The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo.

abstract：:Reactivations of persistent viral infections pose a significant medical problem in immunocompromised cancer, transplant, and AIDS patients, yet little is known about how persistent viral infections are immunologically controlled. Here we describe a mouse model for investigating the role of the immune response in contr...

journal_title：Journal of virology

authors： Hasenkrug KJ,Brooks DM,Dittmer U

更新日期：1998-08-01 00:00:00

abstract：:Hepatitis delta virus (HDV) contains two types of hepatitis delta antigens (HDAg) in the virion. The small form (S-HDAg) is required for HDV RNA replication, whereas the large form (L-HDAg) potently inhibits it by a dominant-negative inhibitory mechanism. The sequential appearance of these two forms in the infected ce...

journal_title：Journal of virology

authors： Modahl LE,Lai MM

更新日期：2000-08-01 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or currently in late-stage clinical trials shows great promise for the treatment of human immunodefic...

journal_title：Journal of virology

authors： Goethals O,Clayton R,Van Ginderen M,Vereycken I,Wagemans E,Geluykens P,Dockx K,Strijbos R,Smits V,Vos A,Meersseman G,Jochmans D,Vermeire K,Schols D,Hallenberger S,Hertogs K

更新日期：2008-11-01 00:00:00

abstract：:We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhib...

journal_title：Journal of virology

authors： Sieg S,King C,Huang Y,Kaplan D

更新日期：1996-07-01 00:00:00

abstract：UNLABELLED:The interferon (IFN)-mediated antiviral response is a central aspect of host defense; however, viruses have evolved multiple strategies to counteract IFN-mediated responses in order to successfully infect the host. Herpes simplex virus 1 (HSV-1), a typical human-restricted DNA virus, is capable of counteract...

journal_title：Journal of virology

authors： Zhang D,Su C,Zheng C

更新日期：2016-05-27 00:00:00

abstract：:Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies wi...

journal_title：Journal of virology

authors： Bedigian HG,Fox RR,Meier H

更新日期：1978-08-01 00:00:00

abstract：:Chronic infection by hepatitis C virus (HCV) can lead to severe hepatitis and cirrhosis and is closely associated with hepatocellular carcinoma. The replication cycle of HCV is poorly understood but is likely to involve interaction with host factors. In this report, we show that NS5B, the HCV RNA-dependent RNA polymer...

journal_title：Journal of virology

authors： Goh PY,Tan YJ,Lim SP,Tan YH,Lim SG,Fuller-Pace F,Hong W

更新日期：2004-05-01 00:00:00

abstract：:SF162 is a primary (PR), non-syncytium-inducing, macrophagetropic human immunodeficiency virus type 1 (HIV-1) clade B isolate which is resistant to antibody-mediated neutralization. Deletion of the first or second hypervariable envelope gp120 region (V1 or V2 loop, respectively) of this virus does not abrogate its abi...

journal_title：Journal of virology

authors： Stamatatos L,Cheng-Mayer C

更新日期：1998-10-01 00:00:00

abstract：:The E7 oncoprotein of human papillomavirus 16 (HPV16) transforms basal and suprabasal cervical epithelial cells and is a tumor-specific antigen in cervical carcinoma, to which immunotherapeutic strategies aimed at cytotoxic T-lymphocyte (CTL) induction are currently directed. By quantifying major histocompatibility co...

journal_title：Journal of virology

authors： Tindle RW,Herd K,Doan T,Bryson G,Leggatt GR,Lambert P,Frazer IH,Street M

更新日期：2001-07-01 00:00:00

abstract：:Structural differences between human leukocyte virus-induced interferon and human fibroblast polyinosinic-polycytidylic acid (rIn-rCn)-induced interferon have been noted in previous studies. This study reports the behavior of human leukocyte and fibroblast interferon, induced by virus and by rIn-rCn, in several lectin...

