MiR-181c modulates the proliferation, migration, and invasion of neuroblastoma cells by targeting Smad7.

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:The aim of this study was to establish and apply a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) for rubella virus (RV) RNA. First, the primer and TaqMan probe concentrations, as well as reaction temperatures were optimized to establish an efficient real-time quantitative RT-PCR assay...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao LH,Ma YY,Wang H,Zhao SP,Zhao WM,Li H,Wang LY

更新日期：2006-10-01 00:00:00

abstract：:It has been reported that over-expression of GRP75 can protect cells under different types of stress. In this study, we investigated the protective effect of GRP75 on the liver both in vivo and in vitro. To evaluate the effect of GRP75 over-expression on oxidative damage in the liver in vitro, cell viability and the m...

journal_title：Acta biochimica et biophysica Sinica

authors： E Q,Liu X,Liu Y,Liu W,Zuo J

更新日期：2013-02-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12), a key enzyme of carbon metabolism, was purified and characterized to homogeneity from skeletal muscle of Camelus dromedarius. The protein was purified approximately 26.8 folds by conventional ammonium sulphate fractionation followed by Blue Sepharose CL-6...

journal_title：Acta biochimica et biophysica Sinica

authors： Fourrat L,Iddar A,Soukri A

更新日期：2007-02-01 00:00:00

abstract：:The low-molecular-weight protein tyrosine phosphatases (PTPase) exist ubiquitously in prokaryotes and eukaryotes and play important roles in the regulation of physiological activities. We report here the expression, purification and characterization of an active and soluble PTPase from Thermus thermophilus HB27 in Esc...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Y,Meng F,Zhang Y

更新日期：2009-08-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta is a pleiotropic cytokine regulating a variety of cellular processes such as cell growth, differentiation, apoptosis, migration, cell adhesion, and immune response. In the well-understood classical TGF-beta signaling pathway, TGF-beta activates Smad signalling via its two cell sur...

journal_title：Acta biochimica et biophysica Sinica

authors： Yan X,Liu Z,Chen Y

更新日期：2009-04-01 00:00:00

abstract：:HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. The expressions of HEATR1 in GC tissues were analyzed using The ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao J,Zhu Y,Fu Q,Zhu Y,Zhao G

更新日期：2020-09-08 00:00:00

abstract：:Sequence analysis of oxazolomycin (OZM) biosynthetic gene cluster from Streptomyces albus JA3453 revealed a gene, ozmH, encoding a hybrid polyketide and non-ribosomal peptide enzyme. Tandem ketosynthase (KS) domains (KS 10-1 and KS 10-2) were characterized and they show significant homology with known KSs. Using an al...

journal_title：Acta biochimica et biophysica Sinica

authors： Song D,Coughlin J,Ju J,Zhou X,Shen B,Zhao C,Deng Z

更新日期：2008-04-01 00:00:00

abstract：:Recent studies have suggested that antibodies can catalyze the generation of unknown oxidants including hydrogen peroxide (H2O2) and ozone (O3) from singlet oxygen (1O2) and water. This study is aimed to detect the effect of antibody-catalyzed water oxidation on atherosclerosis. Our results showed that both H2O2 and O...

journal_title：Acta biochimica et biophysica Sinica

authors： Peng KJ,Huang YS,An LN,Han XQ,Zhang JG,Wang QL,Sun J,Wang SR

更新日期：2006-06-01 00:00:00

abstract：:Carbon monoxide (CO) is often viewed as a lethal gas in light of its capacity to prevent oxygen uptake in hemoglobin; however, it also functions to regulate a variety of proteins and physiological processes. Here we show that CO is an important chemical cue, to which neurons respond strongly, and this response is then...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Liu B,Zhang Q,Wu X,Yu Y,Jesse FF,Li L

