Downregulation of lncRNA AFAP1-AS1 by oridonin inhibits the epithelial-to-mesenchymal transition and proliferation of pancreatic cancer cells.

abstract：:Growth arrest specific 2 (GAS2) modulates cell cycle, apoptosis, and Calpain activity. GAS2-Calpain2 axis is required for the growth of BCR-ABL(+) hematopoietic cells and chronic myeloid leukemia cells. However, the expression of GAS2 in acute leukemia patients remains unclear and what role GAS2-Calpain2 axis plays in...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun L,Zhou H,Liu H,Ge Y,Zhang X,Ma W,Wu D,Zhao Y

更新日期：2015-10-01 00:00:00

abstract：:Caveolin-1 is regulated by estrogen in vascular smooth muscle cells. Raloxifene, a selective estrogen receptor modulator that possibly has cardioprotective properties without an increased risk of cancer or other side effects of estrogen, may be used in women with risk of coronary artery disease. However, the relations...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang FL,He H,Liu XX,Tu B,Zeng XW,Su JX,Wang X,Hu Q

更新日期：2006-11-01 00:00:00

abstract：:Germ cell nuclear factor (GCNF) is a transcription factor that can repress gene transcription and plays an important role during spermatogenesis. Peroxisome proliferator-activated receptor delta (PPARdelta) is a nuclear hormone receptor belonging to the steroid receptor superfamily. It can activate the expression of m...

journal_title：Acta biochimica et biophysica Sinica

authors： He C,Ding N,Kang J

更新日期：2008-03-01 00:00:00

abstract：:Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased and down-regulation of ASS1 was closely corre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tao X,Zuo Q,Ruan H,Wang H,Jin H,Cheng Z,Lv Y,Qin W,Wang C

更新日期：2019-03-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is a major cause of acute kidney damage, which often occurs in deceased donor kidney transplants. Cathelicidin PR-39 peptide possesses anti-inflammatory and wound repair effects through tissue angiogenesis and anti-apoptosis. This study assessed the role of PR-39 in anti-apoptosis in ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Xue W,Xiang H,Zheng J,Zhao Y,Jiao L,Jiao Z

更新日期：2016-08-01 00:00:00

abstract：:Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Liu J,Zhao Z,Wen L,Li H,Ren J,Liu H

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have indicated that noggin exerts its neural inducing effect by binding and antagonizing bone morphogenetic protein 4 (BMP4). In order to further clarify the relationship between the structure and the function of noggin, and elucidate the possible mechanism responsible for noggin-BMP4 interaction, we ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu WD,Feng XL,Ren CP,Shi JL,Yang XY,Zhao M,Zhou L,Lan K,Yao KT

更新日期：2005-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) function as negative regulators of gene expression involved in cancer metastasis. The aim of this study is to investigate the potential roles of miR-218 in non-small cell lung cancer and validate its regulation mechanism. Functional studies showed that miR-218 overexpression inhibited cell migration...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang C,Ge S,Hu C,Yang N,Zhang J

更新日期：2013-12-01 00:00:00

abstract：:The recombinant peptide, DBAYL, a promising therapeutic peptide for type 2 diabetes, is a new, potent, and highly selective agonist for VPAC2 generated through site-directed mutagenesis based on sequence alignments of pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal peptide (VIP), and rela...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma Y,Luo T,Xu W,Ye Z,Hong A

更新日期：2012-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in post-transcriptional gene silencing of target messenger RNAs, which are involved in virtually all biological processes. Previously, we have demonstrated that spheroid body-forming cells from the MKN-45 cancer cell line possessed gastric cancer stem cell (CSC) properties. In t...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Ma L,Wang Z,Wang L,Liu C,Chen R,Zhang J

更新日期：2014-02-01 00:00:00

abstract：:Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and thus irreversibly inactivate ribosome for protein synthesis. Cinnamomin is a multifunctional type II RIP isolated in our laborat...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu H,Liu WY

更新日期：2004-03-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120) binds to cell surface receptors and mediates HIV entry. Previous studies suggest the cell surface protein disulfide isomerase (PDI) might interact with disulfide bond(s) of gp120 and thus facilitate HIV-1 entry. In the present study, a kineti...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Zhou Z,Guo ZY,Chi CW

更新日期：2010-05-15 00:00:00

abstract：:RNA interference (RNAi), a posttranscriptional gene silencing process mediated by small double-stranded RNA specifically complementary to the targeted transcript, has been used extensively in the development of novel therapeutic approaches against various human diseases including chronic myelogenous leukemia (CML). He...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang F,Zhang Y,Cao YL,Wang SH,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% of primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been de...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou W,Feng X,Li H,Wang L,Zhu B,Liu W,Zhao M,Yao K,Ren C

更新日期：2009-01-01 00:00:00

abstract：:CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative prote...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong MQ,Gu Y,Hu XB,Sun Y,Ma L,Li XL,Sun LX,Sun J,Qian J,Zhu CL

