Gene coexpression networks analysis of sickle stroke risk.

abstract：:Deregulated proliferation of vascular smooth muscle cells (VSMCs) is one common phenomenon of atherosclerosis progression. Long noncoding RNAs (lncRNAs) are one group of noncoding RNAs that play essential roles in many cell biological processes, including cell development, growth, and migration. However, the role of a...

journal_title：Journal of cellular biochemistry

authors： Wang H,Jin Z,Pei T,Song W,Gong Y,Chen D,Zhang L,Zhang M,Zhang G

更新日期：2019-03-01 00:00:00

abstract：:Tumor necrosis factor a (TNFa) is an inflammatory cytokine that plays a crucial role in the immune response and the progression of cervical lesions. There is a growing body of data evaluating the value of a genetic variant in the TNFa gene with the risk of developing cervical cancer. The aim of this study was to explo...

journal_title：Journal of cellular biochemistry

authors： Babapour N,Mehramiz M,Rastgar Moghadam A,Behboodi N,Yousefi Z,Maftouh M,Talebian S,Khazaei M,Jafarian A,Sharifi-Sistani N,Avan A,Hasanzadeh M

更新日期：2019-04-01 00:00:00

abstract：:This study aims to explore the effect of miR-330 targeting VAV1 on amyloid β-protein (Aβ) production, oxidative stress (OS), and mitochondrial dysfunction in Alzheimer's disease (AD) mice through the MAPK signaling pathway. Putative targeted gene of miR-330 was performed by a miRNA target prediction website and dual-l...

journal_title：Journal of cellular biochemistry

authors： Zhou Y,Wang ZF,Li W,Hong H,Chen J,Tian Y,Liu ZY

更新日期：2018-07-01 00:00:00

abstract：:The present study aimed to determine the roles of miRNA-543 in osteoporosis in rats induced by ovariectomy. The osteoporosis rat model was established by ovariectomy induction. MiRNA-543 expression in osteoblasts was measured by quantitative real-time polymerase chain reaction. The cell proliferation and apoptosis wer...

journal_title：Journal of cellular biochemistry

authors： Li X,Ning L,Zhao X,Wan S

更新日期：2018-12-02 00:00:00

abstract：OBJECTIVE:To investigate the correlation between serum protein level of insulin growth factor 1 (IGF-1) and the degree of liver fibrosis in patients with chronic hepatitis C (CHC) combined with type 2 diabetes mellitus (T2DM). METHODS:The cases are divided into four groups. Then serum levels of IFG-1, alanine aminotra...

journal_title：Journal of cellular biochemistry

authors： Cao LH,Lu FM,Lu XJ,Zhu LY

更新日期：2018-11-01 00:00:00

abstract：:Previous studies suggest that there may be species differences in the utilization of cis-elements of the type I collagen genes. The present study was designed to examine this possibility by focusing on two regions of the proalpha1(I) collagen promoter. One is the GC-rich A1 region (-194/168) that modulates transcripti...

journal_title：Journal of cellular biochemistry

authors： Peterkofsky B,Gosiewska A,Singh K,Pearlman S,Mahmoodian F

更新日期：1999-06-01 00:00:00

abstract：:Oral tumors are one of important tumors which could be associated with serious problems in infant and children. It has been showed that a variety of cellular and molecular pathways including genetics and epigenetics mechanisms (eg, chromosomal alterations, and microRNA) involved in pathogenesis events present in oral ...

journal_title：Journal of cellular biochemistry

authors： Khanmohammadi R,Mir F,Baniebrahimi G,Mirzaei H

更新日期：2018-03-01 00:00:00

abstract：:We recently demonstrated the activation of extracellular signal- regulated protein kinase 1 and 2 (ERK1 and ERK2) by IGF-1, FGF-2, and PDGF-BB in normal human osteoblastic (HOB) cells as well as in rat and mouse osteoblastic cells. In this report, we have examined whether c-Jun NH2-Terminal Kinase (JNK) pathway is act...

journal_title：Journal of cellular biochemistry

authors： Chaudhary LR,Avioli LV

更新日期：1998-04-01 00:00:00

abstract：:Despite important advances in regenerative medicine and tissue engineering, still, wound healing remains a challenging clinical problem. Cell therapy has opened a new viewpoint in medicine as well as wound management, although it has some limitations. On the other hand, there are some hopes for the eliminated of cellu...

