Prothrombin cleavage by human vascular smooth muscle cells: a potential alternative pathway to the coagulation cascade.

abstract：:Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Defects in this mechanism correlate with severe obstetric complications as implantation failure and preeclampsia. Lysophosphatidic acid (LPA) participates in embr...

journal_title：Journal of cellular biochemistry

authors： Beltrame JS,Sordelli MS,Cañumil VA,Franchi AM,Ribeiro ML

更新日期：2018-01-01 00:00:00

abstract：:The identification and purification of murine multipotent mesenchymal stem cells (MSCs) have been difficult due to their low frequency, the presence of contaminating cell types and lack of unambiguous markers. Using a magnetic micro-beads negative selection technique to remove hematopoietic cells from mouse bone marro...

journal_title：Journal of cellular biochemistry

authors： McKenzie KP,Mayer DC,Aubin JE

更新日期：2013-05-01 00:00:00

abstract：:S49 murine lymphoma cells were examined for expression of various nucleoside transport systems using a non-metabolized nucleoside, formycin B, as substrate. Nitrobenzylthioinosine (NBTI)-sensitive, facilitated transport was the primary nucleoside transport system of the cells. The cells also expressed very low levels ...

journal_title：Journal of cellular biochemistry

authors： Plagemann PG

更新日期：1991-05-01 00:00:00

abstract：:Adipose-derived mesenchymal stromal cells (ADSCs) exhibited high potential in tissue repair and regeneration, and it has been proved that ADSCs could protect brain cells from apoptosis and maintaining blood-brain barrier stability after cerebral vascular disease. In this study, we evaluated the therapeutic potential a...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Deng H,Hu Y,Pan C,Wu G,Li Q,Tang Z

更新日期：2019-09-01 00:00:00

abstract：:Osteoporosis (OP) is a multifactorial and common bone disease worldwide. The clinical diagnosis and treatment of osteoporosis has limitations since changes in bone density occur slightly. Thus, it is critically needed to look for new biomarkers to identify and cure osteoporosis. CircRNAs are important molecular regula...

journal_title：Journal of cellular biochemistry

authors： Huang Y,Xie J,Li E

更新日期：2019-09-01 00:00:00

abstract：:Leptin is a protein involved in the regulation of food intake and in the immune and inflammatory responses, among other functions. Evidences demonstrate that obesity is directly associated with high levels of leptin, suggesting that leptin may directly link obesity with the elevated cardiovascular and renal risk assoc...

journal_title：Journal of cellular biochemistry

authors： Blanca AJ,Ruiz-Armenta MV,Zambrano S,Salsoso R,Miguel-Carrasco JL,Fortuño A,Revilla E,Mate A,Vázquez CM

更新日期：2016-10-01 00:00:00

abstract：:The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental role during proliferation and adipogenic induction of preadipocytes. Using 3T3-L1 cells as model, we de...

journal_title：Journal of cellular biochemistry

authors： Pagano E,Coso O,Calvo JC

更新日期：2008-05-01 00:00:00

abstract：:The microtubule binding protein, nucleolar spindle-associated protein 1 (NUSAP1), has a crucial function in mitosis and its expression is closely associated with carcinogenesis. Herein, we aimed to determine the function of NUSAP1 in the development of human esophageal squamous cell carcinoma (ESCC), and the associati...

journal_title：Journal of cellular biochemistry

authors： Guan C,Liu Z,Lu C,Xiao M,Shi H,Ni R,Bian Z

更新日期：2019-02-21 00:00:00

abstract：:This report demonstrates that the expression of melanoma growth stimulatory activity (MGSA) mRNA can be modulated in a positive fashion in the Hs294T human melanoma cell line by PDGF and MGSA. There is close correlation between MGSA expression and the pattern of cell growth in Hs294T cells. ...

journal_title：Journal of cellular biochemistry

authors： Bordoni R,Thomas G,Richmond A

更新日期：1989-04-01 00:00:00

abstract：:The role of beta-catenin in skeletal development and osteogenic cell differentiation is well established, but the molecular mechanisms attending these effects remain largely unknown. We conducted a structure/function analysis of beta-catenin to gain further insights on these mechanisms. Retroviral transduction of a fu...

journal_title：Journal of cellular biochemistry

authors： Salazar VS,Mbalaviele G,Civitelli R

更新日期：2008-06-01 00:00:00

abstract：:The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on met...

