Role of peroxisome proliferator-activated receptor gamma in glucose-induced insulin secretion.

abstract：:To investigate whether apelin-13 induced THP-1 monocytes (MCs) adhesion to ECV304 human umbilical vein endothelial cells (HUVECs) via 14-3-3 signaling transduction pathway and the potential novel physiological function and signaling transduction pathway of apelin-APJ, HUVECs ECV304 were cultured in DMEM and MCs THP-1 ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Zhang X,Li F,Chen L,Li L,Qin X,Gao J,Su T,Zeng Y,Liao D

更新日期：2010-06-15 00:00:00

abstract：:G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are distributed in many locations in the human genome, including promoter regions, and are viewed as promising therapeutic targets. Uncoupling protein-1 (UCP1) is a mitochondrial thermogenic gene critical f...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao Y,Uhler JP

更新日期：2018-07-01 00:00:00

abstract：:The present study aims to characterize the effect of chronic intermittent hypoxia and HIF1α on the non-alcoholic steatohepatitis (NASH) process in mice, and to explore the role of the Treg/Th17 balance in the formation of NASH inflammation and fibrosis. To achieve this purpose, simple steatosis was induced in mice by ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Li W,Zhu W,He W,Zhao H,Xiang Y,Liu C,Wu W

更新日期：2018-12-01 00:00:00

abstract：:It has been reported that over-expression of GRP75 can protect cells under different types of stress. In this study, we investigated the protective effect of GRP75 on the liver both in vivo and in vitro. To evaluate the effect of GRP75 over-expression on oxidative damage in the liver in vitro, cell viability and the m...

journal_title：Acta biochimica et biophysica Sinica

authors： E Q,Liu X,Liu Y,Liu W,Zuo J

更新日期：2013-02-01 00:00:00

abstract：:Defective DNA damage response is a threat to genome stability and a proven cause of tumorigenesis. C21ORF2 (chromosome 21 open reading frame 2) is a novel gene on chromosome 21, and the C21ORF2 protein is found to interact with NEK1. Earlier studies showed that C21ORF2 might be associated with some human genetic disea...

journal_title：Acta biochimica et biophysica Sinica

authors： Fang X,Lin H,Wang X,Zuo Q,Qin J,Zhang P

更新日期：2015-10-01 00:00:00

abstract：:Cotton fiber developmental transition from elongation to secondary cell wall biosynthesis is a critical growth shifting phase that affects fiber final length, strength, and other properties. Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotto...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou X,Hu W,Li B,Yang Y,Zhang Y,Thow K,Fan L,Qu Y

更新日期：2019-11-18 00:00:00

abstract：:Dipeptidyl peptidase IV (DPPIV), which belongs to the prolyl oligopeptidase family of serine proteases, is known to have a variety of regulatory biological functions and has been shown to be implicated in type 2 diabetes. It is therefore important to develop selective human DPPIV (hDPPIV) inhibitors. In this study, we...

journal_title：Acta biochimica et biophysica Sinica

authors： Hiramatsu H,Kyono K,Yamamoto A,Saeki K,Shima H,Sugiyama S,Inaka K,Shimizu R

更新日期：2007-05-01 00:00:00

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:Rabies virus (RV) causes a fatal disease in both human and animals. The disease can be prevented by post-exposure prophylaxis in individuals exposed to RV. However, the neutralization effect is limited after the virus enters into the host cells. So, it is important to identify new targets for rabies therapy. In this s...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Sun L,Yu P,Li A,Li C,Tang Q,Li D,Liang M

更新日期：2015-10-01 00:00:00

abstract：:Galectin-3 (Gal-3) which shows affinity of β-galactosides is a cancer-related protein. Thus, it is important to understand its ligand binding mechanism and then design its specific inhibitor. It was suggested that the positions of water molecules in Gal-3 ligand-binding site could be replaced by appropriate chemical g...

