Membrane signalling and progesterone in female and male osteoblasts. I. Involvement Of intracellular Ca(2+), inositol trisphosphate, and diacylglycerol, but not cAMP.

abstract：:Survivin is recognized as an attractive target in cancer therapy because of its selective overexpression in the majority of tumors. Upregulated expression of this protein correlates with increased tumor grade, recurrence risk and decreased cancer patients survival. In this study, we assessed the efficacy of two surviv...

journal_title：Journal of cellular biochemistry

authors： Croci DO,Cogno IS,Vittar NB,Salvatierra E,Trajtenberg F,Podhajcer OL,Osinaga E,Rabinovich GA,Rivarola VA

更新日期：2008-10-01 00:00:00

abstract：:Platelets are critical regulators of liver regeneration, but the mechanisms are still not fully understood. Platelets have been shown to contain a wide variety of microRNAs (miRNAs) and play an important role in many diseases. However, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate th...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Li W,Liang G,Peng J,Xu X

更新日期：2020-07-21 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are used to transport peptides, proteins, different types of ribonucleic acids (or mimics of these molecules), and DNA into live cells, both plant and mammalian. Leishmania belongs to the class of protozoa having, in comparison to mammalian cells, a different lipid composition of the m...

journal_title：Journal of cellular biochemistry

authors： Keller AA,Breitling R,Hemmerich P,Kappe K,Braun M,Wittig B,Schaefer B,Lorkowski S,Reissmann S

更新日期：2014-02-01 00:00:00

abstract：:We aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, ...

journal_title：Journal of cellular biochemistry

authors： Su Q,Wang Y,Yang X,Li XD,Qi YF,He XJ,Wang YJ

更新日期：2017-12-01 00:00:00

abstract：:Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α-modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expre...

journal_title：Journal of cellular biochemistry

authors： Liang Y,Zhang T,Shi M,Zhang S,Guo Y,Gao J,Yang X

更新日期：2019-04-01 00:00:00

abstract：:3,6-Anhydro-l-galactose (l-AHG) is a bioactive sugar that is a major component of agarose. Recently, l-AHG was reported to have anti-melanogenic potential in human epidermal melanocytes (HEMs) and B16F10 melanoma cells; however, its underlying molecular mechanisms remain unknown. At noncytotoxic concentrations, l-AHG ...

journal_title：Journal of cellular biochemistry

authors： Kim JH,Kim DH,Cho KM,Kim KH,Kang NJ

更新日期：2018-09-01 00:00:00

abstract：:As the most common neurodegenerative disease, Alzheimer's disease (AD) is characterized by memory, perception, and behavioral damage, which may ultimately lead to emotional fluctuation and even lethal delirium. Increasing studies indicate that microRNAs (miRNAs) are associated with pathological features of AD. However...

journal_title：Journal of cellular biochemistry

authors： Li J,Chen W,Yi Y,Tong Q

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The current study was designed to investigate the inhibitory effects of ginsenoside Rd (Gs-Rd) on human glioma U251 cells in vitro and its possible underlying mechanisms. METHODS:The groups included blank control group, low concentration Gs-Rd treatment group (20 μM), mid concentration Gs-Rd treatment group ...

journal_title：Journal of cellular biochemistry

authors： Gu B,Wang J,Song Y,Wang Q,Wu Q

更新日期：2019-03-01 00:00:00

abstract：:Human bone marrow mesenchymal stem cells (hMSCs) are promising candidates for cell therapy and tissue engineering. The life span of hMSCs during in vitro culture is limited. Human telomerase catalytic subunit (hTERT) gene transduction can prolong the life span of hMSCs and maintain their potential of osteogenic differ...

journal_title：Journal of cellular biochemistry

authors： Huang G,Zheng Q,Sun J,Guo C,Yang J,Chen R,Xu Y,Wang G,Shen D,Pan Z,Jin J,Wang J

更新日期：2008-03-01 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1), a major regulator of the plasmin-dependent pericellular proteolytic cascade, is prominently expressed during the tissue response to injury although the factors that impact PAI-1 induction and their role in the repair process are unclear. Kinetic modeling using establishe...

journal_title：Journal of cellular biochemistry

authors： Qi L,Higgins CE,Higgins SP,Law BK,Simone TM,Higgins PJ

更新日期：2014-10-01 00:00:00

abstract：:Previously, we showed that Janus kinase 2 (JAK2) is important in advanced glycation end-product (AGE)-induced effects in renal interstitial (NRK-49F) fibroblasts. Leptin is a JAK2-activating cytokine via the long form leptin receptor (Ob-Rb). Leptin and connective tissue growth factor (CTGF) may be involved in renal f...

