Ultrasound/microbubble enhances foreign gene expression in ECV304 cells and murine myocardium.

abstract：:Receptor of human interleukin 4 (hIL4R) has been found to be present on many types of cancer, so it may be a good target for cancer therapy. Here, fusion toxin gene DT4H has been constructed by fusing DNA sequence encoding the first 389 amino acids of diphtherial toxin (DT), which can not bind its own receptor, to hum...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang YJ,Hu XB,Li SX,Tian LP,Yang SL,Gong Y

更新日期：2004-06-01 00:00:00

abstract：:Mediator complex subunit 1 (Med1)/Thyroid hormone receptor-associated protein 220 (TRAP220), an essential component of thyroid hormone receptor-associated proteins (TRAP)/mediator, plays important roles in hormone responses and tumorigenesis. However, the role of Med1 in the DNA damage response has not been studied. I...

journal_title：Acta biochimica et biophysica Sinica

authors： Kim HJ,Yun J

更新日期：2017-06-01 00:00:00

abstract：:Cotton fiber developmental transition from elongation to secondary cell wall biosynthesis is a critical growth shifting phase that affects fiber final length, strength, and other properties. Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotto...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou X,Hu W,Li B,Yang Y,Zhang Y,Thow K,Fan L,Qu Y

更新日期：2019-11-18 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal isc...

journal_title：Acta biochimica et biophysica Sinica

authors： Han F,Dou M,Wang Y,Xu C,Li Y,Ding X,Xue W,Zheng J,Tian P,Ding C

更新日期：2020-02-03 00:00:00

abstract：:In the present study, paclitaxel (PTX) were encapsulated with polyethylene glycol (PEG)-polylactide (PLA)/D-α tocopheryl polyethylene glycol 1000 succinate (TPGS) (PEG-PLA/TPGS) and the enhanced anti-tumor activity of this PTX mixed micelles (PTX-MM) was evaluated in lung cancer cells. The PTX-MM prepared by a solvent...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang G,Zang B,Wang X,Liu G,Zhao J

更新日期：2015-12-01 00:00:00

abstract：:It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA) exert different effects on the biological function of the vascular endothelial cell (EC), resulting in altered regulation of angiogenesis. However, the specific mechanism is still unclear. Our study focused on the effects of nHA ...

journal_title：Acta biochimica et biophysica Sinica

authors： Mo W,Yang C,Liu Y,He Y,Wang Y,Gao F

更新日期：2011-12-01 00:00:00

abstract：:In this study, we identified five miRNAs highly expressed in the small-cell lung cancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1)....

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Zhu L,Jin Y,Ji H,Yan X,Zhu X

更新日期：2012-02-01 00:00:00

abstract：:Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that the transfection of hepatitis C virus core (HCVc) protein led to malignant transformation in normal biliary cells, and that tumor suppressor gene RASSF1A was downregulated in m...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo N,Chen R,Li Z,Liu Y,Cheng D,Zhou Q,Zhou J,Lin Q

更新日期：2011-05-01 00:00:00

abstract：:The Hippo pathway plays important roles in organ development, tissue regeneration, and human diseases, such as cancer. In the canonical Hippo pathway, the MST1/2-LATS1/2 kinase cascade phosphorylates and inhibits transcription coactivators Yes-associated protein and transcription coactivator with PDZ-binding motif and...

journal_title：Acta biochimica et biophysica Sinica

authors： Cao X,Wang C,Liu J,Zhao B

更新日期：2020-07-10 00:00:00

abstract：:Osteosarcoma is the most common primary malignant bone tumor, which occurs in adolescents. As reported by our previous studies, HER4 indicates a poor prognosis of primary osteosarcoma. However, its mechanisms in the pathogenesis of osteosarcoma have not yet been studied. The purpose of this study was to investigate th...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Huang Q,Wang S,Huang Z,Yu F,Lin J

更新日期：2020-04-20 00:00:00

abstract：:Acyl-coenzymeA:cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in intestine and fetal liver of healthy human. Our previous studies have shown that in monocytic cells the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the CCAAT/enhancer binding protein (...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo D,Zhang X,Li Q,Qian L,Xu J,Lu M,Hu X,Zhu M,Chang CC,Song B,Chang T,Xiong Y,Li B

更新日期：2016-11-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a fascinating target for cancer therapy due to its significant role in the crossroad of multiple signaling pathways associated with cell proliferation and regulation. Hsp90 inhibitors have the potential to be developed into anti-cancer drugs. Here, we identified nicotinic-mycoepoxydien...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Xiao S,Chen J,Wang M,Zheng Z,Song S,Zhang L

更新日期：2015-06-01 00:00:00

abstract：:Inter-species nuclear transfer could be used to preserve North Goat (Capra ibex), an endangered species. We established the culture conditions for ibex-hirus reconstructed embryos and optimized the method for DNA extractions of a single cell and early cloned embryo. By using mitochondria-specific probes of ibex and hi...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Y,Liu SZ,Zhang YL,Jiang MX,Sun QY,Chen DY

更新日期：2004-05-01 00:00:00

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:In this study, we confirmed that sesamin, an active lignan isolated from sesame seed and oil, is a novel skin-tanning compound. The melanin content and tyrosinase activity were increased by sesamin in a dose-dependent manner in B16 melanoma cells. The mRNA and protein levels of tyrosinase were also enhanced after the ...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Z,Li S,Liu Y,Deng P,Huang J,He G

