Stepping stones in the path of glucocorticoid-driven apoptosis of lymphoid cells.

abstract：:Osteosarcoma is the most common primary malignant bone tumor, which occurs in adolescents. As reported by our previous studies, HER4 indicates a poor prognosis of primary osteosarcoma. However, its mechanisms in the pathogenesis of osteosarcoma have not yet been studied. The purpose of this study was to investigate th...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Huang Q,Wang S,Huang Z,Yu F,Lin J

更新日期：2020-04-20 00:00:00

abstract：:Several discriminate functions for predicting core promoters that based on the potential cooperation between transcription factor binding sites (TFBSs) are discussed. It is demonstrated that the promoter predicting accuracy is improved when the cooperation among TFBSs is taken into consideration. The core promoter reg...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma XT,Qian MP,Tang HX

更新日期：2004-04-01 00:00:00

abstract：:HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. The expressions of HEATR1 in GC tissues were analyzed using The ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao J,Zhu Y,Fu Q,Zhu Y,Zhao G

更新日期：2020-09-08 00:00:00

abstract：:Adiponectin, an adipokine synthesized and secreted majorly by adipose tissue, is reported to exert cardioprotective properties via anti-inflammation and antiapoptosis. Lipopolysaccharide (LPS) is a common inflammation and apoptosis inducer of cardiomyocytes. However, few studies have reported the roles of adiponectin ...

journal_title：Acta biochimica et biophysica Sinica

authors： Hao R,Su G,Sun X,Kong X,Zhu C,Su G

更新日期：2019-02-01 00:00:00

abstract：:Proteomic techniques are promising strategies in the surveillance of hepatocellular carcinoma (HCC). This study aimed to investigate the serum profiling with magnetic bead (MB) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and to further identify the biomarkers for H...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu T,Xue R,Huang X,Zhang D,Dong L,Wu H,Shen X

更新日期：2011-07-01 00:00:00

abstract：:It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA) exert different effects on the biological function of the vascular endothelial cell (EC), resulting in altered regulation of angiogenesis. However, the specific mechanism is still unclear. Our study focused on the effects of nHA ...

journal_title：Acta biochimica et biophysica Sinica

authors： Mo W,Yang C,Liu Y,He Y,Wang Y,Gao F

更新日期：2011-12-01 00:00:00

abstract：:Several studies have shown that combination treatment with natural products and chemotherapy agents can improve the sensitivity and cytotoxicity of chemotherapy agents. Resveratrol, a natural product, has many biological effects including antitumor and antiviral activities, as well as vascular protective effect. The a...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu S,Li X,Xu R,Ye L,Kong H,Zeng X,Wang H,Xie W

更新日期：2016-06-01 00:00:00

abstract：:Emerging evidence suggests that specific spatio-temporal microRNA (miRNA) expression is required for heart development. In recent years, hundreds of miRNAs have been discovered. In contrast, functional annotations are available only for a very small fraction of these regulatory molecules. In order to provide a global ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu G,Ding M,Chen J,Huang J,Wang H,Jing Q,Shen B

更新日期：2010-09-01 00:00:00

abstract：:Gliomas are the most common brain tumors of the central nervous system. In this study, we investigated the molecular mechanisms and biological function of SIRT6 in human gliomas. The expression levels of SIRT6 in glioma tissues and cells were analyzed by qRT-PCR and western blot analysis. CCK8 and clonogenicity assays...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen X,Li D,Gao Y,Cao Y,Hao B

更新日期：2018-04-01 00:00:00

abstract：:The major goal of researchers and oncologists is to develop promising ground for novel therapeutic strategies to prevent recurrence or relapse of cancer. Recent evidences suggest that a subset of cells called cancer stem cells (CSCs) are present within the tumor mass which possess tumorigenic capacity and may be respo...

