Metformin inhibits tumorigenesis in HBV-induced hepatocellular carcinoma by suppressing HULC overexpression caused by HBX.

abstract：:The retinoblastoma susceptibility gene product, p105Rb (RB), is generally believed to be an important regulator in the control of cell growth, differentiation, and apoptosis. Several cellular factors that form complexes with RB and exert their cellular regulatory functions have been identified, such as the newly ident...

journal_title：Journal of cellular biochemistry

authors： Cui Y,Mirkia K,Florence Fu YH,Zhu L,Yokoyama KK,Chiu R

更新日期：2002-01-01 00:00:00

abstract：:Calcium-dependent cell adhesion molecules (CAMs) mediate intercellular adhesion in epithelial cells and in preimplantation mammalian embryos. One of these molecules, cell-CAM 120/80, is found on cells as a 120-kd membrane glycoprotein and as a soluble 80-kd species in conditioned culture medium [Damsky et al: Cell 34:...

journal_title：Journal of cellular biochemistry

authors： Wheelock MJ,Buck CA,Bechtol KB,Damsky CH

更新日期：1987-07-01 00:00:00

abstract：:The bcl-2 gene has a unique function among mammalian oncogenes as a negative regulator of apoptosis. Its expression pattern in embryonic and adult tissues is consistent with a role in maintaining in vivo survival of specific cell types. The biochemical function of bcl-2 is unknown, but its localization to mitochondria...

journal_title：Journal of cellular biochemistry

authors： Park JR,Hockenbery DM

更新日期：1996-01-01 00:00:00

abstract：:Stroke is one of the most destructive complications of sickle cell disease (SCD), and SCD is also the most common cause of childhood stroke. Sickle cell stroke is complex and has a genetic endothelial basis. Here, we further investigated this genetic basis using weighted gene coexpression network analysis. This system...

journal_title：Journal of cellular biochemistry

authors： Liu FF,Wang J,Hu F,Wei Q,Li K

更新日期：2019-09-01 00:00:00

abstract：:Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that help...

journal_title：Journal of cellular biochemistry

authors： Upadhyay S,Sharma N,Gupta KB,Dhiman M

更新日期：2018-07-01 00:00:00

abstract：:Serological proteins of neuroblastoma were profiled and analyzed by ProteinChip-SELDI-TOF MS technology with five types of protein chips. By comparing with normal control, a number of protein or polypeptide signals were found significantly and consistently different in their intensities (expression levels) in tumor se...

journal_title：Journal of cellular biochemistry

authors： He QY,Zhu R,Ren Y,Tam PK,Chiu JF

更新日期：2005-05-01 00:00:00

abstract：:microRNAs (miRNAs) are noncoding RNAs that regulates the expression of target messenger RNAs (mRNAs). c-FLIP is an inhibitor of cell apoptosis through inhibition of caspase 8. miR-150, miR-504, and miR-519d were related to cancer cell proliferation, invasion, and migration in colorectal cancer (CRC). However, the role...

journal_title：Journal of cellular biochemistry

authors： Rong G,Yang X,Wu H,Wu Y

更新日期：2018-12-12 00:00:00

abstract：:The identification and purification of murine multipotent mesenchymal stem cells (MSCs) have been difficult due to their low frequency, the presence of contaminating cell types and lack of unambiguous markers. Using a magnetic micro-beads negative selection technique to remove hematopoietic cells from mouse bone marro...

journal_title：Journal of cellular biochemistry

authors： McKenzie KP,Mayer DC,Aubin JE

更新日期：2013-05-01 00:00:00

abstract：:Induction of definitive endoderm (DE) cells is a prerequisite for the whole process of embryonic stem (ES) cells differentiating into hepatic or pancreatic progenitor cells. We have established an efficient method to induce mouse ES cell-derived DE cells in suspension embryonic body (EB) culture. Similar to previous s...

journal_title：Journal of cellular biochemistry

authors： Li F,He Z,Li Y,Liu P,Chen F,Wang M,Zhu H,Ding X,Wangensteen KJ,Hu Y,Wang X

更新日期：2011-04-01 00:00:00

abstract：:Growing evidence has shown that a large number of miRNAs are abnormally expressed in cervical cancer (CC) tissues and play irreplaceable roles in tumorigenesis, progression, and metastasis. This study aimed to identify new biomarkers and pivotal genes associated with CC prognosis through comprehensive bioinformatics a...