journal_title：Journal of cellular biochemistry

authors： Lee CI,Guh JY,Chen HC,Lin KH,Yang YL,Hung WC,Lai YH,Chuang LY

更新日期：2004-11-15 00:00:00

abstract：:Male pronucleus formation involves sperm nucleus decondensation and sperm chromatin remodeling. In sea urchins, male pronucleus decondensation was shown to be modulated by protein kinase C and a cdc2-like kinase sensitive to olomoucine in vitro assays. It was further demonstrated that olomoucine blocks SpH2B and SpH1 ...

journal_title：Journal of cellular biochemistry

authors： Monardes A,Iribarren C,Morin V,Bustos P,Puchi M,Imschenetzky M

更新日期：2005-10-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a condition associated with high rates of mortality and lengthy hospital stays. In the current study, SAP mouse models were established in BALB/c wild-type and P21-activated kinase 1 (PAK1) knockdown mice with the objective of determining the expression of microRNA-542-5p (miR-542-5p...

journal_title：Journal of cellular biochemistry

authors： Wu XM,Ji KQ,Wang HY,Zhao Y,Jia J,Gao XP,Zang B

更新日期：2019-01-01 00:00:00

abstract：:Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP14) is an efficient extracellular matrix (ECM) degrading enzyme that plays important roles in tissue homeostasis and cell invasion. Like a number of type I membrane proteins, MT1-MMP can be internalized from the cell surface through early and recycling endosomes to...

journal_title：Journal of cellular biochemistry

authors： Hakulinen J,Sankkila L,Sugiyama N,Lehti K,Keski-Oja J

更新日期：2008-12-01 00:00:00

abstract：:The retinoblastoma is the most common intraocular malignant tumor in infants and children; it is one of the deadliest forms of cancer due to its limited sensitivity to chemotherapy and radiotherapy. In several cancers, chemoresistance is associated with autophagy induction. Non-coding RNAs, including long non-coding R...

journal_title：Journal of cellular biochemistry

authors： Huang J,Yang Y,Fang F,Liu K

更新日期：2018-05-01 00:00:00

abstract：:Adenosine triphosphate (ATP), which plays a crucial role in both developing and mature cochleae, is released from greater epithelial ridge (GER) supporting cells of the rat cochlea, but the organelles in which ATP is stored have not yet been identified. Thus, we studied the organelles involved in ATP storage and sugge...

journal_title：Journal of cellular biochemistry

authors： Chen J,Hou S,Yang J

更新日期：2019-12-01 00:00:00

abstract：:During neonatal development, cardiac myocytes undergo a transition from hyperplastic to hypertrophic growth. Whether these cells are terminally differentiated and permanently withdrawn from the cell cycle shortly after birth is controversial. Nevertheless, the clinical observation that functionally significant myocard...

journal_title：Journal of cellular biochemistry

authors： Chim SS,Fung K,Waye MM,Lee C,Tsui SK

更新日期：2000-06-12 00:00:00

abstract：:To ascertain whether p53 deficiency in vivo leads to the deregulation of DNA methylation machinery prior to tumor development, we investigated the expression profile of DNA methyltransferases in the thymus and the liver of p53(+/+), p53(+/-), and p53(-/-) mice at 7 weeks of age before tumor development. The expression...

journal_title：Journal of cellular biochemistry

authors： Park IY,Sohn BH,Choo JH,Joe CO,Seong JK,Lee YI,Chung JH

更新日期：2005-02-15 00:00:00

abstract：:The dysregulation of miR-125a-3p has been observed in multiple tumor types. Nevertheless, the function of miR-125a-3p in papillary thyroid carcinoma (PTC) is yet to be explored. Herein, we find that miR-125a-3p is markedly downregulated in PTC tissues, and its level is inversely related to the histological grade of PT...

journal_title：Journal of cellular biochemistry

authors： Song M,Wang N,Li Z,Zhang Y,Zheng Y,Yi P,Chen J

更新日期：2020-02-01 00:00:00

abstract：:Curcumin is a dietary polyphenol and a bioactive phytochemical that possesses anti-inflammatory, antioxidant, anticancer, and chemopreventive properties, which make it capable of affecting multiple sites along the stem cell pathways to induce apoptosis in these cells. Curcumin's function is through suppression of cyto...

journal_title：Journal of cellular biochemistry

authors： Zendehdel E,Abdollahi E,Momtazi-Borojeni AA,Korani M,Alavizadeh SH,Sahebkar A

