Epitope mapping and identification on a 3D model built for the tartary buckwheat allergic protein TBb.

abstract：:N6-methyladenosine (m6A), a methylation in the N6 position of adenosine especially in the mRNA, exerts diverse physiological and pathological functions. However, the precise role of m6A methylation in hypoxic preconditioning (HPC) is still unknown. Here, we observed that HPC treatment protected H9c2 cells against H2O2...

journal_title：Acta biochimica et biophysica Sinica

authors： Su Y,Xu R,Zhang R,Qu Y,Zuo W,Ji Z,Geng H,Pan M,Ma G

更新日期：2020-12-29 00:00:00

abstract：:Prion diseases are a group of transmissible fatal neurodegenerative disorders of humans and animals, including bovine spongiform encephalopathy, scrapie, and Creutzfeldt-Jakob disease. Microglia, the resident macrophages of the central nervous system, are exquisitely sensitive to pathological tissue alterations, alter...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang S,Yang L,Kouadir M,Tan R,Lu Y,Chang J,Xu B,Yin X,Zhou X,Zhao D

更新日期：2013-09-01 00:00:00

abstract：:Constitutively activated signal transducer and activator of transcription 3 (STAT3) plays an important role in the formation of many tumors including ovarian cancer. In this study, RNA interference specific to STAT3 was employed to study its effects on the inhibition of STAT3 signaling and on the growth of ovarian can...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang F,Tong X,Fu L,Zhang R

更新日期：2008-06-01 00:00:00

abstract：:Defective DNA damage response is a threat to genome stability and a proven cause of tumorigenesis. C21ORF2 (chromosome 21 open reading frame 2) is a novel gene on chromosome 21, and the C21ORF2 protein is found to interact with NEK1. Earlier studies showed that C21ORF2 might be associated with some human genetic disea...

journal_title：Acta biochimica et biophysica Sinica

authors： Fang X,Lin H,Wang X,Zuo Q,Qin J,Zhang P

更新日期：2015-10-01 00:00:00

abstract：:Cortactin, an actin-binding protein and a substrate of Src, is encoded by the EMS1 oncogene. Cortactin is known to activate Arp2/3 complex-mediated actin polymerization and interact with dynamin, a large GTPase and proline rich domain-containing protein. Transferrin endocytosis was significantly reduced in cells by kn...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen L,Wang ZW,Zhu JW,Zhan X

更新日期：2006-02-01 00:00:00

abstract：:Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang M,Wang C,Lu B

更新日期：2019-02-01 00:00:00

abstract：:Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not b...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen S,Wu Z,Ke Y,Shu P,Chen C,Lin R,Shi Q

更新日期：2019-11-18 00:00:00

abstract：:The destruction of proteins via the ubiquitin-proteasome system is a multi-step, complex process involving polyubiquitination of substrate proteins, followed by proteolytic degradation by the macromolecular 26S proteasome complex. Inhibitors of the proteasome promote the accumulation of proteins that are deleterious t...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu H,Wang T,Xin Z,Zhan Y,Gu G,Li X,Wang X,Yang S,Liu C

更新日期：2019-09-06 00:00:00

abstract：:The aim of this study was to establish and apply a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) for rubella virus (RV) RNA. First, the primer and TaqMan probe concentrations, as well as reaction temperatures were optimized to establish an efficient real-time quantitative RT-PCR assay...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao LH,Ma YY,Wang H,Zhao SP,Zhao WM,Li H,Wang LY

更新日期：2006-10-01 00:00:00

abstract：:Proteomic techniques are promising strategies in the surveillance of hepatocellular carcinoma (HCC). This study aimed to investigate the serum profiling with magnetic bead (MB) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and to further identify the biomarkers for H...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu T,Xue R,Huang X,Zhang D,Dong L,Wu H,Shen X

更新日期：2011-07-01 00:00:00

abstract：:It is important to determine the electron transfer activity and proton pumping ability of the cytochrome bc1 complex for better understanding its structure and function. In this study, several methods for determining the electron transfer and proton pumping of the bc1 complex, including the traditional and the new met...

journal_title：Acta biochimica et biophysica Sinica

authors： Qu Y,Dong F

更新日期：2015-02-01 00:00:00

abstract：:Reactive oxygen species (ROS), including H(2)O(2), play a critical role in the pathophysiology of osteoporosis. Therefore, agents or antioxidants that can inhibit ROS production have a high clinical value in the treatment of osteoporosis. Curculigoside (CUR), one of the main bioactive phenolic compounds isolated from ...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Y,Zhao L,Wang Y,Xu J,Nie Y,Guo Y,Tong Y,Qin L,Zhang Q

更新日期：2012-05-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a fascinating target for cancer therapy due to its significant role in the crossroad of multiple signaling pathways associated with cell proliferation and regulation. Hsp90 inhibitors have the potential to be developed into anti-cancer drugs. Here, we identified nicotinic-mycoepoxydien...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Xiao S,Chen J,Wang M,Zheng Z,Song S,Zhang L

更新日期：2015-06-01 00:00:00

abstract：:Metformin, a first line medication for type II diabetes, initially entered the spotlight as a promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk and improved clinical outcomes in diabetic patients taking metformin. To uncover the anti-cancer mechanisms of metformin, preclinical stu...

journal_title：Acta biochimica et biophysica Sinica

authors： Saini N,Yang X

更新日期：2018-02-01 00:00:00

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:Genomic walking is one of the most useful approaches in genome-related research. Three kinds of PCR-based methods are available for this purpose. However, none of them has been generally applied because they are either insensitive or inefficient. Here we present an efficient PCR protocol, an optimized adaptor PCR meth...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu P,Hu RY,Ding XY

