High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.

abstract：:In this study, a mistletoe lectin (ML) was purified from Chinese mistletoe and the effect of this 60 kDa Chinese ML on human gammadelta T cell cytotoxicity, apoptosis and modulation of the cytokine network was studied. The cytotoxic properties of delta T cells was evaluated by using a (51)Cr release test and employed ...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong F,Ma Y,Ma A,Yu Q,Zhang J,Nie H,Chen X,Shen B,Li N,Zhang D

更新日期：2007-06-01 00:00:00

abstract：:The critical molecular mechanism in the development of the pulmonary fibrosis remains unknown, leaving diagnosed patients with a poor prognosis. To isolate the genes specifically up-regulated in pulmonary fibrosis, we established a rat silicosis model 360 d after treatment with crystalline silica suspension. Radiograp...

journal_title：Acta biochimica et biophysica Sinica

authors： Jin Z,Liu B,Feng D,Chen C,Li X,Hu Y,Peng J,Liu Y,Du J,Fu C,Wen J

更新日期：2008-08-01 00:00:00

abstract：:Acyl-coenzymeA:cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in intestine and fetal liver of healthy human. Our previous studies have shown that in monocytic cells the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the CCAAT/enhancer binding protein (...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo D,Zhang X,Li Q,Qian L,Xu J,Lu M,Hu X,Zhu M,Chang CC,Song B,Chang T,Xiong Y,Li B

更新日期：2016-11-01 00:00:00

abstract：:Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Liu J,Zhao Z,Wen L,Li H,Ren J,Liu H

更新日期：2018-03-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis. In this study, we explored the expression patterns of Snail1 and a cardiac fibrosis marker-...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Du J,Zhang J,Weng M,Li X,Pu D,Gao L,Deng S,Xia S,She Q

更新日期：2012-11-01 00:00:00

abstract：:G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are distributed in many locations in the human genome, including promoter regions, and are viewed as promising therapeutic targets. Uncoupling protein-1 (UCP1) is a mitochondrial thermogenic gene critical f...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao Y,Uhler JP

更新日期：2018-07-01 00:00:00

abstract：:Thyroid cancer is one of the common malignancies of the endocrine system and the number of thyroid cancer cases is increasing constantly. Significant work has focused on the molecular mechanisms of thyroid cancer, but many mechanisms remain undiscovered. In this study, we employed a comprehensive analysis of whole-tra...

journal_title：Acta biochimica et biophysica Sinica

authors： Guan Y,Bhandari A,Xia E,Kong L,Zhang X,Wang O

更新日期：2020-02-03 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is a common cause of acute renal failure in many clinical settings. Our study aimed to elucidate the role of lentiviral vector-mediated KSR1 gene silencing in inflammatory factor expression and proliferation of renal tubular epithelial cells (RTECs) in a rat model of I/R injury. Male S...

journal_title：Acta biochimica et biophysica Sinica

authors： Bai Y,Han G,Guo K,Yu L,Du X,Xu Y

更新日期：2018-08-01 00:00:00

abstract：:Mammalian STE20-like kinase 1 (Mst1) is the mammalian homologue of Drosophila Hippo, a major inhibitor of cell proliferation in Drosophila. It ubiquitously encodes serine threonine kinase that belongs to the family of protein kinases related to yeast STE20, and is involved in cell proliferation, apoptosis, oncogenesis...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu C,Liu C,Huang W,Tu S,Wan F

更新日期：2013-04-01 00:00:00

abstract：:Neuron restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-induced or kindling-evoked seizure activity. However, whether NRSF functions in pentylenetetrazol (PTZ)-i...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu M,Sheng Z,Cai L,Zhao K,Tian Y,Fei J

更新日期：2012-06-01 00:00:00

abstract：:Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are well known as tumor suppressors that are closely related to tumor occurrence and progression. It was reported that ING4 and PTEN showed synergistic antitumor activities in nasopharyngeal carcinoma cells. The two tu...

