Abstract:
:IFI 16 is a member of the HIN-200 family of transcriptional regulators that suppress cell growth, modulate the cell cycle and have been linked to cellular differentiation. We hypothesized that the activity of IFI 16 depends on its level of expression and therefore studied the transcriptional activity of the IFI 16 promoter. A discrete sequence within the 5' untranslated region was required for constitutive activity of the promoter and the functional motif within this region was shown to be a consensus AP-1 site. Interestingly, this AP-1 site was also critical for IFN-induced activation of the promoter and consistent with these observations, treatment of cells with IFNgamma resulted in a rapid and robust induction of AP-1 activity that preceded expression of IFI 16. These experiments define the transcriptional mechanisms of IFI 16 gene regulation and provide evidence suggesting that AP-1 activation may be an important event in IFN signaling.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Clarke CJ,Apostolidis V,Hii LL,Gough DJ,Trapani JA,Johnstone RWdoi
10.1002/jcb.10475subject
Has Abstractpub_date
2003-05-01 00:00:00pages
80-93issue
1eissn
0730-2312issn
1097-4644journal_volume
89pub_type
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