Abstract:
:The Hippo pathway plays important roles in organ development, tissue regeneration, and human diseases, such as cancer. In the canonical Hippo pathway, the MST1/2-LATS1/2 kinase cascade phosphorylates and inhibits transcription coactivators Yes-associated protein and transcription coactivator with PDZ-binding motif and thus regulates transcription of genes important for cell proliferation and apoptosis. However, recent studies have depicted a much more complicate picture of the Hippo pathway with many new components and regulatory stimuli involving both chemical and mechanical signals. Furthermore, accumulating evidence indicates that the Hippo pathway also plays important roles in the determination of cell fates, such as self-renewal and differentiation. Here, we review regulations of the Hippo pathway and its functions in stemness and differentiation emphasizing recent discoveries.
journal_name
Acta Biochim Biophys Sin (Shanghai)journal_title
Acta biochimica et biophysica Sinicaauthors
Cao X,Wang C,Liu J,Zhao Bdoi
10.1093/abbs/gmaa048subject
Has Abstractpub_date
2020-07-10 00:00:00pages
736-748issue
7eissn
1672-9145issn
1745-7270pii
5842208journal_volume
52pub_type
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journal_title:Acta biochimica et biophysica Sinica
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更新日期:2009-03-01 00:00:00
abstract::AMP-activated protein kinase (AMPK) is indispensable for the development and maintenance of brown adipose tissue (BAT), and its activity is inhibited due to obesity. The isocitrate dehydrogenase 2 (IDH2) is a mitochondrial enzyme responsible for the production of α-ketoglutarate, a key intermediate metabolite integrat...
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abstract::Caveolin-1 is regulated by estrogen in vascular smooth muscle cells. Raloxifene, a selective estrogen receptor modulator that possibly has cardioprotective properties without an increased risk of cancer or other side effects of estrogen, may be used in women with risk of coronary artery disease. However, the relations...
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abstract::G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are distributed in many locations in the human genome, including promoter regions, and are viewed as promising therapeutic targets. Uncoupling protein-1 (UCP1) is a mitochondrial thermogenic gene critical f...
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journal_title:Acta biochimica et biophysica Sinica
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doi:10.1093/abbs/gmp104
更新日期:2010-01-01 00:00:00
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journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmv129
更新日期:2016-02-01 00:00:00