journal_title：Journal of cellular biochemistry

authors： Gao C,Zhou C,Zhuang J,Liu L,Liu C,Li H,Liu G,Wei J,Sun C

更新日期：2018-08-01 00:00:00

abstract：:Long-term treatment with heparin has been associated with an increased risk of osteoporosis. Given the importance of heparan sulfate proteoglycans for bone metabolism, it can be anticipated that heparin due to its structural similarity with heparan sulfate chains somehow interferes with the biological activities of th...

journal_title：Journal of cellular biochemistry

authors： Hausser HJ,Brenner RE

更新日期：2004-04-01 00:00:00

abstract：:Heavy metals are toxic to living organisms. Some have no known beneficial biological function, while others have essential roles in physiological reactions. Mechanisms which deal with heavy metal stress must protect against the deleterious effects of heavy metals, yet avoid depleting the cell of a heavy metal which is...

journal_title：Journal of cellular biochemistry

authors： Brown NL,Camakaris J,Lee BT,Williams T,Morby AP,Parkhill J,Rouch DA

更新日期：1991-06-01 00:00:00

abstract：:In this study, we found that wounding of a confluent monolayer of squamous cell carcinoma (SCC) cells induced epithelial-mesenchymal transition (EMT) specifically at the edge of the wound. This process required the combined stimulation of TGFβ, TNFα, and PDGF-D. Such a combined cytokine treatment of confluent monolaye...

journal_title：Journal of cellular biochemistry

authors： Okui G,Tobiume K,Rizqiawan A,Yamamoto K,Shigeishi H,Ono S,Higashikawa K,Kamata N

更新日期：2013-09-01 00:00:00

abstract：:Macromolecules are sulfated during the vegetative growth of Dictyostelium discoideum. A characterisation of the structures of sulfated oligosaccharides associated with these macromolecules indicates that the oligosaccharides are heterogeneous. Endoglycosidase and pronase digestion were used with gel-filtration chromat...

journal_title：Journal of cellular biochemistry

authors： Davis SJ

更新日期：1988-10-01 00:00:00

abstract：:We investigated the association of DNA polymerase and DNA primase activity with the nuclear matrix in HeLa S3 cells diluted with fresh medium after having been cultured without any medium change for 7 days. Flow cytometric analysis demonstrated that just before dilution about 85% of the cells were in the G1 phase of t...

journal_title：Journal of cellular biochemistry

authors： Martelli AM,Capitani S,Neri LM

更新日期：1998-10-01 00:00:00

abstract：:A better understanding of breast cancer pathogenesis would contribute to improved diagnosis and therapy and potentially decreased mortality rates. Here, we found that the MORC family CW-type zinc finger 4 (MORC4) overexpression in breast cancer tissues is associated with poor survival, and the short-interfering RNA kn...

journal_title：Journal of cellular biochemistry

authors： Yang Z,Zhuang Q,Hu G,Geng S

更新日期：2019-03-01 00:00:00

abstract：:Lack of guidelines for personalized chemotherapy treatment after surgery has caused gastric cancer (GC) patients' unnecessary exposure to toxicity and the financial burden of chemotherapy treatments. In our study, we aimed to identify potential biomarkers to predict GC patients' susceptibility to platinum-based on Gen...

journal_title：Journal of cellular biochemistry

authors： Pan J,Xiang Z,Dai Q,Wang Z,Liu B,Li C

更新日期：2019-08-01 00:00:00

abstract：:Periodontitis, a common chronic inflammatory disease of the periodontium, is caused by dental plaque formation induced by microorganisms. Recent studies have demonstrated that lncRNAs play a critical role in the regulation of gene expression and in the pathogenesis of diseases. To demonstrate that periodontitis is ass...

journal_title：Journal of cellular biochemistry

authors： Zou Y,Li C,Shu F,Tian Z,Xu W,Xu H,Tian H,Shi R,Mao X

更新日期：2015-04-01 00:00:00

abstract：:The testis-specific linker histone H1t gene is transcribed exclusively in pachytene primary spermatocytes. Tissue specific expression of the gene is mediated in part by transcriptional factors that bind elements located within the proximal and distal promoter. A 40 bp promoter element, designated H1t/TE, that is locat...

journal_title：Journal of cellular biochemistry

authors： Wilkerson DC,Wolfe SA,Grimes SR

更新日期：2003-04-15 00:00:00

abstract：:Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

journal_title：Journal of cellular biochemistry

authors： Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

更新日期：2018-12-01 00:00:00

abstract：:Large doses of bone morphogenetic protein 2 (BMP2) are used clinically to induce bone formation in challenging bone defects. However, complications after treatment include swelling, ectopic bone formation, and adjacent bone resorption. While BMP2 can be effective, it is important to characterize the mechanism of the d...