journal_title：Journal of virology

authors： Jankowski WJ,Davey MW,O'Malley JA,Sulkowski E,Carter WA

更新日期：1975-11-01 00:00:00

abstract：:An in vitro system for production of hepatitis B virus (HBV) was established by infection of human hepatoma (HepG2) cells. HBV particles obtained from the serum of a chronic hepatitis B surface antigen (subtype ad) carrier were used to inoculate HepG2 cells. HBV envelope and core proteins were synthesized de novo by t...

journal_title：Journal of virology

authors： Bchini R,Capel F,Dauguet C,Dubanchet S,Petit MA

更新日期：1990-06-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV), a positive-strand RNA virus that belongs to the Arteriviridae family of Nidovirales, has been identified as the causative agent of PRRS. Nsp1alpha is the amino (N)-terminal protein in a polyprotein encoded by the PRRSV genome and is reported to be cru...

journal_title：Journal of virology

authors： Sun Y,Xue F,Guo Y,Ma M,Hao N,Zhang XC,Lou Z,Li X,Rao Z

更新日期：2009-11-01 00:00:00

abstract：:A panel of 16 monoclonal antibodies recognizing M protein (M1) of influenza virus was generated. Competition analyses resulted in localization of 14 monoclonal antibodies to three antigenic sites. Three monoclonal antibodies localized to site 1B recognized a peptide synthesized to M1 (residues 220 to 236) with enzyme-...

journal_title：Journal of virology

authors： Bucher D,Popple S,Baer M,Mikhail A,Gong YF,Whitaker C,Paoletti E,Judd A

更新日期：1989-09-01 00:00:00

abstract：:Human papillomaviruses (HPV) link their life cycles to epithelial differentiation and induce productive replication of viral DNA in suprabasal cells. Viral-DNA amplification requires cells to remain active in the cell cycle upon differentiation. This is in contrast to normal cells, which lose proliferative capability ...

journal_title：Journal of virology

authors： Melar-New M,Laimins LA

更新日期：2010-05-01 00:00:00

abstract：:Picornaviruses are a family of positive-strand RNA viruses that are responsible for a variety of devastating human and animal diseases. An attenuated strain of mengovirus (vMC24) is serologically indistinguishable from the lethal murine wild-type mengovirus and encephalomyocarditis virus (EMCV). Immunogen-specific sti...

journal_title：Journal of virology

authors： Neal ZC,Splitter GA

更新日期：1995-08-01 00:00:00

abstract：:Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, effective therapeutic, or prophylactic. As with other betacoronaviruses, attachment and entry o...

journal_title：Journal of virology

authors： Tandon R,Sharp JS,Zhang F,Pomin VH,Ashpole NM,Mitra D,McCandless MG,Jin W,Liu H,Sharma P,Linhardt RJ

更新日期：2021-01-13 00:00:00

abstract：:The herpes simplex virus 1 (HSV-1) infected-cell protein 0 (ICP0) has the characteristics of a promiscuous transactivator of genes introduced into cells by infection or transfection. To identify cellular proteins interacting with ICP0, we used a domain of exon II of ICP0 that is known to be crucial for regulatory func...

journal_title：Journal of virology

authors： Kawaguchi Y,Van Sant C,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:Kilham rat virus (KRV) was grown in a rat nephroma cell line and was purified by two isopycnic centrifugations in cesium chloride. The virus contains single-stranded deoxyribonucleic acid (DNA) with a molecular weight of approximately 1.6 x 10(6). The DNA was extracted from the virion by both phenol extraction and by ...

journal_title：Journal of virology

authors： Salzman LA,White WL,Kakefuda T

更新日期：1971-06-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV lytic cycle was induced by histone deacetylase (HDAC) inhibitors and pr...

journal_title：Journal of virology

authors： Ye J,Gradoville L,Miller G

更新日期：2010-12-01 00:00:00

abstract：:Several lines of evidence suggest that various cofactors may be required for prion replication. PrP binds to polyanions, and RNAs were shown to promote the conversion of PrP(C) into PrP(Sc) in vitro. In the present study, we investigated strain-specific differences in RNA requirement during in vitro conversion and the...

