, 95%CI = 5.0-45.0; PARP1: HR = 3.4, 95%CI = 1.8-6.6; FANCF: HR = 6.0, 95%CI = 1.8-20.0). SUCRA results revealed that the mutation of MDC1 gene was related to the worst prognosis in patients with BC (SUCRA = 17.32%). DNA damage response gene mutations were associated to the poor prognosis in patients with BC and the BC patients with MDC1 gene mutation had the worst prognosis. J. Cell. Biochem. 118: 4728-4734, 2017. © 2017 Wiley Periodicals, Inc.

journal_name

J Cell Biochem

journal_title

Journal of cellular biochemistry

authors

Liu C,Chang H,Li XH,Qi YF,Wang JO,Zhang Y,Yang XH

doi

10.1002/jcb.26140

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

4728-4734

issue

12

eissn

0730-2312

issn

1097-4644

journal_volume

118

pub_type

杂志文章,meta分析

相关文献

JOURNAL OF CELLULAR BIOCHEMISTRY文献大全
  • Identification of Key Gene Modules of Neuropathic Pain by Co-Expression Analysis.

    abstract：:Neuropathic pain (NP) is a substantial clinical problem causing great injury to people word-widely. Although gene expression analyses had been performed previously, the mechanisms underlying the etiology and development of NP are still poorly understood. To understand the function genes involved in the etiology and de...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.26098

    authors： Zhang Y,Wang J,Ji LJ,Li L,Wei M,Zhen S,Wen CC

    更新日期：2017-12-01 00:00:00

  • Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis.

    abstract：:Reduced insulin receptor protein levels have been reported in the kidney cortex from diabetic humans and animals. We recently reported that, targeted deletion of insulin receptor (IR) from proximal tubules (PT) resulted in hyperglycemia in non-obese mice. To elucidate the mechanism, we examined human proximal tubule c...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.25632

    authors： Pandey G,Shankar K,Makhija E,Gaikwad A,Ecelbarger C,Mandhani A,Srivastava A,Tiwari S

    更新日期：2017-02-01 00:00:00

  • Heterogeneous induction of an invasive phenotype in prostate cancer cells by coculturing with patient-derived fibroblasts.

    abstract：:Prostate cancer (PCa) cells frequently invade the surrounding stroma, leading to heterogeneous formation of structural atypia. The surrounding stroma contains multiple functionally diverse populations of fibroblasts that trigger numerous changes in PCa cells including motility. Thus, we hypothesized that direct or ind...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.29893

    authors： Ishii K,Nakagawa Y,Matsuda C,Katoh D,Ichishi M,Shirai T,Hirokawa Y,Fujiwara M,Sugimura Y,Watanabe M

    更新日期：2021-01-22 00:00:00

  • Acute physical exercise increases leptin-induced hypothalamic extracellular signal-regulated kinase1/2 phosphorylation and thermogenesis of obese mice.

    abstract：:The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypothalamus by leptin. The hypothalamic extracellular signal-regulated kinase-1/2 (E...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27426

    authors： Gaspar RC,Muñoz VR,Kuga GK,Nakandakari SCBR,Minuzzi LG,Botezelli JD,da Silva ASR,Cintra DE,de Moura LP,Ropelle ER,Pauli JR

    更新日期：2019-01-01 00:00:00

  • Effects of c-Jun and a negative dominant mutation of c-Jun on differentiation and gene expression in lens epithelial cells.

    abstract：:We have used a retroviral vector (RCAS) to overexpress wild-type chicken c-Jun or a deletion mutant of chicken c-Jun (Jun delta 7) lacking the DNA binding region to investigate the possible role of c-Jun in lens epithelial cell proliferation and differentiation. Both constructs were efficiently expressed in primary cu...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.240580212

    authors： Rinaudo JA,Vacchiano E,Zelenka PS

    更新日期：1995-06-01 00:00:00

  • Osteosarcoma cells enhance angiogenesis visualized by color-coded imaging in the in vivo Gelfoam® assay.

    abstract：:We previously described a color-coded imaging model that can quantify the length of nascent blood vessels using Gelfoam® implanted in nestin-driven green fluorescent protein (ND-GFP) nude mice. In ND-GFP mice, nascent blood vessels are labeled with GFP. We report here that osteosarcoma cells promote angiogenesis in th...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24799

    authors： Uehara F,Tome Y,Miwa S,Hiroshima Y,Yano S,Yamamoto M,Mii S,Maehara H,Bouvet M,Kanaya F,Hoffman RM