journal_title：Journal of cellular biochemistry

authors： Hyzy SL,Olivares-Navarrete R,Schwartz Z,Boyan BD

更新日期：2012-10-01 00:00:00

abstract：AIM:To detect the expression and identify the role of Ribosomal protein S15A (RPS15A) in human breast cancer (BC). METHODS:Immunohistochemistry (IHC) was carried out for detecting the levels of RPS15A protein. Quantitative PCR was used to evaluate the mRNA level of RPS15A in one normal breast and three BC cell lines. ...

journal_title：Journal of cellular biochemistry

authors： Kong L,Wei Q,Hu X,Chen L,Li J

更新日期：2020-01-01 00:00:00

abstract：:Lysis of human culture-derived macrophages by extracellular ATP has recently been described, and treatment of macrophages with interferon-gamma rendered those cells significantly more sensitive to lysis. In addition, cell death occurred more rapidly in interferon (IFN)-treated cells than in untreated macrophages. In a...

journal_title：Journal of cellular biochemistry

authors： Blanchard DK,Hoffman SL,Djeu JY

更新日期：1995-03-01 00:00:00

abstract：:The signal transduction system that mediates bacterial chemotaxis allows cells to modulate their swimming behavior in response to fluctuations in chemical stimuli. Receptors at the cell surface receive information from the surroundings. Signals are then passed from the receptors to cytoplasmic chemotaxis components: C...

journal_title：Journal of cellular biochemistry

authors： Lukat GS,Stock JB

更新日期：1993-01-01 00:00:00

abstract：:Male pronucleus formation involves sperm nucleus decondensation and sperm chromatin remodeling. In sea urchins, male pronucleus decondensation was shown to be modulated by protein kinase C and a cdc2-like kinase sensitive to olomoucine in vitro assays. It was further demonstrated that olomoucine blocks SpH2B and SpH1 ...

journal_title：Journal of cellular biochemistry

authors： Monardes A,Iribarren C,Morin V,Bustos P,Puchi M,Imschenetzky M

更新日期：2005-10-01 00:00:00

abstract：:Circular RNA (circRNA) has been reported to have great scientific significance and clinical value in multiple cancers including colorectal cancer (CRC). However, the biological function of most circRNAs in CRC is still in its infancy. Herein, we discovered the differential expressed circRNAs (DECs) between CRC tissues...

journal_title：Journal of cellular biochemistry

authors： Xu D,Wu Y,Wang X,Hu X,Qin W,Li Y,Wang Y,Zhang Z,Lu S,Sun T,Wu Z,Fu D,Fu B,Zhang J,Chen Q,Wei M,Zhao L,Wu H

更新日期：2020-03-01 00:00:00

abstract：:Acetaminophen (APAP) is a widely used over-the-counter analgesic and antipyretic. It can cause hepatotoxicity. Recent studies demonstrated that hydrogen sulfide (H2 S) exhibits cell protection in several cell types. This study was designed to investigate whether H 2 S ameliorated APAP-induced acute liver injury and to...

journal_title：Journal of cellular biochemistry

authors： Li X,Lin J,Lin Y,Huang Z,Pan Y,Cui P,Yu C,Cai C,Xia J

更新日期：2019-03-01 00:00:00

abstract：:Homocysteine-thiolactone (HcyT) is a toxic product whose synthesis is directly proportional to plasma homocysteine (Hcy) levels. Previous studies demonstrated that the interaction between HcyT and low density lipoproteins (LDL) induces the formation of homocystamide-LDL adducts (Hcy-LDL). Structural and functional alt...

journal_title：Journal of cellular biochemistry

authors： Ferretti G,Bacchetti T,Moroni C,Vignini A,Nanetti L,Curatola G

更新日期：2004-05-15 00:00:00

abstract：:Taxol, a microtubule stabilizing agent, has been extensively investigated for its antitumor activity. The cytotoxic effect of taxol is generally attributed to its antimicrotubule activity and is believed to be cell cycle dependent. Herein, we report that taxol induces hyperphosphorylation and reorganization of the vim...

journal_title：Journal of cellular biochemistry

authors： Chu JJ,Chen KD,Lin YL,Fei CY,Chiang AS,Chiang CD,Lai YK

更新日期：1998-03-15 00:00:00

abstract：:Two monoclonal antibodies that cause changes in the morphology of cultured myogenic cells are described. Antibody JG9 causes myoblasts to round up and causes myotubes to become thin, cable-like structures with multiple round swellings. Antibody JG22 causes both myoblasts and myotubes to become round refractile cells p...

journal_title：Journal of cellular biochemistry

authors： Greve JM,Gottlieb DI

更新日期：1982-01-01 00:00:00