Correlation between circulating endothelial progenitor cells and serum carcinoembryonic antigen level in colorectal cancer.

abstract：:MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell apoptosis. Zinc finger E-box binding homeobox factor 1 (ZEB1) is a crucial mediator of epithelial-mesenchymal transition (EMT). It induces mali...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao L,Li R,Xu S,Li Y,Zhao P,Dong W,Liu Z,Zhao Q,Tan B

更新日期：2018-02-01 00:00:00

abstract：:Here we report that tgdA, a novel gene encoding a putative transglycosylase, affects both the morphological differentiation and the yield of blue-pigmented compound actinorhodin in Streptomyces coelicolor. The tgdA null mutant displays sparse aerial hyphae and irregular spore chains frequently lacking chromosomal DNA....

journal_title：Acta biochimica et biophysica Sinica

authors： Xie P,Zeng A,Lv X,Cheng Q,Qin Z

更新日期：2013-04-01 00:00:00

abstract：:Proteomic techniques are promising strategies in the surveillance of hepatocellular carcinoma (HCC). This study aimed to investigate the serum profiling with magnetic bead (MB) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and to further identify the biomarkers for H...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu T,Xue R,Huang X,Zhang D,Dong L,Wu H,Shen X

更新日期：2011-07-01 00:00:00

abstract：:Dementia, a devastating neurological disorder commonly found in the elderly, is characterized by severe cognitive and memory impairment. Ample clinical and epidemiological evidence has depicted a close association between dementia and heart failure. While cerebral blood under perfusion and neurohormonal activation due...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang M,Li C,Zhang Y,Ren J

更新日期：2020-01-02 00:00:00

abstract：:Trehalose-6-phosphate phosphatase (TPP) is an essential enzyme for growth of mycobacteria, which has been identified to be a potential anti-tuberculosis drug target. However, the biochemical and ligand-binding properties and the 3D structure of TPP remain unclear so far. In the present study, we expressed the recombin...

journal_title：Acta biochimica et biophysica Sinica

authors： Shi L,Zhang H,Qiu Y,Wang Q,Wu X,Wang H,Zhang X,Lin D

更新日期：2013-10-01 00:00:00

abstract：:To study the molecular basis of heterosis, suppression subtractive hybridization was used to investigate the differences in gene expression between porcine Longissimus dorsi of F1 hybrids Large WhitexMeishan and their female parents Meishan. From two specific subtractive cDNA libraries, the clones selected by reverse ...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang T,Xiong YZ,Lei MG,Xu DQ,Deng CY

更新日期：2006-07-01 00:00:00

abstract：:Mercaptopropionic acid (MPA) and cysteamine (Cys) capped CdTe quantum dots (QDs) were successfully prepared and used to investigate the combined influence of surface modification, size distribution, and interaction time on their cytotoxicity in human pancreatic carcinoma (PANC-1) cells. Results indicated that the smal...

journal_title：Acta biochimica et biophysica Sinica

authors： Chang S,Kang B,Liu X,Dai Y,Chen D

更新日期：2012-03-01 00:00:00

abstract：:A lectin with a novel N-terminal amino acid sequence was purified from the rhizomes of Aspidistra elatior Blume by ammonium sulphate precipitation, ion exchange chromatography on diethylaminoethyl-Sepharose and carboxymethyl-Sepharose and gel filtration chromatography on Sephacryl S-100. The A. elatior Blume lectin (A...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu X,Wu C,Liu C,Luo Y,Li J,Zhao X,Damme EV,Bao J

更新日期：2007-07-01 00:00:00

abstract：:hPFTAIRE1 is a Cdc2-related kinase family member. To search its substrates and regulatory proteins, hPFTAIRE1 was fused to LexA and used as a bait to screen a human brain LexA two-hybrid library. In this screening, seven hPFTAIRE1 interacting proteins, including promyelocytic leukemia zinc finger (PLZF), were obtained...