更新日期：2006-08-01 00:00:00

abstract：:Necroptosis is a type of regulated cell death that has been implicated in various diseases. Receptor-interacting protein 3 (RIP3), a member of the RIP family, is an important mediator of the necroptotic pathway. Cleavage of RIP3 at Asp328 by caspase-8 abolishes the kinase activity of RIP3, which is critical for necrop...

journal_title：Acta biochimica et biophysica Sinica

authors： Shang L,Ding W,Li N,Liao L,Chen D,Huang J,Xiong K

更新日期：2017-02-06 00:00:00

abstract：:T helper cell type 1 (Th1) and 2 (Th2) play central roles in immune regulation. To identify the novel genes differentially expressed between Th1 and Th2 cells, CD4+ T cells were isolated from DO11.10 transgenic mice and induced under Th1 or Th2 conditions. Microarray showed differential expression of neutrophilic gran...

journal_title：Acta biochimica et biophysica Sinica

authors： Xie D,Liu Z,Li Z,Ji Y,Chen J,Sun B

更新日期：2007-01-01 00:00:00

abstract：:Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the kil...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang HF,Chen YZ,Wu Y

更新日期：2005-07-01 00:00:00

abstract：:The diamagnetic levitation as a novel ground-based model for simulating a reduced gravity environment has been widely applied in many fields. In this study, a special designed superconducting magnet, which can produce three apparent gravity levels (0, 1, and 2 g), namely high magneto-gravitational environment (HMGE), ...

journal_title：Acta biochimica et biophysica Sinica

authors： Qian A,Di S,Gao X,Zhang W,Tian Z,Li J,Hu L,Yang P,Yin D,Shang P

更新日期：2009-07-01 00:00:00

abstract：:Two full-length cDNAs, named CaM1a and CaM1b, encoding the highly conserved calmodulin1 (CaM1) proteins, were isolated from the cDNA library of amphioxus Branchiostoma belcheri tsingtauense. There are only two nucleotide differences between them, producing one amino acid difference between CaM1a and CaM1b. Comparison ...

journal_title：Acta biochimica et biophysica Sinica

authors： Luan J,Liu Z,Zhang S,Li H,Fan C,Li L

更新日期：2007-04-01 00:00:00

abstract：:Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. This study ai...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Hu J,Yu T,You S,Zhang Y,Hu L

更新日期：2019-05-23 00:00:00

abstract：:Ischemia/reperfusion injury (IRI) is a major cause of acute kidney damage, which often occurs in deceased donor kidney transplants. Cathelicidin PR-39 peptide possesses anti-inflammatory and wound repair effects through tissue angiogenesis and anti-apoptosis. This study assessed the role of PR-39 in anti-apoptosis in ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Xue W,Xiang H,Zheng J,Zhao Y,Jiao L,Jiao Z

更新日期：2016-08-01 00:00:00

abstract：:Thyroid cancer is one of the common malignancies of the endocrine system and the number of thyroid cancer cases is increasing constantly. Significant work has focused on the molecular mechanisms of thyroid cancer, but many mechanisms remain undiscovered. In this study, we employed a comprehensive analysis of whole-tra...

journal_title：Acta biochimica et biophysica Sinica

authors： Guan Y,Bhandari A,Xia E,Kong L,Zhang X,Wang O

更新日期：2020-02-03 00:00:00

abstract：:Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activation by the agonists. ...

journal_title：Acta biochimica et biophysica Sinica

authors： Drastichova Z,Novotny J

更新日期：2012-08-01 00:00:00

abstract：:To test the hypothesis that hypoxia inducible factor-1 alpha (HIF-1alpha) up-regulated the expression of heme oxygenase-1 (HO-1) gene in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension, 8 male Wistar rats in each of 5 groups were exposed to hypoxia for 0, 3, 7, 14 or 21 d, respectively. Mean pul...

journal_title：Acta biochimica et biophysica Sinica

authors： Li QF,Dai AG

更新日期：2004-02-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is a Gram-positive pathogen which causes tuberculosis in both animals and humans. All tested rH-NS formulations induced a specific Th1 response, as indicated by increased production of interferon γ (IFN-γ) and interleukin 2 (IL-2) by lymphocytes in the spleen of mice which were immuniz...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Chen S,Pan B,Guan Z,Yang Z,Duan L,Cai H

更新日期：2016-10-01 00:00:00

abstract：:Inter-species nuclear transfer could be used to preserve North Goat (Capra ibex), an endangered species. We established the culture conditions for ibex-hirus reconstructed embryos and optimized the method for DNA extractions of a single cell and early cloned embryo. By using mitochondria-specific probes of ibex and hi...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Y,Liu SZ,Zhang YL,Jiang MX,Sun QY,Chen DY

更新日期：2004-05-01 00:00:00

abstract：:Abnormal development of central nervous system (CNS) caused by neural tube defects is not only a major contributor in the prevalence of stillbirths and neonatal deaths but also causes lifelong physical disability in surviving infants. Due to insufficient known investigated causes, CNS developmental abnormality has bro...

journal_title：Acta biochimica et biophysica Sinica

authors： Jia S,Zhang L,Zhang K,Wang L,Khan A,Zhang J,Sun Y,Wang Y,Song M,Lyu Y,Li M,Lu X,Niu B,Liu Z,Xie J

更新日期：2020-06-20 00:00:00

abstract：:MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleo...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang B,Qin W,Zhao B,Shi Y,Yao C,Li J,Xiao H,Jin Y

更新日期：2009-06-01 00:00:00