journal_title：Journal of cellular biochemistry

authors： Golchin A,Hosseinzadeh S,Ardeshirylajimi A

更新日期：2018-07-01 00:00:00

abstract：:Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largel...

journal_title：Journal of cellular biochemistry

authors： Sui J,Liu Q,Zhang H,Kong Y

更新日期：2019-06-01 00:00:00

abstract：:The aim of the present study was to test the hypothesis that the decreased renal tubular reabsorption of calcium observed in estrogen deficiency is associated with a local regulation of either PTHrP or PTH/PTHrP receptor genes in the kidney. Rats were randomly sham-operated (S) or ovariectomized receiving either vehic...

journal_title：Journal of cellular biochemistry

authors： Cros M,Silve C,Graulet AM,Morieux C,Ureña P,de Vernejoul MC,Bouizar Z

更新日期：1998-07-01 00:00:00

abstract：:4-hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by elucidating the signaling cascad...

journal_title：Journal of cellular biochemistry

authors： Vaillancourt F,Morquette B,Shi Q,Fahmi H,Lavigne P,Di Battista JA,Fernandes JC,Benderdour M

更新日期：2007-04-01 00:00:00

abstract：:Bone marrow-derived stromal cells (BMSC) possess a population of vascular progenitor cells that enable them to acquire a histology and immunophenotype coherent with endothelial cells (EC). Recent evidence indicates that a hypoxic environment such as that encountered in tumor masses regulates BMSC angiogenic properties...

journal_title：Journal of cellular biochemistry

authors： Annabi B,Naud E,Lee YT,Eliopoulos N,Galipeau J

更新日期：2004-04-15 00:00:00

abstract：:The 4-quinolone antibiotics nalidixic acid and ciprofloxacin are potent inhibitors of the bacterial type II topoisomerase DNA gyrase. Treatment of mouse L1210 leukemia cells with these drugs resulted in a delayed inhibition of cell proliferation. Prior to inhibition of cell proliferation, there was a time-dependent de...

journal_title：Journal of cellular biochemistry

authors： Lawrence JW,Darkin-Rattray S,Xie F,Neims AH,Rowe TC

更新日期：1993-02-01 00:00:00

abstract：:Phospholipase D (PLD) and ADP-ribosylation factor 6 (ARF6) have been implicated in vesicular trafficking and rearrangement of the actin cytoskeleton. We have explored the co-localization of rat PLD1b and rat PLD2 with wild type and mutant forms of ARF6 in HeLa cells and studied their activation by ARF6 and the role of...

journal_title：Journal of cellular biochemistry

authors： Hiroyama M,Exton JH

更新日期：2005-05-01 00:00:00

abstract：:Curcumin is a dietary polyphenol and a bioactive phytochemical that possesses anti-inflammatory, antioxidant, anticancer, and chemopreventive properties, which make it capable of affecting multiple sites along the stem cell pathways to induce apoptosis in these cells. Curcumin's function is through suppression of cyto...

journal_title：Journal of cellular biochemistry

authors： Zendehdel E,Abdollahi E,Momtazi-Borojeni AA,Korani M,Alavizadeh SH,Sahebkar A

更新日期：2019-04-01 00:00:00

abstract：:Cellular life-span of neonatal human brain microvascular endotheliocytes (HBME) was estimated by population doubling levels (PDLs) for serial subcultivations until spontaneous proliferation stoppage, and was 2.4-fold longer for continuous administration with the 6-O-phosphorylated derivative (TocP) of alpha-tocopherol...

journal_title：Journal of cellular biochemistry

authors： Tanaka Y,Moritoh Y,Miwa N

更新日期：2007-10-15 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) action is known to be initiated by its binding to multiple cell surface receptors containing serine/threonine kinase domains that act to stimulate a cascade of signaling events in a variety of cell types. We have previously shown that TGF-beta1 and BMP-2 treatment of primar...

journal_title：Journal of cellular biochemistry

authors： Nesti LJ,Caterson EJ,Li WJ,Chang R,McCann TD,Hoek JB,Tuan RS

更新日期：2007-05-15 00:00:00

abstract：:Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated...

journal_title：Journal of cellular biochemistry

authors： Yang F,Li T,Dong Z,Mi R

更新日期：2018-02-01 00:00:00

abstract：:p150(glued) is the largest subunit of dynactin protein complex, through which cargo vesicles link to the microtubule minus-end directed motor protein dynein. In addition, p150(glued) also locates in the mother centriole where it organizes the subdistal appendage. The components of appendage are dynamically regulated t...