journal_title：Acta biochimica et biophysica Sinica

authors： Bhattacharyya S,Khanduja KL

更新日期：2010-04-01 00:00:00

abstract：:Genomic walking is one of the most useful approaches in genome-related research. Three kinds of PCR-based methods are available for this purpose. However, none of them has been generally applied because they are either insensitive or inefficient. Here we present an efficient PCR protocol, an optimized adaptor PCR meth...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu P,Hu RY,Ding XY

更新日期：2006-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) function as negative regulators of gene expression involved in cancer metastasis. The aim of this study is to investigate the potential roles of miR-218 in non-small cell lung cancer and validate its regulation mechanism. Functional studies showed that miR-218 overexpression inhibited cell migration...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang C,Ge S,Hu C,Yang N,Zhang J

更新日期：2013-12-01 00:00:00

abstract：:Recent studies have demonstrated that the expression of the long non-coding RNA (lncRNA) AFAP1-AS1 in pancreatic cancer is negatively correlated with survival and prognosis. However, the effects of oridonin and lncRNA AFAP1-AS1 on the epithelial-to-mesenchymal transition (EMT) and migration of pancreatic cancer cells ...

journal_title：Acta biochimica et biophysica Sinica

authors： Lou S,Xu J,Wang B,Li S,Ren J,Hu Z,Xu B,Luo F

更新日期：2019-08-05 00:00:00

abstract：:Human glioma is the most common primary brain tumor and is associated with high morbidity and mortality. Aberrant expressions of microRNAs (miRNAs) are involved in glioma progression. In the present study, we aimed to elucidate the roles of miR-4530 in the pathogenesis of gliomas. miR-4530 expression was examined in h...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang T,Zhang Y,Cui B,Wang M,Li Y,Gao K

更新日期：2020-12-29 00:00:00

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120) binds to cell surface receptors and mediates HIV entry. Previous studies suggest the cell surface protein disulfide isomerase (PDI) might interact with disulfide bond(s) of gp120 and thus facilitate HIV-1 entry. In the present study, a kineti...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Zhou Z,Guo ZY,Chi CW

更新日期：2010-05-15 00:00:00

abstract：:Here we report that tgdA, a novel gene encoding a putative transglycosylase, affects both the morphological differentiation and the yield of blue-pigmented compound actinorhodin in Streptomyces coelicolor. The tgdA null mutant displays sparse aerial hyphae and irregular spore chains frequently lacking chromosomal DNA....

journal_title：Acta biochimica et biophysica Sinica

authors： Xie P,Zeng A,Lv X,Cheng Q,Qin Z

更新日期：2013-04-01 00:00:00

abstract：:Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are well known as tumor suppressors that are closely related to tumor occurrence and progression. It was reported that ING4 and PTEN showed synergistic antitumor activities in nasopharyngeal carcinoma cells. The two tu...

journal_title：Acta biochimica et biophysica Sinica

authors： Rakshit N,Yang S,Zhou W,Xu Y,Deng C,Yang J,Yu H,Wei W

更新日期：2016-08-01 00:00:00

abstract：:Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role of RhoA in the mechanisms underlying growth, migration, and invasion of squamous cell carcinoma of tongue (TSCC). Stable RhoA knockdown of TSCC cell lines SCC-4 and CAL2...

journal_title：Acta biochimica et biophysica Sinica

authors： Yan G,Zou R,Chen Z,Fan B,Wang Z,Wang Y,Yin X,Zhang D,Tong L,Yang F,Jiang W,Fu W,Zheng J,Bergo MO,Dalin M,Zheng J,Chen S,Zhou J

更新日期：2014-08-01 00:00:00

abstract：:Although Ca(V)1.3 channels are known to be essential for neuronal excitation and signal transduction in the auditory system, their expression patterns in the cochlea are still not fully understood, particularly in the regions where non-sensory cells are located. We performed immunohistochemistry, western blotting and ...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen J,Chu H,Xiong H,Chen Q,Zhou L,Bing D,Liu Y,Gao Y,Wang S,Huang X,Cui Y

