AKT primes snail-induced EMT concomitantly with the collective migration of squamous cell carcinoma cells.

abstract：:Diastolic cardiac dysfunction can be caused by abnormality in cTnI expression during cardiogenesis. In this study, we investigated the effects of estrogen on the abnormal expression of cTnI in the hearts of neonatal mice and its potential epigenetic mechanisms. We then evaluated suberoylanilide hydroxamic acid (SAHA),...

journal_title：Journal of cellular biochemistry

authors： Peng C,Luo X,Xing Q,Sun H,Huang X

更新日期：2016-10-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of tumors. However, the role of lncRNAs, especially the lncRNA-related ceRNA regulatory network, in glioblastoma (GBM) has not been fully elucidated. The goal of the current study was ...

journal_title：Journal of cellular biochemistry

authors： Liu Z,Wang X,Yang G,Zhong C,Zhang R,Ye J,Zhong Y,Hu J,Ozal B,Zhao S

更新日期：2020-07-01 00:00:00

abstract：:We have previously demonstrated the direct involvement of a type 1 Ser/Thr phosphatase (PPase 1) in endothelial cell (EC) barrier regulation [Am. J. Physiol. 269:L99-L108, 1995]. To further extend this observation, we microinjected either the Ser/Thr PPase inhibitor, calyculin, or the PPase 1 inhibitory protein, I-2 i...

journal_title：Journal of cellular biochemistry

authors： Verin AD,Csortos C,Durbin SD,Aydanyan A,Wang P,Patterson CE,Garcia JG

更新日期：2000-07-19 00:00:00

abstract：:Vascularization is essential for bone development, fracture healing, and bone tissue engineering. We have previously described that coculture of primary human osteoblasts (hOBs) and human umbilical vein endothelial cells (HUVECs) improves differentiation of both cell types. Investigating the role of microRNAs (miRNAs)...

journal_title：Journal of cellular biochemistry

authors： Strassburg S,Nabar N,Lampert F,Goerke SM,Pfeifer D,Finkenzeller G,Stark GB,Simunovic F

更新日期：2017-07-01 00:00:00

abstract：:HepG2 is an immortalized human hepatoma cell line that has been used for research into bioartificial liver systems. However, a low level of ammonia detoxification is its biggest drawback. In this work, a recombinant HepG2 cell line with stable overexpression of human arginase I (hArgI) and human ornithine transcarbamy...

journal_title：Journal of cellular biochemistry

authors： Tang N,Wang Y,Wang X,Zhou L,Zhang F,Li X,Chen Y

更新日期：2012-02-01 00:00:00

abstract：:The phenotypic modulation of VSMCs is a key cellular event driving neointimal formation and vascular remodeling. As a multifaceted cytokine of cell-mediated immunity, IFN-γ has been shown to play a critical role in the pathogenesis of vascular proliferative diseases. Although the important function of IFN-γ on regulat...

journal_title：Journal of cellular biochemistry

authors： Wang K,Li W,Yu Q,Guo B,Yang B,Zhang C,Li M,Li J,Hu S,Zheng Q,Song Z

更新日期：2017-03-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postnatal growth plate (G...

journal_title：Journal of cellular biochemistry

authors： Wu LN,Lu M,Genge BR,Guo GY,Nie D,Wuthier RE

更新日期：2002-01-01 00:00:00

abstract：:We previously developed and characterized a highly invasive and metastatic triple-negative breast cancer (TNBC) variant by serial orthotopic implantation of MDA-MB-231 human breast cancer cells in nude mice. Eventually, a highly invasive and metastatic variant of human TNBC was isolated after lymph node metastases was...

journal_title：Journal of cellular biochemistry

authors： Yano S,Takehara K,Tazawa H,Kishimoto H,Kagawa S,Bouvet M,Fujiwara T,Hoffman RM

更新日期：2017-03-01 00:00:00

abstract：:Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. I...

journal_title：Journal of cellular biochemistry

authors： Nie YQ,Cao J,Zhou YJ,Liang X,Du YL,Wan YJ,Li YY

更新日期：2014-05-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are used to transport peptides, proteins, different types of ribonucleic acids (or mimics of these molecules), and DNA into live cells, both plant and mammalian. Leishmania belongs to the class of protozoa having, in comparison to mammalian cells, a different lipid composition of the m...

journal_title：Journal of cellular biochemistry

authors： Keller AA,Breitling R,Hemmerich P,Kappe K,Braun M,Wittig B,Schaefer B,Lorkowski S,Reissmann S