    更新日期：2014-09-01 00:00:00

  • The inhibitory effects of ginsenoside Rd on the human glioma U251 cells and its underlying mechanisms.

    abstract：OBJECTIVE:The current study was designed to investigate the inhibitory effects of ginsenoside Rd (Gs-Rd) on human glioma U251 cells in vitro and its possible underlying mechanisms. METHODS:The groups included blank control group, low concentration Gs-Rd treatment group (20 μM), mid concentration Gs-Rd treatment group ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27732

    authors： Gu B,Wang J,Song Y,Wang Q,Wu Q

    更新日期：2019-03-01 00:00:00

  • MiR-10a functions as a tumor suppressor in prostate cancer via targeting KDM4A.

    abstract：:Deregulation of microRNAs contributes to the abnormal cell growth which is frequently observed in cancer. In the current study, we detected the expression and regulatory relationship between miR-10a and Lysine-specific demethylase 4A (KDM4A) to reveal their function in prostate cancer (PCa) progression. We found that ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27774

    authors： Mu H,Xiang L,Li S,Rao D,Wang S,Yu K

    更新日期：2019-04-01 00:00:00

  • A new role for 5-methoxytryptophol on bone cells function in vitro.

    abstract：:The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on met...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.25005

    authors： Satué M,Ramis JM,del Mar Arriero M,Monjo M

    更新日期：2015-04-01 00:00:00

  • Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2 signaling.

    abstract：:Baicalein, a flavonoid present in the root of Scutellaria baicalensis, is well known for its antibacterial, antiviral, anti-inflammatory, antithrombotic, and antioxidant effects. Here we show that baicalein also attenuates cardiac hypertrophy. Aortic banding (AB) was performed to induce cardiac hypertrophy secondary t...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24445

    authors： Zong J,Zhang DP,Zhou H,Bian ZY,Deng W,Dai J,Yuan Y,Gan HW,Guo HP,Tang QZ

    更新日期：2013-05-01 00:00:00

  • Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells.

    abstract：:We recently demonstrated the activation of extracellular signal- regulated protein kinase 1 and 2 (ERK1 and ERK2) by IGF-1, FGF-2, and PDGF-BB in normal human osteoblastic (HOB) cells as well as in rat and mouse osteoblastic cells. In this report, we have examined whether c-Jun NH2-Terminal Kinase (JNK) pathway is act...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Chaudhary LR,Avioli LV

    更新日期：1998-04-01 00:00:00

  • Biochemical characterization of a cellular structure retaining vegetally localized RNAs in Xenopus late stage oocytes.

    abstract：:Two pathways operate during Xenopus oogenesis to localize a small number of RNAs to the vegetal cortex. Correct localization of these RNAs is essential to normal development as the proteins they encode are involved in specifying cell type and in patterning the early embryo. Binding these RNAs to the vegetal cortex and...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/1097-4644(20010315)80:4<560::aid-jcb1010>3

    authors： Bubunenko M,King ML

    更新日期：2001-01-01 00:00:00

  • Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease.

    abstract：:Amyloid-β protein (Aβ) is the main component of senile plaques in the brains of Alzheimer disease (AD) patients. Aβ is proteolytically derived from amyloid-β precursor protein by β- and γ-secretases. Secreted Aβ is then eliminated from the central nervous system by multiple clearance mechanisms, including phagocytosis...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1002/jcb.26129

    authors： Kikuchi K,Kidana K,Tatebe T,Tomita T

    更新日期：2017-12-01 00:00:00

  • Silencing interleukin 1α underlies a novel inhibitory role of miR-181c-5p in alleviating low-grade inflammation of rats with irritable bowel syndrome.

    abstract：:Irritable bowel syndrome (IBS) is a common disorder of unknown etiology. Studies have found a close relation between IBS and microRNAs (miRNAs), but the study concerning the relationship between IBS and miR-181c-5p in IBS is still blank. Thus, this study aims to explore the role of miR-181c-5p in IBS via interleukin 1...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28794

    authors： Ji LJ,Li F,Zhao P,Weng LP,Wei J,Yan J,Liu LN

    更新日期：2019-09-01 00:00:00

  • Endothelial cell fatty acid unsaturation mediates cold-induced oxidative stress.

