Biochemical and molecular study on interleukin-1β gene expression and relation of single nucleotide polymorphism in promoter region with Type 2 diabetes mellitus.

abstract：:The immediate-early (IE) promoter of human cytomegalovirus (HCMV) constitutes a primary genetic switch, which determines the progression of viral infection. Earlier reports by others have shown mitogen-activated protein kinase kinase kinase-1 (MEKK1) to be able to up-regulate HCMV-IE promoter through downstream mitoge...

journal_title：Journal of cellular biochemistry

authors： Sun B,Harrowe G,Reinhard C,Yoshihara C,Chu K,Zhuo S

更新日期：2001-01-01 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. While Gemcitabine-based chemotherapy is the first-line treatment for locally advanced pancreatic cancer, its resistance is a large obstacle in the field. Understanding the molecular basis of gemcitabine resistance is therefore ...

journal_title：Journal of cellular biochemistry

authors： Peng T,Dou QP

更新日期：2017-09-01 00:00:00

abstract：:To determine the role of thrombin high-affinity receptor occupancy and enzymic activity in thrombin initiation of cell proliferation, we have utilized thrombin derivatives which separate these functions. We previously showed that enzymically active gamma-thrombin stimulates ion fluxes without binding to high-affinity ...

journal_title：Journal of cellular biochemistry

authors： Carney DH,Stiernberg J,Fenton JW 2nd

更新日期：1984-01-01 00:00:00

abstract：:Embryonic data and ultrastructural analyses suggest that the primitive endothelium signals undifferentiated mesenchymal cells to migrate to the forming blood vessel and subsequently regulates mural cell growth and behavior. Upon maturation of the blood vessel, chemotactic and mitogenic signals are apparently diminishe...

journal_title：Journal of cellular biochemistry

authors： Dodge AB,Lu X,D'Amore PA

更新日期：1993-09-01 00:00:00

abstract：:MUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression. In this study, qRT-PCR screening of mouse tissues determined that Muc4 mRNA also was robustly expressed in mouse ...

journal_title：Journal of cellular biochemistry

authors： Chapela PJ,Broaddus RR,Hawkins SM,Lessey BA,Carson DD

更新日期：2015-11-01 00:00:00

abstract：:Cancer of the ovary is the leading cause of death from gynecologic malignancy. To understand better these aggressive tumors, the development of in vitro models to study human ovarian cancer is critical. However, the establishment of long-term cell lines has been difficult, due to the generalized poor survival of patie...

journal_title：Journal of cellular biochemistry

authors： Becker JL,Prewett TL,Spaulding GF,Goodwin TJ

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Whether obesity categories can be used to predict cardiovascular disease (CVD) in Chinese adults remains unclear. This aim of this study was to examine the predictive values of obesity categories for CVD risk factors in Chinese adults. METHODS:This study comprised a sample size of 3480 men and 6364 women age...

journal_title：Journal of cellular biochemistry

authors： Yin D,Yan Y,Xu N,Hui Y,Han G,Ma N,Yang C,Wang G

更新日期：2018-11-02 00:00:00

abstract：:It has drawn a lot of attention to target signal transducer and activator of transcription 3 (STAT3) as a potential strategy for cancer therapeutics. Using several myelogenous cell lines, the effect of genipin (an active compound of Gardenia fruit) on the STAT3 pathway and apoptosis was investigated. Genipin suppresse...

journal_title：Journal of cellular biochemistry

authors： Lee JC,Ahn KS,Jeong SJ,Jung JH,Kwon TR,Rhee YH,Kim SH,Kim SY,Yoon HJ,Zhu S,Chen CY,Kim SH

更新日期：2011-06-01 00:00:00

abstract：:Arsenic is a well-known environmental toxicant but the mechanism by which it causes cytotoxicity is poorly understood. Arsenite induces apoptosis in glutathione (GSH)-deficient GCS-2 cells by causing cell cycle dysfunction and down-regulating critical signaling pathways. This study was designed to examine the effect o...

journal_title：Journal of cellular biochemistry

authors： Habib GM

更新日期：2010-05-15 00:00:00

abstract：:The protective effect of melatonin, 6-hydroxymelatonin and N-acetylserotonin against alpha-naphthylisothiocyanate (ANIT)-induced liver injury was investigated and compared in rats injected once with the hepatotoxicant (75 mg/kg body weight). In rats injected with ANIT alone, liver injury with cholestasis developed wit...

