Kips off to Myc: implications for TGF beta signaling.

abstract：:Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer molecules. N-end rule pathway has been shown to be involved...

journal_title：Journal of cellular biochemistry

authors： Pore SK,Ganguly A,Sau S,Godeshala S,Kanugula AK,Ummanni R,Kotamraju S,Banerjee R

更新日期：2020-01-01 00:00:00

abstract：:In previous publications, we showed that extracellular glycosaminoglycans reduced the membrane potential, caused cell blebbing and swelling and decreased the intracellular pH independently of cell surface receptors. These phenomena were explained by Donnan effects. The effects were so large that they could not be attr...

journal_title：Journal of cellular biochemistry

authors： Hagenfeld D,Kathagen N,Prehm P

更新日期：2014-07-01 00:00:00

abstract：:It has been reported that the antitumor drug doxorubicin (Dox) exerts its toxic effects via GATA-4 depletion and that over-expression of GATA-4 reverses Dox-induced toxicity and apoptosis; however, the precise mechanisms remain unclear. In this study, we observed, for the first time, that EGF protects cells against Do...

journal_title：Journal of cellular biochemistry

authors： Yao CX,Shi JC,Ma CX,Xiong CJ,Song YL,Zhang SF,Zhang SF,Zang MX,Xue LX

更新日期：2015-08-01 00:00:00

abstract：:Deregulated proliferation of vascular smooth muscle cells (VSMCs) is one common phenomenon of atherosclerosis progression. Long noncoding RNAs (lncRNAs) are one group of noncoding RNAs that play essential roles in many cell biological processes, including cell development, growth, and migration. However, the role of a...

journal_title：Journal of cellular biochemistry

authors： Wang H,Jin Z,Pei T,Song W,Gong Y,Chen D,Zhang L,Zhang M,Zhang G

更新日期：2019-03-01 00:00:00

abstract：:Berberine (BBR) is an isoquinoline alkaloid derived from various medicinal herbs. Previous studies have suggested that BBR exerts antimicrobial, antitumor, and antidiabetic effects and can be used to treat Helicobacter pylori-induced chronic gastritis. However, the exact mechanism by which BBR inhibits H. pylori infec...

journal_title：Journal of cellular biochemistry

authors： Wu X,Li X,Dang Z,Jia Y

更新日期：2018-07-01 00:00:00

abstract：:Long noncoding RNA HOXD cluster antisense RNA 1 (HOXD-AS1) has been found to play a crucial role in the tumorigenesis and progression of human cancer. However, the role of HOXD-AS1 in papillary thyroid cancer is still unknown. The purpose of this study was to investigate the clinical value and biological function of H...

journal_title：Journal of cellular biochemistry

authors： Xu K,Feng Y

更新日期：2019-04-01 00:00:00

abstract：:Estrogen receptor (ER)-alpha can signal either via estrogen response element (ERE)-mediated pathways or via alternate pathways involving protein-protein or membrane signaling. We previously demonstrated that, as compared to wild type (WT) controls, mice expressing a mutant ER-alpha lacking the ability to bind EREs (no...

journal_title：Journal of cellular biochemistry

authors： Rudnik V,Sanyal A,Syed FA,Monroe DG,Spelsberg TC,Oursler MJ,Khosla S

更新日期：2008-02-15 00:00:00

abstract：:Despite the historical use of estrogens in the treatment of prostate cancer (PCa) little is known about their direct biological effects on the prostate, their role in carcinogenesis, and what mechanisms mediate their therapeutic effects on PCa. It is now known that estrogens alone, or in synergism with an androgen, ar...

journal_title：Journal of cellular biochemistry

authors： Ho SM

更新日期：2004-02-15 00:00:00

abstract：:Bone formation is under the control of a set of transcription factors. Ids are inhibitory helix-loop-helix (HLH) transcription factors and expression of Id genes in osteoblasts is under the control of calciotropic agents such as BMP and vitamin D. However, the function of Ids during bone formation in vivo has not yet ...

journal_title：Journal of cellular biochemistry

authors： Maeda Y,Tsuji K,Nifuji A,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is no evidence about it...

journal_title：Journal of cellular biochemistry

authors： Yaribeygi H,Mohammadi MT,Rezaee R,Sahebkar A

更新日期：2018-09-01 00:00:00

abstract：:O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is a post-translational modification, which is believed antagonises phosphorylation. We have studied the O-GlcNAc level during Xenopus oocyte meiotic resumption, taking advantage of the high synchrony of this model which is dependent upon a burst of phosphorylation...