更新日期：2014-02-01 00:00:00

abstract：:Activation of cytokine signaling via the leukemia inhibitory factor receptor (LIFR) plays an integral role in hematopoiesis, osteogenesis, and placental development, along with mediating neurotrophic mechanisms. However, the regulatory control of the LIFR gene has remained largely unexplored. Here, we characterize the...

journal_title：Journal of cellular biochemistry

authors： Qadi AA,Taberlay PC,Phillips JL,Young A,West AC,Brettingham-Moore KH,Dickinson JL,Holloway AF

更新日期：2016-01-01 00:00:00

abstract：:Bladder cancer-associated transcript 1 (BLACAT1) is a novel identified long noncoding RNA (lncRNA) in bladder cancer, and has been suggested to function as an oncogenic lncRNA in several types of human cancer. However, its involvement in the progression of small-cell lung cancer (SCLC) remained unknown. The aim of our...

journal_title：Journal of cellular biochemistry

authors： Chen W,Hang Y,Xu W,Wu J,Chen L,Chen J,Mao Y,Song J,Song J,Wang H

更新日期：2018-09-11 00:00:00

abstract：:Glioblastoma is one of the most malignant cancers, with a distinguishing dismal prognosis: surgery followed by chemo- and radiotherapy represents the current standard of care, and chemo- and radioresistance underlie disease recurrence and short overall survival of patients suffering from this malignancy. ATM is a kina...

journal_title：Journal of cellular biochemistry

authors： Romano FJ,Guadagno E,Solari D,Borrelli G,Pignatiello S,Cappabianca P,Del Basso De Caro M

更新日期：2018-06-01 00:00:00

abstract：:The retinoblastoma protein (RB) recruits histone deacetylase (HDAC) to repress E2F-mediated transactivation that plays a critical role in cell cycle regulation. RB is also involved in activation of expression of a number of tissue specific- and differentiation-related genes. In this study, we examined the mechanism by...

journal_title：Journal of cellular biochemistry

authors： Charles A,Tang X,Crouch E,Brody JS,Xiao ZX

更新日期：2001-08-21 00:00:00

abstract：:Mounting evidence showed that microRNAs involve in development and chemoresistance of various human cancers. We explored the roles and mechanisms of miR-144 in resistance to cisplatin (CDDP) of cervical cancer cells. miR-144 and LIM homeobox 2 (LHX2) expression in CDDP-resistant and the parental cells was determined b...

journal_title：Journal of cellular biochemistry

authors： Shi F,Su J,Liu Z,Wang J,Wang T

更新日期：2019-09-01 00:00:00

abstract：:Long noncoding RNA HOXD cluster antisense RNA 1 (HOXD-AS1) has been found to play a crucial role in the tumorigenesis and progression of human cancer. However, the role of HOXD-AS1 in papillary thyroid cancer is still unknown. The purpose of this study was to investigate the clinical value and biological function of H...

journal_title：Journal of cellular biochemistry

authors： Xu K,Feng Y

更新日期：2019-04-01 00:00:00

abstract：:Allele-specific transcription is a characteristic feature of imprinted genes. Many imprinted genes are also transcribed in a tissue- or cell type-specific manner. Overlapping epigenetic signals must, therefore, modulate allele-specific and tissue-specific expression at imprinted loci. In addition, long-range interacti...

journal_title：Journal of cellular biochemistry

authors： Hanel ML,Lau JC,Paradis I,Drouin R,Wevrick R

更新日期：2005-04-01 00:00:00

abstract：:The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypothalamus by leptin. The hypothalamic extracellular signal-regulated kinase-1/2 (E...

journal_title：Journal of cellular biochemistry

authors： Gaspar RC,Muñoz VR,Kuga GK,Nakandakari SCBR,Minuzzi LG,Botezelli JD,da Silva ASR,Cintra DE,de Moura LP,Ropelle ER,Pauli JR

更新日期：2019-01-01 00:00:00

abstract：:Mechanotransduction is a key process by which cells perceive extracellular mechanical cues/intercellular physical interactions and transform them into intracellular biochemical signals. This physiological process is crucial during bone development and bone remodeling throughout childhood and adult life, whereas severa...

journal_title：Journal of cellular biochemistry

authors： Adamopoulos C,Gargalionis AN,Piperi C,Papavassiliou AG

更新日期：2017-02-01 00:00:00

abstract：:We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteristics. Dying cells showed morphological characteristics of apoptosis,...

