The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters.

abstract：:Receptor of human interleukin 4 (hIL4R) has been found to be present on many types of cancer, so it may be a good target for cancer therapy. Here, fusion toxin gene DT4H has been constructed by fusing DNA sequence encoding the first 389 amino acids of diphtherial toxin (DT), which can not bind its own receptor, to hum...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang YJ,Hu XB,Li SX,Tian LP,Yang SL,Gong Y

更新日期：2004-06-01 00:00:00

abstract：:Trehalose-6-phosphate phosphatase (TPP) is an essential enzyme for growth of mycobacteria, which has been identified to be a potential anti-tuberculosis drug target. However, the biochemical and ligand-binding properties and the 3D structure of TPP remain unclear so far. In the present study, we expressed the recombin...

journal_title：Acta biochimica et biophysica Sinica

authors： Shi L,Zhang H,Qiu Y,Wang Q,Wu X,Wang H,Zhang X,Lin D

更新日期：2013-10-01 00:00:00

abstract：:Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% of primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been de...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou W,Feng X,Li H,Wang L,Zhu B,Liu W,Zhao M,Yao K,Ren C

更新日期：2009-01-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is a major cause of acute kidney damage, which often occurs in deceased donor kidney transplants. Cathelicidin PR-39 peptide possesses anti-inflammatory and wound repair effects through tissue angiogenesis and anti-apoptosis. This study assessed the role of PR-39 in anti-apoptosis in ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Xue W,Xiang H,Zheng J,Zhao Y,Jiao L,Jiao Z

更新日期：2016-08-01 00:00:00

abstract：:Hepatocellular carcinoma is a common malignant cancer with high incidence. And long non-coding RNAs (lncRNAs) play pivotal roles in the development of different types of cancers. In this study, we aimed to investigate the role of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of hepatocel...

journal_title：Acta biochimica et biophysica Sinica

authors： Dong H,Zhang Y,Xu Y,Ma R,Liu L,Luo C,Jiang W

更新日期：2019-06-20 00:00:00

abstract：:Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and thus irreversibly inactivate ribosome for protein synthesis. Cinnamomin is a multifunctional type II RIP isolated in our laborat...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu H,Liu WY

更新日期：2004-03-01 00:00:00

abstract：:Necroptosis is a type of regulated cell death that has been implicated in various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family, is an important mediator of the necroptotic pathway. Cleavage of RIP3 at Asp328 by caspase-8 abolishes the kinase activity of RIP3, which is critical for necrop...

journal_title：Acta biochimica et biophysica Sinica

authors： Shang L,Ding W,Li N,Liao L,Chen D,Huang J,Xiong K

更新日期：2017-02-06 00:00:00

abstract：:Many harpins have been found in plant pathogen bacteria that can elicit disease and insect resistance in plants, and promote plant growth. In this work, we overexpressed and purified Xanthomonas oryzae pv. oryzae harpin, harpin(Xoo), in Escherichia coli BL21/pGEX-hpa1. Harpin(Xoo) was fused to the C-terminus of glutat...

journal_title：Acta biochimica et biophysica Sinica

authors： Li M,Shao M,Lu XZ,Wang JS

更新日期：2005-10-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is a common cause of acute renal failure in many clinical settings. Our study aimed to elucidate the role of lentiviral vector-mediated KSR1 gene silencing in inflammatory factor expression and proliferation of renal tubular epithelial cells (RTECs) in a rat model of I/R injury. Male S...

journal_title：Acta biochimica et biophysica Sinica

authors： Bai Y,Han G,Guo K,Yu L,Du X,Xu Y

更新日期：2018-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is one of the deadliest malignant tumors, and many genes play important roles in its development. The hepatocyte nuclear factor-1a (HNF-1a) gene encodes HNF-1a, which is a transcriptional activator. HNF-1a regulates the tissue-specific expression of multiple genes, especially in pancre...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan Z,Fan K,Deng S,Gong Y,Qian Y,Huang Q,Yang C,Cheng H,Jin K,Luo G,Liu C,Yu X