journal_title：Acta biochimica et biophysica Sinica

authors： Rakshit N,Yang S,Zhou W,Xu Y,Deng C,Yang J,Yu H,Wei W

更新日期：2016-08-01 00:00:00

abstract：:Caveolin-1 is regulated by estrogen in vascular smooth muscle cells. Raloxifene, a selective estrogen receptor modulator that possibly has cardioprotective properties without an increased risk of cancer or other side effects of estrogen, may be used in women with risk of coronary artery disease. However, the relations...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang FL,He H,Liu XX,Tu B,Zeng XW,Su JX,Wang X,Hu Q

更新日期：2006-11-01 00:00:00

abstract：:To explore new targets for hepatoma research, we used a surface display library to screen novel tumor cell-specific peptides. The bacterial FliTrx system was screened with living normal liver cell line L02 and hepatoma cell line HepG2 successively to search for hepatoma-specific peptides. Three clones (Hep1, Hep2, and...

journal_title：Acta biochimica et biophysica Sinica

authors： Li W,Lei P,Yu B,Wu S,Peng J,Zhao X,Zhu H,Kirschfink M,Shen G

更新日期：2008-05-01 00:00:00

abstract：:The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. This translocation creates a fusion between the acute myelogenous leukemia 1 (AML1, a transcription factor) gene on chromosome 21 and the eight-twenty-one (ETO, a zinc finger nuclear protein) gene on chromosome 8,...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang HT,Wu DH,Xue XY,Liang WX,Miao XY,Pang H,Chen SJ

更新日期：2004-08-01 00:00:00

abstract：:Dementia, a devastating neurological disorder commonly found in the elderly, is characterized by severe cognitive and memory impairment. Ample clinical and epidemiological evidence has depicted a close association between dementia and heart failure. While cerebral blood under perfusion and neurohormonal activation due...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang M,Li C,Zhang Y,Ren J

更新日期：2020-01-02 00:00:00

abstract：:Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang M,Wang C,Lu B

更新日期：2019-02-01 00:00:00

abstract：:The low-molecular-weight protein tyrosine phosphatases (PTPase) exist ubiquitously in prokaryotes and eukaryotes and play important roles in the regulation of physiological activities. We report here the expression, purification and characterization of an active and soluble PTPase from Thermus thermophilus HB27 in Esc...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Y,Meng F,Zhang Y

更新日期：2009-08-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignant bone tumor, which occurs in adolescents. As reported by our previous studies, HER4 indicates a poor prognosis of primary osteosarcoma. However, its mechanisms in the pathogenesis of osteosarcoma have not yet been studied. The purpose of this study was to investigate th...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Huang Q,Wang S,Huang Z,Yu F,Lin J

更新日期：2020-04-20 00:00:00

abstract：:Hypoxia is a key component of the tumor microenvironment and represents a well-documented source of therapeutic failure in clinical oncology. Recent work has provided support for the idea that non-coding RNAs, and in particular, microRNAs, may play important roles in the adaptive response to low oxygen in tumors. Spec...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang X,Zuo J

更新日期：2014-03-01 00:00:00

abstract：:Reactive oxygen species (ROS), including H(2)O(2), play a critical role in the pathophysiology of osteoporosis. Therefore, agents or antioxidants that can inhibit ROS production have a high clinical value in the treatment of osteoporosis. Curculigoside (CUR), one of the main bioactive phenolic compounds isolated from ...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Y,Zhao L,Wang Y,Xu J,Nie Y,Guo Y,Tong Y,Qin L,Zhang Q

更新日期：2012-05-01 00:00:00

abstract：:Gene therapy has emerged as a promising approach for the lethal disorder of Duchenne muscular dystrophy (DMD). Using a novel non-viral delivery system, the human ribosomal DNA (hrDNA) targeting vector, we targeted a minidystrophin-GFP fusion gene into the hrDNA locus of HT1080 cells with a high site-specific integrate...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang J,Liu X,Yu J,Sheng L,Shi Y,Li Z,Hu Y,Xue J,Wu L,Liang Y,Xia J,Liang D