更新日期：2019-04-01 00:00:00

abstract：:The activity of α-type cytosolic phospholipase A2 (cPLA2 α, group IVA PLA2 ), which releases arachidonic acid (AA), is mainly regulated by the Ca2+ -induced intracellular translocation/attachment of the enzyme to substrate membranes and its phosphorylation. We previously reported that tumor necrosis factor-α (TNFα) st...

journal_title：Journal of cellular biochemistry

authors： Nakamura H,Moriyama Y,Watanabe K,Tomizawa S,Yamazaki R,Takahashi H,Murayama T

更新日期：2017-12-01 00:00:00

abstract：:Peptidylarginine deiminase is localized in the cytosol of the luminal and glandular epithelia of the nonpregnant murine uterus and its expression is regulated by sex hormones [Takahara et al., [1989]: J Biol Chem 264, 13361-13368; Takahara et al. [1992]: J Biol Chem 267,520-525]. Here, we demonstrate that changes occu...

journal_title：Journal of cellular biochemistry

authors： Arai T,Kusubata M,Kohsaka T,Shiraiwa M,Sugawara K,Takahara H

更新日期：1995-07-01 00:00:00

abstract：:Mechanotransduction is a key process by which cells perceive extracellular mechanical cues/intercellular physical interactions and transform them into intracellular biochemical signals. This physiological process is crucial during bone development and bone remodeling throughout childhood and adult life, whereas severa...

journal_title：Journal of cellular biochemistry

authors： Adamopoulos C,Gargalionis AN,Piperi C,Papavassiliou AG

更新日期：2017-02-01 00:00:00

abstract：:We performed a network meta-analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different antiplatelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes were compared using odds ratios and 95% credible intervals. E...

journal_title：Journal of cellular biochemistry

authors： Wa D,Zhu P,Long Z

更新日期：2019-06-01 00:00:00

abstract：:WNT family genes have participated in the progression and development of many cancers, however, the association between colon adenocarcinoma (COAD) and WNTs have been rarely reported. This study investigated the significance of WNT genes expression in COAD from the standpoint of diagnosis and prognosis. The RNA-sequen...

journal_title：Journal of cellular biochemistry

authors： Ruan GT,Zhu LC,Gong YZ,Liao XW,Wang XK,Liao C,Wang S,Yan L,Xie HL,Zhou X,Li YZ,Gao F

更新日期：2020-06-01 00:00:00

abstract：:We have previously demonstrated that the antagonists of calmodulin (CaM) induce apoptosis of cholangiocarcinoma cells partially through Fas-mediated apoptosis pathways. Recently, CaM has been shown to bind to Fas, which is regulated during Fas or CaM antagonist-mediated apoptosis in Jurkat cells and osteoclasts. Accor...

journal_title：Journal of cellular biochemistry

authors： Chen Y,Pawar P,Pan G,Ma L,Liu H,McDonald JM

更新日期：2008-02-15 00:00:00

abstract：:Beta-dystroglycan (beta-DG) is a widely expressed transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton, and thereby contributing to plasma membrane integrity and signal transduction. We previously observed nuclear localization of beta-DG in cultured cell lines, im...

journal_title：Journal of cellular biochemistry

authors： Lara-Chacón B,de León MB,Leocadio D,Gómez P,Fuentes-Mera L,Martínez-Vieyra I,Ortega A,Jans DA,Cisneros B

更新日期：2010-06-01 00:00:00

abstract：:Extracellular matrix metalloproteinases (MMPs) are activated in dilated cardiomyopathic (DCM) hearts [Tyagi et al. (1996): Mol Cell Biochem 155:13-21]. To examine whether the MMP activation is occurring at the gene expression level, we performed differential display mRNA analysis on tissue from six dilated cardiomyopa...

journal_title：Journal of cellular biochemistry

authors： Tyagi SC,Kumar S,Voelker DJ,Reddy HK,Janicki JS,Curtis JJ

更新日期：1996-11-01 00:00:00

abstract：:The expression of STRO-1, the essential mesenchymal stem cell marker, was found to decrease with advancing passages in few tissues. Because STRO-1 was identified and isolated from human gingiva, we were interested to know its status after a few passages. Human gingival mesenchymal stem cells (HGMSCs) were isolated fro...

journal_title：Journal of cellular biochemistry

authors： Ranga Rao S,Subbarayan R

更新日期：2019-03-01 00:00:00

abstract：:Human DNA replication depends on the activation of thousands of origins distributed within the genome. The actual distribution of origins is not known, nor whether this distribution is unique to a cell type, or if it changes with the proliferative state of the cell. In this study, we have employed a real-time PCR-base...

journal_title：Journal of cellular biochemistry

authors： Valenzuela MS,Hu L,Lueders J,Walker R,Meltzer PS

更新日期：2012-01-01 00:00:00