Biological characteristics of dengue virus and potential targets for drug design.

Abstract:

:Dengue infection is a major cause of morbidity in tropical and subtropical regions, bringing nearly 40% of the world population at risk and causing more than 20,000 deaths per year. But there is neither a vaccine for dengue disease nor antiviral drugs to treat the infection. In recent years, dengue infection has been particularly prevalent in India, Southeast Asia, Brazil, and Guangdong Province, China. In this article, we present a brief summary of the biological characteristics of dengue virus and associated flaviviruses, and outline the progress on studies of vaccines and drugs based on potential targets of the dengue virus.

authors

Qi RF,Zhang L,Chi CW

doi

10.1111/j.1745-7270.2008.00382.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

91-101

issue

2

eissn

1672-9145

issn

1745-7270

journal_volume

40

pub_type

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