journal_title：Journal of cellular biochemistry

authors： Chen H,Tritton TR,Kenny N,Absher M,Chiu JF

更新日期：1996-04-01 00:00:00

abstract：:Skeletal muscle atrophy is a well-known adverse effect of chronic treatment with glucocorticoids and it also occurs when stress conditions such as sepsis and cachexia increase the release of endogenous glucocorticoids. Although the mechanisms of action of these hormones have been elucidated, the possible molecular mec...

journal_title：Journal of cellular biochemistry

authors： Massaccesi L,Goi G,Tringali C,Barassi A,Venerando B,Papini N

更新日期：2016-08-01 00:00:00

abstract：:We are interested in understanding the molecular events associated with the growth-arrest of vascular SMCs. We constructed a subtracted cDNA library enriched in nucleotide sequences associated with quiescent SMCs. This library was screened with similarly subtracted 32P-labeled cDNAs to identify growth-arrest associate...

journal_title：Journal of cellular biochemistry

authors： Ge L,Liau G

更新日期：1995-02-01 00:00:00

abstract：:Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the c...

journal_title：Journal of cellular biochemistry

authors： Benzakour O,Kanthou C,Lupu F,Dennehy U,Goodwin C,Scully MF,Kakkar VV,Cooper DN

更新日期：1995-12-01 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is the major negative regulator of the plasmin-dependent pericellular proteolytic cascade. PAI-1 gene expression is normally growth state regulated but frequently elevated in chronic fibroproliferative and neoplastic diseases affecting both stromal restructuring and cellu...

journal_title：Journal of cellular biochemistry

authors： Qi L,Allen RR,Lu Q,Higgins CE,Garone R,Staiano-Coico L,Higgins PJ

更新日期：2006-10-01 00:00:00

abstract：:Interleukin-1β (IL-1β) assumes a centric role in the regulation of immune and inflammatory responses and thus has been recognized in immune mediated diseases like type 2 diabetes mellitus (T2DM). We aimed to investigate expressed level of IL-1β and its relation with IL-1β -511T>C polymorphism in T2DM patients. This st...

journal_title：Journal of cellular biochemistry

authors： Tayel SI,Fouda EAM,Elshayeb EI,Eldakamawy ARA,El-Kousy SM

更新日期：2018-07-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is devastating for its delayed presence, difficulty in diagnosis, and high mortality. Other studies have supported the important role of microRNAs (miRNAs) in the pathogenesis of CCA, and the role of miR-194 was investigated in several human cancers, though, the molecular mechanism of miR-194 ...

journal_title：Journal of cellular biochemistry

authors： Gao J,Dai C,Yu X,Yin XB,Zhou F

更新日期：2020-10-01 00:00:00

abstract：:The low density lipoprotein receptor related protein-1 (LRP-1) is a cargo transport receptor that undergoes constitutive endocytosis and recycling. Platelet-derived growth factor-BB (PDGF-BB) binds to LRP-1 and may bridge LRP-1 to PDGF receptors. Bridging of LRP-1 to other receptors by bifunctional ligands may represe...

journal_title：Journal of cellular biochemistry

authors： Wu L,Arandjelovic S,Gonias SL

更新日期：2004-12-15 00:00:00

abstract：:Our study was aimed to investigate the mechanism of rs4759314 located in HOTAIR involved in congenital heart disease. Luciferase assay was performed to evaluate whether rs4759314 affected the transcription efficiency of HOTAIR promoter, and confirm miR-545 target gene. Real-time PCR, Western-blot and IHC were carried ...

journal_title：Journal of cellular biochemistry

authors： Li Y,Zhao W,Shi R,Jia J,Li X,Cheng J

更新日期：2018-11-01 00:00:00

abstract：:Stimulation of transient receptor potential M3 (TRPM3) cation channels with pregnenolone sulfate induces an influx of Ca2+ ions into the cells and a rise in the intracellular Ca2+ concentration, leading to the activation of the activator protein-1 (AP-1) transcription factor. Here, we show that expression of a constit...

journal_title：Journal of cellular biochemistry

authors： Lesch A,Rössler OG,Thiel G

更新日期：2017-08-01 00:00:00

abstract：:Phosphoinositide specific phospholipase C (PI-PLC) enzymes interfere with the metabolism of inositol phospholipids (PI), molecules involved in signal transduction, a complex process depending on various components. Many evidences support the hypothesis that, in the glia, isoforms of PI-PLC family display different exp...

journal_title：Journal of cellular biochemistry

authors： Lo Vasco VR,Fabrizi C,Panetta B,Fumagalli L,Cocco L

更新日期：2010-07-01 00:00:00