Activation of liver X receptors promotes inflammatory cytokine mRNA degradation by upregulation of tristetraprolin.


:Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFα mRNA degradation. Moreover, T0901317 destabilized TNFα mRNA through its 3'-untranslated region. In addition, T0901317 increased the expression of tristetraprolin (TTP), while antagonizing TTP with siRNA abrogated T0901317-mediated inflammatory cytokine mRNA decay. Interestingly, T0901317 repressed LPS-induced phosphorylation of ERK1/2 and p38 mitogen-activated protein kinase (MAPK) in THP-1 macrophages. The evidence presented here confirms that LXR activation with T0901317 inhibits the phosphorylation of ERK1/2 and p38 MAPK, likely resulting in the increased expression of TTP and the decay of LPS-induce inflammatory cytokine mRNAs.


Xiao J,Chen Q,Tang D,Ou W,Wang J,Mo Z,Tang C,Peng L,Wang D




Has Abstract


2017-03-01 00:00:00














  • Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer.

    abstract::Lung cancer is one of the most lethal cancers in China because of high incidence and high mortality. Cyclooxygenase-2 (COX-2) and vessel endothelial growth factor C (VEGF-C) were found to play an important role in lymphangiogenesis of malignant tumors. In this study, we investigated whether lymphatic microvessel densi...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Guo X,Chen Y,Xu Z,Xu Z,Qian Y,Yu X

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  • Leptin promotes fatty acid oxidation and OXPHOS via the c-Myc/PGC-1 pathway in cancer cells.

    abstract::Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Leptin is a hormone secreted by adipose tissue. Recent reports have shown that leptin can induce cancer cell proliferation and regulate cell energy metabolism, but the regulatory mechanism is still unclear. Her...

    journal_title:Acta biochimica et biophysica Sinica

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    authors: Liu Q,Sun Y,Fei Z,Yang Z,Duan K,Zi J,Cui Q,Yu M,Xiong W

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  • An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Zhu H,Wang T,Xin Z,Zhan Y,Gu G,Li X,Wang X,Yang S,Liu C

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  • miR-27b-3p/MARCH7 regulates invasion and metastasis of endometrial cancer cells through Snail-mediated pathway.

    abstract::Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. This study ai...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Liu L,Hu J,Yu T,You S,Zhang Y,Hu L

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  • Viral suppression function of intracellular antibody against C-terminal domain of rabies virus phosphoprotein.

    abstract::Rabies virus (RV) causes a fatal disease in both human and animals. The disease can be prevented by post-exposure prophylaxis in individuals exposed to RV. However, the neutralization effect is limited after the virus enters into the host cells. So, it is important to identify new targets for rabies therapy. In this s...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Liu Y,Sun L,Yu P,Li A,Li C,Tang Q,Li D,Liang M

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  • MiRNA-218, a new regulator of HMGB1, suppresses cell migration and invasion in non-small cell lung cancer.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Zhang C,Ge S,Hu C,Yang N,Zhang J

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  • Cloning, sequence analysis and identification of a nonsense mutation-mediated mRNA decay of porcine GSTM2 gene.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Huang J,Xiong Y,Deng C,Zuo B,Xu D,Lei M,Jiang S

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  • Predicting polymerase II core promoters by cooperating transcription factor binding sites in eukaryotic genes.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Ma XT,Qian MP,Tang HX

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  • Cloning and isolation of a Conus cysteine-rich protein homologous to Tex31 but without proteolytic activity.

    abstract::We cloned and isolated a cysteine-rich protein, designated Mr30, from Conus marmoreus. Mr30 belongs to the cysteine-rich secretory protein family that is highly homologous to Tex31 previously obtained from Conus textile and reported as a protease responsible for processing of pro-conotoxins. Mr30, purified by a proced...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Qian J,Guo ZY,Chi CW

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  • The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters.

    abstract::Acyl-coenzymeA:cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in intestine and fetal liver of healthy human. Our previous studies have shown that in monocytic cells the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the CCAAT/enhancer binding protein (...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Guo D,Zhang X,Li Q,Qian L,Xu J,Lu M,Hu X,Zhu M,Chang CC,Song B,Chang T,Xiong Y,Li B