更新日期：2020-03-18 00:00:00

abstract：:Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang M,Wang C,Lu B

更新日期：2019-02-01 00:00:00

abstract：:It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA) exert different effects on the biological function of the vascular endothelial cell (EC), resulting in altered regulation of angiogenesis. However, the specific mechanism is still unclear. Our study focused on the effects of nHA ...

journal_title：Acta biochimica et biophysica Sinica

authors： Mo W,Yang C,Liu Y,He Y,Wang Y,Gao F

更新日期：2011-12-01 00:00:00

abstract：:To investigate whether apelin-13 induced THP-1 monocytes (MCs) adhesion to ECV304 human umbilical vein endothelial cells (HUVECs) via 14-3-3 signaling transduction pathway and the potential novel physiological function and signaling transduction pathway of apelin-APJ, HUVECs ECV304 were cultured in DMEM and MCs THP-1 ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Zhang X,Li F,Chen L,Li L,Qin X,Gao J,Su T,Zeng Y,Liao D

更新日期：2010-06-15 00:00:00

abstract：:Nuclear factor kappa B (NF-κB) plays a prominent role in the pathogenesis of infectious diseases. Staphylococcus aureus (S. aureus), which can attach to and invade human osteoblasts, is the most common causative agent of osteomyelitis. To determine whether S. aureus can activate NF-κB in human osteoblasts and explore ...

journal_title：Acta biochimica et biophysica Sinica

authors： Ning R,Zhang X,Guo X,Li Q

更新日期：2010-12-01 00:00:00

abstract：:Ghrelin is a brain-gut peptide that serves as a natural ligand for growth hormone secretagogue receptor (GHSR). It also exists abundantly in the cardiovascular system. In order to evaluate the possible role of ghrelin in the development of atherosclerosis, the effect of ghrelin on the expression of cell differentiatio...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang M,Yuan F,Chen H,Qiu X,Fang W

更新日期：2007-12-01 00:00:00

abstract：:Metformin, a first line medication for type II diabetes, initially entered the spotlight as a promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk and improved clinical outcomes in diabetic patients taking metformin. To uncover the anti-cancer mechanisms of metformin, preclinical stu...

journal_title：Acta biochimica et biophysica Sinica

authors： Saini N,Yang X

更新日期：2018-02-01 00:00:00

abstract：:Allergic protein TBb, a major allergen in tartary buckwheat, was divided into four epitope-containing fragments and was named F1, F2, F3, and F4, respectively. Results of immunological assays revealed that F2 had the strongest IgE-binding activity to patient's sera, which indicated that it might contain the linear IgE...

journal_title：Acta biochimica et biophysica Sinica

authors： Li P,Cui X,Li Y,Wang Z

更新日期：2011-06-01 00:00:00

abstract：:Recent studies have demonstrated that the expression of the long non-coding RNA (lncRNA) AFAP1-AS1 in pancreatic cancer is negatively correlated with survival and prognosis. However, the effects of oridonin and lncRNA AFAP1-AS1 on the epithelial-to-mesenchymal transition (EMT) and migration of pancreatic cancer cells ...

journal_title：Acta biochimica et biophysica Sinica

authors： Lou S,Xu J,Wang B,Li S,Ren J,Hu Z,Xu B,Luo F

更新日期：2019-08-05 00:00:00

abstract：:Bcl-2, a prominent member of the Bcl-2 family proteins, is responsible for the dysregulation of apoptosis and resistance to chemotherapy. In this study, we investigated whether small hairpin RNA (shRNA) targeting at Bcl-2 mRNA could enhance cytarabine (Ara-C)-induced apoptosis in Raji cells. Bcl-2 shRNA was transfecte...