journal_title：Journal of cellular biochemistry

authors： Satué M,Ramis JM,del Mar Arriero M,Monjo M

更新日期：2015-04-01 00:00:00

abstract：:Death associated protein kinase 1 (DAPK1) was initially discovered in the progress of gamma-interferon induced programmed cell death, it is a key factor in the central nervous system, including Parkinson's disease (PD). However, the underlying mechanisms of DAPK1 in PD remain unclear and this research work aims to exp...

journal_title：Journal of cellular biochemistry

authors： Lu Y,Gong Z,Jin X,Zhao P,Zhang Y,Wang Z

更新日期：2020-04-10 00:00:00

abstract：:Sepsis is usually accompanied by pulmonary inflammations, leading to acute lung injury. During this process, endogenous factors that play a regulatory role could be exploited to therapeutically alleviate such lethal tissue injury. Here, we showed that ulinastatin (UTI) administration could reduce lung tissue necrosis ...

journal_title：Journal of cellular biochemistry

authors： Wu J,Yan X,Jin G

更新日期：2018-09-22 00:00:00

abstract：:IFI 16 is a member of the HIN-200 family of transcriptional regulators that suppress cell growth, modulate the cell cycle and have been linked to cellular differentiation. We hypothesized that the activity of IFI 16 depends on its level of expression and therefore studied the transcriptional activity of the IFI 16 pro...

journal_title：Journal of cellular biochemistry

authors： Clarke CJ,Apostolidis V,Hii LL,Gough DJ,Trapani JA,Johnstone RW

更新日期：2003-05-01 00:00:00

abstract：:Growth and differentiation factor 7(GDF7), also later called as bone morphogenetic protein (BMP)12, is a new member of the BMP superfamily, which induces formation of tendon-like tissue formation in the ectopic implantation experiments. We examined the effect of BMP12 on proliferation and expression of phenotype-relat...

journal_title：Journal of cellular biochemistry

authors： Furuya K,Nifuji A,Rosen V,Noda M

更新日期：1999-02-01 00:00:00

abstract：:Coriander (Coriandrum sativum L.) is such an herb from the Apiaceae family, used both for its medicinal and nutritional properties for many centuries. In this study, the effects of C. sativum extract on gene expression, viability, colony formation, migration, and invasion of PC-3 and LNCaP prostate cancer cell lines h...

journal_title：Journal of cellular biochemistry

authors： Elmas L,Secme M,Mammadov R,Fahrioglu U,Dodurga Y

更新日期：2019-03-01 00:00:00

abstract：:microRNA (miRNA) is a family of small, non-coding RNA first discovered as an important regulator of development in Caenorhabditis elegans (C. elegans). Numerous miRNAs have been found in C. elegans, and some of them are well conserved in many organisms. Though, the biologic function of miRNAs in C. elegans was largely...

journal_title：Journal of cellular biochemistry

authors： Liu J,Yang B,Ai J

更新日期：2013-05-01 00:00:00

abstract：:Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types, androgen-deprivation insensitive cells exist prior to hormonal manipulation. We established several LNCaP subclones with distinct insensitivities to androgen deprivation from a p...

journal_title：Journal of cellular biochemistry

authors： Terada N,Shiraishi T,Zeng Y,Aw-Yong KM,Mooney SM,Liu Z,Takahashi S,Luo J,Lupold SE,Kulkarni P,Getzenberg RH

更新日期：2014-09-01 00:00:00

abstract：:We have previously shown that post-transcriptional mechanisms involving the 26S proteasome regulate the cyclin-dependent kinase inhibitors (CKIs), p21(Cip1) and p27(Kip1) during preadipocyte proliferation. Earlier studies further demonstrated that the anti-inflammatory, anti-carcinogenic phytochemical, helenalin is a ...

journal_title：Journal of cellular biochemistry

authors： Fernandes KM,Auld CA,Hopkins RG,Morrison RF

更新日期：2008-10-15 00:00:00

abstract：:Cervical cancer is one of the leading killers for female worldwide. Nevertheless, the less knowledge of molecular mechanism for cervical cancer limited the improvement of treatment effects. High-mobility group box 2 (HMGB2) belongs to the HMGB family, which could play diverse roles in cell proliferation. This work mai...

journal_title：Journal of cellular biochemistry

authors： Zhang P,Lu Y,Gao S

更新日期：2019-10-01 00:00:00

abstract：:In a previous work, taking advantage of the gene-array screening technology, we analysed the effects of histone deacetylase (HDAC) inhibitor sodium butyrate (NaBt), on gene transcription in HT29 human adenocarcinoma cell line. In this study, we focused our attention on p55CDC/Cdc20 gene, whose expression was dramatica...