journal_title：Journal of cellular biochemistry

authors： Lefebvre T,Baert F,Bodart JF,Flament S,Michalski JC,Vilain JP

更新日期：2004-11-15 00:00:00

abstract：:The lining of the trachea consists of a pseudostratified, mucociliary epithelium that under a variety of conditions, such as vitamin A deficiency, toxic and mechanical injury, becomes a stratified squamous epithelium. Several in vitro cell culture models have been established to study the process of differentiation of...

journal_title：Journal of cellular biochemistry

authors： Kim YS,Hwang SM,Lee SJ,Jung JS

更新日期：2002-01-01 00:00:00

abstract：:The function of the c-myc proto-oncogene in cell cycle progression remains unclear. In order to examine the role c-myc may play in cell cycle progression, we have expressed the hormone-inducible MycER protein in the nontransformed, EGF-dependent mouse keratinocyte cell line BALB/MK. We have found that activation of My...

journal_title：Journal of cellular biochemistry

authors： Alexandrow MG,Moses HL

更新日期：1998-09-15 00:00:00

abstract：OBJECTIVE:This study was designed to explore the protective effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against ischemia/reperfusion (I/R) injury-induced cardiomyocytes apoptosis. METHODS:The H9c2 cell I/R injury model was induced by simultaneous shortage of nutrients and oxygen. TSG administration...

journal_title：Journal of cellular biochemistry

authors： Sun T,Liu H,Cheng Y,Yan L,Krittanawong C,Li S,Qian W,Su W,Chen X,Hou X,Zhang H

更新日期：2019-03-19 00:00:00

abstract：:Emerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform α is a crucial regulator of breast hormone responsiveness and its hypermethylation...

journal_title：Journal of cellular biochemistry

authors： Daraei A,Izadi P,Khorasani G,Nafissi N,Naghizadeh MM,Younosi N,Meysamie A,Mansoori Y,Nariman-Saleh-Fam Z,Bastami M,Saadatian Z,Zendehbad Z,Tavakkoly-Bazzaz J

更新日期：2019-08-01 00:00:00

abstract：:Hamster embryo cells metabolize benzo(a)pyrene to derivatives that covalently modify the nuclear macromolecules including proteins. Not all proteins are modified to the same extent nor by the same metabolites. In particular, a protein of apparent molecular weight 32,000 is highly modified by derivatives of trans-9,10-...

journal_title：Journal of cellular biochemistry

authors： MacLeod MC,Mansfield BK,Selkirk JK

更新日期：1982-01-01 00:00:00

abstract：:As a microaerobe, Helicobacter pylori employs the global regulator SpoT for defending against oxidative stress in vitro. However, the mechanisms how SpoT affects bacterial gene expression is still unknown. Moreover, the function of SpoT in H. pylori colonization in the host is remaining undetermined. To explore the fu...

journal_title：Journal of cellular biochemistry

authors： Sun Y,Li X,Li W,Zhao M,Wang L,Liu S,Zeng J,Liu Z,Jia J

更新日期：2012-11-01 00:00:00

abstract：:It has been proposed that buckling of actin stress fibers (SFs) may be associated with their disassembly. However, much of the detail remains unknown partly because the use of an elastic membrane sheet, conventionally necessary for inducing SF buckling with a mechanical compression to adherent cells, may limit high qu...

journal_title：Journal of cellular biochemistry

authors： Deguchi S,Matsui TS,Sato M

更新日期：2012-03-01 00:00:00

abstract：:ZC3H12D belongs to a recently discovered family of proteins containing four members of which the most studied and best described is the RNase ZC3H12A (MCPIP1/Regnase-1). ZC3H12A is a crucial negative regulator of inflammation. It accelerates the turnover of transcripts of a spectrum of proinflammatory cytokines, as we...

journal_title：Journal of cellular biochemistry

authors： Wawro M,Kochan J,Krzanik S,Jura J,Kasza A

更新日期：2017-03-01 00:00:00

abstract：:Electrical activity in embryonic brain tissue has typically been studied using Micro Electrode Array (MEA) technology to make dozens of simultaneous recordings from dissociated neuronal cultures, brain stem cell progenitors, or brain slices from fetal rodents. Although these rodent neuronal primary culture electrical ...

