Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription.

abstract：:The role of excision repair cross-complimentary group 1 (ERCC1) gene polymorphisms in breast and ovarian cancer development has long been controversial and existing data were inconsistent. Here, we conducted a comprehensive meta-analysis to better clarify the association. Case-control studies published from December 2...

journal_title：Journal of cellular biochemistry

authors： Yang F,Mu X,Bian C,Zhang H,Yi T,Zhao X,Lin X

更新日期：2019-09-01 00:00:00

abstract：:Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single agents, HDAC inhibitors may cause c...

journal_title：Journal of cellular biochemistry

authors： Marchion DC,Bicaku E,Daud AI,Richon V,Sullivan DM,Munster PN

更新日期：2004-05-15 00:00:00

abstract：:The higher ordered structure of the chicken alpha 2(1) procollagen gene was analyzed in chromatin isolated from expressing (lung) and nonexpressing (reticulocyte and erythrocyte) tissues. Digestion of DNA with methylation sensitive restriction endonucleases revealed that this gene was methylated in all tissues examine...

journal_title：Journal of cellular biochemistry

authors： Truter SL,Parker MI

更新日期：1994-02-01 00:00:00

abstract：:Alkaline phosphatase (ALP) refers to a group of nonspecific phosphomonoesterases located primarily in cell plasma membrane. It has been described in different cell lines that ecto-ALP is directly or indirectly involved in the modulation of organic cation transport. We aimed to investigate, in Caco-2 cells, a putative ...

journal_title：Journal of cellular biochemistry

authors： Calhau C,Martel F,Hipólito-Reis C,Azevedo I

更新日期：2002-01-01 00:00:00

abstract：:The four-subunit protease complex γ-secretase cleaves many single-pass transmembrane (TM) substrates, including Notch and β-amyloid precursor protein to generate amyloid-β (Aβ), central to Alzheimer's disease. Two of the subunits anterior pharynx-defective 1 (APH-1) and presenilin (PS) exist in two homologous forms AP...

journal_title：Journal of cellular biochemistry

authors： Dehury B,Kepp KP

更新日期：2021-01-01 00:00:00

abstract：:Chromium(VI) resistant Chinese hamster ovary (CHO) cell lines were established in this study by exposing parental CHO-K1 cells to sequential increases in CrO3 concentration. The final concentration of CrO3 used for selection was 7 microM for Cr7 and 16 microM for Cr16 cells. Cr16-1 was a subclone derived from Cr16 cel...

journal_title：Journal of cellular biochemistry

authors： Lu YY,Yang JL

更新日期：1995-04-01 00:00:00

abstract：:A quantitative PCR method was used to map a functional origin of DNA replication in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in normal human fibroblasts. This PCR method measures the abundance of specific sequences in short fragments of newly replicated DNA from logarithmically growing cells. Qua...

journal_title：Journal of cellular biochemistry

authors： Cohen SM,Brylawski BP,Cordeiro-Stone M,Kaufman DG

更新日期：2002-01-01 00:00:00

abstract：:The transcription factors of the nuclear hormone receptor family regulate gene expression via a complex network of macromolecular interactions. The ligand dependent activity of the vitamin D receptor is of particular interest because it modulates gene expression by the heterodimeric interaction with retinoid X recepto...

journal_title：Journal of cellular biochemistry

authors： Berghöfer-Hochheimer Y,Zurek C,Langer G,Munder T

更新日期：1997-08-01 00:00:00

abstract：:We have recently described the isolation and purification to homogeneity of a new sialoglycopeptide from bovine brain cell surfaces that reversibly inhibits protein synthesis and DNA synthesis of normal but not transformed cells. Active inhibitory preparations, however, were shown to contain a protease activity that w...

journal_title：Journal of cellular biochemistry

authors： Sharifi BG,Bascom CC,Fattaey H,Nash S,Johnson TC

更新日期：1986-01-01 00:00:00

abstract：:Copy number variation (CNV) and abnormal expression of microRNAs (miRNAs) always lead to deregulation of genes in cancer, including gastric cancer (GC). However, little is known about how CNVs affect the expression of miRNAs. By integrating CNV and miRNA profiles in the same samples, we identified eight miRNAs (miR-12...

