AMPKα1 regulates Idh2 transcription through H2B O-GlcNAcylation during brown adipogenesis.

abstract：:MicroRNAs are highly conserved endogenous small noncoding RNAs and demonstrated to play important roles in the metastatic cascade of papillary thyroid carcinoma (PTC), including the process of anoikis resistance. In this study, the correlation between miRNA-363-3p (miR-363-3p) expression and PTC metastasis was analyze...

journal_title：Acta biochimica et biophysica Sinica

authors： Pan Y,Zhu X,Wang K,Chen Y

更新日期：2019-08-05 00:00:00

abstract：:Hypoxia is a key component of the tumor microenvironment and represents a well-documented source of therapeutic failure in clinical oncology. Recent work has provided support for the idea that non-coding RNAs, and in particular, microRNAs, may play important roles in the adaptive response to low oxygen in tumors. Spec...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang X,Zuo J

更新日期：2014-03-01 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang H,Dong F,Wang Y,Wang X,Hong D,Liu Y,Zhou J

更新日期：2020-02-03 00:00:00

abstract：:The effect of the guanosine triphosphatase activating proteins (GAPs) on spermatogenesis has been studied for years, though no GAPs have been explored in epididymis, an essential organ for sperm maturation. In this study, a new GAP member, designated as MacGAP, was cloned in human epididymis. The MacGAP gene encodes a...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Liu Q,Liu S,Zhang J,Zhang Y

更新日期：2008-10-01 00:00:00

abstract：:It is important to determine the electron transfer activity and proton pumping ability of the cytochrome bc1 complex for better understanding its structure and function. In this study, several methods for determining the electron transfer and proton pumping of the bc1 complex, including the traditional and the new met...

journal_title：Acta biochimica et biophysica Sinica

authors： Qu Y,Dong F

更新日期：2015-02-01 00:00:00

abstract：:Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and thus irreversibly inactivate ribosome for protein synthesis. Cinnamomin is a multifunctional type II RIP isolated in our laborat...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu H,Liu WY

更新日期：2004-03-01 00:00:00

abstract：:Germ cell nuclear factor (GCNF) is a transcription factor that can repress gene transcription and plays an important role during spermatogenesis. Peroxisome proliferator-activated receptor delta (PPARdelta) is a nuclear hormone receptor belonging to the steroid receptor superfamily. It can activate the expression of m...

journal_title：Acta biochimica et biophysica Sinica

authors： He C,Ding N,Kang J

更新日期：2008-03-01 00:00:00

abstract：:The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, fi...

journal_title：Acta biochimica et biophysica Sinica

authors： Guamán Ortiz LM,Croce AL,Aredia F,Sapienza S,Fiorillo G,Syeda TM,Buzzetti F,Lombardi P,Scovassi AI

更新日期：2015-10-01 00:00:00

abstract：:The Hippo pathway was initially identified in Drosophila by genetic mosaic screens for tumor suppressor genes. Researches indicated that the Hippo pathway is a key regulator of organ size and is conserved during evolution. Furthermore, studies of mouse models and clinical samples demonstrated the importance of Hippo p...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu C,Li L,Zhao B

更新日期：2015-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell apoptosis. Zinc finger E-box binding homeobox factor 1 (ZEB1) is a crucial mediator of epithelial-mesenchymal transition (EMT). It induces mali...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao L,Li R,Xu S,Li Y,Zhao P,Dong W,Liu Z,Zhao Q,Tan B

更新日期：2018-02-01 00:00:00

abstract：:Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased and down-regulation of ASS1 was closely corre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tao X,Zuo Q,Ruan H,Wang H,Jin H,Cheng Z,Lv Y,Qin W,Wang C

更新日期：2019-03-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cell lines, suggesting its great potential in cancer therapy. Many components in TRAIL-mediated signaling pathway have been identified, but how they interact with each other to determine the network dynamics and final apoptosis remain...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang T,Wu M,Chen Q,Sun Z

更新日期：2010-02-01 00:00:00

abstract：:CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative prote...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong MQ,Gu Y,Hu XB,Sun Y,Ma L,Li XL,Sun LX,Sun J,Qian J,Zhu CL

更新日期：2005-05-01 00:00:00

abstract：:Lung cancer is one of the most lethal cancers in China because of high incidence and high mortality. Cyclooxygenase-2 (COX-2) and vessel endothelial growth factor C (VEGF-C) were found to play an important role in lymphangiogenesis of malignant tumors. In this study, we investigated whether lymphatic microvessel densi...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo X,Chen Y,Xu Z,Xu Z,Qian Y,Yu X

更新日期：2009-03-01 00:00:00

abstract：:The present study aims to characterize the effect of chronic intermittent hypoxia and HIF1α on the non-alcoholic steatohepatitis (NASH) process in mice, and to explore the role of the Treg/Th17 balance in the formation of NASH inflammation and fibrosis. To achieve this purpose, simple steatosis was induced in mice by ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Li W,Zhu W,He W,Zhao H,Xiang Y,Liu C,Wu W

更新日期：2018-12-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the key devastating bacterial pathogen responsible for tuberculosis. Increasing emergence of multi-drug-resistant, extensively drug-resistant, and rifampicin/isoniazid-resistant strains of Mtb makes the discovery of validated drug targets an urgent priority. As a vital translational...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang J,Hong J,Luo L,Liu K,Meng C,Ji ZL,Lin D

更新日期：2019-02-01 00:00:00

abstract：:Here we report that tgdA, a novel gene encoding a putative transglycosylase, affects both the morphological differentiation and the yield of blue-pigmented compound actinorhodin in Streptomyces coelicolor. The tgdA null mutant displays sparse aerial hyphae and irregular spore chains frequently lacking chromosomal DNA....