    更新日期:2016-11-01 00:00:00

  • Expression patterns of Ca(V)1.3 channels in the rat cochlea.

    abstract::Although Ca(V)1.3 channels are known to be essential for neuronal excitation and signal transduction in the auditory system, their expression patterns in the cochlea are still not fully understood, particularly in the regions where non-sensory cells are located. We performed immunohistochemistry, western blotting and ...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Chen J,Chu H,Xiong H,Chen Q,Zhou L,Bing D,Liu Y,Gao Y,Wang S,Huang X,Cui Y

    更新日期:2012-06-01 00:00:00

  • Cinnamomin--a versatile type II ribosome-inactivating protein.

    abstract::Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and thus irreversibly inactivate ribosome for protein synthesis. Cinnamomin is a multifunctional type II RIP isolated in our laborat...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章,评审


    authors: Xu H,Liu WY

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  • GAS2-Calpain2 axis contributes to the growth of leukemic cells.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Sun L,Zhou H,Liu H,Ge Y,Zhang X,Ma W,Wu D,Zhao Y

    更新日期:2015-10-01 00:00:00

  • Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics.

    abstract::A number of significant studies in the field of cell biology have revealed another pattern of intracellular signal transduction in which cells transmit information through the dynamics of key signaling molecules. Dynamical properties of p53 have been demonstrated to be the key factor in dictating cell fate, including ...

    journal_title:Acta biochimica et biophysica Sinica

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    authors: Shi G,Wang Q,Zhou X,Li J,Liu H,Gu J,Wang H,Wu Y,Ding L,Ni S,Tang Z

    更新日期:2017-04-01 00:00:00

  • Cloning and overexpression of CYP6F1, a cytochrome P450 gene, from deltamethrin-resistant Culex pipiens pallens.

    abstract::CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative prote...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Gong MQ,Gu Y,Hu XB,Sun Y,Ma L,Li XL,Sun LX,Sun J,Qian J,Zhu CL

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  • LT(K63/R72), a new mutant of Escherichia coli heat-labile enterotoxin, exhibits characteristics more similar to LT(K63) than LT(R72).

    abstract::LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which ...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Feng Q,Yang J,Luo P,Zhang WJ,Zou QM

    更新日期:2005-02-01 00:00:00

  • Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells.

    abstract::Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are well known as tumor suppressors that are closely related to tumor occurrence and progression. It was reported that ING4 and PTEN showed synergistic antitumor activities in nasopharyngeal carcinoma cells. The two tu...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Rakshit N,Yang S,Zhou W,Xu Y,Deng C,Yang J,Yu H,Wei W

    更新日期:2016-08-01 00:00:00

  • Endothelial cells modified by adenovirus vector containing nine copies hypoxia response elements and human vascular endothelial growth factor as the novel seed cells for bone tissue engineering.

    abstract::Vascularization is one of the hotspots during the development of new therapeutic strategies for bone tissue engineering, which can alleviate hypoxic circumstance and prevent transplant failure. Vascular endothelial growth factor (VEGF) gene transfection using recombinant adenovirus (Ad) vector can effectively promote ...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Song X,Shi L,Chen L,Liu X,Qu X,Wang K,Wei F

    更新日期:2017-11-01 00:00:00

  • Proteomic profiling of cotton fiber developmental transition from cell elongation to secondary wall deposition.

    abstract::Cotton fiber developmental transition from elongation to secondary cell wall biosynthesis is a critical growth shifting phase that affects fiber final length, strength, and other properties. Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotto...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Zhou X,Hu W,Li B,Yang Y,Zhang Y,Thow K,Fan L,Qu Y

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  • Chronic intermittent hypoxia promotes the development of experimental non-alcoholic steatohepatitis by modulating Treg/Th17 differentiation.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Liu J,Li W,Zhu W,He W,Zhao H,Xiang Y,Liu C,Wu W

    更新日期:2018-12-01 00:00:00

  • New methods for determining proton pumping ability and electron transfer activity of the cytochrome bc1 complex.