journal_title：Journal of cellular biochemistry

authors： Iacomino G,Medici MC,Napoli D,Russo GL

更新日期：2006-11-01 00:00:00

abstract：:Recently increasing emphasis is placed on preventive health and management of chronic comorbidities avoiding long-term toxicities of antiretroviral therapy (ART). Drawing from this background we decided to use the Saos-2, osteosarcoma cell line, as a cellular model, to evaluate the effects of some antiretroviral drugs...

journal_title：Journal of cellular biochemistry

authors： Esposito V,Perna A,Lucariello A,Carleo MA,Viglietti R,Sangiovanni V,Coppola N,Guerra G,De Luca A,Chirianni A

更新日期：2015-10-01 00:00:00

abstract：:Phosphoinositide 3-kinase proteins are composed by a catalytic p110 subunit and a regulatory p85 subunit. There are three classes of PI3K, named class I-III, on the bases of the protein domain constituting and determining their specificity. The first one is the best characterized and includes a number of key elements ...

journal_title：Journal of cellular biochemistry

authors： Feola A,Cimini A,Migliucci F,Iorio R,Zuchegna C,Rothenberger R,Cito L,Porcellini A,Unteregger G,Tombolini V,Giordano A,Di Domenico M

更新日期：2013-09-01 00:00:00

abstract：:All-trans-retinoic acid (ATRA) has been shown to inhibit the growth of a number of ovarian tumor cell lines while others have been found to be resistant to retinoid suppression of growth. Interestingly, two synthetic retinoids, CD437 and 4-HPR, inhibit the growth of both ATRA-sensitive (CA-OV-3) and ATRA-resistant (SK...

journal_title：Journal of cellular biochemistry

authors： Holmes WF,Soprano DR,Soprano KJ

更新日期：2003-05-15 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. The pathogenesis of H. pylori is believed to be associated with infection-initiated chronic gastritis, which is characterized by enhanced expression of many i...

journal_title：Journal of cellular biochemistry

authors： Lamb A,Chen LF

更新日期：2013-03-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a unique population of multipotent cells that exhibit pluripotent properties to a certain extent and are significantly heterogeneous in terms of the cell population. We isolate a small cell subpopulation from bovine BMSCs, bovine small stem cells (bSSCs), and herein characterize t...

journal_title：Journal of cellular biochemistry

authors： Pan S,Chen YC,Zhao N,Feng X,Yang DD,Wang Y,Jin ZB

更新日期：2019-08-01 00:00:00

abstract：:The HFE (HLA-H) gene is a strong candidate gene for hereditary haemochromatosis and was localized on the short arm of chromosome 6 to 6p21.3-p22. In addition, the sequence of the homologous mouse and rat cDNA and a partial sequence from the mouse gene have been reported recently. In this report, we describe the locati...

journal_title：Journal of cellular biochemistry

authors： Albig W,Drabent B,Burmester N,Bode C,Doenecke D

更新日期：1998-05-01 00:00:00

abstract：:Amyloid-β protein (Aβ) is the main component of senile plaques in the brains of Alzheimer disease (AD) patients. Aβ is proteolytically derived from amyloid-β precursor protein by β- and γ-secretases. Secreted Aβ is then eliminated from the central nervous system by multiple clearance mechanisms, including phagocytosis...

journal_title：Journal of cellular biochemistry

authors： Kikuchi K,Kidana K,Tatebe T,Tomita T

更新日期：2017-12-01 00:00:00

abstract：:We provided evidence that calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells. In cells labeled for 16 hr with 3H-arachidonic acid, ionomycin and Ca2(+)-mobilizing hormones such as bradykinin, thrombin and platelet activating factor induced arachidoni...

journal_title：Journal of cellular biochemistry

authors： Briand SI,Bernier SG,Guillemette G

更新日期：1996-12-01 00:00:00

abstract：:Endometrial cancer is one of the most common gynecological malignant tumors. The roles of competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this study, we constructed a ceRNA network to reveal the core ceRNAs in endometrial cancer. Differentially expressed genes were summarized from The C...

journal_title：Journal of cellular biochemistry

authors： Wang Y,Huang T,Sun X,Wang Y

更新日期：2019-11-01 00:00:00