journal_title：Journal of cellular biochemistry

authors： Calvo JR,Reiter RJ,García JJ,Ortiz GG,Tan DX,Karbownik M

更新日期：2001-01-01 00:00:00

abstract：:Rhodopsin mutations cause autosomal dominant form of retinitis pigmentosa (RP). T17M rhodopsin predisposes cells to endoplasmic reticulum stress induced apoptosis. However, the pathogenic role of T17M rhodopsin in RP is not completely understood. Complement C3 has a protective role in RP pathogenesis. This study aimed...

journal_title：Journal of cellular biochemistry

authors： Xiong S,Yu Y,Zhou X,Xia X,Jiang H

更新日期：2017-12-01 00:00:00

abstract：:The mitogen regulated protein/proliferin (MRP/PLF) gene is transcribed in primary mouse embryo fibroblasts (MEFs), but the pre-mRNA is not properly converted into a stable cytoplasmic mRNA and instead is rapidly degraded, apparently in the nucleus [Malyankar et al. (1994): Proc Natl Acad Sci USA 91:335-359]. In 3T3 ce...

journal_title：Journal of cellular biochemistry

authors： Malyankar UM,Rittling SR,Denhardt DT

更新日期：1996-02-01 00:00:00

abstract：:Chronic renal failure is often associated with a resistance to the biologically active form of vitamin D(3), the nuclear hormone 1alpha, 25-dihydroxyvitamin D(3) (VD). The actions of VD are mediated by the vitamin D receptor (VDR), a ligand-dependent transcription factor that binds as a dimeric complex with the retino...

journal_title：Journal of cellular biochemistry

authors： Toell A,Degenhardt S,Grabensee B,Carlberg C

更新日期：1999-09-01 00:00:00

abstract：:Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to...

journal_title：Journal of cellular biochemistry

authors： Niu Z,Zhao X,Liu H,Quan J,Lin Y,Li J,Wang J,Liu M,Song W,Chen A,Liu S

更新日期：2018-06-01 00:00:00

abstract：:Based on a consideration of the probable structure of calmodulin and some natural peptides known to interact with it, two calmodulin-binding peptides were designed. These peptides bind to calmodulin in helical conformations and are capable of forming electrostatic and hydrophobic interactions with calmodulin. Their di...

journal_title：Journal of cellular biochemistry

authors： DeGrado WF,Prendergast FG,Wolfe HR Jr,Cox JA

更新日期：1985-01-01 00:00:00

abstract：:The ERK-MAPK signaling pathway plays a pivotal role during mesenchymal stem cell (MSC) differentiation. Studies have demonstrated that ERK-MAPK promotes adipogenesis and osteogenesis through the phosphorylation of differentiation-associated transcription factors and that it is the only active signaling in all three li...

journal_title：Journal of cellular biochemistry

authors： Mei Y,Bian C,Li J,Du Z,Zhou H,Yang Z,Zhao RC

更新日期：2013-06-01 00:00:00

abstract：:Syndecans are cell-surface heparan sulfate proteoglycans, which perform a variety of functions in the cell. Most important, they are co-receptors for growth factors and mediate cell-cell and cell-matrix interactions. Four syndecans (syndecan 1-4) have been described in different species. The aim of this work was the c...

journal_title：Journal of cellular biochemistry

authors： Berndt C,Casaroli-Marano RP,Vilaró S,Reina M

更新日期：2001-01-01 00:00:00

abstract：:Roscovitine (ROSC), a selective cyclin-dependent kinase (CDK) inhibitor, arrests human estrogen receptor-α (ER-α) positive MCF-7 breast cancer cells in the G(2) phase of the cell cycle and concomitantly induces apoptosis via a p53-dependent pathway. The effect of ROSC is markedly diminished in MCF-7 cells maintained i...

journal_title：Journal of cellular biochemistry

authors： Węsierska-Gądek J,Gritsch D,Zulehner N,Komina O,Maurer M

更新日期：2011-03-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is devastating for its delayed presence, difficulty in diagnosis, and high mortality. Other studies have supported the important role of microRNAs (miRNAs) in the pathogenesis of CCA, and the role of miR-194 was investigated in several human cancers, though, the molecular mechanism of miR-194 ...

journal_title：Journal of cellular biochemistry

authors： Gao J,Dai C,Yu X,Yin XB,Zhou F

更新日期：2020-10-01 00:00:00

abstract：:Genistein, a natural isoflavone phytoestrogen present in soybeans, caused a dose-dependent growth inhibition of the two hormone-sensitive cell lines T47D and ZR75.1 and of the two hormone-independent cell lines MDAMB-231 and BT20. Flow cytometric analysis of cells treated for 4 days with 15 and 30 microM genistein sho...