journal_title：Journal of virology

authors： Saá P,Sferrazza GF,Ottenberg G,Oelschlegel AM,Dorsey K,Lasmézas CI

更新日期：2012-10-01 00:00:00

abstract：:By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee (Trichechus manatus latirostris), one of the most endangered marine mammals in United States coastal waters. The nucleotide seque...

journal_title：Journal of virology

authors： Rector A,Bossart GD,Ghim SJ,Sundberg JP,Jenson AB,Van Ranst M

更新日期：2004-11-01 00:00:00

abstract：:Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to restriction in animal movements. Therefore, many new types of vaccines, par...

journal_title：Journal of virology

authors： Celma CC,Boyce M,van Rijn PA,Eschbaumer M,Wernike K,Hoffmann B,Beer M,Haegeman A,De Clercq K,Roy P

更新日期：2013-09-01 00:00:00

abstract：:The tegument of herpesviruses is a highly complex structural layer between the nucleocapsid and the envelope of virions. Tegument proteins play both structural and regulatory functions during replication and spread, but the interactions and functions of many of these proteins are poorly understood. Here we focus on tw...

journal_title：Journal of virology

authors： Albecka A,Owen DJ,Ivanova L,Brun J,Liman R,Davies L,Ahmed MF,Colaco S,Hollinshead M,Graham SC,Crump CM

更新日期：2017-01-03 00:00:00

abstract：:SERINC5 is a 10-transmembrane-domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by sequences in the viral Env glycoprotein gp120, and the antiviral effect of SERINC5 is counteracted by t...

journal_title：Journal of virology

authors： Featherstone A,Aiken C

更新日期：2020-09-29 00:00:00

abstract：:Recently it has been shown that kaposica, an immune evasion protein of Kaposi's sarcoma-associated herpesvirus, inactivates complement by acting on C3-convertases by accelerating their decay as well as by acting as a cofactor in factor I-mediated inactivation of their subunits C3b and C4b. Here, we have mapped the fun...

journal_title：Journal of virology

authors： Mullick J,Singh AK,Panse Y,Yadav V,Bernet J,Sahu A

更新日期：2005-05-01 00:00:00

abstract：:Three amber mutations were introduced proximal to the syn3 locus of the herpes simplex virus type 1 glycoprotein B (gB) gene specifying gB derivatives lacking the carboxy-terminal 28, 49, or 64 amino acids. A complementation system that utilized gBs expressed in COS cells to complement gB-null virus K delta T was esta...

journal_title：Journal of virology

authors： Baghian A,Huang L,Newman S,Jayachandra S,Kousoulas KG

更新日期：1993-04-01 00:00:00

abstract：:Determinants of glycosylation site usage were explored by using the hemagglutinin-neuraminidase (HN) glycoprotein of the paramyxovirus Newcastle disease virus. The amino acid sequence of the HN protein, a type II glycoprotein, has six N-linked glycosylation addition sites, G1 to G6, two of which, G5 and G6, are not us...

journal_title：Journal of virology

authors： McGinnes LW,Morrison TG

更新日期：1997-04-01 00:00:00

abstract：:The E8 open reading frame of bovine papillomavirus type 4 encodes a small hydrophobic polypeptide which contributes to cell transformation by conferring anchorage-independent growth. Using an in vitro translation system, we show that the E8 polypeptide binds to ductin, the 16-kDa proteolipid that forms transmembrane c...

journal_title：Journal of virology

authors： Faccini AM,Cairney M,Ashrafi GH,Finbow ME,Campo MS,Pitts JD

更新日期：1996-12-01 00:00:00

abstract：:Persistent human immunodeficiency virus (HIV) infection of human monocytes and macrophages increases I kappa B alpha degradation, resulting in the activation of NF-kappa B, a key transcription factor in the regulation of the HIV long terminal repeat. The signal transduction pathways leading to NF-kappa B activation in...

journal_title：Journal of virology

authors： Folgueira L,Algeciras A,MacMorran WS,Bren GD,Paya CV

更新日期：1996-04-01 00:00:00