    abstract：:Ultraprofound hypothermia (< 5 degrees C) induces changes to cell membranes such as liquid-to-gel lipid transitions and oxidative stress that have a negative effect on membrane function and cell survival. We hypothesized that fatty acid substitution of endothelial cell lipids and alterations in their unsaturation woul...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.20961

    authors： Zieger MA,Gupta MP,Siddiqui RA

    更新日期：2006-10-15 00:00:00

  • Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation.

    abstract：:Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types, androgen-deprivation insensitive cells exist prior to hormonal manipulation. We established several LNCaP subclones with distinct insensitivities to androgen deprivation from a p...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24805

    authors： Terada N,Shiraishi T,Zeng Y,Aw-Yong KM,Mooney SM,Liu Z,Takahashi S,Luo J,Lupold SE,Kulkarni P,Getzenberg RH

    更新日期：2014-09-01 00:00:00

  • Gene array identification of osteoclast genes: differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor.

    abstract：:Treatment of adherent peripheral blood mononuclear cells (PBMCs) with macrophage colony stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) stimulates the formation of multinucleate osteoclast-like cells. Treatment with M-CSF alone results in the formation of macrophage-like cells. Through th...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.10780

    authors： Day CJ,Kim MS,Stephens SR,Simcock WE,Aitken CJ,Nicholson GC,Morrison NA

    更新日期：2004-02-01 00:00:00

  • Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line.

    abstract：:In a previous work, taking advantage of the gene-array screening technology, we analysed the effects of histone deacetylase (HDAC) inhibitor sodium butyrate (NaBt), on gene transcription in HT29 human adenocarcinoma cell line. In this study, we focused our attention on p55CDC/Cdc20 gene, whose expression was dramatica...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.21014

    authors： Iacomino G,Medici MC,Napoli D,Russo GL

    更新日期：2006-11-01 00:00:00

  • Giant cell tumor of bone: a unique paradigm of stromal-hematopoietic cellular interactions.

    abstract：:Giant cell tumor of bone is a progressive, potentially malignant process which destroys skeletal tissue by virtue of its osteoclast complement. As a biological entity it provides a unique natural model of bone resorption by osteoclasts whose recruitment and development is controlled by a neoplastic population of fibro...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1002/jcb.240550305

    authors： Robinson D,Einhorn TA

    更新日期：1994-07-01 00:00:00

  • Wip1 cooperates with KPNA2 to modulate the cell proliferation and migration of colorectal cancer via a p53-dependent manner.

    abstract：:Due to the increasing incidence and mortality, the early diagnosis, specific targeted therapies, and prognosis for colorectal cancer (CRC) attract more and more attention. Wild-type p53-induced phosphatase 1 (Wip1) and karyopherin α2 (KPNA2) have been regarded as oncogenes in many cancers, including CRC. Wip1 dephosph...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28840

    authors： Wang P,Zhao Y,Liu K,Liu X,Liang J,Zhou H,Wang Z,Zhou Z,Xu N

    更新日期：2019-09-01 00:00:00

  • Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.

    abstract：:Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these fibrous proteins. Its catalytic activity depends upon both its copper cofactor an...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1002/jcb.10413

    authors： Kagan HM,Li W

    更新日期：2003-03-01 00:00:00

  • MicroRNA expression in cervical cancer: Novel diagnostic and prognostic biomarkers.

    abstract：:Growing evidence has shown that a large number of miRNAs are abnormally expressed in cervical cancer (CC) tissues and play irreplaceable roles in tumorigenesis, progression, and metastasis. This study aimed to identify new biomarkers and pivotal genes associated with CC prognosis through comprehensive bioinformatics a...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27029

    authors： Gao C,Zhou C,Zhuang J,Liu L,Liu C,Li H,Liu G,Wei J,Sun C

    更新日期：2018-08-01 00:00:00

  • Prevention of geranylgeranoic acid-induced apoptosis by phospholipid hydroperoxide glutathione peroxidase gene.