journal_title：Journal of cellular biochemistry

authors： An J,Pan Y,Yan Z,Li W,Cui J,Yuan J,Tian L,Xing R,Lu Y

更新日期：2013-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) were once viewed only as mediators of toxicity, but it is now recognized that they also contribute to redox signaling through oxidation of specific cysteine thiols on regulatory proteins. Cells in sparse cultures have increased ROS relative to confluent cultures, but it is not known wheth...

journal_title：Journal of cellular biochemistry

authors： Spielberger JC,Moody AD,Watson WH

更新日期：2008-08-01 00:00:00

abstract：:Cervical cancer (CC) is one of the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes, which has been reported to significantly alter the cellular physiology of tumor cells. However, little is known about the role of phospholipid scramblase 1 (PLSCR1) in pathogenesis of ...

journal_title：Journal of cellular biochemistry

authors： Zhao Y,Yuan X,Li X,Zhang Y

更新日期：2018-10-22 00:00:00

abstract：:Interleukin-1β (IL-1β) assumes a centric role in the regulation of immune and inflammatory responses and thus has been recognized in immune mediated diseases like type 2 diabetes mellitus (T2DM). We aimed to investigate expressed level of IL-1β and its relation with IL-1β -511T>C polymorphism in T2DM patients. This st...

journal_title：Journal of cellular biochemistry

authors： Tayel SI,Fouda EAM,Elshayeb EI,Eldakamawy ARA,El-Kousy SM

更新日期：2018-07-01 00:00:00

abstract：:Sepsis is usually accompanied by pulmonary inflammations, leading to acute lung injury. During this process, endogenous factors that play a regulatory role could be exploited to therapeutically alleviate such lethal tissue injury. Here, we showed that ulinastatin (UTI) administration could reduce lung tissue necrosis ...

journal_title：Journal of cellular biochemistry

authors： Wu J,Yan X,Jin G

更新日期：2018-09-22 00:00:00

abstract：:Long noncoding RNA HOXD cluster antisense RNA 1 (HOXD-AS1) has been found to play a crucial role in the tumorigenesis and progression of human cancer. However, the role of HOXD-AS1 in papillary thyroid cancer is still unknown. The purpose of this study was to investigate the clinical value and biological function of H...

journal_title：Journal of cellular biochemistry

authors： Xu K,Feng Y

更新日期：2019-04-01 00:00:00

abstract：:Estrogen and androgen are both critical for the maintenance of bone, but the target cells, mechanisms, and responses could be sex-specific. To compare sex-specific actions of estrogen and androgen on osteoclasts, human peripheral blood mononuclear precursor cells from adult Caucasian males (n = 3) and females (n = 3) ...

journal_title：Journal of cellular biochemistry

authors： Wang J,Stern PH

更新日期：2011-12-01 00:00:00

abstract：:p150(glued) is the largest subunit of dynactin protein complex, through which cargo vesicles link to the microtubule minus-end directed motor protein dynein. In addition, p150(glued) also locates in the mother centriole where it organizes the subdistal appendage. The components of appendage are dynamically regulated t...

journal_title：Journal of cellular biochemistry

authors： Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

更新日期：2015-09-01 00:00:00

abstract：:Long-term treatment with heparin has been associated with an increased risk of osteoporosis. Given the importance of heparan sulfate proteoglycans for bone metabolism, it can be anticipated that heparin due to its structural similarity with heparan sulfate chains somehow interferes with the biological activities of th...

journal_title：Journal of cellular biochemistry

authors： Hausser HJ,Brenner RE

更新日期：2004-04-01 00:00:00

abstract：:Bone marrow macrophages fuse on the bone surface to form multinucleated osteoclasts that then organize to efficiently resorb bone. Many, if not all, of the stages of macrophage fusion involve cytoskeletal components that reorganize the cells. Recruitment may involve chemotactic responses to bone matrix protein and cal...

journal_title：Journal of cellular biochemistry

authors： Oursler MJ

更新日期：2010-08-01 00:00:00

abstract：:Perinuclear actin shells have been reported in a variety of organisms. The shells have been identified by staining perinuclear material with fluorescently-labelled phalloidin, but have not been localized to a specific subcellular compartment at the ultrastructural level. We show here that the shells of 3T3 cells lie i...