journal_title：Acta biochimica et biophysica Sinica

authors： Gao YK,Jiang M,Yang T,Chen JY

更新日期：2006-03-01 00:00:00

abstract：:The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. This translocation creates a fusion between the acute myelogenous leukemia 1 (AML1, a transcription factor) gene on chromosome 21 and the eight-twenty-one (ETO, a zinc finger nuclear protein) gene on chromosome 8,...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang HT,Wu DH,Xue XY,Liang WX,Miao XY,Pang H,Chen SJ

更新日期：2004-08-01 00:00:00

abstract：:The subfamily of voltage-dependent potassium (Kv) channel interacting protein 4 (KChIP4) is made up of the auxiliary interacting protein of voltage-dependent potassium channels. In this study, the structure of four splicing variants of the human KChIP4 gene was analyzed. Three of the four isoforms of the KChIP4 gene, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Deng XY,Cai F,Xia K,Pan Q,Long ZG,Wu LQ,Liang DS,Dai HP,Zhang ZH,Xia JH

更新日期：2005-04-01 00:00:00

abstract：:Hypoxia is a key component of the tumor microenvironment and represents a well-documented source of therapeutic failure in clinical oncology. Recent work has provided support for the idea that non-coding RNAs, and in particular, microRNAs, may play important roles in the adaptive response to low oxygen in tumors. Spec...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang X,Zuo J

更新日期：2014-03-01 00:00:00

abstract：:It has been shown that Fructus Ligustri Lucidi (FLL), a promising traditional Chinese medicine, can inhibit the growth of tumors. However, the effective component and molecular mechanism of FLL act to inhibit tumor proliferation are unclear. In this study, we demonstrated that oleanolic acid (OA), a principal chemical...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang P,Li H,Chen D,Ni J,Kang Y,Wang S

更新日期：2007-10-01 00:00:00

abstract：:It is important to determine the electron transfer activity and proton pumping ability of the cytochrome bc1 complex for better understanding its structure and function. In this study, several methods for determining the electron transfer and proton pumping of the bc1 complex, including the traditional and the new met...

journal_title：Acta biochimica et biophysica Sinica

authors： Qu Y,Dong F

更新日期：2015-02-01 00:00:00

abstract：:Metformin, a first line medication for type II diabetes, initially entered the spotlight as a promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk and improved clinical outcomes in diabetic patients taking metformin. To uncover the anti-cancer mechanisms of metformin, preclinical stu...

journal_title：Acta biochimica et biophysica Sinica

authors： Saini N,Yang X

更新日期：2018-02-01 00:00:00

abstract：:The critical molecular mechanism in the development of the pulmonary fibrosis remains unknown, leaving diagnosed patients with a poor prognosis. To isolate the genes specifically up-regulated in pulmonary fibrosis, we established a rat silicosis model 360 d after treatment with crystalline silica suspension. Radiograp...

journal_title：Acta biochimica et biophysica Sinica

authors： Jin Z,Liu B,Feng D,Chen C,Li X,Hu Y,Peng J,Liu Y,Du J,Fu C,Wen J

更新日期：2008-08-01 00:00:00

abstract：:In this study, we identified five miRNAs highly expressed in the small-cell lung cancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1)....

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Zhu L,Jin Y,Ji H,Yan X,Zhu X

更新日期：2012-02-01 00:00:00

abstract：:Cortactin, an actin-binding protein and a substrate of Src, is encoded by the EMS1 oncogene. Cortactin is known to activate Arp2/3 complex-mediated actin polymerization and interact with dynamin, a large GTPase and proline rich domain-containing protein. Transferrin endocytosis was significantly reduced in cells by kn...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen L,Wang ZW,Zhu JW,Zhan X

更新日期：2006-02-01 00:00:00

abstract：:MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu H,Li S,Liu J,Ni B