journal_title：Journal of cellular biochemistry

authors： Napoli A,Obeid I

更新日期：2016-03-01 00:00:00

abstract：:Membrane vesicles were prepared by incubation of human erythrocytes with dimyristoylphosphatidylcholine [3] and isolated by isopycnic centrifugation on Dextran density gradients. Protein analyses were carried out with crossed immunoelectrophoresis and dodecylsulfate polyacrylamide gel electrophoresis. The right-side-o...

journal_title：Journal of cellular biochemistry

authors： Weitz M,Bjerrum OJ,Ott P,Brodbeck U

更新日期：1982-01-01 00:00:00

abstract：:In mice, the first round of DNA replication occurs in fertilized eggs (1-cell embryos), while the onset of zygotic gene transcription begins approximately 20 hours after fertilization, a time that normally coincides with formation of a 2-cell embryo. One approach to investigating the mechanisms that control these deve...

journal_title：Journal of cellular biochemistry

authors： Majumder S,DePamphilis ML

更新日期：1994-05-01 00:00:00

abstract：:Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

journal_title：Journal of cellular biochemistry

authors： Yang JA,He JM,Lu JM,Jie LJ

更新日期：2018-06-01 00:00:00

abstract：:It is known that the MyoD family members (MyoD, Myf5, myogenin, and MRF4) play a pivotal role in the complex mechanism of skeletal muscle cell differentiation. However, fragmentary information on transcription factor-specific regulation is available and data on their post-transcriptional and post-translational behavio...

journal_title：Journal of cellular biochemistry

authors： Ferri P,Barbieri E,Burattini S,Guescini M,D'Emilio A,Biagiotti L,Del Grande P,De Luca A,Stocchi V,Falcieri E

更新日期：2009-12-15 00:00:00

abstract：:Protein synthesis inhibitors paradoxically increase the expression of early-gene products, including various cytokines, through a process known as superinduction. Superinduction is cell-specific and the mechanisms involved are not fully understood but are usually attributed to decreased mRNA degradation. There is, how...

journal_title：Journal of cellular biochemistry

authors： Hershko DD,Robb BW,Wray CJ,Luo GJ,Hasselgren PO

更新日期：2004-04-01 00:00:00

abstract：:Hepatic copper levels differ among patients with Wilson disease (WD) and normal individuals depending on the dietary intake, copper bioavailability, and genetic factors. Copper chloride (CuCl2 ) caused dose-dependent reduction in cell viability of human teratocarcinoma (HepG2) cell line, measured using the 3-(4,5-dime...

journal_title：Journal of cellular biochemistry

authors： Agnihotry S,Dhusia K,Srivastav AK,Upadhyay J,Verma V,Shukla PK,Ramteke PW,Gautam B

更新日期：2019-11-01 00:00:00

abstract：:Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was ...

journal_title：Journal of cellular biochemistry

authors： Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer M

更新日期：2009-12-15 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non-toxic to most normal cells, therefore, it is a promising agent for cancer therapy. However, some cancer cell lines were resistant to TRAIL cytoxicity, including...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Liu N,Zhang J,Liu S,Liu Y,Zheng D

更新日期：2005-10-15 00:00:00

abstract：:The catalytic domain of protein tyrosine phosphatase SHP-1 possesses distinct substrate specificity. It recognizes the P-3 to P-5 residues of its substrates via the beta5-loop-beta6 region. To study the substrate specificity further, we determined the structure of the catalytic domain of SHP-1 (C455S) complexed with a...

journal_title：Journal of cellular biochemistry

authors： Yang J,Cheng Z,Niu T,Liang X,Zhao ZJ,Zhou GW

更新日期：2001-06-26 00:00:00

abstract：:Gastric cancer (GC) is one of the most common cancers worldwide and has especially high morbidity and mortality in China. LEM domain containing 1 (LEMD1), an important cancer-testis antigen, has been reported to be overexpressed in various cancers and promotes the progression of cancers. However, the biological charac...

journal_title：Journal of cellular biochemistry

authors： Li Q,Ge Y,Chen X,Wang L,Xia Y,Xu Z,Li Z,Wang W,Yang L,Zhang D,Xu Z

更新日期：2019-09-01 00:00:00