Abstract：
:The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells have mechanisms to carefully monitor events in the extracellular environment and have the ability to respond through cellular and molecular changes. The generation of inorganic phosphate during the process of differentiation may be one such signal. In addition to the requirement of inorganic phosphate as a component of hydroxyapatite mineral, Ca(10)(PO(4))(6)(OH)(2), a number of studies have also suggested it is required in the events preceding mineralization. However, contrasting results, physiological relevance, and the lack of a clear mechanism(s) have created some debate as to the significance of elevated phosphate in the differentiation process. More recently, a number of studies have begun to shed light on possible cellular and molecular consequences of elevated intracellular inorganic phosphate. These results suggest a model in which the generation of inorganic phosphate during osteoblast differentiation may in and of itself represent a signal capable of facilitating the temporal coordination of expression and regulation of multiple factors necessary for mineralization. The regulation of protein function and gene expression by elevated inorganic phosphate during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the changing extracellular environment.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Beck GR Jrdoi
10.1002/jcb.10622subject
Has Abstractpub_date
2003-10-01 00:00:00pages
234-43issue
2eissn
0730-2312issn
1097-4644journal_volume
90pub_type
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journal_title：Journal of cellular biochemistry
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更新日期：2017-04-01 00:00:00
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更新日期：2002-01-01 00:00:00
abstract：:Chrysophanol is a phytochemical typically extracted from rhubarb. Similar to other extracts from rhubarb, chrysophanol possesses anticancer activity against diverse cancerous cells. However, the apoptotic effects of chrysophanol in ovarian cancer remain unknown. In the current study, we examined the antitumorigenic ac...
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更新日期：2018-12-01 00:00:00
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更新日期：2011-08-01 00:00:00
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更新日期：1985-01-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.20818
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Expression of forkhead box (FOX) superfamily members has been shown to be decreased in cancer, which was linked to poor prognosis of patients. The aim of this study was to investigate the expression of a new FOX superfamily member, FOXS1, in gastric cancer, and the influence of FOXS1 overexpression on the tu...
journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章,评审
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更新日期：1994-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-05-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.26899
更新日期：2018-07-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.24044
更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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更新日期：2017-07-01 00:00:00
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更新日期：2019-03-01 00:00:00
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更新日期：2009-12-15 00:00:00
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pub_type： 杂志文章
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更新日期：2018-10-28 00:00:00
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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更新日期：2001-04-02 00:00:00
