MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells.

abstract：:The recombinant peptide, DBAYL, a promising therapeutic peptide for type 2 diabetes, is a new, potent, and highly selective agonist for VPAC2 generated through site-directed mutagenesis based on sequence alignments of pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal peptide (VIP), and rela...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma Y,Luo T,Xu W,Ye Z,Hong A

更新日期：2012-11-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression plays a critical role in osteosarcoma (OS) pathogenesis. In this study, we elucidated the involvement of miR-487a in OS and the underlying molecular mechanisms. We found that miR-487a was upregulated in OS clinical samples and cell lines. Knockdown of miR-487a suppressed OS cell gr...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu Z,Wu S,Xu G,Wu W,Mao B,Zhao S

更新日期：2020-06-20 00:00:00

abstract：:Inter-species nuclear transfer could be used to preserve North Goat (Capra ibex), an endangered species. We established the culture conditions for ibex-hirus reconstructed embryos and optimized the method for DNA extractions of a single cell and early cloned embryo. By using mitochondria-specific probes of ibex and hi...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Y,Liu SZ,Zhang YL,Jiang MX,Sun QY,Chen DY

更新日期：2004-05-01 00:00:00

abstract：:An L-amino acid oxidase (LAAO), NA-LAAO, was purified from the venom of Naja atra. Its N-terminal sequence shows great similarity with LAAOs from other snake venoms. NA-LAAO dose-dependently induced aggregation of washed human platelets. However, it had no activity on platelets in platelet-rich plasma. A low concentra...

journal_title：Acta biochimica et biophysica Sinica

authors： Li R,Zhu S,Wu J,Wang W,Lu Q,Clemetson KJ

更新日期：2008-01-01 00:00:00

abstract：:Neuron restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-induced or kindling-evoked seizure activity. However, whether NRSF functions in pentylenetetrazol (PTZ)-i...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu M,Sheng Z,Cai L,Zhao K,Tian Y,Fei J

更新日期：2012-06-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is the most common category and disease entity of non-Hodgkin lymphoma. Osalmide and pterostilbene are natural products with anticancer activities via different mechanism. In this study, using a new synthetic strategy for the two natural products, we obtained the compound DCZ0801,...

journal_title：Acta biochimica et biophysica Sinica

authors： Xi M,He W,Li B,Zhou J,Xu Z,Wu H,Zhang Y,Song D,Hu L,Lu Y,Bu W,Kong Y,Chen G,Chang S,Shi J,Zhu W

更新日期：2020-04-20 00:00:00

abstract：:Several essential biological progresses in mammals are regulated by circadian rhythms. Though the molecular mechanisms of oscillating these circadian rhythms have been uncovered, the specific functions of the circadian genes are not very clear. It has been reported that knocking down circadian genes by microRNA is a u...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao X,Zhu X,Cheng S,Xie Y,Wang Z,Liu Y,Jiang Z,Xiao J,Guo H,Wang Y

更新日期：2014-04-01 00:00:00

abstract：:Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activation by the agonists. ...

journal_title：Acta biochimica et biophysica Sinica

authors： Drastichova Z,Novotny J

更新日期：2012-08-01 00:00:00

abstract：:Hyperglycemia, a diagnostic characteristic of diabetes mellitus, is detrimental to pancreatic β cells. Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a prot...

journal_title：Acta biochimica et biophysica Sinica

authors： Lai D,Huang M,Zhao L,Tian Y,Li Y,Liu D,Wu Y,Deng F

更新日期：2019-12-13 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is hepatic manifestation of a metabolic syndrome and includes a spectrum of hepatic steatosis, steatohepatitis, and fibrosis. Interleukin-17 (IL-17) has been reported to play a critical role in inflammatory progression of some liver diseases. The present study was designed to ...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu R,Tao A,Zhang S,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:The diamagnetic levitation as a novel ground-based model for simulating a reduced gravity environment has been widely applied in many fields. In this study, a special designed superconducting magnet, which can produce three apparent gravity levels (0, 1, and 2 g), namely high magneto-gravitational environment (HMGE), ...