更新日期：2012-06-01 00:00:00

abstract：:The Hippo pathway was initially identified in Drosophila by genetic mosaic screens for tumor suppressor genes. Researches indicated that the Hippo pathway is a key regulator of organ size and is conserved during evolution. Furthermore, studies of mouse models and clinical samples demonstrated the importance of Hippo p...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu C,Li L,Zhao B

更新日期：2015-01-01 00:00:00

abstract：:Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that the transfection of hepatitis C virus core (HCVc) protein led to malignant transformation in normal biliary cells, and that tumor suppressor gene RASSF1A was downregulated in m...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo N,Chen R,Li Z,Liu Y,Cheng D,Zhou Q,Zhou J,Lin Q

更新日期：2011-05-01 00:00:00

abstract：:The recombinant peptide, DBAYL, a promising therapeutic peptide for type 2 diabetes, is a new, potent, and highly selective agonist for VPAC2 generated through site-directed mutagenesis based on sequence alignments of pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal peptide (VIP), and rela...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma Y,Luo T,Xu W,Ye Z,Hong A

更新日期：2012-11-01 00:00:00

abstract：:A gene encoding a special thermophilic multifunctional amylase OPMA-N was cloned from Bacillus sp. ZW2531-1. OPMA-N has an additional 124-residue N-terminal domain compared with typical amylases and forms a relatively independent domain with a β-pleated sheet and random coil structure. Here we reported an unusual subs...

journal_title：Acta biochimica et biophysica Sinica

authors： Li F,Zhu X,Li Y,Cao H,Zhang Y

更新日期：2011-04-01 00:00:00

abstract：:The low-molecular-weight protein tyrosine phosphatases (PTPase) exist ubiquitously in prokaryotes and eukaryotes and play important roles in the regulation of physiological activities. We report here the expression, purification and characterization of an active and soluble PTPase from Thermus thermophilus HB27 in Esc...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Y,Meng F,Zhang Y

更新日期：2009-08-01 00:00:00

abstract：:Many N-methyl-d-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmitter system makes the glutamic acid receptor blockers inefficient and unsafe. Thus, regulating the downstre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tian Y,He Y,Song W,Zhang E,Xia X

更新日期：2017-09-01 00:00:00

abstract：:Many harpins have been found in plant pathogen bacteria that can elicit disease and insect resistance in plants, and promote plant growth. In this work, we overexpressed and purified Xanthomonas oryzae pv. oryzae harpin, harpin(Xoo), in Escherichia coli BL21/pGEX-hpa1. Harpin(Xoo) was fused to the C-terminus of glutat...

journal_title：Acta biochimica et biophysica Sinica

authors： Li M,Shao M,Lu XZ,Wang JS

更新日期：2005-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell apoptosis. Zinc finger E-box binding homeobox factor 1 (ZEB1) is a crucial mediator of epithelial-mesenchymal transition (EMT). It induces mali...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao L,Li R,Xu S,Li Y,Zhao P,Dong W,Liu Z,Zhao Q,Tan B

更新日期：2018-02-01 00:00:00

abstract：:In the present study, we tested the effect of cold water stress (CWS) on dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model, and found that CWS pretreatment elicited less MPTP neurotoxicity. To understand the molecular mechanism underlying this phen...

journal_title：Acta biochimica et biophysica Sinica

authors： Xia M,Bian M,Yu Q,Liu J,Huang Y,Jin X,Lu S,Yu M,Huang F

更新日期：2011-06-01 00:00:00

abstract：:Hyperglycemia, a diagnostic characteristic of diabetes mellitus, is detrimental to pancreatic β cells. Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a prot...

journal_title：Acta biochimica et biophysica Sinica

authors： Lai D,Huang M,Zhao L,Tian Y,Li Y,Liu D,Wu Y,Deng F

更新日期：2019-12-13 00:00:00