Heat shock protein 90 mediates the apoptosis and autophage in nicotinic-mycoepoxydiene-treated HeLa cells.

abstract：:Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role of RhoA in the mechanisms underlying growth, migration, and invasion of squamous cell carcinoma of tongue (TSCC). Stable RhoA knockdown of TSCC cell lines SCC-4 and CAL2...

journal_title：Acta biochimica et biophysica Sinica

authors： Yan G,Zou R,Chen Z,Fan B,Wang Z,Wang Y,Yin X,Zhang D,Tong L,Yang F,Jiang W,Fu W,Zheng J,Bergo MO,Dalin M,Zheng J,Chen S,Zhou J

更新日期：2014-08-01 00:00:00

abstract：:Two full-length cDNAs, named CaM1a and CaM1b, encoding the highly conserved calmodulin1 (CaM1) proteins, were isolated from the cDNA library of amphioxus Branchiostoma belcheri tsingtauense. There are only two nucleotide differences between them, producing one amino acid difference between CaM1a and CaM1b. Comparison ...

journal_title：Acta biochimica et biophysica Sinica

authors： Luan J,Liu Z,Zhang S,Li H,Fan C,Li L

更新日期：2007-04-01 00:00:00

abstract：:Erythrocyte senescence is characterized by exposure of cell surface epitopes on cell membrane proteins leading to immune mediated removal of red blood cells. One mechanism for antigen formation is tyrosine phosphorylation (Tyr-P) of the transmembrane protein band 3 by Syk kinase. Our aim was to test the hypothesis tha...

journal_title：Acta biochimica et biophysica Sinica

authors： Bordin L,Fiore C,Bragadin M,Brunati AM,Clari G

更新日期：2009-10-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human malignant diseases and the sixth leading cause of cancer-related deaths in China. Gemcitabine is the only first-line chemotherapeutic agent used for the palliative treatment of patients with PDAC, but chemo-resistance limits their efficacy. Here, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Yao J,Li Z,Wang X,Xu P,Zhao L,Qian J

更新日期：2016-02-01 00:00:00

abstract：:The unique temporal expression pattern of miR-200c in epididymis during post-natal development in juvenile rats was revealed by our home-made miRNA microarray in this paper. It was found that miR-200c expressed in the lowest level at Day 7 and then increased to the highest at Day 36 followed by a dramatic decrease. Th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang J,Ruan K

更新日期：2010-09-01 00:00:00

abstract：:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) play a vital role in viral control and clearance. Recent studies have elucidated that Tapasin, an endoplasmic reticulum chaperone, is a well-known molecule that appears to be essential in peptide-loading process. The Janus kinase/signal transducers and ac...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu S,Chen X,Tang Y,Zhang Y,Li D,Chen J,Wang J,Tang Z,Zang G,Yu Y

更新日期：2018-02-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is a Gram-positive pathogen which causes tuberculosis in both animals and humans. All tested rH-NS formulations induced a specific Th1 response, as indicated by increased production of interferon γ (IFN-γ) and interleukin 2 (IL-2) by lymphocytes in the spleen of mice which were immuniz...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Chen S,Pan B,Guan Z,Yang Z,Duan L,Cai H

更新日期：2016-10-01 00:00:00

abstract：:Proteomic techniques are promising strategies in the surveillance of hepatocellular carcinoma (HCC). This study aimed to investigate the serum profiling with magnetic bead (MB) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) and to further identify the biomarkers for H...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu T,Xue R,Huang X,Zhang D,Dong L,Wu H,Shen X

更新日期：2011-07-01 00:00:00

abstract：:Mediator complex subunit 1 (Med1)/Thyroid hormone receptor-associated protein 220 (TRAP220), an essential component of thyroid hormone receptor-associated proteins (TRAP)/mediator, plays important roles in hormone responses and tumorigenesis. However, the role of Med1 in the DNA damage response has not been studied. I...

journal_title：Acta biochimica et biophysica Sinica

authors： Kim HJ,Yun J

更新日期：2017-06-01 00:00:00

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12), a key enzyme of carbon metabolism, was purified and characterized to homogeneity from skeletal muscle of Camelus dromedarius. The protein was purified approximately 26.8 folds by conventional ammonium sulphate fractionation followed by Blue Sepharose CL-6...

journal_title：Acta biochimica et biophysica Sinica

authors： Fourrat L,Iddar A,Soukri A

更新日期：2007-02-01 00:00:00

abstract：:Canonical meiosis is characterized by two sequential rounds of nuclear divisions following one round of DNA replication-reductional segregation of homologous chromosomes during the first division and equational segregation of sister chromatids during the second division. Meiosis in an inverted order of two nuclear div...

journal_title：Acta biochimica et biophysica Sinica

authors： Li W,He X

更新日期：2020-07-10 00:00:00

abstract：:G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are distributed in many locations in the human genome, including promoter regions, and are viewed as promising therapeutic targets. Uncoupling protein-1 (UCP1) is a mitochondrial thermogenic gene critical f...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao Y,Uhler JP

更新日期：2018-07-01 00:00:00

abstract：:Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC), and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis. In this study, we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC. The results showed that miR-1827 l...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo X,Wang Z,Sun Q,Sun C,Hua H,Huang Q

更新日期：2020-10-19 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal isc...