journal_title：Acta biochimica et biophysica Sinica

authors： Su J,Zhang T,Wang P,Liu F,Tai G,Zhou Y

更新日期：2015-03-01 00:00:00

abstract：:LRRC4 is a novel relatively specific gene, which displays significant down-regulation in primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this study, we investigated the growth inhibitory effect of LRRC4 on tumorigencity in vivo and on cell proliferation in vitro by a tetracycline-...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang QH,Wang LL,Cao L,Peng C,Li XL,Tang K,Li WF,Liao P,Wang JR,Li GY

更新日期：2005-08-01 00:00:00

abstract：:Ghrelin is a brain-gut peptide that serves as a natural ligand for growth hormone secretagogue receptor (GHSR). It also exists abundantly in the cardiovascular system. In order to evaluate the possible role of ghrelin in the development of atherosclerosis, the effect of ghrelin on the expression of cell differentiatio...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang M,Yuan F,Chen H,Qiu X,Fang W

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to investigate the pro-apoptotic mechanism of C-phycocyanin (C-PC)-mediated photodynamic therapy (PDT) in a murine tumor model and cultured MCF-7 cells. The mice were divided into four groups: control, He-Ne laser radiation, C-PC treatment, and C-PC treatment + He-Ne laser radiation. The effe...

journal_title：Acta biochimica et biophysica Sinica

authors： Li B,Chu X,Gao M,Li W

更新日期：2010-01-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is a Gram-positive pathogen which causes tuberculosis in both animals and humans. All tested rH-NS formulations induced a specific Th1 response, as indicated by increased production of interferon γ (IFN-γ) and interleukin 2 (IL-2) by lymphocytes in the spleen of mice which were immuniz...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Chen S,Pan B,Guan Z,Yang Z,Duan L,Cai H

更新日期：2016-10-01 00:00:00

abstract：:Genomic walking is one of the most useful approaches in genome-related research. Three kinds of PCR-based methods are available for this purpose. However, none of them has been generally applied because they are either insensitive or inefficient. Here we present an efficient PCR protocol, an optimized adaptor PCR meth...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu P,Hu RY,Ding XY

更新日期：2006-08-01 00:00:00

abstract：:Cumulative work on glucocorticoid (GC) regulation of genes in lymphoid cell cultures has revealed that apoptotic sensitivity to GCs depends on sufficient active GC receptors in the cells. The actions of the ligand-driven GC receptor that lead to apoptosis depend on interactions with other major cell-signaling systems,...

journal_title：Acta biochimica et biophysica Sinica

authors： Thompson EB

更新日期：2008-07-01 00:00:00

abstract：:Hypoxia is a key component of the tumor microenvironment and represents a well-documented source of therapeutic failure in clinical oncology. Recent work has provided support for the idea that non-coding RNAs, and in particular, microRNAs, may play important roles in the adaptive response to low oxygen in tumors. Spec...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang X,Zuo J

更新日期：2014-03-01 00:00:00

abstract：:Dengue infection is a major cause of morbidity in tropical and subtropical regions, bringing nearly 40% of the world population at risk and causing more than 20,000 deaths per year. But there is neither a vaccine for dengue disease nor antiviral drugs to treat the infection. In recent years, dengue infection has been ...

journal_title：Acta biochimica et biophysica Sinica

authors： Qi RF,Zhang L,Chi CW

更新日期：2008-02-01 00:00:00

abstract：:Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are well known as tumor suppressors that are closely related to tumor occurrence and progression. It was reported that ING4 and PTEN showed synergistic antitumor activities in nasopharyngeal carcinoma cells. The two tu...

journal_title：Acta biochimica et biophysica Sinica

authors： Rakshit N,Yang S,Zhou W,Xu Y,Deng C,Yang J,Yu H,Wei W

更新日期：2016-08-01 00:00:00

abstract：:At initial stages in the Rhizobium legume symbiosis, most nodulation genes are controlled by NodD protein and plant inducers. Some genetic studies and other reports have suggested that NodD may be activated by its direct interaction with plant inducers. However, there has been no molecular evidence of such an inducing...