更新日期：2011-10-01 00:00:00

abstract：:The flacherie disease in the silkworm is caused by the infectious flacherie virus (IFV). IFV relies on its 5' region of genomic RNA to recruit host-related factors to implement viral translation and replication. To identify host proteins bound to the 5'-region of IFV RNA and identify proteins important for its functio...

journal_title：Acta biochimica et biophysica Sinica

authors： Li M,He X,Liu H,Fu Z,He X,Lu X

更新日期：2015-02-01 00:00:00

abstract：:Nocardia, Rhodococcus and Streptomyces, all members of the actinomycetes family, are Gram-positive eubacteria with high G+C content and able to form mycelium. We report here a newly identified plasmid pXT107 of Nocardia sp. 107, one of the smallest circular plasmids found in Nocardia. The complete nucleotide sequence ...

journal_title：Acta biochimica et biophysica Sinica

authors： Xia HY,Tian YQ,Zhang R,Lin KC,Qin ZJ

更新日期：2006-09-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported to interact with proteins containing the polyglutamine (polyQ) domain. The present study was undertaken to evaluate the potential contributions of the polyQ and polyproline (polyP) domains to the co-localization of mutant huntingtin (htt) and GAPDH. Ov...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu J,Lin F,Qin Z

更新日期：2007-11-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality in the world. Ischemia/reperfusion (I/R) injury-induced cardiomyocytes death is the main obstacle that limits the heart function recovery of the AMI patients. Reactive oxygen species (ROS) generated by mitochondria is the main path...

journal_title：Acta biochimica et biophysica Sinica

authors： Li L,Zhang M,Chen W,Wang R,Ye Z,Wang Y,Li X,Cai C

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to investigate the pro-apoptotic mechanism of C-phycocyanin (C-PC)-mediated photodynamic therapy (PDT) in a murine tumor model and cultured MCF-7 cells. The mice were divided into four groups: control, He-Ne laser radiation, C-PC treatment, and C-PC treatment + He-Ne laser radiation. The effe...

journal_title：Acta biochimica et biophysica Sinica

authors： Li B,Chu X,Gao M,Li W

更新日期：2010-01-01 00:00:00

abstract：:The subfamily of voltage-dependent potassium (Kv) channel interacting protein 4 (KChIP4) is made up of the auxiliary interacting protein of voltage-dependent potassium channels. In this study, the structure of four splicing variants of the human KChIP4 gene was analyzed. Three of the four isoforms of the KChIP4 gene, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Deng XY,Cai F,Xia K,Pan Q,Long ZG,Wu LQ,Liang DS,Dai HP,Zhang ZH,Xia JH

更新日期：2005-04-01 00:00:00

abstract：:Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. This study ai...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Hu J,Yu T,You S,Zhang Y,Hu L

更新日期：2019-05-23 00:00:00

abstract：:Edaravone is a novel free radical scavenger that exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Recently, it was reported that edaravone could alleviate the pathology and cognitive deficits of Alzheimer's disease patients. However, its relevance t...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Lu F,Li W,Qin L,Yao Y,Ge X,Yu Q,Liang X,Zhao D,Li X,Zhang J

更新日期：2017-01-01 00:00:00

abstract：:Growth arrest specific 2 (GAS2) modulates cell cycle, apoptosis, and Calpain activity. GAS2-Calpain2 axis is required for the growth of BCR-ABL(+) hematopoietic cells and chronic myeloid leukemia cells. However, the expression of GAS2 in acute leukemia patients remains unclear and what role GAS2-Calpain2 axis plays in...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun L,Zhou H,Liu H,Ge Y,Zhang X,Ma W,Wu D,Zhao Y

更新日期：2015-10-01 00:00:00

abstract：:MicroRNAs are highly conserved endogenous small noncoding RNAs and demonstrated to play important roles in the metastatic cascade of papillary thyroid carcinoma (PTC), including the process of anoikis resistance. In this study, the correlation between miRNA-363-3p (miR-363-3p) expression and PTC metastasis was analyze...

journal_title：Acta biochimica et biophysica Sinica

authors： Pan Y,Zhu X,Wang K,Chen Y

更新日期：2019-08-05 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120) binds to cell surface receptors and mediates HIV entry. Previous studies suggest the cell surface protein disulfide isomerase (PDI) might interact with disulfide bond(s) of gp120 and thus facilitate HIV-1 entry. In the present study, a kineti...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Zhou Z,Guo ZY,Chi CW

更新日期：2010-05-15 00:00:00

abstract：:Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that som...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu X,Shao X,Guo ZY,Chi CW

更新日期：2010-07-01 00:00:00

abstract：:Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not b...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen S,Wu Z,Ke Y,Shu P,Chen C,Lin R,Shi Q

更新日期：2019-11-18 00:00:00

abstract：:Aberrant microRNA (miRNA) expression plays a critical role in osteosarcoma (OS) pathogenesis. In this study, we elucidated the involvement of miR-487a in OS and the underlying molecular mechanisms. We found that miR-487a was upregulated in OS clinical samples and cell lines. Knockdown of miR-487a suppressed OS cell gr...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu Z,Wu S,Xu G,Wu W,Mao B,Zhao S

更新日期：2020-06-20 00:00:00

abstract：:hPFTAIRE1 is a Cdc2-related kinase family member. To search its substrates and regulatory proteins, hPFTAIRE1 was fused to LexA and used as a bait to screen a human brain LexA two-hybrid library. In this screening, seven hPFTAIRE1 interacting proteins, including promyelocytic leukemia zinc finger (PLZF), were obtained...

journal_title：Acta biochimica et biophysica Sinica

authors： Gao YK,Jiang M,Yang T,Chen JY

更新日期：2006-03-01 00:00:00