journal_title：Acta biochimica et biophysica Sinica

authors： Xie P,Zeng A,Lv X,Cheng Q,Qin Z

更新日期：2013-04-01 00:00:00

abstract：:The study was undertaken to examine the effects of C-peptide on glomerular volume (V(GLOM)), mesangial matrix synthesis, and degradation in streptozotocin (STZ)-diabetic rats with poor or moderate glycemic control. Series 1 (poor glycemic control) included groups of healthy rats, hyperglycemic rats, diabetic insulin-t...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun W,Gao X,Zhao X,Cui D,Xia Q

更新日期：2010-12-01 00:00:00

abstract：:Although viral vectors are efficient systems to transfer foreign genes into cells or target tissues, safety issues remain in relation to human gene therapy. Microbubbles currently used as ultrasound contrast agents have been applied in transfection of genes. This study was designed to test the transfection efficiency ...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo DP,Li XY,Sun P,Wang ZG,Chen XY,Chen Q,Fan LM,Zhang B,Shao LZ,Li XR

更新日期：2004-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis. In this study, we explored the expression patterns of Snail1 and a cardiac fibrosis marker-...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Y,Du J,Zhang J,Weng M,Li X,Pu D,Gao L,Deng S,Xia S,She Q

更新日期：2012-11-01 00:00:00

abstract：:Growth arrest specific 2 (GAS2) modulates cell cycle, apoptosis, and Calpain activity. GAS2-Calpain2 axis is required for the growth of BCR-ABL(+) hematopoietic cells and chronic myeloid leukemia cells. However, the expression of GAS2 in acute leukemia patients remains unclear and what role GAS2-Calpain2 axis plays in...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun L,Zhou H,Liu H,Ge Y,Zhang X,Ma W,Wu D,Zhao Y

更新日期：2015-10-01 00:00:00

abstract：:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) play a vital role in viral control and clearance. Recent studies have elucidated that Tapasin, an endoplasmic reticulum chaperone, is a well-known molecule that appears to be essential in peptide-loading process. The Janus kinase/signal transducers and ac...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu S,Chen X,Tang Y,Zhang Y,Li D,Chen J,Wang J,Tang Z,Zang G,Yu Y

更新日期：2018-02-01 00:00:00

abstract：:Thyroid cancer is one of the common malignancies of the endocrine system and the number of thyroid cancer cases is increasing constantly. Significant work has focused on the molecular mechanisms of thyroid cancer, but many mechanisms remain undiscovered. In this study, we employed a comprehensive analysis of whole-tra...

journal_title：Acta biochimica et biophysica Sinica

authors： Guan Y,Bhandari A,Xia E,Kong L,Zhang X,Wang O

更新日期：2020-02-03 00:00:00

abstract：:Emodin, a natural anthraquinone extracted from the Chinese herbs rhubarb and giant knotweed rhizome, has been reported to enhance osteoblast differentiation. However, the mechanisms underlying its ability to regulate osteogenesis are unclear. The objective of this study was to determine the role of emodin in osteoblas...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen X,Zhang S,Chen X,Hu Y,Wu J,Chen S,Chang J,Wang G,Gao Y

更新日期：2017-10-01 00:00:00

abstract：:The ORF of genome segment 6 (S6) of rice ragged stunt oryzavirus (RRSV) Philippines isolate was cloned and sequenced based on the S6 sequence of the Thailand isolate. Pns6, the 71 kD product of S6 expressed in E. coli, was demonstrated to be a viral non-structural protein of RRSV by Western blotting. The gel mobility ...

journal_title：Acta biochimica et biophysica Sinica

authors： Shao CG,Lü HJ,Wu JH,Gong ZX

更新日期：2004-07-01 00:00:00

abstract：:Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Liu J,Zhao Z,Wen L,Li H,Ren J,Liu H

更新日期：2018-03-01 00:00:00

abstract：:Bcl-2, a prominent member of the Bcl-2 family proteins, is responsible for the dysregulation of apoptosis and resistance to chemotherapy. In this study, we investigated whether small hairpin RNA (shRNA) targeting at Bcl-2 mRNA could enhance cytarabine (Ara-C)-induced apoptosis in Raji cells. Bcl-2 shRNA was transfecte...

journal_title：Acta biochimica et biophysica Sinica

authors： He D,Fang B

更新日期：2009-02-01 00:00:00

abstract：:In the present study, we tested the effect of cold water stress (CWS) on dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model, and found that CWS pretreatment elicited less MPTP neurotoxicity. To understand the molecular mechanism underlying this phen...

journal_title：Acta biochimica et biophysica Sinica

authors： Xia M,Bian M,Yu Q,Liu J,Huang Y,Jin X,Lu S,Yu M,Huang F

更新日期：2011-06-01 00:00:00

abstract：:An L-amino acid oxidase (LAAO), NA-LAAO, was purified from the venom of Naja atra. Its N-terminal sequence shows great similarity with LAAOs from other snake venoms. NA-LAAO dose-dependently induced aggregation of washed human platelets. However, it had no activity on platelets in platelet-rich plasma. A low concentra...

journal_title：Acta biochimica et biophysica Sinica

authors： Li R,Zhu S,Wu J,Wang W,Lu Q,Clemetson KJ

更新日期：2008-01-01 00:00:00

abstract：:Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. This study ai...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Hu J,Yu T,You S,Zhang Y,Hu L

更新日期：2019-05-23 00:00:00