Identification of a potential prognostic lncRNA-miRNA-mRNA signature in endometrial cancer based on the competing endogenous RNA network.

Abstract:

:Endometrial cancer is one of the most common gynecological malignant tumors. The roles of competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this study, we constructed a ceRNA network to reveal the core ceRNAs in endometrial cancer. Differentially expressed genes were summarized from The Cancer Genome Atlas database, whereupon 140 genes were identified for building the network. Further correlation, survival, and enrichment analyses suggested that these genes may help towards elucidating the molecular mechanisms of endometrial cancer. After validation of the findings with the GSE17025 data set, LINC00958, microRNA-761, and DOLPP1 were highlighted as the critical genes in the ceRNA network. Our work suggests that LINC00958 may regulate DOLPP1 by "sponging" miR-761 in endometrial cancer.

journal_name

J Cell Biochem

authors

Wang Y,Huang T,Sun X,Wang Y

doi

10.1002/jcb.29200

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

18845-18853

issue

11

eissn

0730-2312

issn

1097-4644

journal_volume

120

pub_type

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