更新日期：2015-05-01 00:00:00

abstract：:The study was undertaken to examine the effects of C-peptide on glomerular volume (V(GLOM)), mesangial matrix synthesis, and degradation in streptozotocin (STZ)-diabetic rats with poor or moderate glycemic control. Series 1 (poor glycemic control) included groups of healthy rats, hyperglycemic rats, diabetic insulin-t...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun W,Gao X,Zhao X,Cui D,Xia Q

更新日期：2010-12-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients in the acute stages is a kind of accessible sample reflecting its features. In our study, we analyzed 45 sputum samples from 45 patients with CAP. Eighte...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen C,Shen T,Tian F,Lin P,Li Q,Cui Z,Zhang Y,Xue M,Ye J,Guo X,Zhou Y

更新日期：2013-12-01 00:00:00

abstract：:The aim of this study was to investigate the pro-apoptotic mechanism of C-phycocyanin (C-PC)-mediated photodynamic therapy (PDT) in a murine tumor model and cultured MCF-7 cells. The mice were divided into four groups: control, He-Ne laser radiation, C-PC treatment, and C-PC treatment + He-Ne laser radiation. The effe...

journal_title：Acta biochimica et biophysica Sinica

authors： Li B,Chu X,Gao M,Li W

更新日期：2010-01-01 00:00:00

abstract：:Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFα mRNA degradation. Moreover, T0901317 destabilized TNFα...

journal_title：Acta biochimica et biophysica Sinica

authors： Xiao J,Chen Q,Tang D,Ou W,Wang J,Mo Z,Tang C,Peng L,Wang D

更新日期：2017-03-01 00:00:00

abstract：:Many N-methyl-d-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmitter system makes the glutamic acid receptor blockers inefficient and unsafe. Thus, regulating the downstre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tian Y,He Y,Song W,Zhang E,Xia X

更新日期：2017-09-01 00:00:00

abstract：:In this study, a mistletoe lectin (ML) was purified from Chinese mistletoe and the effect of this 60 kDa Chinese ML on human gammadelta T cell cytotoxicity, apoptosis and modulation of the cytokine network was studied. The cytotoxic properties of delta T cells was evaluated by using a (51)Cr release test and employed ...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong F,Ma Y,Ma A,Yu Q,Zhang J,Nie H,Chen X,Shen B,Li N,Zhang D

更新日期：2007-06-01 00:00:00

abstract：:NifA is the general transcriptional activator of nitrogen fixation genes in diazotrophic bacteria. In Rhizobium leguminosarum bv. viciae strain 8401/pRL1JI, the NifA gene is part of a gene cluster (fixABCXNifAB). In this study, results showed that in R. leguminosarum bv.viciae 8401/pRL1JI, host factor required (Hfq), ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang Y,Hong G

更新日期：2009-09-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported to interact with proteins containing the polyglutamine (polyQ) domain. The present study was undertaken to evaluate the potential contributions of the polyQ and polyproline (polyP) domains to the co-localization of mutant huntingtin (htt) and GAPDH. Ov...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu J,Lin F,Qin Z

更新日期：2007-11-01 00:00:00

abstract：:It has been reported that oncostatin M (OSM) could initiate cardiomyocyte dedifferentiation both in vivo and in vitro. OSM-induced cardiomyocyte dedifferentiation might be a new target for the treatment of diabetic cardiomyopathy (DCM). This study was designed to determine the role of OSM in cardiomyocyte dedifferenti...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang X,Ma S,Zhang R,Li S,Zhu D,Han D,Li X,Li C,Yan W,Sun D,Xu B,Wang Y,Cao F

更新日期：2016-03-01 00:00:00

abstract：:LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which ...

journal_title：Acta biochimica et biophysica Sinica

authors： Feng Q,Yang J,Luo P,Zhang WJ,Zou QM

更新日期：2005-02-01 00:00:00

abstract：:The mechanisms of chronic neuropathic pain are not clear. Serum microRNAs (miRNAs) might show a special feature for chronic nervous lesions. However, little is known about the changes in circulating miRNAs for the neuropathic pain. Therefore, changes in the circulating miRNAs expression profile for the neuropathic pai...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu Y,Zhang X,Pu S,Wu J,Lv Y,Du D