journal_title：Acta biochimica et biophysica Sinica

authors： He D,Fang B

更新日期：2009-02-01 00:00:00

abstract：:Constitutively activated signal transducer and activator of transcription 3 (STAT3) plays an important role in the formation of many tumors including ovarian cancer. In this study, RNA interference specific to STAT3 was employed to study its effects on the inhibition of STAT3 signaling and on the growth of ovarian can...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang F,Tong X,Fu L,Zhang R

更新日期：2008-06-01 00:00:00

abstract：:Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are well known as tumor suppressors that are closely related to tumor occurrence and progression. It was reported that ING4 and PTEN showed synergistic antitumor activities in nasopharyngeal carcinoma cells. The two tu...

journal_title：Acta biochimica et biophysica Sinica

authors： Rakshit N,Yang S,Zhou W,Xu Y,Deng C,Yang J,Yu H,Wei W

更新日期：2016-08-01 00:00:00

abstract：:The mechanisms of chronic neuropathic pain are not clear. Serum microRNAs (miRNAs) might show a special feature for chronic nervous lesions. However, little is known about the changes in circulating miRNAs for the neuropathic pain. Therefore, changes in the circulating miRNAs expression profile for the neuropathic pai...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu Y,Zhang X,Pu S,Wu J,Lv Y,Du D

更新日期：2014-11-01 00:00:00

abstract：:The plasminogen activator inhibitor type-2 (PAI-2) dependent apoptosis protection is due to the 33 amino acids fragment located between helix C and D of PAI-2, this fragment may interact with some unknown intracellular proteins. In this study we used the fragment between helix C and D of PAI-2 as a bait to perform a y...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan J,Zhang YQ,Li P,Tong C,Tan L,Zhu YS

更新日期：2004-09-01 00:00:00

abstract：:MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu H,Li S,Liu J,Ni B

更新日期：2012-05-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression plays a critical role in osteosarcoma (OS) pathogenesis. In this study, we elucidated the involvement of miR-487a in OS and the underlying molecular mechanisms. We found that miR-487a was upregulated in OS clinical samples and cell lines. Knockdown of miR-487a suppressed OS cell gr...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu Z,Wu S,Xu G,Wu W,Mao B,Zhao S

更新日期：2020-06-20 00:00:00

abstract：:Two full-length cDNAs, named CaM1a and CaM1b, encoding the highly conserved calmodulin1 (CaM1) proteins, were isolated from the cDNA library of amphioxus Branchiostoma belcheri tsingtauense. There are only two nucleotide differences between them, producing one amino acid difference between CaM1a and CaM1b. Comparison ...

journal_title：Acta biochimica et biophysica Sinica

authors： Luan J,Liu Z,Zhang S,Li H,Fan C,Li L

更新日期：2007-04-01 00:00:00

abstract：:Raman spectroscopy was used for the first time to detect the effect of independent UVA (ultraviolet-A: 320-400 nm) and UVB (ultraviolet-B: 280-320 nm) irradiation on the calf thymus DNA in aqueous solution. After both UVA and UVB irradiation for 1 h or 3 h, the damage to the conformation of DNA was moderate, but the r...

journal_title：Acta biochimica et biophysica Sinica

authors： Tang YL,Guo ZY

更新日期：2005-01-01 00:00:00

abstract：:Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC), and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis. In this study, we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC. The results showed that miR-1827 l...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo X,Wang Z,Sun Q,Sun C,Hua H,Huang Q

更新日期：2020-10-19 00:00:00

abstract：:The aim of this study was to establish and apply a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) for rubella virus (RV) RNA. First, the primer and TaqMan probe concentrations, as well as reaction temperatures were optimized to establish an efficient real-time quantitative RT-PCR assay...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao LH,Ma YY,Wang H,Zhao SP,Zhao WM,Li H,Wang LY

更新日期：2006-10-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120) binds to cell surface receptors and mediates HIV entry. Previous studies suggest the cell surface protein disulfide isomerase (PDI) might interact with disulfide bond(s) of gp120 and thus facilitate HIV-1 entry. In the present study, a kineti...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Zhou Z,Guo ZY,Chi CW

更新日期：2010-05-15 00:00:00