    abstract：:Micromolar concentrations (0.5 approximately 5 microM) of all-trans geranylgeranoic acid (GGA) induced cell death in a guinea pig cell line, 104C1, whereas under the same conditions GGA was unable to kill 104C1/O4C, a clone established from 104C1 cells by transfection of them with the human phospholipid hydroperoxide ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.20627

    authors： Shidoji Y,Okamoto K,Muto Y,Komura S,Ohishi N,Yagi K

    更新日期：2006-01-01 00:00:00

  • Suppressive effect of regucalcin on cell differentiation and mineralization in osteoblastic MC3T3-E1 cells.

    abstract：:The role of regucalcin in the regulation of osteoblastic cell function was investigated. Osteoblastic MC3T3-E1 cells with subconfluent monolayers were cultured in a medium containing regucalcin (10(-10)-10(-8) M) without fetal bovine serum (FBS). The proliferation of osteoblastic cells was not significantly altered in...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.20524

    authors： Yamaguchi M,Kobayashi M,Uchiyama S

    更新日期：2005-10-15 00:00:00

  • "New"-clear functions of PDK1: beyond a master kinase in the cytosol?

    abstract：:Activation of cytosolic phosphoinositide-3 kinase (PI-3K) signaling pathway has been well established to regulate gene expression, cell cycle, and survival by feeding signals to the nucleus. In addition, strong evidences accumulated over the past few years indicate the presence of an autonomous inositol lipid metaboli...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1002/jcb.20651

    authors： Kikani CK,Dong LQ,Liu F

    更新日期：2005-12-15 00:00:00

  • Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis.

    abstract：:Accumulating studies demonstrate the critical role of circular RNAs (circRNAs) in the pathogenesis of various types of cancers. Previously, hsa_circ_0034642 has been found elevated in glioma tissues compared with the normal tissues, as proved by high-throughput microarray. We further investigated its expression level ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28646

    authors： Yi C,Li H,Li D,Qin X,Wang J,Liu Y,Liu Z,Zhang J

    更新日期：2019-08-01 00:00:00

  • Functional characterization of human mesenchymal stem cells that maintain osteochondral fates.

    abstract：:Adult stem cells are essential for tissue renewal, regeneration and repair, and their expansion in defined culture medium is on focus for regenerative medicine and genetic pathologies. The bone marrow has been shown to be very rich is pluripotent mesenchymal stem cells (MSCs) capable of forming bone, cartilage and als...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.20778

    authors： Romero-Prado M,Blázquez C,Rodríguez-Navas C,Muñoz J,Guerrero I,Delgado-Baeza E,García-Ruiz JP

    更新日期：2006-08-15 00:00:00

  • Remodelling of the nuclear periphery during muscle cell differentiation in vitro.

    abstract：:We have examined the composition and ultrastructure of the nuclear periphery during in vitro myogenesis of the rat myoblast cell line, L6E9. Immunofluorescence labelling and immunoblotting showed that lamins A/C and B were all present in undifferentiated cells, but that they increased significantly before extensive ce...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-4644(199607)62:1<76::aid-jcb9>3

    authors： Chaly N,Munro SB,Swallow MA

    更新日期：1996-07-01 00:00:00

  • Affinity isolation of active murine erythroleukemia cell chromatin: uniform distribution of ubiquitinated histone H2A between active and inactive fractions.

    abstract：:This laboratory recently reported the development of a biotin-cellulose/streptavidin affinity chromatography method based on the DNase I sensitivity of active chromatin to isolate a DNA fraction from murine erythroleukemia (MEL) cells that is more than 15-fold enriched in active genes (Dawson et al.: Journal of Biolog...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.240460210

    authors： Dawson BA,Herman T,Haas AL,Lough J

    更新日期：1991-06-01 00:00:00

  • Phosphatidylethanolamine-binding protein 4 promotes the epithelial-to-mesenchymal transition in non-small cell lung cancer cells by activating the sonic hedgehog signaling pathway.

    abstract：:Phosphatidylethanolamine-binding protein 4 (PEBP4), a member of the PEBP family, has been reported to play a pivotal role in tumor progression. However, its role in epithelial-to-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells remains unclear. Here, we investigated the effects and underlying m...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27817

    authors： Jian W,Bai Y,Li X,Kang J,Lei Y,Xue Y

    更新日期：2019-04-01 00:00:00