journal_title：Acta biochimica et biophysica Sinica

authors： Li F,Hou B,Chen L,Yao Z,Hong G

更新日期：2008-09-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is indispensable for the development and maintenance of brown adipose tissue (BAT), and its activity is inhibited due to obesity. The isocitrate dehydrogenase 2 (IDH2) is a mitochondrial enzyme responsible for the production of α-ketoglutarate, a key intermediate metabolite integrat...

journal_title：Acta biochimica et biophysica Sinica

authors： Cao Y,Liu X,Zhao J,Du M

更新日期：2021-01-12 00:00:00

abstract：:Carbon monoxide (CO) is often viewed as a lethal gas in light of its capacity to prevent oxygen uptake in hemoglobin; however, it also functions to regulate a variety of proteins and physiological processes. Here we show that CO is an important chemical cue, to which neurons respond strongly, and this response is then...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Liu B,Zhang Q,Wu X,Yu Y,Jesse FF,Li L

更新日期：2015-05-01 00:00:00

abstract：:Mediator complex subunit 1 (Med1)/Thyroid hormone receptor-associated protein 220 (TRAP220), an essential component of thyroid hormone receptor-associated proteins (TRAP)/mediator, plays important roles in hormone responses and tumorigenesis. However, the role of Med1 in the DNA damage response has not been studied. I...

journal_title：Acta biochimica et biophysica Sinica

authors： Kim HJ,Yun J

更新日期：2017-06-01 00:00:00

abstract：:Receptor of human interleukin 4 (hIL4R) has been found to be present on many types of cancer, so it may be a good target for cancer therapy. Here, fusion toxin gene DT4H has been constructed by fusing DNA sequence encoding the first 389 amino acids of diphtherial toxin (DT), which can not bind its own receptor, to hum...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang YJ,Hu XB,Li SX,Tian LP,Yang SL,Gong Y

更新日期：2004-06-01 00:00:00

abstract：:Erythrocyte senescence is characterized by exposure of cell surface epitopes on cell membrane proteins leading to immune mediated removal of red blood cells. One mechanism for antigen formation is tyrosine phosphorylation (Tyr-P) of the transmembrane protein band 3 by Syk kinase. Our aim was to test the hypothesis tha...

journal_title：Acta biochimica et biophysica Sinica

authors： Bordin L,Fiore C,Bragadin M,Brunati AM,Clari G

更新日期：2009-10-01 00:00:00

abstract：:Hyperglycemia, a diagnostic characteristic of diabetes mellitus, is detrimental to pancreatic β cells. Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a prot...

journal_title：Acta biochimica et biophysica Sinica

authors： Lai D,Huang M,Zhao L,Tian Y,Li Y,Liu D,Wu Y,Deng F

更新日期：2019-12-13 00:00:00

abstract：:Raman spectroscopy was used for the first time to detect the effect of independent UVA (ultraviolet-A: 320-400 nm) and UVB (ultraviolet-B: 280-320 nm) irradiation on the calf thymus DNA in aqueous solution. After both UVA and UVB irradiation for 1 h or 3 h, the damage to the conformation of DNA was moderate, but the r...

journal_title：Acta biochimica et biophysica Sinica

authors： Tang YL,Guo ZY

更新日期：2005-01-01 00:00:00

abstract：:Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. This study ai...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Hu J,Yu T,You S,Zhang Y,Hu L

更新日期：2019-05-23 00:00:00

abstract：:Mercaptopropionic acid (MPA) and cysteamine (Cys) capped CdTe quantum dots (QDs) were successfully prepared and used to investigate the combined influence of surface modification, size distribution, and interaction time on their cytotoxicity in human pancreatic carcinoma (PANC-1) cells. Results indicated that the smal...

journal_title：Acta biochimica et biophysica Sinica

authors： Chang S,Kang B,Liu X,Dai Y,Chen D

更新日期：2012-03-01 00:00:00

abstract：:Edaravone is a novel free radical scavenger that exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Recently, it was reported that edaravone could alleviate the pathology and cognitive deficits of Alzheimer's disease patients. However, its relevance t...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Lu F,Li W,Qin L,Yao Y,Ge X,Yu Q,Liang X,Zhao D,Li X,Zhang J

更新日期：2017-01-01 00:00:00