更新日期：2009-12-01 00:00:00

abstract：:Osteoarthritis (OA) is an age-related joint disease that is characterized by the degeneration of articular chondrocytes. Nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is associated with inflammation response. We investigated the role of PARP-1 in interleukin-1β (IL-1β)-stimulated human articular chondrocytes a...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Zhou L,Lv D,Liu H,He T,Wang X

更新日期：2015-06-01 00:00:00

abstract：:Tuberculosis remains a major global health problem and effective vaccines are urgently needed. In this study, we used the combined DNA- and protein-based vaccines of immunodominant antigen Rv0577 to boost BCG and evaluated their immunogenicity in BALB/c mice. Our data suggest that the booster vaccine may substantially...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu D,Chen W,Mi Y,Gong X,Luo T,Bao L

更新日期：2016-04-01 00:00:00

abstract：:Human glioma is the most common primary brain tumor and is associated with high morbidity and mortality. Aberrant expressions of microRNAs (miRNAs) are involved in glioma progression. In the present study, we aimed to elucidate the roles of miR-4530 in the pathogenesis of gliomas. miR-4530 expression was examined in h...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang T,Zhang Y,Cui B,Wang M,Li Y,Gao K

更新日期：2020-12-29 00:00:00

abstract：:T helper cell type 1 (Th1) and 2 (Th2) play central roles in immune regulation. To identify the novel genes differentially expressed between Th1 and Th2 cells, CD4+ T cells were isolated from DO11.10 transgenic mice and induced under Th1 or Th2 conditions. Microarray showed differential expression of neutrophilic gran...

journal_title：Acta biochimica et biophysica Sinica

authors： Xie D,Liu Z,Li Z,Ji Y,Chen J,Sun B

更新日期：2007-01-01 00:00:00

abstract：:Rabies virus (RV) causes a fatal disease in both human and animals. The disease can be prevented by post-exposure prophylaxis in individuals exposed to RV. However, the neutralization effect is limited after the virus enters into the host cells. So, it is important to identify new targets for rabies therapy. In this s...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Sun L,Yu P,Li A,Li C,Tang Q,Li D,Liang M

更新日期：2015-10-01 00:00:00

abstract：:Gastric ulcers (GUs) are common pathologies that affect many people around the world. Excessive alcohol consumption is one of the main causes of GUs; however, there are still lack of effective drugs for the prevention or therapy of GUs. In this study, we evaluated the protective effects and possible mechanisms of kaem...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Q,Hu X,Xuan Y,Ying J,Fei Y,Rong J,Zhang Y,Zhang J,Liu C,Liu Z

更新日期：2018-03-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality in the world. Ischemia/reperfusion (I/R) injury-induced cardiomyocytes death is the main obstacle that limits the heart function recovery of the AMI patients. Reactive oxygen species (ROS) generated by mitochondria is the main path...

journal_title：Acta biochimica et biophysica Sinica

authors： Li L,Zhang M,Chen W,Wang R,Ye Z,Wang Y,Li X,Cai C

更新日期：2018-10-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a risk factor for cardiovascular disease and has a strong correlation with heart failure. However, the effects of HHcy on cardiac tissue remain less well understood. To elucidate the role of p53-dependent apoptosis in HHcy-induced cardiac injury, we fed ApoE(-/-) mice with high methionin...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma S,Zhang H,Sun W,Gong H,Wang Y,Ma C,Wang J,Cao C,Yang X,Tian J,Jiang Y

更新日期：2013-05-01 00:00:00

abstract：:Mutant N-terminal huntingtin (Htt) protein resulting from Huntington's disease (HD) with expanded polyglutamine accumulates and forms aggregates in vulnerable neurons. Both ubiquitin proteasomal and autophagic pathways contribute to the degradation of mutant Htt. Here, we focus on the involvement of chaperone-mediated...

journal_title：Acta biochimica et biophysica Sinica

authors： Qi L,Zhang XD

更新日期：2014-02-01 00:00:00