更新日期：2014-11-01 00:00:00

abstract：:Mammalian STE20-like kinase 1 (Mst1) is the mammalian homologue of Drosophila Hippo, a major inhibitor of cell proliferation in Drosophila. It ubiquitously encodes serine threonine kinase that belongs to the family of protein kinases related to yeast STE20, and is involved in cell proliferation, apoptosis, oncogenesis...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu C,Liu C,Huang W,Tu S,Wan F

更新日期：2013-04-01 00:00:00

abstract：:The Hippo pathway was initially identified in Drosophila by genetic mosaic screens for tumor suppressor genes. Researches indicated that the Hippo pathway is a key regulator of organ size and is conserved during evolution. Furthermore, studies of mouse models and clinical samples demonstrated the importance of Hippo p...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu C,Li L,Zhao B

更新日期：2015-01-01 00:00:00

abstract：:Several studies have shown that combination treatment with natural products and chemotherapy agents can improve the sensitivity and cytotoxicity of chemotherapy agents. Resveratrol, a natural product, has many biological effects including antitumor and antiviral activities, as well as vascular protective effect. The a...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu S,Li X,Xu R,Ye L,Kong H,Zeng X,Wang H,Xie W

更新日期：2016-06-01 00:00:00

abstract：:Previous studies have indicated that noggin exerts its neural inducing effect by binding and antagonizing bone morphogenetic protein 4 (BMP4). In order to further clarify the relationship between the structure and the function of noggin, and elucidate the possible mechanism responsible for noggin-BMP4 interaction, we ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu WD,Feng XL,Ren CP,Shi JL,Yang XY,Zhao M,Zhou L,Lan K,Yao KT

更新日期：2005-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is one of the deadliest malignant tumors, and many genes play important roles in its development. The hepatocyte nuclear factor-1a (HNF-1a) gene encodes HNF-1a, which is a transcriptional activator. HNF-1a regulates the tissue-specific expression of multiple genes, especially in pancre...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan Z,Fan K,Deng S,Gong Y,Qian Y,Huang Q,Yang C,Cheng H,Jin K,Luo G,Liu C,Yu X

更新日期：2020-03-18 00:00:00

abstract：:Erythrocyte senescence is characterized by exposure of cell surface epitopes on cell membrane proteins leading to immune mediated removal of red blood cells. One mechanism for antigen formation is tyrosine phosphorylation (Tyr-P) of the transmembrane protein band 3 by Syk kinase. Our aim was to test the hypothesis tha...

journal_title：Acta biochimica et biophysica Sinica

authors： Bordin L,Fiore C,Bragadin M,Brunati AM,Clari G

更新日期：2009-10-01 00:00:00

abstract：:Raman spectroscopy was used for the first time to detect the effect of independent UVA (ultraviolet-A: 320-400 nm) and UVB (ultraviolet-B: 280-320 nm) irradiation on the calf thymus DNA in aqueous solution. After both UVA and UVB irradiation for 1 h or 3 h, the damage to the conformation of DNA was moderate, but the r...

journal_title：Acta biochimica et biophysica Sinica

authors： Tang YL,Guo ZY

更新日期：2005-01-01 00:00:00

abstract：:Cotton fiber developmental transition from elongation to secondary cell wall biosynthesis is a critical growth shifting phase that affects fiber final length, strength, and other properties. Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotto...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou X,Hu W,Li B,Yang Y,Zhang Y,Thow K,Fan L,Qu Y

更新日期：2019-11-18 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) isoforms (alpha and gamma) are known to be expressed in pancreatic islets as well as in insulin-producing cell lines. Ligands of PPAR have been shown to enhance glucose-induced insulin secretion in rat pancreatic islets. However, their effect on insulin secretion is st...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu ZK,Chen NG,Ma CY,Meng ZX,Sun YJ,Han X

更新日期：2006-01-01 00:00:00