    abstract::It is important to determine the electron transfer activity and proton pumping ability of the cytochrome bc1 complex for better understanding its structure and function. In this study, several methods for determining the electron transfer and proton pumping of the bc1 complex, including the traditional and the new met...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Qu Y,Dong F

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  • Cloning, expression, purification and crystallization of NHR3 domain from acute myelogenous leukemia-related protein AML1-ETO.

    abstract::The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. This translocation creates a fusion between the acute myelogenous leukemia 1 (AML1, a transcription factor) gene on chromosome 21 and the eight-twenty-one (ETO, a zinc finger nuclear protein) gene on chromosome 8,...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Yang HT,Wu DH,Xue XY,Liang WX,Miao XY,Pang H,Chen SJ

    更新日期:2004-08-01 00:00:00

  • MicroRNA-363-3p suppresses anoikis resistance in human papillary thyroid carcinoma via targeting integrin alpha 6.

    abstract::MicroRNAs are highly conserved endogenous small noncoding RNAs and demonstrated to play important roles in the metastatic cascade of papillary thyroid carcinoma (PTC), including the process of anoikis resistance. In this study, the correlation between miRNA-363-3p (miR-363-3p) expression and PTC metastasis was analyze...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Pan Y,Zhu X,Wang K,Chen Y

    更新日期:2019-08-05 00:00:00

  • Effect of exogenous ghrelin on cell differentiation antigen 40 expression in endothelial cells.

    abstract::Ghrelin is a brain-gut peptide that serves as a natural ligand for growth hormone secretagogue receptor (GHSR). It also exists abundantly in the cardiovascular system. In order to evaluate the possible role of ghrelin in the development of atherosclerosis, the effect of ghrelin on the expression of cell differentiatio...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Zhang M,Yuan F,Chen H,Qiu X,Fang W

    更新日期:2007-12-01 00:00:00

  • Expressional analysis of an EREBP transcription factor gene OsEBP-89 in rice.

    abstract::OsEBP-89 gene encodes an ethylene responsive element binding protein (EREBP) transcription factor from rice (Oryza sativa). Northern blot analysis revealed that OsEBP-89 was expressed in root, stem, seeds, flowers and leaves of rice. Histochemical assay showed that GUS expressed mainly in phloem of vascular tissues of...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Shen H,Wang ZY

    更新日期:2004-01-01 00:00:00

  • Biochemical characterization and ligand-binding properties of trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis.

    abstract::Trehalose-6-phosphate phosphatase (TPP) is an essential enzyme for growth of mycobacteria, which has been identified to be a potential anti-tuberculosis drug target. However, the biochemical and ligand-binding properties and the 3D structure of TPP remain unclear so far. In the present study, we expressed the recombin...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Shi L,Zhang H,Qiu Y,Wang Q,Wu X,Wang H,Zhang X,Lin D

    更新日期:2013-10-01 00:00:00

  • Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis.

    abstract::Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not b...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Chen S,Wu Z,Ke Y,Shu P,Chen C,Lin R,Shi Q

    更新日期:2019-11-18 00:00:00

  • A subunit vaccine based on rH-NS induces protection against Mycobacterium tuberculosis infection by inducing the Th1 immune response and activating macrophages.

    abstract::Mycobacterium tuberculosis (Mtb) is a Gram-positive pathogen which causes tuberculosis in both animals and humans. All tested rH-NS formulations induced a specific Th1 response, as indicated by increased production of interferon γ (IFN-γ) and interleukin 2 (IL-2) by lymphocytes in the spleen of mice which were immuniz...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Liu Y,Chen S,Pan B,Guan Z,Yang Z,Duan L,Cai H

    更新日期:2016-10-01 00:00:00

  • Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma.

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    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Tao X,Zuo Q,Ruan H,Wang H,Jin H,Cheng Z,Lv Y,Qin W,Wang C

    更新日期:2019-03-01 00:00:00

  • ZnPcS2P2-based photodynamic therapy induces mitochondria-dependent apoptosis in K562 cells.

    abstract::Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the kil...

    journal_title:Acta biochimica et biophysica Sinica

    pub_type: 杂志文章


    authors: Huang HF,Chen YZ,Wu Y

    更新日期:2005-07-01 00:00:00