Abstract:
:Several essential biological progresses in mammals are regulated by circadian rhythms. Though the molecular mechanisms of oscillating these circadian rhythms have been uncovered, the specific functions of the circadian genes are not very clear. It has been reported that knocking down circadian genes by microRNA is a useful strategy to explore the function of the circadian rhythms. In this study, through a forward bioinformatics screening approach, we identified miR-29a/b/c as potent inhibitors for the human circadian gene hPER1. We further found that miR-29a/b/c could directly target hPER1 3'untranslated region (UTR) and down-regulate hPER1 at both mRNA and protein expression levels in human A549 cells. Thus, our findings suggested that the expression of hPER1 is regulated by miR-29a/b/c, which may also provide a new clue for the function of hPER1.
journal_name
Acta Biochim Biophys Sin (Shanghai)journal_title
Acta biochimica et biophysica Sinicaauthors
Zhao X,Zhu X,Cheng S,Xie Y,Wang Z,Liu Y,Jiang Z,Xiao J,Guo H,Wang Ydoi
10.1093/abbs/gmu007subject
Has Abstractpub_date
2014-04-01 00:00:00pages
313-7issue
4eissn
1672-9145issn
1745-7270pii
gmu007journal_volume
46pub_type
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