Abstract:
:Here we report that tgdA, a novel gene encoding a putative transglycosylase, affects both the morphological differentiation and the yield of blue-pigmented compound actinorhodin in Streptomyces coelicolor. The tgdA null mutant displays sparse aerial hyphae and irregular spore chains frequently lacking chromosomal DNA. Elevated actinorhodin production coincides with the overexpression of actII-orf4 in mutant. tgdA expression is temporally and developmentally regulated. The tgdA orthologs in Streptomyces avermilitis and Streptomyces lividans also affect differentiation.
journal_name
Acta Biochim Biophys Sin (Shanghai)journal_title
Acta biochimica et biophysica Sinicaauthors
Xie P,Zeng A,Lv X,Cheng Q,Qin Zdoi
10.1093/abbs/gmt012subject
Has Abstractpub_date
2013-04-01 00:00:00pages
296-302issue
4eissn
1672-9145issn
1745-7270pii
gmt012journal_volume
45pub_type
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