更新日期：2005-05-01 00:00:00

abstract：:NifA is the general transcriptional activator of nitrogen fixation genes in diazotrophic bacteria. In Rhizobium leguminosarum bv. viciae strain 8401/pRL1JI, the NifA gene is part of a gene cluster (fixABCXNifAB). In this study, results showed that in R. leguminosarum bv.viciae 8401/pRL1JI, host factor required (Hfq), ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang Y,Hong G

更新日期：2009-09-01 00:00:00

abstract：:To study the molecular basis of heterosis, suppression subtractive hybridization was used to investigate the differences in gene expression between porcine Longissimus dorsi of F1 hybrids Large WhitexMeishan and their female parents Meishan. From two specific subtractive cDNA libraries, the clones selected by reverse ...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang T,Xiong YZ,Lei MG,Xu DQ,Deng CY

更新日期：2006-07-01 00:00:00

abstract：:We cloned and isolated a cysteine-rich protein, designated Mr30, from Conus marmoreus. Mr30 belongs to the cysteine-rich secretory protein family that is highly homologous to Tex31 previously obtained from Conus textile and reported as a protease responsible for processing of pro-conotoxins. Mr30, purified by a proced...

journal_title：Acta biochimica et biophysica Sinica

authors： Qian J,Guo ZY,Chi CW

更新日期：2008-02-01 00:00:00

abstract：:To test the hypothesis that hypoxia inducible factor-1 alpha (HIF-1alpha) up-regulated the expression of heme oxygenase-1 (HO-1) gene in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension, 8 male Wistar rats in each of 5 groups were exposed to hypoxia for 0, 3, 7, 14 or 21 d, respectively. Mean pul...

journal_title：Acta biochimica et biophysica Sinica

authors： Li QF,Dai AG

更新日期：2004-02-01 00:00:00

abstract：:Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang M,Wang C,Lu B

更新日期：2019-02-01 00:00:00

abstract：:Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Leptin is a hormone secreted by adipose tissue. Recent reports have shown that leptin can induce cancer cell proliferation and regulate cell energy metabolism, but the regulatory mechanism is still unclear. Her...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Q,Sun Y,Fei Z,Yang Z,Duan K,Zi J,Cui Q,Yu M,Xiong W

更新日期：2019-07-10 00:00:00

abstract：:Two full-length cDNAs, named CaM1a and CaM1b, encoding the highly conserved calmodulin1 (CaM1) proteins, were isolated from the cDNA library of amphioxus Branchiostoma belcheri tsingtauense. There are only two nucleotide differences between them, producing one amino acid difference between CaM1a and CaM1b. Comparison ...

journal_title：Acta biochimica et biophysica Sinica

authors： Luan J,Liu Z,Zhang S,Li H,Fan C,Li L

更新日期：2007-04-01 00:00:00

abstract：:Carbon monoxide (CO) is often viewed as a lethal gas in light of its capacity to prevent oxygen uptake in hemoglobin; however, it also functions to regulate a variety of proteins and physiological processes. Here we show that CO is an important chemical cue, to which neurons respond strongly, and this response is then...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Liu B,Zhang Q,Wu X,Yu Y,Jesse FF,Li L

更新日期：2015-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis. In this study, we explored the expression patterns of Snail1 and a cardiac fibrosis marker-...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Du J,Zhang J,Weng M,Li X,Pu D,Gao L,Deng S,Xia S,She Q

更新日期：2012-11-01 00:00:00

abstract：:G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are distributed in many locations in the human genome, including promoter regions, and are viewed as promising therapeutic targets. Uncoupling protein-1 (UCP1) is a mitochondrial thermogenic gene critical f...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao Y,Uhler JP

更新日期：2018-07-01 00:00:00

abstract：:MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu H,Li S,Liu J,Ni B

更新日期：2012-05-01 00:00:00

abstract：:Constitutively activated signal transducer and activator of transcription 3 (STAT3) plays an important role in the formation of many tumors including ovarian cancer. In this study, RNA interference specific to STAT3 was employed to study its effects on the inhibition of STAT3 signaling and on the growth of ovarian can...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang F,Tong X,Fu L,Zhang R

更新日期：2008-06-01 00:00:00

abstract：:Nuclear factor kappa B (NF-κB) plays a prominent role in the pathogenesis of infectious diseases. Staphylococcus aureus (S. aureus), which can attach to and invade human osteoblasts, is the most common causative agent of osteomyelitis. To determine whether S. aureus can activate NF-κB in human osteoblasts and explore ...

journal_title：Acta biochimica et biophysica Sinica

authors： Ning R,Zhang X,Guo X,Li Q

更新日期：2010-12-01 00:00:00

abstract：:The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. This translocation creates a fusion between the acute myelogenous leukemia 1 (AML1, a transcription factor) gene on chromosome 21 and the eight-twenty-one (ETO, a zinc finger nuclear protein) gene on chromosome 8,...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang HT,Wu DH,Xue XY,Liang WX,Miao XY,Pang H,Chen SJ

更新日期：2004-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) function as key regulators of gene expression in various cancers. In this study, the aim is to explore the roles and regulation mechanism of miR-181c in neuroblastoma (NB) cells. We found that miR-181c was downregulated in metastatic NB tissues, compared with primary NB tissues. Then functional stud...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Wang H,Li J,Yue W

更新日期：2014-01-01 00:00:00