journal_title：Acta biochimica et biophysica Sinica

authors： Qian A,Di S,Gao X,Zhang W,Tian Z,Li J,Hu L,Yang P,Yin D,Shang P

更新日期：2009-07-01 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA domains, is a novel member of the vertebrate eIF2α kinase family. Containing a catalytic domain in C-terminus and two Z-DNA binding domains (Zα1 and Zα2) in N-terminus, PKZ can be activated through the binding of Zα to Z-DNA. However, the regulatory function of PKZ Zα remains to be...

journal_title：Acta biochimica et biophysica Sinica

authors： Lu P,Deng S,Wu C,Zhu Y,Liu Y,Lin G,Yan Y,Hu C

更新日期：2013-12-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cell lines, suggesting its great potential in cancer therapy. Many components in TRAIL-mediated signaling pathway have been identified, but how they interact with each other to determine the network dynamics and final apoptosis remain...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang T,Wu M,Chen Q,Sun Z

更新日期：2010-02-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human malignant diseases and the sixth leading cause of cancer-related deaths in China. Gemcitabine is the only first-line chemotherapeutic agent used for the palliative treatment of patients with PDAC, but chemo-resistance limits their efficacy. Here, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Yao J,Li Z,Wang X,Xu P,Zhao L,Qian J

更新日期：2016-02-01 00:00:00

abstract：:Several studies have shown that combination treatment with natural products and chemotherapy agents can improve the sensitivity and cytotoxicity of chemotherapy agents. Resveratrol, a natural product, has many biological effects including antitumor and antiviral activities, as well as vascular protective effect. The a...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu S,Li X,Xu R,Ye L,Kong H,Zeng X,Wang H,Xie W

更新日期：2016-06-01 00:00:00

abstract：:LRRC4 is a novel relatively specific gene, which displays significant down-regulation in primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this study, we investigated the growth inhibitory effect of LRRC4 on tumorigencity in vivo and on cell proliferation in vitro by a tetracycline-...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang QH,Wang LL,Cao L,Peng C,Li XL,Tang K,Li WF,Liao P,Wang JR,Li GY

更新日期：2005-08-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta is a pleiotropic cytokine regulating a variety of cellular processes such as cell growth, differentiation, apoptosis, migration, cell adhesion, and immune response. In the well-understood classical TGF-beta signaling pathway, TGF-beta activates Smad signalling via its two cell sur...

journal_title：Acta biochimica et biophysica Sinica

authors： Yan X,Liu Z,Chen Y

更新日期：2009-04-01 00:00:00

abstract：:Mercaptopropionic acid (MPA) and cysteamine (Cys) capped CdTe quantum dots (QDs) were successfully prepared and used to investigate the combined influence of surface modification, size distribution, and interaction time on their cytotoxicity in human pancreatic carcinoma (PANC-1) cells. Results indicated that the smal...

journal_title：Acta biochimica et biophysica Sinica

authors： Chang S,Kang B,Liu X,Dai Y,Chen D

更新日期：2012-03-01 00:00:00

abstract：:Abnormal development of central nervous system (CNS) caused by neural tube defects is not only a major contributor in the prevalence of stillbirths and neonatal deaths but also causes lifelong physical disability in surviving infants. Due to insufficient known investigated causes, CNS developmental abnormality has bro...

journal_title：Acta biochimica et biophysica Sinica

authors： Jia S,Zhang L,Zhang K,Wang L,Khan A,Zhang J,Sun Y,Wang Y,Song M,Lyu Y,Li M,Lu X,Niu B,Liu Z,Xie J

更新日期：2020-06-20 00:00:00

abstract：:Canonical meiosis is characterized by two sequential rounds of nuclear divisions following one round of DNA replication-reductional segregation of homologous chromosomes during the first division and equational segregation of sister chromatids during the second division. Meiosis in an inverted order of two nuclear div...