journal_title：Journal of cellular biochemistry

authors： Clubb BH,Locke M

更新日期：1998-08-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) pathway is dysregulated in more than 50% of all human malignancies and is a major target in cancer treatment. In this study, we explored the underlying mechanism involving microRNA-145-3p (miR-145-3p) in the development and progression of non-small cell lung cancer (NSCLC) by t...

journal_title：Journal of cellular biochemistry

authors： Chen GM,Zheng AJ,Cai J,Han P,Ji HB,Wang LL

更新日期：2018-01-01 00:00:00

abstract：:Recent studies demonstrate that reactive oxygen species (ROS) are important mediators of acute pancreatitis, whether induced experimentally or in necrotizing pancreatitis in humans; however, the cellular processes involved remain unclear. Adapter protein CrkII, plays a central role for convergence of cellular signals ...

journal_title：Journal of cellular biochemistry

authors： Andreolotti AG,Bragado MJ,Tapia JA,Jensen RT,Garcia-Marin LJ

更新日期：2006-02-01 00:00:00

abstract：:Human DNA replication depends on the activation of thousands of origins distributed within the genome. The actual distribution of origins is not known, nor whether this distribution is unique to a cell type, or if it changes with the proliferative state of the cell. In this study, we have employed a real-time PCR-base...

journal_title：Journal of cellular biochemistry

authors： Valenzuela MS,Hu L,Lueders J,Walker R,Meltzer PS

更新日期：2012-01-01 00:00:00

abstract：:Arsenic is the first metal to be identified as a human carcinogen. Arsenite, one inorganic form of arsenic, has been found to induce sister chromatid exchange, chromosome aberrations, and gene amplification in a variety of in vitro systems. In this study of arsenite-induced genotoxicity represented a micronuclei produ...

journal_title：Journal of cellular biochemistry

authors： Liu YC,Huang H

更新日期：1997-03-01 00:00:00

abstract：:Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unkn...

journal_title：Journal of cellular biochemistry

authors： Lim S,Jang HJ,Park EH,Kim JK,Kim JM,Kim EK,Yea K,Kim YH,Lee-Kwon W,Ryu SH,Suh PG

更新日期：2012-11-01 00:00:00

abstract：:CD38 is a type II transmembrane glycoprotein found mainly on the plasma membrane involved in the metabolism of cADPR and NAADP, two nucleotides with calcium mobilizing activity independent of inositol trisphosphate. Recent data report the presence of CD38 in different cellular compartments raising new questions about ...

journal_title：Journal of cellular biochemistry

authors： Trubiani O,Guarnieri S,Eleuterio E,Di Giuseppe F,Orciani M,Angelucci S,Di Primio R

更新日期：2008-03-01 00:00:00

abstract：:MicroRNA are a series of small non-coding RNAs that have emerged as critical regulators of skeletal muscle development. Here, we concentrated on the function of miR-660 during bovine skeletal myogenesis from our previous high-throughput sequencing results, then analyzed its expression profiles and characterized relate...

journal_title：Journal of cellular biochemistry

authors： Yue B,Wu J,Wang Y,Zhang C,Fang X,Chen H

更新日期：2017-08-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinical emergencies with no effective pharmaceutical treatment. This study aims to determine the protective effects of Nrf2-transfected human amniotic mesenchymal stem cells (hAMSCs) against lipopolysaccharide (LPS)-induced lung injury in mice...

journal_title：Journal of cellular biochemistry

authors： Zhang S,Jiang W,Ma L,Liu Y,Zhang X,Wang S

更新日期：2018-02-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is still an unresolved source of tumor-related death internationally. Current studies have discovered that microRNAs (miRNAs) are associated with diverse cancers development, including NSCLC. Our paper focused on the functional character of miR-4286 in NSCLC. miR-4286 level in 68 cas...

journal_title：Journal of cellular biochemistry

authors： An X,Ge J,Guo H,Mi H,Zhou J,Liu Y,Weiyue,Wu Z

更新日期：2019-10-01 00:00:00

abstract：:Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression ...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Liu Y,Xu X

更新日期：2018-07-01 00:00:00