更新日期：2012-05-01 00:00:00

abstract：:T helper cell type 1 (Th1) and 2 (Th2) play central roles in immune regulation. To identify the novel genes differentially expressed between Th1 and Th2 cells, CD4+ T cells were isolated from DO11.10 transgenic mice and induced under Th1 or Th2 conditions. Microarray showed differential expression of neutrophilic gran...

journal_title：Acta biochimica et biophysica Sinica

authors： Xie D,Liu Z,Li Z,Ji Y,Chen J,Sun B

更新日期：2007-01-01 00:00:00

abstract：:Luffin-a, a single-chain Type I ribosome-inactivating protein, which is known to be the most toxic of the luffin family and apparently possesses antitumor activity, was isolated from Luffa cylindrica seeds. In the present study, mature alpha-luffin was cloned from L. cylindrica and it was found that mature alpha-luffi...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Wang R,He W,He F,Huang G

更新日期：2010-08-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis. In this study, we explored the expression patterns of Snail1 and a cardiac fibrosis marker-...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Du J,Zhang J,Weng M,Li X,Pu D,Gao L,Deng S,Xia S,She Q

更新日期：2012-11-01 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) is fatal and there is currently no effective clinical treatment. The antibiotic doxycycline has shown anti-cancer effect in several kinds of solid tumors including prostate cancer. In this study, a combination of doxycycline and doxorubicin was used to investigate the synerg...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu C,Yan X,Yu A,Wang Y

更新日期：2017-11-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DPPIV), which belongs to the prolyl oligopeptidase family of serine proteases, is known to have a variety of regulatory biological functions and has been shown to be implicated in type 2 diabetes. It is therefore important to develop selective human DPPIV (hDPPIV) inhibitors. In this study, we...

journal_title：Acta biochimica et biophysica Sinica

authors： Hiramatsu H,Kyono K,Yamamoto A,Saeki K,Shima H,Sugiyama S,Inaka K,Shimizu R

更新日期：2007-05-01 00:00:00

abstract：:The ability to self-renew is one of the most important properties of embryonic stem (ES) cells. Pluripotin (SC1), a small molecule with high activity and low toxicity, promotes self-renewal in mouse ES cells. SC1 can noticeably change the morphology of retinoic acid (RA)-induced F9 embryonic carcinoma cells (F9 cells)...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Ren X,Ke J,Zhang Y,Wei Q,Shi Z,Ai Z,Guo Z

更新日期：2018-08-01 00:00:00

abstract：:Tuberculosis remains a major global health problem and effective vaccines are urgently needed. In this study, we used the combined DNA- and protein-based vaccines of immunodominant antigen Rv0577 to boost BCG and evaluated their immunogenicity in BALB/c mice. Our data suggest that the booster vaccine may substantially...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu D,Chen W,Mi Y,Gong X,Luo T,Bao L

更新日期：2016-04-01 00:00:00

abstract：:Sequence analysis of oxazolomycin (OZM) biosynthetic gene cluster from Streptomyces albus JA3453 revealed a gene, ozmH, encoding a hybrid polyketide and non-ribosomal peptide enzyme. Tandem ketosynthase (KS) domains (KS 10-1 and KS 10-2) were characterized and they show significant homology with known KSs. Using an al...

journal_title：Acta biochimica et biophysica Sinica

authors： Song D,Coughlin J,Ju J,Zhou X,Shen B,Zhao C,Deng Z

更新日期：2008-04-01 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang H,Dong F,Wang Y,Wang X,Hong D,Liu Y,Zhou J

更新日期：2020-02-03 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cell lines, suggesting its great potential in cancer therapy. Many components in TRAIL-mediated signaling pathway have been identified, but how they interact with each other to determine the network dynamics and final apoptosis remain...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang T,Wu M,Chen Q,Sun Z

更新日期：2010-02-01 00:00:00

abstract：:Neuron restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-induced or kindling-evoked seizure activity. However, whether NRSF functions in pentylenetetrazol (PTZ)-i...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu M,Sheng Z,Cai L,Zhao K,Tian Y,Fei J

更新日期：2012-06-01 00:00:00