journal_title：Acta biochimica et biophysica Sinica

authors： Li W,He X

更新日期：2020-07-10 00:00:00

abstract：:Defective DNA damage response is a threat to genome stability and a proven cause of tumorigenesis. C21ORF2 (chromosome 21 open reading frame 2) is a novel gene on chromosome 21, and the C21ORF2 protein is found to interact with NEK1. Earlier studies showed that C21ORF2 might be associated with some human genetic disea...

journal_title：Acta biochimica et biophysica Sinica

authors： Fang X,Lin H,Wang X,Zuo Q,Qin J,Zhang P

更新日期：2015-10-01 00:00:00

abstract：:Although viral vectors are efficient systems to transfer foreign genes into cells or target tissues, safety issues remain in relation to human gene therapy. Microbubbles currently used as ultrasound contrast agents have been applied in transfection of genes. This study was designed to test the transfection efficiency ...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo DP,Li XY,Sun P,Wang ZG,Chen XY,Chen Q,Fan LM,Zhang B,Shao LZ,Li XR

更新日期：2004-12-01 00:00:00

abstract：:Nuclear factor kappa B (NF-κB) plays a prominent role in the pathogenesis of infectious diseases. Staphylococcus aureus (S. aureus), which can attach to and invade human osteoblasts, is the most common causative agent of osteomyelitis. To determine whether S. aureus can activate NF-κB in human osteoblasts and explore ...

journal_title：Acta biochimica et biophysica Sinica

authors： Ning R,Zhang X,Guo X,Li Q

更新日期：2010-12-01 00:00:00

abstract：:Rabies virus (RV) causes a fatal disease in both human and animals. The disease can be prevented by post-exposure prophylaxis in individuals exposed to RV. However, the neutralization effect is limited after the virus enters into the host cells. So, it is important to identify new targets for rabies therapy. In this s...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Sun L,Yu P,Li A,Li C,Tang Q,Li D,Liang M

更新日期：2015-10-01 00:00:00

abstract：:RNA interference (RNAi), a posttranscriptional gene silencing process mediated by small double-stranded RNA specifically complementary to the targeted transcript, has been used extensively in the development of novel therapeutic approaches against various human diseases including chronic myelogenous leukemia (CML). He...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang F,Zhang Y,Cao YL,Wang SH,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Erythrocyte senescence is characterized by exposure of cell surface epitopes on cell membrane proteins leading to immune mediated removal of red blood cells. One mechanism for antigen formation is tyrosine phosphorylation (Tyr-P) of the transmembrane protein band 3 by Syk kinase. Our aim was to test the hypothesis tha...

journal_title：Acta biochimica et biophysica Sinica

authors： Bordin L,Fiore C,Bragadin M,Brunati AM,Clari G

更新日期：2009-10-01 00:00:00

abstract：:The major goal of researchers and oncologists is to develop promising ground for novel therapeutic strategies to prevent recurrence or relapse of cancer. Recent evidences suggest that a subset of cells called cancer stem cells (CSCs) are present within the tumor mass which possess tumorigenic capacity and may be respo...

journal_title：Acta biochimica et biophysica Sinica

authors： Bhattacharyya S,Khanduja KL

更新日期：2010-04-01 00:00:00

abstract：:The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, fi...

journal_title：Acta biochimica et biophysica Sinica

authors： Guamán Ortiz LM,Croce AL,Aredia F,Sapienza S,Fiorillo G,Syeda TM,Buzzetti F,Lombardi P,Scovassi AI

更新日期：2015-10-01 00:00:00

abstract：:HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. The expressions of HEATR1 in GC tissues were analyzed using The ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao J,Zhu Y,Fu Q,Zhu Y,Zhao G

更新日期：2020-09-08 00:00:00

abstract：:The critical molecular mechanism in the development of the pulmonary fibrosis remains unknown, leaving diagnosed patients with a poor prognosis. To isolate the genes specifically up-regulated in pulmonary fibrosis, we established a rat silicosis model 360 d after treatment with crystalline silica suspension. Radiograp...

journal_title：Acta biochimica et biophysica Sinica

authors： Jin Z,Liu B,Feng D,Chen C,Li X,Hu Y,Peng J,Liu Y,Du J,Fu C,Wen J

更新日期：2008-08-01 00:00:00