journal_title：Acta biochimica et biophysica Sinica

authors： Han F,Dou M,Wang Y,Xu C,Li Y,Ding X,Xue W,Zheng J,Tian P,Ding C

更新日期：2020-02-03 00:00:00

abstract：:Nocardia, Rhodococcus and Streptomyces, all members of the actinomycetes family, are Gram-positive eubacteria with high G+C content and able to form mycelium. We report here a newly identified plasmid pXT107 of Nocardia sp. 107, one of the smallest circular plasmids found in Nocardia. The complete nucleotide sequence ...

journal_title：Acta biochimica et biophysica Sinica

authors： Xia HY,Tian YQ,Zhang R,Lin KC,Qin ZJ

更新日期：2006-09-01 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang H,Dong F,Wang Y,Wang X,Hong D,Liu Y,Zhou J

更新日期：2020-02-03 00:00:00

abstract：:Melanoma is the most malignant and aggressive form of skin carcinoma originating in the pigment-producing melanocytes. In this study, to further investigate the molecular mechanisms of the development and progression of melanoma, we explored the impacts of long non-coding RNA (lncRNA) CASC2 on melanoma cell functions....

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang X,Zhou H,Dan X,Jiang L,Wu Y

更新日期：2018-03-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a risk factor for cardiovascular disease and has a strong correlation with heart failure. However, the effects of HHcy on cardiac tissue remain less well understood. To elucidate the role of p53-dependent apoptosis in HHcy-induced cardiac injury, we fed ApoE(-/-) mice with high methionin...

journal_title：Acta biochimica et biophysica Sinica

authors： Ma S,Zhang H,Sun W,Gong H,Wang Y,Ma C,Wang J,Cao C,Yang X,Tian J,Jiang Y

更新日期：2013-05-01 00:00:00

abstract：:CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative prote...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong MQ,Gu Y,Hu XB,Sun Y,Ma L,Li XL,Sun LX,Sun J,Qian J,Zhu CL

更新日期：2005-05-01 00:00:00

abstract：:Mammalian STE20-like kinase 1 (Mst1) is the mammalian homologue of Drosophila Hippo, a major inhibitor of cell proliferation in Drosophila. It ubiquitously encodes serine threonine kinase that belongs to the family of protein kinases related to yeast STE20, and is involved in cell proliferation, apoptosis, oncogenesis...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu C,Liu C,Huang W,Tu S,Wan F

更新日期：2013-04-01 00:00:00

abstract：:Acyl-coenzymeA:cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in intestine and fetal liver of healthy human. Our previous studies have shown that in monocytic cells the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the CCAAT/enhancer binding protein (...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo D,Zhang X,Li Q,Qian L,Xu J,Lu M,Hu X,Zhu M,Chang CC,Song B,Chang T,Xiong Y,Li B

更新日期：2016-11-01 00:00:00

abstract：:Cumulative work on glucocorticoid (GC) regulation of genes in lymphoid cell cultures has revealed that apoptotic sensitivity to GCs depends on sufficient active GC receptors in the cells. The actions of the ligand-driven GC receptor that lead to apoptosis depend on interactions with other major cell-signaling systems,...

journal_title：Acta biochimica et biophysica Sinica

authors： Thompson EB

更新日期：2008-07-01 00:00:00

abstract：:A number of significant studies in the field of cell biology have revealed another pattern of intracellular signal transduction in which cells transmit information through the dynamics of key signaling molecules. Dynamical properties of p53 have been demonstrated to be the key factor in dictating cell fate, including ...

journal_title：Acta biochimica et biophysica Sinica

authors： Shi G,Wang Q,Zhou X,Li J,Liu H,Gu J,Wang H,Wu Y,Ding L,Ni S,Tang Z

更新日期：2017-04-01 00:00:00

abstract：:Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Liu J,Zhao Z,Wen L,Li H,Ren J,Liu H

更新日期：2018-03-01 00:00:00

abstract：:Caveolin-1 is regulated by estrogen in vascular smooth muscle cells. Raloxifene, a selective estrogen receptor modulator that possibly has cardioprotective properties without an increased risk of cancer or other side effects of estrogen, may be used in women with risk of coronary artery disease. However, the relations...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang FL,He H,Liu XX,Tu B,Zeng XW,Su JX,Wang X,Hu Q

更新日期：2006-11-01 00:00:00

abstract：:To study the molecular basis of heterosis, suppression subtractive hybridization was used to investigate the differences in gene expression between porcine Longissimus dorsi of F1 hybrids Large WhitexMeishan and their female parents Meishan. From two specific subtractive cDNA libraries, the clones selected by reverse ...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang T,Xiong YZ,Lei MG,Xu DQ,Deng CY

更新日期：2006-07-01 00:00:00

abstract：:Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the kil...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang HF,Chen YZ,Wu Y

更新日期：2005-07-01 00:00:00

abstract：:At initial stages in the Rhizobium legume symbiosis, most nodulation genes are controlled by NodD protein and plant inducers. Some genetic studies and other reports have suggested that NodD may be activated by its direct interaction with plant inducers. However, there has been no molecular evidence of such an inducing...

journal_title：Acta biochimica et biophysica Sinica

authors： Li F,Hou B,Chen L,Yao Z,Hong G

更新日期：2008-09-01 00:00:00

abstract：:Many harpins have been found in plant pathogen bacteria that can elicit disease and insect resistance in plants, and promote plant growth. In this work, we overexpressed and purified Xanthomonas oryzae pv. oryzae harpin, harpin(Xoo), in Escherichia coli BL21/pGEX-hpa1. Harpin(Xoo) was fused to the C-terminus of glutat...

journal_title：Acta biochimica et biophysica Sinica

authors： Li M,Shao M,Lu XZ,Wang JS

更新日期：2005-10-01 00:00:00