Critical role of Cys168 in noggin protein's biological function.

abstract：:Human-induced pluripotent stem (iPS) cells share the same key properties as embryonic stem cells, and may be generated from patient- or disease-specific sources, which makes them attractive for personalized medicine, drug screens, or cellular therapy. Long-term cultivation and maintenance of normal iPS cells in an und...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu T,Chen Q,Huang Y,Huang Q,Jiang L,Guo L

更新日期：2012-03-01 00:00:00

abstract：:Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Leptin is a hormone secreted by adipose tissue. Recent reports have shown that leptin can induce cancer cell proliferation and regulate cell energy metabolism, but the regulatory mechanism is still unclear. Her...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Q,Sun Y,Fei Z,Yang Z,Duan K,Zi J,Cui Q,Yu M,Xiong W

更新日期：2019-07-10 00:00:00

abstract：:Hyperhomocysteinemia (HHcy), which is an independent risk factor for atherosclerosis, might cause dysregulation of gene expression, but the characteristics and key links involved in its pathogenic mechanisms are still poorly understood. The objective of the present study was to investigate the effect of HHcy on DNA me...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Y,Sun T,Xiong J,Cao J,Li G,Wang S

更新日期：2007-09-01 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is a major cause of acute kidney damage, which often occurs in deceased donor kidney transplants. Cathelicidin PR-39 peptide possesses anti-inflammatory and wound repair effects through tissue angiogenesis and anti-apoptosis. This study assessed the role of PR-39 in anti-apoptosis in ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Xue W,Xiang H,Zheng J,Zhao Y,Jiao L,Jiao Z

更新日期：2016-08-01 00:00:00

abstract：:Mammalian STE20-like kinase 1 (Mst1) is the mammalian homologue of Drosophila Hippo, a major inhibitor of cell proliferation in Drosophila. It ubiquitously encodes serine threonine kinase that belongs to the family of protein kinases related to yeast STE20, and is involved in cell proliferation, apoptosis, oncogenesis...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu C,Liu C,Huang W,Tu S,Wan F

更新日期：2013-04-01 00:00:00

abstract：:Some barley mutants can synthesize neither anthocyanins nor proanthocyanidins in the seed coat, which is related to several genes in locus Ant13, but the exact model of action remains unknown. We used the cDNA microarray technology with barley transcription-deficient mutant (ant13-152) that does not synthesize proanth...

journal_title：Acta biochimica et biophysica Sinica

authors： Pang JS,He MY,Liu B

更新日期：2004-10-01 00:00:00

abstract：:Emerging evidence suggests that specific spatio-temporal microRNA (miRNA) expression is required for heart development. In recent years, hundreds of miRNAs have been discovered. In contrast, functional annotations are available only for a very small fraction of these regulatory molecules. In order to provide a global ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu G,Ding M,Chen J,Huang J,Wang H,Jing Q,Shen B

更新日期：2010-09-01 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) is fatal and there is currently no effective clinical treatment. The antibiotic doxycycline has shown anti-cancer effect in several kinds of solid tumors including prostate cancer. In this study, a combination of doxycycline and doxorubicin was used to investigate the synerg...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu C,Yan X,Yu A,Wang Y

更新日期：2017-11-01 00:00:00

abstract：:It has been shown that Fructus Ligustri Lucidi (FLL), a promising traditional Chinese medicine, can inhibit the growth of tumors. However, the effective component and molecular mechanism of FLL act to inhibit tumor proliferation are unclear. In this study, we demonstrated that oleanolic acid (OA), a principal chemical...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang P,Li H,Chen D,Ni J,Kang Y,Wang S

更新日期：2007-10-01 00:00:00

abstract：:The recombinant peptide, DBAYL, a promising therapeutic peptide for type 2 diabetes, is a new, potent, and highly selective agonist for VPAC2 generated through site-directed mutagenesis based on sequence alignments of pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal peptide (VIP), and rela...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma Y,Luo T,Xu W,Ye Z,Hong A

更新日期：2012-11-01 00:00:00

abstract：:Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFα mRNA degradation. Moreover, T0901317 destabilized TNFα...

journal_title：Acta biochimica et biophysica Sinica

authors： Xiao J,Chen Q,Tang D,Ou W,Wang J,Mo Z,Tang C,Peng L,Wang D

更新日期：2017-03-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a risk factor for cardiovascular disease and has a strong correlation with heart failure. However, the effects of HHcy on cardiac tissue remain less well understood. To elucidate the role of p53-dependent apoptosis in HHcy-induced cardiac injury, we fed ApoE(-/-) mice with high methionin...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma S,Zhang H,Sun W,Gong H,Wang Y,Ma C,Wang J,Cao C,Yang X,Tian J,Jiang Y

更新日期：2013-05-01 00:00:00

abstract：:Several discriminate functions for predicting core promoters that based on the potential cooperation between transcription factor binding sites (TFBSs) are discussed. It is demonstrated that the promoter predicting accuracy is improved when the cooperation among TFBSs is taken into consideration. The core promoter reg...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma XT,Qian MP,Tang HX

更新日期：2004-04-01 00:00:00

abstract：:MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu H,Li S,Liu J,Ni B