journal_title：Journal of cellular biochemistry

authors： Cappelletti V,Fioravanti L,Miodini P,Di Fronzo G

更新日期：2000-09-14 00:00:00

abstract：:Intact embryonic chick neural retina cells have at their surface an N-acetylgalactosaminyltransferase which catalyzes the incorporation of N-acetylgalactosamine from UDP-N-acetylgalactosamine into endogenous macromolecular acceptors. The enzyme along with its endogenous acceptors can be isolated as a particulate compl...

journal_title：Journal of cellular biochemistry

authors： Balsamo J,Pratt RS,Emmerling MR,Grunwald GB,Lilien J

更新日期：1986-01-01 00:00:00

abstract：:Loss of sensitivity to the negative growth regulator transforming growth factor beta (TGF beta) is a feature of many different tumor types and is likely involved in tumor progression. In some cases this loss of sensitivity to TGF beta has been shown to be manifest in the absence of membrane-associated TGF beta recepto...

journal_title：Journal of cellular biochemistry

authors： Alexandrow MG,Moses HL

更新日期：1997-09-15 00:00:00

abstract：:Our laboratory pioneered patient-derived orthotopic xenograft (PDOX) mouse models using surgical orthotopic implantation (SOI). PDOX models are patient-like, in contrast to the ectopic subcutaneous-transplant cancer models. In the present study, we demonstrate that an undifferentiated pleomorphic soft-tissue sarcoma (...

journal_title：Journal of cellular biochemistry

authors： Kiyuna T,Murakami T,Tome Y,Igarashi K,Kawaguchi K,Russell T,Eckardt MA,Crompton J,Singh A,Bernthal N,Bukata S,Federman N,Kanaya F,Eilber FC,Hoffman RM

更新日期：2017-02-01 00:00:00

abstract：:The bone morphogenetic proteins were originally identified based on their ability to induce ectopic bone formation in vivo and have since been identified as members of the transforming growth factor-beta gene superfamily. It has been well established that the bone morphogenetic cytokines enhance osteogenic activity in...

journal_title：Journal of cellular biochemistry

authors： Gimble JM,Morgan C,Kelly K,Wu X,Dandapani V,Wang CS,Rosen V

更新日期：1995-07-01 00:00:00

abstract：:Fibroblast growth factor 2 (FGF-2) has been found to play an anti-anabolic and/or a catabolic role in adult human articular cartilage via regulation of multiple signaling pathways. Upon FGF-2 stimulation, a molecular crosstalk between the mitogen activated protein kinase (MAPK) and protein kinase C δ (PKCδ) pathways a...

journal_title：Journal of cellular biochemistry

authors： Yan D,Chen D,Im HJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Dysfunction of the peritoneum as a dialysis organ may result from progressive membrane injury on peritoneal dialysis (PD). It has been increasingly recognized that the human peritoneal mesothelial cells (HPMCs) play a key role in peritoneal membrane early injury. Recently, it has been reported that bioincomp...

journal_title：Journal of cellular biochemistry

authors： Zhu N,Gu L,Jia J,Wang X,Wang L,Yang M,Yuan W

更新日期：2019-03-01 00:00:00

abstract：:Cutaneous melanoma (CM) has become a major public health concern. Studies illustrate that minichromosome maintenance protein 7 (MCM7) participate in various diseases including skin disease. Our study aimed to study the effects of MCM7 silencing on CM cell autophagy and apoptosis by modulating the AKT threonine kinase ...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Ma S,Ye Z,Zhou X

更新日期：2020-02-01 00:00:00

abstract：:Bone is a target tissue of progestins, but the mechanisms by which they act are still unclear. We examined the early (5-60 s) effects of progesterone and progesterone covalently bound to BSA (P-CMO BSA), which does not enter the cell, on the cytosolic free Ca(2+) concentration ([Ca(2+)]i) and the formation of inositol...

journal_title：Journal of cellular biochemistry

authors： Grosse B,Kachkache M,Le Mellay V,Lieberherr M

更新日期：2000-08-02 00:00:00

abstract：:Adipose-derived mesenchymal stromal cells (ADSCs) exhibited high potential in tissue repair and regeneration, and it has been proved that ADSCs could protect brain cells from apoptosis and maintaining blood-brain barrier stability after cerebral vascular disease. In this study, we evaluated the therapeutic potential a...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Deng H,Hu Y,Pan C,Wu G,Li Q,Tang Z

更新日期：2019-09-01 00:00:00

abstract：:The c-myc oncoprotein plays a critical role in the regulation of cellular proliferation and apoptosis. To mediate these biological functions, a variety of target genes are activated or repressed by c-myc, but few genes have yet been identified that directly mediate c-myc's role in proliferation or apoptosis. During a ...

journal_title：Journal of cellular biochemistry

authors： Vaknin UA,Hann SR

更新日期：2006-04-01 00:00:00