The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster.

Abstract:

:The HFE (HLA-H) gene is a strong candidate gene for hereditary haemochromatosis and was localized on the short arm of chromosome 6 to 6p21.3-p22. In addition, the sequence of the homologous mouse and rat cDNA and a partial sequence from the mouse gene have been reported recently. In this report, we describe the location of the human and the mouse HFE (HLA-H) gene within the histone gene clusters on the human chromosome 6 and the mouse chromosome 13. Both the human and the murine gene were located on syntenic regions within the histone gene clusters in the vicinity of the histone H1t gene. The genomic sequence of the human HFE (HLA-H) gene and the 3' portion of the homologous mouse gene were determined. Comparison of the genomic sequences from man and mouse and the cDNA sequence from rat shows significant similarities, also beyond the transcribed region of the mouse gene.

journal_name

J Cell Biochem

authors

Albig W,Drabent B,Burmester N,Bode C,Doenecke D

doi

10.1002/(sici)1097-4644(19980501)69:2<117::aid-jcb

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

117-26

issue

2

eissn

0730-2312

issn

1097-4644

pii

10.1002/(SICI)1097-4644(19980501)69:2<117::AID-JCB

journal_volume

69

pub_type

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