journal_title：Journal of cellular biochemistry

authors： Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

更新日期：2015-09-01 00:00:00

abstract：:The microenvironment of the cancer cell is pivotal to its phenotypic regulation. One of the central components of the microenvironment is temperature. An elevation in environmental temperature has been shown to increase the cancer cell's susceptibility to chemo- and radiation therapy. The goal of the studies described...

journal_title：Journal of cellular biochemistry

authors： Zeng Y,Kulkarni P,Inoue T,Getzenberg RH

更新日期：2009-05-01 00:00:00

abstract：:The emergence of multi-drug resistant strains and co-occurrence of tuberculosis with HIV creates a major burden to the human health globally. Failure of primary antibacterial therapy necessitates the identification of new mycobacterial drugs. In this study, a comprehensive analysis involving bottom-up systems biology ...

journal_title：Journal of cellular biochemistry

authors： Khan S,Somvanshi P,Bhardwaj T,Mandal RK,Dar SA,Wahid M,Jawed A,Lohani M,Khan M,Areeshi MY,Haque S

更新日期：2018-03-01 00:00:00

abstract：:Extracts of thymic lymphoma that are obtained from AKR mice and are kept in the cold for at least several days can induce lipolytic activity in rat adipocyte suspensions. Freshly prepared extracts have low activity but contain a low molecular weight material of less than 10,000 daltons that aggregates on standing in t...

journal_title：Journal of cellular biochemistry

authors： Kitada S,Hays EF,Mead JF,Zabin I

更新日期：1982-01-01 00:00:00

abstract：:Exposure of cells to ionizing radiation (IR) determines cellular lesions, such as DNA and membrane damage, which involve a coordinate network of signal transduction pathways responsible for resistance to or delay of apoptosis, depending on cell type and administered dose. Since, after IR exposure, the apoptotic profil...

journal_title：Journal of cellular biochemistry

authors： Cataldi A,Rapino M,Centurione L,Sabatini N,Grifone G,Garaci F,Rana R

更新日期：2003-08-01 00:00:00

abstract：:Syndecans are proteoglycans that act as signaling molecules. Previously, we showed that syndecan-2 (SYND2) is involved in the control of osteoblastic (OB) cell apoptosis. Here, we show a novel functional interaction between SYND2 and protein kinase C delta (PKCdelta). Overexpression of SYND2 in MG63 OB cells resulted ...

journal_title：Journal of cellular biochemistry

authors： Orosco A,Fromigué O,Haÿ E,Marie PJ,Modrowski D

更新日期：2006-07-01 00:00:00

abstract：:Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

更新日期：2016-05-01 00:00:00

abstract：:The expression of STRO-1, the essential mesenchymal stem cell marker, was found to decrease with advancing passages in few tissues. Because STRO-1 was identified and isolated from human gingiva, we were interested to know its status after a few passages. Human gingival mesenchymal stem cells (HGMSCs) were isolated fro...

journal_title：Journal of cellular biochemistry

authors： Ranga Rao S,Subbarayan R

更新日期：2019-03-01 00:00:00

abstract：:Several molecules extracted from natural products exhibit different biological activities, such as ion channel modulation, activation of signaling pathways, and anti-inflammatory or antitumor activity. In this study, we tested the antitumor ability of natural compounds extracted from the Raputia praetermissa plant. Am...

journal_title：Journal of cellular biochemistry

authors： Vital WD,Torquato HFV,Jesus LOP,Judice WAS,Silva MFDGFD,Rodrigues T,Justo GZ,Veiga TAM,Paredes-Gamero EJ

更新日期：2019-06-01 00:00:00

abstract：:Leptin, a hormone primarily produced by adipocytes, contributes to the regulation of bone health by modulating bone density, growth and adiposity. Upon leptin binding, multiple sites of the long form of the leptin receptor (LepRb) are phosphorylated to trigger activation of downstream signaling pathways. To address th...

journal_title：Journal of cellular biochemistry

authors： McCabe IC,Fedorko A,Myers MG Jr,Leinninger G,Scheller E,McCabe LR

更新日期：2019-03-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSC), are multipotent cells that give rise to multiple lineages including osteoblasts, adipocytes, muscle, and fibroblasts. MSCs are useful for clinical applications such as cell therapy because they can be isolated from an individual and expanded for use in tissue repair, a...

journal_title：Journal of cellular biochemistry

authors： Cakouros D,Raices RM,Gronthos S,Glackin CA

更新日期：2010-08-15 00:00:00