更新日期：2012-05-01 00:00:00

abstract：:Defective DNA damage response is a threat to genome stability and a proven cause of tumorigenesis. C21ORF2 (chromosome 21 open reading frame 2) is a novel gene on chromosome 21, and the C21ORF2 protein is found to interact with NEK1. Earlier studies showed that C21ORF2 might be associated with some human genetic disea...

journal_title：Acta biochimica et biophysica Sinica

authors： Fang X,Lin H,Wang X,Zuo Q,Qin J,Zhang P

更新日期：2015-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell apoptosis. Zinc finger E-box binding homeobox factor 1 (ZEB1) is a crucial mediator of epithelial-mesenchymal transition (EMT). It induces mali...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao L,Li R,Xu S,Li Y,Zhao P,Dong W,Liu Z,Zhao Q,Tan B

更新日期：2018-02-01 00:00:00

abstract：:To test the hypothesis that hypoxia inducible factor-1 alpha (HIF-1alpha) up-regulated the expression of heme oxygenase-1 (HO-1) gene in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension, 8 male Wistar rats in each of 5 groups were exposed to hypoxia for 0, 3, 7, 14 or 21 d, respectively. Mean pul...

journal_title：Acta biochimica et biophysica Sinica

authors： Li QF,Dai AG

更新日期：2004-02-01 00:00:00

abstract：:The unique temporal expression pattern of miR-200c in epididymis during post-natal development in juvenile rats was revealed by our home-made miRNA microarray in this paper. It was found that miR-200c expressed in the lowest level at Day 7 and then increased to the highest at Day 36 followed by a dramatic decrease. Th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang J,Ruan K

更新日期：2010-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in post-transcriptional gene silencing of target messenger RNAs, which are involved in virtually all biological processes. Previously, we have demonstrated that spheroid body-forming cells from the MKN-45 cancer cell line possessed gastric cancer stem cell (CSC) properties. In t...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Ma L,Wang Z,Wang L,Liu C,Chen R,Zhang J

更新日期：2014-02-01 00:00:00

abstract：:To investigate whether apelin-13 induced THP-1 monocytes (MCs) adhesion to ECV304 human umbilical vein endothelial cells (HUVECs) via 14-3-3 signaling transduction pathway and the potential novel physiological function and signaling transduction pathway of apelin-APJ, HUVECs ECV304 were cultured in DMEM and MCs THP-1 ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Zhang X,Li F,Chen L,Li L,Qin X,Gao J,Su T,Zeng Y,Liao D

更新日期：2010-06-15 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang H,Dong F,Wang Y,Wang X,Hong D,Liu Y,Zhou J

更新日期：2020-02-03 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is hepatic manifestation of a metabolic syndrome and includes a spectrum of hepatic steatosis, steatohepatitis, and fibrosis. Interleukin-17 (IL-17) has been reported to play a critical role in inflammatory progression of some liver diseases. The present study was designed to ...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu R,Tao A,Zhang S,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. The expressions of HEATR1 in GC tissues were analyzed using The ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao J,Zhu Y,Fu Q,Zhu Y,Zhao G

更新日期：2020-09-08 00:00:00

abstract：:Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang M,Wang C,Lu B

更新日期：2019-02-01 00:00:00

abstract：:To study the molecular basis of heterosis, suppression subtractive hybridization was used to investigate the differences in gene expression between porcine Longissimus dorsi of F1 hybrids Large WhitexMeishan and their female parents Meishan. From two specific subtractive cDNA libraries, the clones selected by reverse ...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang T,Xiong YZ,Lei MG,Xu DQ,Deng CY

更新日期：2006-07-01 00:00:00

abstract：:Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activation by the agonists. ...

journal_title：Acta biochimica et biophysica Sinica

authors： Drastichova Z,Novotny J

更新日期：2012-08-01 00:00:00

abstract：:Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and thus irreversibly inactivate ribosome for protein synthesis. Cinnamomin is a multifunctional type II RIP isolated in our laborat...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu H,Liu WY

更新日期：2004-03-01 00:00:00

abstract：:Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not b...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen S,Wu Z,Ke Y,Shu P,Chen C,Lin R,Shi Q

更新日期：2019-11-18 00:00:00

abstract：:N6-methyladenosine (m6A), a methylation in the N6 position of adenosine especially in the mRNA, exerts diverse physiological and pathological functions. However, the precise role of m6A methylation in hypoxic preconditioning (HPC) is still unknown. Here, we observed that HPC treatment protected H9c2 cells against H2O2...

journal_title：Acta biochimica et biophysica Sinica

authors： Su Y,Xu R,Zhang R,Qu Y,Zuo W,Ji Z,Geng H,Pan M,Ma G

更新日期：2020-12-29 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) isoforms (alpha and gamma) are known to be expressed in pancreatic islets as well as in insulin-producing cell lines. Ligands of PPAR have been shown to enhance glucose-induced insulin secretion in rat pancreatic islets. However, their effect on insulin secretion is st...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu ZK,Chen NG,Ma CY,Meng ZX,Sun YJ,Han X

更新日期：2006-01-01 00:00:00